Improving Memory, Focus Stopping Cognitive Decline With Such 5 Compounds

 

Dr. Dale Bredesen on Preventing and Reversing Alzheimer’s Disease

Video taken from the channel: FoundMyFitness


 

Dementia: Can your brain keep up with the game?

Video taken from the channel: Demystifying Medicine


 

What is Mild Cognitive Impairment? (Symptoms, Causes, Treatment, Prevention)

Video taken from the channel: healthery


 

Reversing Alzheimer’s, Cognitive Decline, & Neurodegenerative Disease

Video taken from the channel: WholisticMatters


 

Preventing Cognitive Decline and Dementia: A Way Forward

Video taken from the channel: NASEM Health and Medicine Division


 

3 Steps to Preventing Cognitive Decline | Inc.

Video taken from the channel: Inc.


 

How Ketogenic Diets and Blueberries Make Your Brain Work Better

Video taken from the channel: Max Lugavere


 

Dr. Dale Bredesen on Preventing and Reversing Alzheimer’s Disease

Video taken from the channel: FoundMyFitness


 

Staying Sharp: Current and Future Approaches to Brain Health and Alzheimer’s Therapeutics

Video taken from the channel: University of California Television (UCTV)


 

Dementia: Can your brain keep up with the game?

Video taken from the channel: Demystifying Medicine


 

What is Mild Cognitive Impairment? (Symptoms, Causes, Treatment, Prevention)

Video taken from the channel: healthery


 

Preventing Cognitive Decline and Dementia: A Way Forward

Video taken from the channel: NASEM Health and Medicine Division


 

3 Steps to Preventing Cognitive Decline | Inc.

Video taken from the channel: Inc.


 

10 Foods That May Help Prevent Dementia

Video taken from the channel: Goodful


Each section discusses clinical evidence, dosages, and products with the brain-boosting compound. 5 Compounds to Improve Memory, Focus & Fight Cognitive Decline #1 Gingko Biloba. Gingko Biloba is one of the oldest trees in the world, its leaf extracts being used for both traditional and folk medicine for thousands of years. Whether you want to improve focus, enhance memory, or protect your brain in the long term, we could all benefit from better brain health.

And as it turns out, one of the most effective and natural ways to improve memory and focus is by heading to the kitchen. Read on for five ways to give your brain some love in the form of food. Flavonoids. Nootropic compounds that may enhance memory have been the subject of research during the past several decades.

These so-called “smart-drugs” have the potential to benefit everyone from college students seeking to improve exam scores to elderly men and women suffering from cognitive decline. 5 Ways to Prevent Cognitive Decline. by Chef Murph Author. By Chef K.T.Murphy What you do in your early adult years can have major repercussions on the health of your brain. Making good lifestyle choices early on can prevent your cognitive abilities from declining as you age.

Staying away from drugs, alcohol and smoking can mean a world of. These 25 tips and tricks are some of the most effective methods for improving memory. have been shown to delay cognitive decline. boost your memory and focus, help prevent. These anecdotal reports are supported by research demonstrating that a ketogenic diet improves memory and mild cognitive impairment. ( 12, 13 ) Conversely, if you’ve been low carb or keto for a while and have noticed a decline in your memory, focus, or. Some of the most popular ingredients in memory pills are natural and even essential for normal brain functioning.

Some of these popular natural ingredients include omega-3 fatty acids, folate, vitamins C, E, B12, B9, and B6, Ginkgo biloba and others. Vit B12 as Methylcobalamin: enhances focus and concentration and improve one’s memory. Vit C as Ascorbic Acid: decrease fatigue and improves mood. Vit D3 as Microencapsulated Cholecalciferol: assist in preventing age-related diseases. BioPQQ: helps to prevent cognitive decline; Algal DHA: Improves memory, focus, concentration and balances out.

The compound is found naturally occurring in the brain and studied for synergistic effects. For elderly, one of the main benefits of phosphatidylserine is preventing cognitive decline. One Japanese study of elderly individuals showed that taking phosphatidylserine for 6 months could stave off cognitive decline and signs of dementia [8]. 4 Ways to Stop Age-Related Memory Loss. Experts offer tips on how to prevent the decline.

Plus, how to tell if it’s a senior moment or an early sign of Alzheimer’s.

List of related literature:

Antioxidant herbs: Ginkgo biloba extract treats Alzheimer’s by normalizing acetylcholine receptors and increasing cholinergic transmission.

“Detoxification: All You Need to Know to Recharge, Renew and Rejuvenate Your Body, Mind and Spirit” by Linda Page
from Detoxification: All You Need to Know to Recharge, Renew and Rejuvenate Your Body, Mind and Spirit
by Linda Page
Healthy Healing Publications, 1998

There you will nd a collection of supplements which, the labels say, ‘may’ enhance memory—for example, ginkgo or omega-3 sh oils.

“Psychology: From Inquiry to Understanding” by Scott Lilienfeld, Steven Jay Lynn, Laura Namy, Nancy Woolf, Graham Jamieson, Anthony Marks, Virginia Slaughter
from Psychology: From Inquiry to Understanding
by Scott Lilienfeld, Steven Jay Lynn, et. al.
Pearson Higher Education AU, 2014

Acetylcholine-supporting compounds include choline, phosphatidylcholine, acetyl-L-carnitine, and many herbal nootropics (that is, natural compounds that improve cognitive functioning), such as ginkgo and ginseng.

“Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging” by Ben Greenfield
from Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging
by Ben Greenfield
Victory Belt Publishing, 2020

Rosemary and peppermint can improve alertness and enhance memory.

“Integrative and Functional Medical Nutrition Therapy: Principles and Practices” by Diana Noland, Jeanne A. Drisko, Leigh Wagner
from Integrative and Functional Medical Nutrition Therapy: Principles and Practices
by Diana Noland, Jeanne A. Drisko, Leigh Wagner
Springer International Publishing, 2020

Herbs such as Rosmarinus officinalis enhance memory and cognition.

“Clinical Naturopathic Medicine” by Leah Hechtman
from Clinical Naturopathic Medicine
by Leah Hechtman
Elsevier Health Sciences APAC, 2018

Examples of treatable and even reversible causes of cognitive decline and memory loss include hormonal imbalances, brain tumors, infections, nutritional deficiencies (e.g., folate and vitamin Focus On: B12 Polypharmacy ), and the side in effects Older of Adults numerous in Chapter medications 8).

“Krause's Food & the Nutrition Care Process, Mea Edition E-Book” by L. Kathleen Mahan, Janice L. Raymond
from Krause’s Food & the Nutrition Care Process, Mea Edition E-Book
by L. Kathleen Mahan, Janice L. Raymond
Elsevier Health Sciences, 2016

A mixed diet containing magnesium, folic acid, calcium, selenium, zinc, omega-3s, and antioxidant foods improves the functions of brain receptors.

“Nutritional Foundations and Clinical Applications E-Book: A Nursing Approach” by Michele Grodner, Sylvia Escott-Stump, Suzanne Dorner
from Nutritional Foundations and Clinical Applications E-Book: A Nursing Approach
by Michele Grodner, Sylvia Escott-Stump, Suzanne Dorner
Elsevier Health Sciences, 2018

Other herbs demonstrated to improve cognitive function include gotu kola (see monograph), Schisandra and Rhodiola.

“Principles and Practice of Phytotherapy E-Book: Modern Herbal Medicine” by Kerry Bone, Simon Mills
from Principles and Practice of Phytotherapy E-Book: Modern Herbal Medicine
by Kerry Bone, Simon Mills
Elsevier Health Sciences, 2013

• Evaluate all herbal and/or nutraceutical products that the individual might be using to improve their memory function.

