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Stacking Leucic Acid (HICA) With BCAAs to Fight Muscle Catabolism — Tiger Fitness Learn how to prevent muscle wasting and muscle tissue breakdown by stacking anti-catabolic supplements such as leucic acid (HICA) and BCAAs. Prevent muscle tissue breakdown by stacking anti-catabolic supplements such as leucic acid (HICA) and BCAAs. In the present study, the BCAAs (branched-chain amino acids) leucine and valine caused a significant suppression in the loss of body weight in mice bearing a cachexia-inducing tumour (MAC16), producing a significant increase in skeletal muscle wet weight, through an increase in protein synthesis and a decrease in degradation. The increase rate of utilization of branched-chain amino acids (BCAA) by muscle is reduced to its plasma concentration during prolonged exercise leading to glycogen.
BCAA supplementation would reduce the serum activities of intramuscular enzymes. XAA Stack 4:1:1 BCAA Ratio + HICA contains L-Leucine (Instantized), L-Isoleucine and L-Valine which are all biosynthesis of proteins. Fortunately, it contains 0gr of sugar and comes in flavours of apple and passion fruit. The ratio in XAA Stack 4:1:1 BCAA Ratio + HICA. Ratios of BCAA’s simply mean the ratio of each amino acid to another.
HICA is the acronym for alpha-hydroxy-isocaproic acid. It is also called leucic acid or DL-2-hydroxy-4-methylvaleric acid. Putting nerd-speak aside, HICA is just a much easier term to remember, and it is actually one of the 5 key ingredients in our MPO (Muscle Performance Optimizer) product. HICA-MAX™ works by decreasing muscle protein breakdown (catabolism).
Its mode of action has been suggested as an independent mTOR signal transducer, which is a “cell-signaler” for muscle protein synthesis. Leucic acid also interrupts muscle protein breakdown by activating nuclear factor kappa B and inhibiting caspase-8. It is the main branch chain (and essential) amino acid that stimulates muscle protein synthesis and is important for everybody who is looking to build muscle or lose fat. Knowing how leucine works is imperative when trying to comprehend what the subject of this article is, since it. So, these study participants weren’t eating the recommended 2 to 3 grams of BCAAs per sitting in their low-calorie diet, but when they took BCAA supplements, it helped them retain muscle.
In a study on endurance athletes, BCAA supplementation decreased muscle breakdown. Other studies have also shown that after strength training, even in resistance-trained athletes, muscle catabolism is increased for 4-14 hours, followed by a muscle-building phase. The initial site of most of the BCAA catabolism is skeletal muscle because of the BCAT high activity.
The BCAT reaction involves the reversible transfer of the BCAA amino group to α-ketoglutarate (α-KG) to form glutamate and the corresponding branched-chain keto acids (BCKAs), α-ketoisocaproate (KIC, ketoleucine), α-keto-β-methylvalerate (KMV, ketoisoleucine), and α.
List of related literature:
|from Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength|
|from Practical Applications in Sports Nutrition|
|from Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health Outcomes in Military Personnel|
|from Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition|
|from Krause’s Food & the Nutrition Care Process E-Book|
|from Cunningham’s Textbook of Veterinary Physiology E-Book|
|from The Longevity Solution: Rediscovering Centuries-Old Secrets to a Healthy, Long Life|
|from Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications|
|from Academy of Nutrition and Dietetics Complete Food and Nutrition Guide, 5th Ed|
|from Encyclopedia of Human Nutrition|