Stacking Leucic Acidity (HICA) With BCAAs to battle Muscle Catabolism

 

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Stacking Leucic Acid (HICA) With BCAAs to Fight Muscle Catabolism — Tiger Fitness Learn how to prevent muscle wasting and muscle tissue breakdown by stacking anti-catabolic supplements such as leucic acid (HICA) and BCAAs. Prevent muscle tissue breakdown by stacking anti-catabolic supplements such as leucic acid (HICA) and BCAAs. In the present study, the BCAAs (branched-chain amino acids) leucine and valine caused a significant suppression in the loss of body weight in mice bearing a cachexia-inducing tumour (MAC16), producing a significant increase in skeletal muscle wet weight, through an increase in protein synthesis and a decrease in degradation. The increase rate of utilization of branched-chain amino acids (BCAA) by muscle is reduced to its plasma concentration during prolonged exercise leading to glycogen.

BCAA supplementation would reduce the serum activities of intramuscular enzymes. XAA Stack 4:1:1 BCAA Ratio + HICA contains L-Leucine (Instantized), L-Isoleucine and L-Valine which are all biosynthesis of proteins. Fortunately, it contains 0gr of sugar and comes in flavours of apple and passion fruit. The ratio in XAA Stack 4:1:1 BCAA Ratio + HICA. Ratios of BCAA’s simply mean the ratio of each amino acid to another.

HICA is the acronym for alpha-hydroxy-isocaproic acid. It is also called leucic acid or DL-2-hydroxy-4-methylvaleric acid. Putting nerd-speak aside, HICA is just a much easier term to remember, and it is actually one of the 5 key ingredients in our MPO (Muscle Performance Optimizer) product. HICA-MAX™ works by decreasing muscle protein breakdown (catabolism).

Its mode of action has been suggested as an independent mTOR signal transducer, which is a “cell-signaler” for muscle protein synthesis. Leucic acid also interrupts muscle protein breakdown by activating nuclear factor kappa B and inhibiting caspase-8. It is the main branch chain (and essential) amino acid that stimulates muscle protein synthesis and is important for everybody who is looking to build muscle or lose fat. Knowing how leucine works is imperative when trying to comprehend what the subject of this article is, since it. So, these study participants weren’t eating the recommended 2 to 3 grams of BCAAs per sitting in their low-calorie diet, but when they took BCAA supplements, it helped them retain muscle.

In a study on endurance athletes, BCAA supplementation decreased muscle breakdown. Other studies have also shown that after strength training, even in resistance-trained athletes, muscle catabolism is increased for 4-14 hours, followed by a muscle-building phase. The initial site of most of the BCAA catabolism is skeletal muscle because of the BCAT high activity.

The BCAT reaction involves the reversible transfer of the BCAA amino group to α-ketoglutarate (α-KG) to form glutamate and the corresponding branched-chain keto acids (BCKAs), α-ketoisocaproate (KIC, ketoleucine), α-keto-β-methylvalerate (KMV, ketoisoleucine), and α.

List of related literature:

On the other hand, it is a potent inhibitor of branched-chain α-keto acid dehydrogenase and may lead to increased catabolism of branched-chain amino acids (BCAAs) [21].

“Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength” by Debasis Bagchi, Sreejayan Nair, Chandan K. Sen
from Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength
by Debasis Bagchi, Sreejayan Nair, Chandan K. Sen
Elsevier Science, 2013

The branched chain amino acids (BCAAs), which are essential amino acids, can be metabolized for energy directly within the muscle itself.

“Practical Applications in Sports Nutrition” by Heather Hedrick Fink, Lisa A. Burgoon, Alan E. Mikesky
from Practical Applications in Sports Nutrition
by Heather Hedrick Fink, Lisa A. Burgoon, Alan E. Mikesky
Jones and Bartlett Publishers, 2006

In rodent tissue in vitro, increased concentrations of BCAAs stimulate protein synthesis and inhibit protein catabolism, whereas other amino acid mixtures lacking BCAAs have no such influence.

“Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health Outcomes in Military Personnel” by Institute of Medicine, Food and Nutrition Board, Committee on Nutrition, Trauma, and the Brain, Laura Pillsbury, Maria Oria, John Erdman
from Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health Outcomes in Military Personnel
by Institute of Medicine, Food and Nutrition Board, et. al.
National Academies Press, 2011

nate, levels of the three BCAAs consumed by mice, we recently determined that restriction of dietary BCAA is as effective as reduction of dietary protein by the same amount with regard to metabolic health, improving glucose tolerance, alleviating b cell metabolic stress, and reducing adiposity (Fontana et al., 2016).

“Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition” by Raffaele De Caterina, J. Alfredo Martinez, Martin Kohlmeier
from Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition
by Raffaele De Caterina, J. Alfredo Martinez, Martin Kohlmeier
Elsevier Science, 2019

Branched-Chain Amino Acids (BCAAs) The BCAAs include leucine, isoleucine, and valine, and they make up 35% to 40% of the essential amino acids (EAAs) in the body’s protein and 14% of the total AAs in muscle.

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from Krause’s Food & the Nutrition Care Process E-Book
by L. Kathleen Mahan, Janice L Raymond
Elsevier Health Sciences, 2016

Thus the overall metabolic activity in muscle during the postabsorptive phase is the destruction of BCAAs and the formation of alanine.

“Cunningham's Textbook of Veterinary Physiology E-Book” by Bradley G. Klein
from Cunningham’s Textbook of Veterinary Physiology E-Book
by Bradley G. Klein
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Importantly, branched-chain amino acids (BCAAs) are metabolized less by the liver, so they may be especially beneficial for muscle growth because of increased availability.18

“The Longevity Solution: Rediscovering Centuries-Old Secrets to a Healthy, Long Life” by Dr. James DiNicolantonio, Dr. Jason Fung
from The Longevity Solution: Rediscovering Centuries-Old Secrets to a Healthy, Long Life
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BCAAs stimulate SCFAs production, and SCFAs with straight chain affect the gut microbiota, which is responsible for production from carbohydrate fermentation and BCAAs.

“Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications” by Joel Faintuch, Salomao Faintuch
from Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications
by Joel Faintuch, Salomao Faintuch
Elsevier Science, 2019

Amino acid supplementssuchasarginine, branched-chain amino acids (BCAAs, orisoleucine, leucine, and valine), and ornithine are said to promote muscle growth, reduce muscle breakdown during exercise, and increase fat loss.

“Academy of Nutrition and Dietetics Complete Food and Nutrition Guide, 5th Ed” by Roberta Larson Duyff
from Academy of Nutrition and Dietetics Complete Food and Nutrition Guide, 5th Ed
by Roberta Larson Duyff
HMH Books, 2017

BCAAs are primarily oxidized in skeletal muscle and not in the liver.

“Encyclopedia of Human Nutrition” by Benjamin Caballero, Lindsay Allen, Andrew Prentice
from Encyclopedia of Human Nutrition
by Benjamin Caballero, Lindsay Allen, Andrew Prentice
Elsevier Science, 2005

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

[email protected]

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9 comments

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  • Colette Nelson is my diet coach is this going to screw my sugar intake how about Trojan horse with these products have glucose they would fuck up my diet?

  • Hey man, sorry to hear about your poor experience. Trust me, i’ve been there:) Because the supplement industry is not regulated, companies can pretty much say anything on the label. Not saying you are, but they’re good at reeling in beginners by using fancy packaging and phrases like “MAXIMUM MUSCLE GROWTH” or “INSANE ANABOLIC STIMULATOR” but in the end you gotta read the labels. If you were having discomfort with HICAmax before a PWO, i’d eliminate the variables and take HICA other times during the day-as soon as you wake up, or right before bed, in between meals even just to figure out if it was indeed the HICA causing the pain or the mix with that and a PWO. Also, my last point is that these BB supplements are suppose to SUPPLEMENT an already solid diet and exercise plan so (and again i’m not saying this is the case) maybe the lack of results had to do with a nutritional fault, intensity lag in the gym, or even lack of sleep. Anyways, again, sucks to hear about your discomfort!

  • Theres a product by PMD platinum that has HICA and bcaas combined i drink up to 3 scoops a day and also mix it with my preworkout shake, which is whey protein, waxy maze, creatine, and glutamine. I have not had any stomach issues or any bad side effects

  • did the product upset ur stomach because u had some other pills working against the HICA. am interested in buying the hica from labrada. did u try to use the hica with out anything else?

  • I would say your body didn’t take it well or it was the other supplement you took with it. I took this for a month and gained 4 pounds of muscle with NO stomach pain at all.. Also if you read the reviews there are hundreds who agree with me. Some people just don’t do we’ll with Bcaas..

  • or that Hica max says not to take with any proteins or amino acids, which the pre work out you said you took probably has amino acids in it.

  • Great video. With my use if HICA along with HMB I believe that these two do absolutely nothing to help grow bigger muscles. However I do feel that it does increase the quality and hardness of those muscles and they may work best as some kind of muscle protector. In other words bodybuilders that use steroids may want to use this stack to see if they help preserve and keep any gains while on the juice.

  • When I first tried Hica max back in 2011 I got the most swolled Ive ever been with 2 months using it and no other supplements besides whey protein postworkout. It works very well. i recently started taking it again and in 2 weeks time can feel the size coming back already. Bottom line is that this stuff works period.

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