“Nursing Diagnosis Handbook E-Book: An Evidence-Based Guide to Planning Care” by Betty J. Ackley, Gail B. Ladwig
from Nursing Diagnosis Handbook E-Book: An Evidence-Based Guide to Planning Care
by Betty J. Ackley, Gail B. Ladwig
Elsevier Health Sciences, 2010

Another measure that can help enhance memory is maintaining good dietary habits.

“Journey Across the Life Span: Human Development and Health Promotion” by Elaine U Polan, Daphne R Taylor
from Journey Across the Life Span: Human Development and Health Promotion
by Elaine U Polan, Daphne R Taylor
F.A. Davis Company, 2019

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

[email protected]

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142 comments

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  • there are many essential nutrients, besides B12 that are exclusively found in useful forms and amounts, in animal foods:

    vitamin A (retinol)
    vitamin D3
    vitamin K2
    Omega 3 (DHA & EPA)
    selenium
    Haem iron
    calcium
    zinc

    and many highly valuable nutrients besides:

    creatine
    choline
    carnitine
    collagen
    taurine

  • red meat, eggs and heme iron (aka animal iron) are all known to be associated with higher rates of Alzheimer’s. Yikes. Stay away from this diet. You need to do your hw

    https://youtu.be/v_ONFix_e4k

  • I don’t see turmeric here. Curcumin in turmeric has been proven to prevent Alzheimer’s. Not to mention that countries with a high turmeric consumption have very Low rates of neurodegenerative diseases.

  • Deberían traducir esto diferentes idiomas entre ellos al español. Mi mamá debería saber esto, muy buena información, ¡muchas gracias!

  • If you are positive in several Herpes viruses, May it be a good idea a continuous retroviral medications for your brain and health in general? (although you do not have any symptoms)

  • So how do we get REAL blood tests done from doctors who know what there doing?? I feel like hell and I do eat crappy food all the time but yet my blood work always comes back PERFECT according to the doctor’s I go to???? Hey clearly do not know what the fuck to look for in health problems

  • I will definitely be saving this video, because I have PTSD, which puts me at risk for Alzheimer’s. I’ve already got some cognitive glitches, so it’s got me really doubling down on prevention. Thanks, man!

  • I have being suffering from herpes virus for couples of years and I had to tryna use herbal treatment from MADIDAHERBALCENTER though I have uses black seed oil and other pills before that. I went for a test last month after using Madida herbal center ‘s herbs and I was tested negative. I felt lucky knowing about Madida herbal center.

  • I was diagnosed a kind of brain problem or Chiari malformation suffered a lot of pains even lost my memory like my middle name scary. But then because I find a good omega3 balance oil here in Norway im getting better our brain we need a good nutrients. Dr Paul Clayton Scientists Nutritionist discussed about the Zinzino omega3 balance oil

  • Thank you for this video, as a RN I see a lot of people with dementia, so anything that could help prevent it I am grateful! FOOD HEALS! ��

  • Train your mind like you train your body.

    Disconnect from technology for moments in a day and give your mind the chance to figure things out. Our phone is making our brains lazy..

  • It is not accurate to say that nerve cells cannot be regenerated. There are preclinical research studies performed in mice showing the unique cannabinoid CBD promoted neurogenesis or the formation of new brain cells in adult mice. Other interventions, including exercise and brain games may promote neurogenesis and neural net connections.

  • Why do u make such lousy videos? For everything in this video you say No treatment, unknown factors, study shows but not confirmed. Every damn thing is don’t know or a maybe etc….Pls make video only if u are 100% convinced and you have all answers���� pleassseee. Don’t waste ppls time. And the music is so happy happy… and the content is so depressing, Are you really serious?? Are you for real?

  • Not very useful to me. Thought this would be a more practical discussion of brain health; things we can really do to offset this horrible brain disease like ways to improve brain health like diet and exercise. Nutrition and exercise to me are the most important things for brain and overall health and she didn’t even mention that here. Will keep searching for more useful info

  • I understand that you are not optimist about the approvement of your drug targetting AMYLOIDE PLAQUES…as they are not the cause of Alzheimer’s desease ( see DALE BREDESEN’s lectures)

  • Only 12 to 18hrs Fasts, very good.
    Suspect that when a Placebo is effective, it’s because it interrupts Nocebo causes of imbalance accumulation, usually too much Carbohydrates.

    Exercise, it’s not that different from Nutrients when you pay attention to consequences. It’s an awareness thing?

    Great (and entertaining) lecture.

  • Hey, guys! If you like this podcast, I would encourage you to check out Dr. Bredesen’s book where he goes in much greater depth, and also check out our show notes. Thanks to the support of fans, we’re able to really put the energy in and go all out on the notes, so make sure to take advantage of those.

    ▶︎ Get Dr. Bredesen’s New York Times and Wallstreet Journal best selling book The End of Alzheimer’s.
    https://amzn.to/2R9rfIn

    ▶︎ Get the episode’s show notes and transcript.
    https://www.foundmyfitness.com/episodes/dale-bredesen

    ▶︎ Submit your raw genetic data to run the APOE report.
    https://www.foundmyfitness.com/genetics

    This podcast is focused on niche content to say the least, so if you enjoy it, please also consider joining the community the nurtures the very existence of the show through their pay-what-you-can pledges. Learn more about that at
    https://www.foundmyfitness.com/crowdsponsor. Thanks for your consideration!

  • Why do u make such lousy videos? For everything in this video you say No treatment, unknown factors, study shows but not confirmed. Every damn thing is don’t know or a maybe etc….Pls make video only if u are 100% convinced and you have all answers���� pleassseee. Don’t waste ppls time. And the music is so happy happy… and the content is so depressing, Are you really serious?? Are you for real?

  • Am guessing at 09:20 talking of low zinc/ high Copper, is referring to serum or RBC or hair element labs? Was going to get a Ceruloplasmin serum lab but maybe the whole panel (figure wont find a dr to get done so will have to pay for. (after paying for required insurance!). Are there signs of low zinc or high copper…? AM good for all the biomarkers done yet. Will get a Hc lab also. https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-018-0444-2

  • Thank you for putting so much effort into this video. It’s very helpful. Especially the running footnotes. Saves me the trouble of looking up everything into the paper again and again:’)

  • Everything is prevention! I read the book, and links to a website were he sell products for this illness, but the vitamins he sell are synthetics, which are no good for the body.

  • mico toxins are increased hundreds of times when exposed to emf from call phones wifi etc yet another reason to wire up and limit exposure

  • The discussion and relationship between chronic inflammation and neurodegeneration is spot on. I have published several books about this relationship and how funneled mistake prone immune arsenal into interstitial spaces increases rather then decreases inflammation which in the case of AD involves the secretion of amyloid by astrocytes. and microglia. #Rejuvenation(2017) #Trafficking(2018) #Rejuvenation2.0(2019)

  • APOE genotype regulates pathology and disease progression in synucleinopathy. Most of the studies in AD have been focused on investigating the role of Aβ and Tau; however, recent studies suggest that α-syn might also play a role in the pathogenesis of AD. ApoE may regulate aSyn pathophysiology directly, independent of its effects on AD or tau (16–18). Aβ and α-syn might directly interact under pathological conditions leading to the formation of toxic oligomers and nanopores that increase intracellular calcium. The interactions between Aβ and α-syn might also result in oxidative stress, lysosomal leakage, and mitochondrial dysfunction.
    https://www.ncbi.nlm.nih.gov/pubmed/32024799 (2020)
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727399/?report=classic

  • Dr Bredesen is so incredible. Super knowledgeable, on top of things, communicates something so complex in such a simple way, stays his course in a non-defensive way in our crazy world of drug and symptom focused medicine. Docs like him and the groundbreaking approaches like this are the future of medicine!! A heartfelt thank you, Dr Bredesen!

  • https://youtu.be/Sq7uVZ_0D3U. The cure that UCLA came up for this disease is not for people this far down the road, but it did cure 9/10 patients in a small study, who were not this far gone. You can read Bredensen’s book or watch the link, but if you’re like me, I opted for reading his report in the medical literature first. This is the title of report 2016, “Reversal of Cognitive Decline in Alzheimer’s Disease” look it for at pubmed, the complete article is free. Sadly it’s a treatment that you will not like and that you must follow for the rest of your life, exercise, keto style, etc…

  • Train your mind like you train your body.

    Disconnect from technology for moments in a day and give your mind the chance to figure things out. Our phone is making our brains lazy..

  • Murine Gut Microbiome Association With APOE Alleles.
    The mechanism(s) whereby APOE alleles may differentially modulate the gut microbiome is not known. In overview, we theorize that apoE alleles differentially modulate the basal inflammation state of intestinal macrophages, which are key regulators of innate lymphoid cells in the gut and, in turn, impact the gut microbiome. The rationale for this includes (i) APOE4 is associated with a greater pro-inflammatory response in multiple studies, e.g., treatment with LPS results in a greater plasma cytokine response in APOE4 positive humans, compared to APOE4 negative individuals (16). Similarly, treatment with bacterial lipoproteins or with LPS has been reported to produce an increased cytokine response in the APOE murine model used here (15, 80). Within the gut, pro-inflammatory signaling from intestinal macrophages to innate lymphoid cells modulates their interactions with multiple cell types to impact the gut microbiome [(81–83), reviewed in (84, 85)]. Hence, the greater propensity of APOE4 to promote inflammation, relative to APOE3, may underlie these microbiome differences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034241/

  • Does his protocol include any of the findings of psychophysiology and heart health? Specifically the role of inner harmony as measured through heart-brain coherence, entrainment, and HRV?
    While this interview was interesting and informative, what I hear is very much reductionistic, mechanistic science. It would appear to be beneficial to include systems thinking including the role of emotion and its impact and heart, brain, and autonomic nervous system.
    I am just pointing out a potential blindspot that could help make his vision, theory, and protocol more holistic and thus comprehensive.

  • Polyunsaturated fats have become the enemy. So high fat fish like salmon, seeds, nuts, vegetable oils…. not sugar. I wonder how long this will take to become mainstream.

  • The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”
    The finding that affected brains show a two-fold increase in X chromosome aneuploidy in the hippocampus and cerebrum areas of the brain most affected by AD suggesting that altered sex chromosome dosage plays a role in the large scale genomic variation in neuronal cells in AD compared to controls.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997486/

  • Today we found out that my mother has a an extremely form of dementia called creutzfeldt jakob disease. One in a million gets this disease. My question to anyone out there, Is there hope? Is there a protocol for this, since it is an extreme form of dementia.. people with this disease die between six week to a year after the first symptoms

  • Funny he doesn’t mention a steady supply of energy as needed for “support” of neuroblastic activity. The brain uses like 20% of your energy.

  • Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
    In this issue of the JCI, Tachibana et al. provide evidence that neuronal LRP1 is an essential player in mediating ApoE4’s effect on Aβ and thus AD risk. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391135/ The authors first investigated the relationship between LRP1 expression and insoluble Aβ levels in human postmortem samples from the temporal cortex. In individuals with an ApoE3/ApoE3 genotype, there was a negative correlation between insoluble Aβ levels and LRP1 expression. In contrast, in ApoE3/ApoE4 and ApoE4/ApoE4 individuals, there was a positive correlation between insoluble Aβ levels and LRP1 expression. These contrasting findings can be best understood as a result of LRP1 contributing more to the clearance of Aβ in the context of the ApoE3/ApoE3 genotype and seeding in the presence of ApoE4. https://www.jci.org/articles/view/127578

  • APOE TREM and Microglia in the Pathogenesis of Tau-mediated Neurodegeneration with David Holtzman MD.
    https://www.youtube.com/watch?v=TQMjjmecPC4
    Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease.
    https://www.ncbi.nlm.nih.gov/pubmed/31932797

  • Lipid peroxidation produces the highly reactive and neurotoxic molecule, 4-hydroxynonenal (HNE) that forms covalent bonds with cysteine residues (Cys) [as well as with Lys and His residues]. Covalently modified Cys significantly alter structure and function of modified proteins. HNE bound to Cys residue(s) on apoE2 and apoE3 lessens the chance of HNE damage other proteins. ApoE4, lacking Cys residues, is unable to scavenge HNE, permitting this latter neurotoxic molecule to lead to oxidative modification of neuronal proteins and eventual cell death. We posit that this lack of HNE scavenging activity in apoE4 significantly contributes to the association of APOE4 inheritance and increased risk of developing AD. Alternatively, and in agreement with preclinical studies that suggest that a high antioxidant diet, continuous lifelong stimulation of synapse formation by learning new tasks, and significant exercise regimens increase cognition and lower brain indices of AD (Opii et al., 2008), persons who inherit one or more copies of the APOE4 allele would be strongly suggested to follow these programs to lower the risk of developing AD. Clearly, no promise that development of AD can be prevented is implied here; rather, that the risk for AD development likely can be materially lowered. https://www.ncbi.nlm.nih.gov/pubmed/32036033

  • Dr.Patrick, thank you for bringing so much information to us….Our mother was one of the Americans that got Alzheimer’s every 38 seconds….Like everybody that has this affect them or their loved ones, we asked, “WHY?”…Here is her story…1st, I am not an Alzheimer’s specialist, just an eye-witness in the discussion…I have been asked to elaborate… I am an M.D..My wife was an R.N. We were both pro-vaccines…My mother and sister were R.N’s..They were both pro-vaccines….My 2 brothers were M.D.’s…They were both pro-vaccines…Our mother was an R.N. who was the Head Nurse and ran the largest ER in our medical center..She slept well, exercised, active, and ate well..She was young at heart and ran circles around younger nurses…They had her take 8-9 vaccines to ”catch-up” with the newest ”updated” CDC schedule to keep her nursing job after a long career in Real Estate…After her vaccines, she got severe ”brain fog” within days, then lost her ability to dial her phone or push the elevator buttons or start her car…She went into diapers and then hospitalized and died a terrible, tragic death, drooling and unable to walk, talk, eat or recognized any of her family…None of the specialists and consults could tell her or us what ”just happened” but all the specialists told us it was ”NOT” from those vaccines….It was called the ”worst case of acute, aggressive dementia of ”UNKNOWN” cause the doctors had ever seen”….Folks, what killed our mother just weeks after her vaccines were all from her fatal doses of neurotoxic aluminum and mercury ingredients from those vaccines..She left behind her husband, 5 children, 4 grandchildren, and now 7 great grandchildren… I started a FB site called Vaccine Support Group ( the link is not shown per this site’s policy ) in their name..

  • APOE genotype regulates pathology and disease progression in synucleinopathy. Most of the studies in AD have been focused on investigating the role of Aβ and Tau; however, recent studies suggest that α-syn might also play a role in the pathogenesis of AD. ApoE may regulate aSyn pathophysiology directly, independent of its effects on AD or tau (16–18). Aβ and α-syn might directly interact under pathological conditions leading to the formation of toxic oligomers and nanopores that increase intracellular calcium. The interactions between Aβ and α-syn might also result in oxidative stress, lysosomal leakage, and mitochondrial dysfunction.
    https://www.ncbi.nlm.nih.gov/pubmed/32024799 (2020)
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727399/?report=classic

  • Is Alzheimer connected with Arteriosclerosis? My dad had Arteriosclerosis and the symptoms were similar to Alzheimer. He passed in 1982.

  • Although expression of ApoE4 led to significantly reduced uptake of Aβ in contrast to the other isoforms, we could show that ApoE4 specifically increased phagocytosis of apoptotic neuronal cells. Our findings show that ApoE4 intrinsically affects microglia physiology by upregulating motility and phagocytic behavior in vitro and may therefore specifically contribute to microglia dysregulation in AD.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509203/

  • Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079066/?report=classic

  • I got this book on Amazon kindle and do feel it is excellent. The lab tests recommended in his book are not covered by my public health care insurance…and I know they are very expensive. I don’t even know if these tests are available in Canada and how much they really do cost. I am trying to figure out how to best include all of his ways of preventing even the slightest degree of decline despite not being able to afford/access these lab tests. I am so grateful that I became aware of this kind of therapy via the ketogenic diet and way of life and do find it very costly…it’s frustrating to have the knowledge and desire without the wallet to match it.

  • I was going to say that the latter types are more executive dominant symptoms because of long chain network being more susceptible to exotic insult like trauma, pathogen, or toxin. It’s probably incredibly difficult to maintain the long form sphaghetti because it developed by pruning long ago. There’s trophism possible to navigate such a delicate environment cross hemisphere or cross-cerebrum, or at the very least very unlikely.

  • Why is Bredesen saying plant-based is a good idea when it’s one source of poor gut health (Lectins, Oxylates,..)? All the biomarkers he lists for preventing Alzheimers are fixed with a Carnivore diet. This was late 2018… perhaps Carnivore was more obscure then?

  • The application of advanced sequencing technologies and improved mass-spectrometry platforms revealed significant changes in gene expression and lipids in Alzheimer’s disease (AD) brain. The results so far have prompted further research using “multi-omics” approaches. These approaches become particularly relevant to the major role of APOE in brain lipid metabolism. https://alzres.biomedcentral.com/articles/10.1186/s13195-019-0558-0
    AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer’s Disease.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870071/?report=classic

  • Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
    In this issue of the JCI, Tachibana et al. provide evidence that neuronal LRP1 is an essential player in mediating ApoE4’s effect on Aβ and thus AD risk. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391135/ The authors first investigated the relationship between LRP1 expression and insoluble Aβ levels in human postmortem samples from the temporal cortex. In individuals with an ApoE3/ApoE3 genotype, there was a negative correlation between insoluble Aβ levels and LRP1 expression. In contrast, in ApoE3/ApoE4 and ApoE4/ApoE4 individuals, there was a positive correlation between insoluble Aβ levels and LRP1 expression. These contrasting findings can be best understood as a result of LRP1 contributing more to the clearance of Aβ in the context of the ApoE3/ApoE3 genotype and seeding in the presence of ApoE4. https://www.jci.org/articles/view/127578

  • Are there any doctors in the UK following this protocol? I would love to get tested, I’ve worked with alot of toxic solvents for many years and not always with the best ppe. I’m sure that has affected my mind in numerous ways. I really don’t fancy dementia in any form. Brilliant video by the way.

  • Thank you for putting so much effort into this video. It’s very helpful. Especially the running footnotes. Saves me the trouble of looking up everything into the paper again and again:’)

  • Mayo clinic youtube radio…*** https://youtu.be/shhkKfE-XaA * All the doctors should get together….. This would further research of eradicating Alzheimer’s faster. Dr. Greger…..***** https://youtu.be/PltrY2W5Lk4

  • Dementia tends to be genetic so if you have a family history of dementia (which almost if not All cases of dementia are because the individuals has a family medical history of the disease) you are more likely to get it
    My family medical history has no cases of dementia and none of my grandparents or great grandparents have suffered from it even acute cases
    Dementia is very much dependent on your genetics

  • The discussion and relationship between chronic inflammation and neurodegeneration is spot on. I have published several books about this relationship and how funneled mistake prone immune arsenal into interstitial spaces increases rather then decreases inflammation which in the case of AD involves the secretion of amyloid by astrocytes. and microglia. #Rejuvenation(2017) #Trafficking(2018) #Rejuvenation2.0(2019)

  • AAV-APOE2 biologic therapy APOE4 has been established as the risk allele for AD, and APOE2 is protective. This set the foundation for the idea that if APOE2 could replace or be overexpressed in APOE4 carriers, there would be a compensatory beneficial therapeutic effect. Indeed, there is a current trial scheduled to start that intends to test the safety of AAVAPOE2 expression in APOE4 carriers (Table 1). Patients will be infused with AAV-APOE2 in the cisterna magna and then followed up for at least 2 years to assess safety of this biologic therapy. There is a robust rodent literature showing the effects of AAV-mediated APOE expression in primarily mouse models of amyloidosis. For example, intracerebral injection of AAV-APOE4 in APP/PS1 and Tg2576 mice resulted in increased Aβ burden whereas AAV-APOE2 lowers Aβ burden [164]. However, a limiting factor of this study is that this was done in the presence of murine Apoe that may itself influence Aβ deposition. In a subsequent study from a second group, expression of AAV-APOE2 was shown to reduce Aβ plaque burden in a trigenic mouse (APP/PS1/APOE4 TR) [165]. This study also showed that gene delivery of APOE2 was most effective before the onset of amyloid burden, suggesting that in order to be a successful therapy the AAV would need to be injected much before the onset of symptoms in patients which poses its own challenges. Further translational studies on non-human primates revealed that intra-cisternal delivery of AAV-APOE2 led to widespread expression in the CNS which established a safe procedure for CNS delivery of biologics [166]. Because of the inherent risk in any surgical procedure inside the CNS, whether such AAV-APOE2 biologics can be directly delivered into the AD-affected areas of the human CNS needs to be cautiously determined. However as Zhao et al showed in mice, even intrathalamic injections were modestly effective in reducing Aβ burden in neuroanatomically distant areas such as hippocampus [165]. Another confounding variable is that while APOE2 may decrease Aβ plaque formation, it may increase tau phosphorylation [12]. By injecting AAV-P301L tau into APOE TR mice, this research group found that mice expressing APOE2 had higher NFT levels compared to mice expressing APOE3 or APOE4. Along with data showing genetic association between APOE2 with PSP in humans, this brings up the question if overexpression of APOE2 could inadvertently exacerbate tau pathology while alleviating amyloid burden. In addition, questions regarding effective dosage to achieve optimum biodistribution and cell type transduction, pre-existing host immunity and long term CNS consequences still remain safety concerns in AAV therapies. In addition, while AAV-APOE2 gene therapy has promise, more knowledge on the neuropsychological and neuropathologic consequences of APOE2 overexpression is needed.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995170/

  • ApoE-2 Brain-Targeted Gene Therapy Through Transferrin and Penetratin Tagged Liposomal Nanoparticles.
    https://www.ncbi.nlm.nih.gov/pubmed/31529284

  • I complete my 3 weeks treatment and i got good result being cured from herpes after using Dr. Ikpoko on YouTube herbal medication as instructed

  • Thank you so much for all the information you disseminate!

    I became disabled from numerous inflammatory based issues, was taking 11 pharmaceuticals, walking with a cane and mostly bed ridden at age 45! Information such as this as motivated me to construct my diet along my my needs and now I take ZERO meds.

    I, as you, do not follow a KETO diet and I am basically vegan with occasional cheese or maybe piece of cake made with egg BUT I do not religiously follow anything when evidence can point to the contrary.

    Now I wished I had concentrated more on biochemistry than computer science.

    Thank you again,
    Levi Patrick

  • I’m no intellect by any means ( school didn’t come easy) but I sure find myself loving these folks you interview and the topics you cover! Even if I can’t understand all those BIG fancy words!��❤����

  • APOE TREM and Microglia in the Pathogenesis of Tau-mediated Neurodegeneration with David Holtzman MD.
    https://www.youtube.com/watch?v=TQMjjmecPC4
    Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease.
    https://www.ncbi.nlm.nih.gov/pubmed/31932797

  • Is there even one doctor or qualified health individual that has understanding or interest in this work of Doctor Bredesen’s, that is in Australia, or am I going to have to travel overseas to even get the suggested tests done in hope of a reversal or elimination of dementia suggested in my wife? Doctors in Australian have shown no interest in even conducting the necessary basic testing, and assume that as soon as a diagnosis is made based on just a MIR, then there is no hope and carers need to fit in with the prescribed path to the currently accepted final stage.

  • OK what can we do to detox from all the nanoAluminum from the geo-engineering program?
    I think it might be to eat at least 3 cups of chopped broccoli every day.

  • Our mother was one of the Americans that got Alzheimer’s every 38 seconds….Like everybody that has this affect them or their loved ones, we asked, “WHY?”…Here is her story…1st, I am not an Alzheimer’s specialist, just an eye-witness in the discussion…I have been asked to elaborate… I am an M.D..My wife was an R.N. We were both pro-vaccines…My mother and sister were R.N’s..They were both pro-vaccines….My 2 brothers were M.D.’s…They were both pro-vaccines…Our mother was an R.N. who was the Head Nurse and ran the largest ER in our medical center..She slept well, exercised, active, and ate well..She was young at heart and ran circles around younger nurses…They had her take 8-9 vaccines to ”catch-up” with the newest ”updated” CDC schedule to keep her nursing job after a long career in Real Estate and was elected the Vice President…After her vaccines, she got severe ”brain fog” within days, then lost her ability to dial her phone or push the elevator buttons or start her car…She went into diapers and then hospitalized and died a terrible, tragic death, drooling and unable to walk, talk, eat or recognized any of her family…None of the specialists and consults could tell her or us what ”just happened” but all the specialists told us it was ”NOT” from those vaccines….It was called the ”worst case of acute, aggressive dementia of ”UNKNOWN” cause the doctors had ever seen”….Folks, what killed our mother just weeks after her vaccines were all from her fatal doses of neurotoxic aluminum and mercury ingredients from those vaccines..She left behind her husband, 5 children, 4 grandchildren, and now 7 great grandchildren… I started a FB site called Vaccine Support Group ( https://www.facebook.com/groups/1313182338778841/ ) in their name..

  • As a practicing physician for over 20 years I can honestly say that this talk was the most eye-opening discussion on Alzheimer’s dementia that I’ve ever heard.

  • this sounds incredibly complicated and incredibly expensive….no humans ever lived on a diet of 70% fat…that idea alone surely flies in the face of 20-30 years of long standinv peer reviewed scientific research on things like heart health..cholesterol levels etc?

  • Lipid peroxidation produces the highly reactive and neurotoxic molecule, 4-hydroxynonenal (HNE) that forms covalent bonds with cysteine residues (Cys) [as well as with Lys and His residues]. Covalently modified Cys significantly alter structure and function of modified proteins. HNE bound to Cys residue(s) on apoE2 and apoE3 lessens the chance of HNE damage other proteins. ApoE4, lacking Cys residues, is unable to scavenge HNE, permitting this latter neurotoxic molecule to lead to oxidative modification of neuronal proteins and eventual cell death. We posit that this lack of HNE scavenging activity in apoE4 significantly contributes to the association of APOE4 inheritance and increased risk of developing AD. Alternatively, and in agreement with preclinical studies that suggest that a high antioxidant diet, continuous lifelong stimulation of synapse formation by learning new tasks, and significant exercise regimens increase cognition and lower brain indices of AD (Opii et al., 2008), persons who inherit one or more copies of the APOE4 allele would be strongly suggested to follow these programs to lower the risk of developing AD. Clearly, no promise that development of AD can be prevented is implied here; rather, that the risk for AD development likely can be materially lowered. https://www.ncbi.nlm.nih.gov/pubmed/32036033

  • Dr.Patrick, thank you for bringing so much information to us….Our mother was one of the Americans that got Alzheimer’s every 38 seconds….Like everybody that has this affect them or their loved ones, we asked, “WHY?”…Here is her story…1st, I am not an Alzheimer’s specialist, just an eye-witness in the discussion…I have been asked to elaborate… I am an M.D..My wife was an R.N. We were both pro-vaccines…My mother and sister were R.N’s..They were both pro-vaccines….My 2 brothers were M.D.’s…They were both pro-vaccines…Our mother was an R.N. who was the Head Nurse and ran the largest ER in our medical center..She slept well, exercised, active, and ate well..She was young at heart and ran circles around younger nurses…They had her take 8-9 vaccines to ”catch-up” with the newest ”updated” CDC schedule to keep her nursing job after a long career in Real Estate…After her vaccines, she got severe ”brain fog” within days, then lost her ability to dial her phone or push the elevator buttons or start her car…She went into diapers and then hospitalized and died a terrible, tragic death, drooling and unable to walk, talk, eat or recognized any of her family…None of the specialists and consults could tell her or us what ”just happened” but all the specialists told us it was ”NOT” from those vaccines….It was called the ”worst case of acute, aggressive dementia of ”UNKNOWN” cause the doctors had ever seen”….Folks, what killed our mother just weeks after her vaccines were all from her fatal doses of neurotoxic aluminum and mercury ingredients from those vaccines..She left behind her husband, 5 children, 4 grandchildren, and now 7 great grandchildren… I started a FB site called Vaccine Support Group ( the link is not shown per this site’s policy ) in their name..

  • Hello, as of today, if you research in any medical page, it is said that there is NO cure for Alzheimer’s I am trying to understand if this is a research that is giving hints of a cure for the future? or do we have actual people that have been cured? do we have this info? Thank you so much

  • How applicable is the ReCODE protocol to any degenerative problem. If, say a 26 year old had a liposarcoma successfully removed but was worried about how to avoid future metastatic spread etc. would the ReCODE approach pick up most of everything he ought to be looking at to make sure he maximizes his immune competence and minimizes his inflammation etc?

  • What does it mean to be APOE4 positive or negative? Having a hard time finding it online. I’m E3/E4, is there more to know for the +/portion?

  • Although expression of ApoE4 led to significantly reduced uptake of Aβ in contrast to the other isoforms, we could show that ApoE4 specifically increased phagocytosis of apoptotic neuronal cells. Our findings show that ApoE4 intrinsically affects microglia physiology by upregulating motility and phagocytic behavior in vitro and may therefore specifically contribute to microglia dysregulation in AD.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509203/

  • THIS is the peak of the information age, ladies and gentleman. We are so lucky to be able to listen in, as these geniuses discuss incredibly complex and interesting topics. Thank you Dr. Patrick and Dr. Bredesen for sharing this for free with the world. The significance might get lost as the view count rises, but always remember, real people benefit from this kind of content. Real people change their life style, for the better, because of these kinds of discussions which share education.

  • Dose anyone know if the Perfect Keto line of supplements are good, particularly the nootropics. I have a sneaking suspicion that I’ve been dealing with (CIRS) from black mold.

  • Relief from Alzheimer: “I placed the MagneMax Necklace on my mother’s head for 30 minutes and her Dizziness was gone. Her character also changed. She actually became
    Adorable and even told me that she Loved the lamp I had made for her.
    I’m bringing Crazy-Glue with me tomorrow to Glue this MagneMax Necklace
    to her Neck in so she’ll ‘Never’ take it off again. Thank you for this
    absolutely Amazing product.” ” http://www.magnemax.com/magnemax-results/

  • Among the many things Dr. Bresden mentioned which can negatively impact the brain, I was really happy to hear him mention mercury in large fish with such authority as so many medical experts will not address the issue, and because of this it is not thought by the majority of the people I know to be a real thing. I am one of those people who ignored the warnings and, eating a lot of tuna and swordfish wound up with dangerously high levels of mercury. I have lab tests to prove it, and yet I often find myself relegated to the fringe zone if I mention this to people I know, which is insult on injury! So… kudos to Dr. Bresden. I stopped eating those fish which tend to have high mercury loads about 10 years ago, but I have read that the mercury which gets in to your brain cannot get back out again, and so would welcome hearing whether or not that is true. I wouldn’t like to think I am destined for one of these alzheimers types.

  • If DHA is necessary for glucose transport in the brain it makes sense that ketogenic diet may work to improve function in the apo e 4 crowd in particular if they are not getting adequate DHA in their diet

  • Great interview Max! I was so hoping to hear how much and how often he eats blueberries… I am following a Ketogenic diet… and wondering if I could could shave my veggies carbs into smaller servings to enable enough blueberries to slide in their place…with enough benefit… all totaling 20 carbs total. That would be asking a lot, but…. Was anything said about this out side of the published interview? My mom had Alzheimer’s, as did her her mother. I am 69…and attempting to do all I possibly can as I go about enjoying and appreciating life. Thanks!

  • I have heard that you shouldn’t take zink without copper. So one should one be tested first before taking either of these minerals?

  • Question for Dr Bredesen…. I am a physician following a plant based diet question for you is concerning the LCHF diet the longevity of the Okinawans is well documented their diet was as far from the LCHF diet as you can get they consumed large quantities of sweet potatoes, seaweed, tofu and small amounts of pork. What is your thought? Also has anyone been on a LCHF diet long enough to know the risk of cancer?

  • The application of advanced sequencing technologies and improved mass-spectrometry platforms revealed significant changes in gene expression and lipids in Alzheimer’s disease (AD) brain. The results so far have prompted further research using “multi-omics” approaches. These approaches become particularly relevant to the major role of APOE in brain lipid metabolism. https://alzres.biomedcentral.com/articles/10.1186/s13195-019-0558-0
    AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer’s Disease.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870071/?report=classic

  • Hi I stumbled across this podcast and found it really interesting as I have had memory issues and I’m only 41 years old. Can someone recommend a video or book or podcast that could explain some of the same information in layman’s terms?

  • I wonder how I could emty my mind of useless informations. This woul help me become more attentive. Because now I’m listnening to this video and to my thoughts in the same time

  • Starting at 25:46 reminded me of the Candida auris ‘outbreak’ that I read about yesterday..
    https://www.nytimes.com/2019/04/06/health/drug-resistant-candida-auris.html

  • Wondering if you have any thoughts on Gilbert Syndrome? At first glance, it looks pretty benign, but if I’ve learned anything over the years, it’s that, when it comes to the body, its just not that simple. It seems like the lack of UGT1A must have some significance up or downstream from just breaking down bilirubin?
    On a personal level, I have been thinking about Gilbert’s in relationship to fasting, which is not recommended for those who have it. Anecdotal evidence hints at cooccurring metabolic/gut/dopamine disfunction, (which might benefit from fasting) but this doesn’t seem to show up in the medical literature.
    As always, love to hear your thoughts and Thanks for your continued work and diligence!

  • I have being suffering from herpes virus for couples of years and I had to tryna use herbal treatment from MADIDAHERBALCENTER though I have uses black seed oil and other pills before that. I went for a test last month after using Madida herbal center ‘s herbs and I was tested negative. I felt lucky knowing about Madida herbal center.

  • Hey, guys! If you like this podcast, I would encourage you to check out Dr. Bredesen’s book where he goes in much greater depth, and also check out our show notes. Thanks to the support of fans, we’re able to really put the energy in and go all out on the notes, so make sure to take advantage of those.

    ▶︎ Get Dr. Bredesen’s New York Times and Wallstreet Journal best selling book The End of Alzheimer’s.
    https://amzn.to/2R9rfIn

    ▶︎ Get the episode’s show notes and transcript.
    https://www.foundmyfitness.com/episodes/dale-bredesen

    ▶︎ Submit your raw genetic data to run the APOE report.
    https://www.foundmyfitness.com/genetics

    This podcast is focused on niche content to say the least, so if you enjoy it, please also consider joining the community the nurtures the very existence of the show through their pay-what-you-can pledges. Learn more about that at
    https://www.foundmyfitness.com/crowdsponsor. Thanks for your consideration!

  • MANY studies have shown that meat consumption is one of the leading factors to global warming. IT IS NOT SUSTAINABLE so I’m not sure where he got that.

  • I’m no intellect by any means ( school didn’t come easy) but I sure find myself loving these folks you interview and the topics you cover! Even if I can’t understand all those BIG fancy words!��❤����

  • OK what can we do to detox from all the nanoAluminum from the geo-engineering program?
    I think it might be to eat at least 3 cups of chopped broccoli every day.

  • Everything is prevention! I read the book, and links to a website were he sell products for this illness, but the vitamins he sell are synthetics, which are no good for the body.

  • Thank you for this excellent video. It’s given me a lot to think about. My diet has been mostly vegetarian with occasional fish & now am down to? 5% grain. Can a reasonable ketosis be obtained?

  • I complete my 3 weeks treatment and i got good result being cured from herpes after using Dr. Ikpoko on YouTube herbal medication as instructed

  • Is Alzheimer connected with Arteriosclerosis? My dad had Arteriosclerosis and the symptoms were similar to Alzheimer. He passed in 1982.

  • I was diagnosed a kind of brain problem or Chiari malformation suffered a lot of pains even lost my memory like my middle name scary. But then because I find a good omega3 balance oil here in Norway im getting better our brain we need a good nutrients. Dr Paul Clayton Scientists Nutritionist discussed about the Zinzino omega3 balance oil

  • https://youtu.be/Sq7uVZ_0D3U. The cure that UCLA came up for this disease is not for people this far down the road, but it did cure 9/10 patients in a small study, who were not this far gone. You can read Bredensen’s book or watch the link, but if you’re like me, I opted for reading his report in the medical literature first. This is the title of report 2016, “Reversal of Cognitive Decline in Alzheimer’s Disease” look it for at pubmed, the complete article is free. Sadly it’s a treatment that you will not like and that you must follow for the rest of your life, exercise, keto style, etc…

  • Dose anyone know if the Perfect Keto line of supplements are good, particularly the nootropics. I have a sneaking suspicion that I’ve been dealing with (CIRS) from black mold.

  • Murine Gut Microbiome Association With APOE Alleles.
    The mechanism(s) whereby APOE alleles may differentially modulate the gut microbiome is not known. In overview, we theorize that apoE alleles differentially modulate the basal inflammation state of intestinal macrophages, which are key regulators of innate lymphoid cells in the gut and, in turn, impact the gut microbiome. The rationale for this includes (i) APOE4 is associated with a greater pro-inflammatory response in multiple studies, e.g., treatment with LPS results in a greater plasma cytokine response in APOE4 positive humans, compared to APOE4 negative individuals (16). Similarly, treatment with bacterial lipoproteins or with LPS has been reported to produce an increased cytokine response in the APOE murine model used here (15, 80). Within the gut, pro-inflammatory signaling from intestinal macrophages to innate lymphoid cells modulates their interactions with multiple cell types to impact the gut microbiome [(81–83), reviewed in (84, 85)]. Hence, the greater propensity of APOE4 to promote inflammation, relative to APOE3, may underlie these microbiome differences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034241/

  • Does his protocol include any of the findings of psychophysiology and heart health? Specifically the role of inner harmony as measured through heart-brain coherence, entrainment, and HRV?
    While this interview was interesting and informative, what I hear is very much reductionistic, mechanistic science. It would appear to be beneficial to include systems thinking including the role of emotion and its impact and heart, brain, and autonomic nervous system.
    I am just pointing out a potential blindspot that could help make his vision, theory, and protocol more holistic and thus comprehensive.

  • Wondering if you have any thoughts on Gilbert Syndrome? At first glance, it looks pretty benign, but if I’ve learned anything over the years, it’s that, when it comes to the body, its just not that simple. It seems like the lack of UGT1A must have some significance up or downstream from just breaking down bilirubin?
    On a personal level, I have been thinking about Gilbert’s in relationship to fasting, which is not recommended for those who have it. Anecdotal evidence hints at cooccurring metabolic/gut/dopamine disfunction, (which might benefit from fasting) but this doesn’t seem to show up in the medical literature.
    As always, love to hear your thoughts and Thanks for your continued work and diligence!

  • The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”
    The finding that affected brains show a two-fold increase in X chromosome aneuploidy in the hippocampus and cerebrum areas of the brain most affected by AD suggesting that altered sex chromosome dosage plays a role in the large scale genomic variation in neuronal cells in AD compared to controls.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997486/

  • Today we found out that my mother has a an extremely form of dementia called creutzfeldt jakob disease. One in a million gets this disease. My question to anyone out there, Is there hope? Is there a protocol for this, since it is an extreme form of dementia.. people with this disease die between six week to a year after the first symptoms

  • Funny he doesn’t mention a steady supply of energy as needed for “support” of neuroblastic activity. The brain uses like 20% of your energy.

  • mico toxins are increased hundreds of times when exposed to emf from call phones wifi etc yet another reason to wire up and limit exposure

  • Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079066/?report=classic

  • If you are positive in several Herpes viruses, May it be a good idea a continuous retroviral medications for your brain and health in general? (although you do not have any symptoms)

  • Love this interview. The way you outline the interview and let us click on the info we are especially interested in is fantastic!!! I love when you get personal and ask…..what do you eat? He was very thorough. Most times someone will say oh…..I try to eat healthy. He really broke it down with times of days, duration, and exactly the foods he eats. Just GREAT!!! Thanks Max. Keep up the great info and interviews you do.

  • So to get healthy, consume lots of plant toxins? I would think KETO Carnivor would be best with maybe a little kale & broccoli sprouts.

  • Starting at 25:46 reminded me of the Candida auris ‘outbreak’ that I read about yesterday..
    https://www.nytimes.com/2019/04/06/health/drug-resistant-candida-auris.html

  • I got this book on Amazon kindle and do feel it is excellent. The lab tests recommended in his book are not covered by my public health care insurance…and I know they are very expensive. I don’t even know if these tests are available in Canada and how much they really do cost. I am trying to figure out how to best include all of his ways of preventing even the slightest degree of decline despite not being able to afford/access these lab tests. I am so grateful that I became aware of this kind of therapy via the ketogenic diet and way of life and do find it very costly…it’s frustrating to have the knowledge and desire without the wallet to match it.

  • Thank you so much for all the information you disseminate!

    I became disabled from numerous inflammatory based issues, was taking 11 pharmaceuticals, walking with a cane and mostly bed ridden at age 45! Information such as this as motivated me to construct my diet along my my needs and now I take ZERO meds.

    I, as you, do not follow a KETO diet and I am basically vegan with occasional cheese or maybe piece of cake made with egg BUT I do not religiously follow anything when evidence can point to the contrary.

    Now I wished I had concentrated more on biochemistry than computer science.

    Thank you again,
    Levi Patrick

  • Watch some parts twice very informative. As said by another comment, I also loved that you put all this information up on text on the screen which allows us to pause and take notes.

  • Almonds, Blueberries, Dark Chocolate, Broccoli, Avocado, Wild Salmon, Grass fed Beef, Eggs, Dark leafy greens, and extra virgin olive oil!

    You’re welcome!:P

    Edit: omg thank you for the likes!

  • Why is Bredesen saying plant-based is a good idea when it’s one source of poor gut health (Lectins, Oxylates,..)? All the biomarkers he lists for preventing Alzheimers are fixed with a Carnivore diet. This was late 2018… perhaps Carnivore was more obscure then?

  • How does one get to the point they are not insulin resistant? I find that I cannot restrict my carb intake too much because then my blood sugar drops n I get shaky & sick. I try not to eat too many refined carbs, but find sometimes it’s hard for me not to have some, especially when my sugar drops. I get so sick, I start to eat anything to make me feel better.

  • Grass-fed beef? Really? Most forms of dementia have been shown to increase in likelihood as cholesterol intake increases as it decreases blood supply overtime through some of the finer capillaries due to plaque build up. Also, grass fed may be kinder to the animals but it isn’t better for the environment due to how much more land it requires to sustain a single individual. It’s far better to just avoid beef altogether for so many reasons and it really should not be promoted as a “health food” in the modern informed world…

  • Are there any doctors in the UK following this protocol? I would love to get tested, I’ve worked with alot of toxic solvents for many years and not always with the best ppe. I’m sure that has affected my mind in numerous ways. I really don’t fancy dementia in any form. Brilliant video by the way.

  • Am guessing at 09:20 talking of low zinc/ high Copper, is referring to serum or RBC or hair element labs? Was going to get a Ceruloplasmin serum lab but maybe the whole panel (figure wont find a dr to get done so will have to pay for. (after paying for required insurance!). Are there signs of low zinc or high copper…? AM good for all the biomarkers done yet. Will get a Hc lab also. https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-018-0444-2

  • Mayo clinic youtube radio…*** https://youtu.be/shhkKfE-XaA * All the doctors should get together….. This would further research of eradicating Alzheimer’s faster. Dr. Greger…..***** https://youtu.be/PltrY2W5Lk4

  • So how do we get REAL blood tests done from doctors who know what there doing?? I feel like hell and I do eat crappy food all the time but yet my blood work always comes back PERFECT according to the doctor’s I go to???? Hey clearly do not know what the fuck to look for in health problems

  • Our mother was one of the Americans that got Alzheimer’s every 38 seconds….Like everybody that has this affect them or their loved ones, we asked, “WHY?”…Here is her story…1st, I am not an Alzheimer’s specialist, just an eye-witness in the discussion…I have been asked to elaborate… I am an M.D..My wife was an R.N. We were both pro-vaccines…My mother and sister were R.N’s..They were both pro-vaccines….My 2 brothers were M.D.’s…They were both pro-vaccines…Our mother was an R.N. who was the Head Nurse and ran the largest ER in our medical center..She slept well, exercised, active, and ate well..She was young at heart and ran circles around younger nurses…They had her take 8-9 vaccines to ”catch-up” with the newest ”updated” CDC schedule to keep her nursing job after a long career in Real Estate and was elected the Vice President…After her vaccines, she got severe ”brain fog” within days, then lost her ability to dial her phone or push the elevator buttons or start her car…She went into diapers and then hospitalized and died a terrible, tragic death, drooling and unable to walk, talk, eat or recognized any of her family…None of the specialists and consults could tell her or us what ”just happened” but all the specialists told us it was ”NOT” from those vaccines….It was called the ”worst case of acute, aggressive dementia of ”UNKNOWN” cause the doctors had ever seen”….Folks, what killed our mother just weeks after her vaccines were all from her fatal doses of neurotoxic aluminum and mercury ingredients from those vaccines..She left behind her husband, 5 children, 4 grandchildren, and now 7 great grandchildren… I started a FB site called Vaccine Support Group ( https://www.facebook.com/groups/1313182338778841/ ) in their name..

  • I wonder how I could emty my mind of useless informations. This woul help me become more attentive. Because now I’m listnening to this video and to my thoughts in the same time

  • ApoE-2 Brain-Targeted Gene Therapy Through Transferrin and Penetratin Tagged Liposomal Nanoparticles.
    https://www.ncbi.nlm.nih.gov/pubmed/31529284

  • Dr Bredesen is so incredible. Super knowledgeable, on top of things, communicates something so complex in such a simple way, stays his course in a non-defensive way in our crazy world of drug and symptom focused medicine. Docs like him and the groundbreaking approaches like this are the future of medicine!! A heartfelt thank you, Dr Bredesen!

  • Hello. How can we get in touch with Dr Bredesen, is there an official website or hospital we could contact. I live outside US and would like to find out about Recode, and if there is distance treatment available? Please it’s urgent

  • Among the many things Dr. Bresden mentioned which can negatively impact the brain, I was really happy to hear him mention mercury in large fish with such authority as so many medical experts will not address the issue, and because of this it is not thought by the majority of the people I know to be a real thing. I am one of those people who ignored the warnings and, eating a lot of tuna and swordfish wound up with dangerously high levels of mercury. I have lab tests to prove it, and yet I often find myself relegated to the fringe zone if I mention this to people I know, which is insult on injury! So… kudos to Dr. Bresden. I stopped eating those fish which tend to have high mercury loads about 10 years ago, but I have read that the mercury which gets in to your brain cannot get back out again, and so would welcome hearing whether or not that is true. I wouldn’t like to think I am destined for one of these alzheimers types.

  • Hello, as of today, if you research in any medical page, it is said that there is NO cure for Alzheimer’s I am trying to understand if this is a research that is giving hints of a cure for the future? or do we have actual people that have been cured? do we have this info? Thank you so much

  • Polyunsaturated fats have become the enemy. So high fat fish like salmon, seeds, nuts, vegetable oils…. not sugar. I wonder how long this will take to become mainstream.

  • As a practicing physician for over 20 years I can honestly say that this talk was the most eye-opening discussion on Alzheimer’s dementia that I’ve ever heard.

  • Is there even one doctor or qualified health individual that has understanding or interest in this work of Doctor Bredesen’s, that is in Australia, or am I going to have to travel overseas to even get the suggested tests done in hope of a reversal or elimination of dementia suggested in my wife? Doctors in Australian have shown no interest in even conducting the necessary basic testing, and assume that as soon as a diagnosis is made based on just a MIR, then there is no hope and carers need to fit in with the prescribed path to the currently accepted final stage.

  • I was going to say that the latter types are more executive dominant symptoms because of long chain network being more susceptible to exotic insult like trauma, pathogen, or toxin. It’s probably incredibly difficult to maintain the long form sphaghetti because it developed by pruning long ago. There’s trophism possible to navigate such a delicate environment cross hemisphere or cross-cerebrum, or at the very least very unlikely.

  • this sounds incredibly complicated and incredibly expensive….no humans ever lived on a diet of 70% fat…that idea alone surely flies in the face of 20-30 years of long standinv peer reviewed scientific research on things like heart health..cholesterol levels etc?

  • Hi I stumbled across this podcast and found it really interesting as I have had memory issues and I’m only 41 years old. Can someone recommend a video or book or podcast that could explain some of the same information in layman’s terms?

  • AAV-APOE2 biologic therapy APOE4 has been established as the risk allele for AD, and APOE2 is protective. This set the foundation for the idea that if APOE2 could replace or be overexpressed in APOE4 carriers, there would be a compensatory beneficial therapeutic effect. Indeed, there is a current trial scheduled to start that intends to test the safety of AAVAPOE2 expression in APOE4 carriers (Table 1). Patients will be infused with AAV-APOE2 in the cisterna magna and then followed up for at least 2 years to assess safety of this biologic therapy. There is a robust rodent literature showing the effects of AAV-mediated APOE expression in primarily mouse models of amyloidosis. For example, intracerebral injection of AAV-APOE4 in APP/PS1 and Tg2576 mice resulted in increased Aβ burden whereas AAV-APOE2 lowers Aβ burden [164]. However, a limiting factor of this study is that this was done in the presence of murine Apoe that may itself influence Aβ deposition. In a subsequent study from a second group, expression of AAV-APOE2 was shown to reduce Aβ plaque burden in a trigenic mouse (APP/PS1/APOE4 TR) [165]. This study also showed that gene delivery of APOE2 was most effective before the onset of amyloid burden, suggesting that in order to be a successful therapy the AAV would need to be injected much before the onset of symptoms in patients which poses its own challenges. Further translational studies on non-human primates revealed that intra-cisternal delivery of AAV-APOE2 led to widespread expression in the CNS which established a safe procedure for CNS delivery of biologics [166]. Because of the inherent risk in any surgical procedure inside the CNS, whether such AAV-APOE2 biologics can be directly delivered into the AD-affected areas of the human CNS needs to be cautiously determined. However as Zhao et al showed in mice, even intrathalamic injections were modestly effective in reducing Aβ burden in neuroanatomically distant areas such as hippocampus [165]. Another confounding variable is that while APOE2 may decrease Aβ plaque formation, it may increase tau phosphorylation [12]. By injecting AAV-P301L tau into APOE TR mice, this research group found that mice expressing APOE2 had higher NFT levels compared to mice expressing APOE3 or APOE4. Along with data showing genetic association between APOE2 with PSP in humans, this brings up the question if overexpression of APOE2 could inadvertently exacerbate tau pathology while alleviating amyloid burden. In addition, questions regarding effective dosage to achieve optimum biodistribution and cell type transduction, pre-existing host immunity and long term CNS consequences still remain safety concerns in AAV therapies. In addition, while AAV-APOE2 gene therapy has promise, more knowledge on the neuropsychological and neuropathologic consequences of APOE2 overexpression is needed.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995170/

  • Hello. How can we get in touch with Dr Bredesen, is there an official website or hospital we could contact. I live outside US and would like to find out about Recode, and if there is distance treatment available? Please it’s urgent

  • Relief from Alzheimer: “I placed the MagneMax Necklace on my mother’s head for 30 minutes and her Dizziness was gone. Her character also changed. She actually became
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  • What does it mean to be APOE4 positive or negative? Having a hard time finding it online. I’m E3/E4, is there more to know for the +/portion?

  • Watch some parts twice very informative. As said by another comment, I also loved that you put all this information up on text on the screen which allows us to pause and take notes.

  • THIS is the peak of the information age, ladies and gentleman. We are so lucky to be able to listen in, as these geniuses discuss incredibly complex and interesting topics. Thank you Dr. Patrick and Dr. Bredesen for sharing this for free with the world. The significance might get lost as the view count rises, but always remember, real people benefit from this kind of content. Real people change their life style, for the better, because of these kinds of discussions which share education.

  • So to get healthy, consume lots of plant toxins? I would think KETO Carnivor would be best with maybe a little kale & broccoli sprouts.

  • How applicable is the ReCODE protocol to any degenerative problem. If, say a 26 year old had a liposarcoma successfully removed but was worried about how to avoid future metastatic spread etc. would the ReCODE approach pick up most of everything he ought to be looking at to make sure he maximizes his immune competence and minimizes his inflammation etc?

  • It is not accurate to say that nerve cells cannot be regenerated. There are preclinical research studies performed in mice showing the unique cannabinoid CBD promoted neurogenesis or the formation of new brain cells in adult mice. Other interventions, including exercise and brain games may promote neurogenesis and neural net connections.

  • If DHA is necessary for glucose transport in the brain it makes sense that ketogenic diet may work to improve function in the apo e 4 crowd in particular if they are not getting adequate DHA in their diet

  • How does one get to the point they are not insulin resistant? I find that I cannot restrict my carb intake too much because then my blood sugar drops n I get shaky & sick. I try not to eat too many refined carbs, but find sometimes it’s hard for me not to have some, especially when my sugar drops. I get so sick, I start to eat anything to make me feel better.

  • I have heard that you shouldn’t take zink without copper. So one should one be tested first before taking either of these minerals?

  • Question for Dr Bredesen…. I am a physician following a plant based diet question for you is concerning the LCHF diet the longevity of the Okinawans is well documented their diet was as far from the LCHF diet as you can get they consumed large quantities of sweet potatoes, seaweed, tofu and small amounts of pork. What is your thought? Also has anyone been on a LCHF diet long enough to know the risk of cancer?