Gut Check What’s Going On With This Particular Microbiome Talk


A HiFi View: Sequencing the Gut Microbiome with Highly Accurate Long Reads

Video taken from the channel: PacBio


The microbiome: how might gut bacteria help treat cancer? | Cancer Research UK (2019)

Video taken from the channel: Cancer Research UK


Your Microbiome: What Is It, and How Can It Help or Hurt You?

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How we study the microbes living in your gut | Dan Knights

Video taken from the channel: TED


AGA: Active Learning Session on the Gut Microbiome

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Twins, microbiomes and personalised health Tim Spector

Video taken from the channel: Wellcome Genome Campus Courses and Conferences


What’s Up With Your Gut Microbiome? | California Academy of Sciences

Video taken from the channel: California Academy of Sciences

You may be asking yourself, gut micro-what? The microbiome is a network of trillions of bacteria living in the gastrointestinal tract, and we are learning the types of bacteria in the gut may be a risk factor for diseases such as d iabetes, cancer, asthma, heart disease, obesity and Alzheimer. Gut Check is a game for 2-4 players where each player attempts to develop a healthy microbiome while interfering with the microbiomes of their opponents.

Give your friends the plagu. Kind of like all that business about following your heart, usually “gut check” talk is figurative, not literal. It’s in your head, after all, where you’re working things out – in matters of love. A discussion about gut check won’t be complete without talking about probiotics and prebiotics.

Probiotics — These are microbes that you consume to improve the quantity and diversity of the gut flora. Prebiotics — These are the types of food that help feed the good bacteria and fungi. Learn Gut Check: Exploring Your Microbiome from University of Colorado Boulder, University of California San Diego. Imagine if there were an organ in your body that weighed as much as your brain, that. The gut microbiome affects the tight junctions that maintain the integrity of the gut barrier.

When tight junctions are weakened, gaps between the cells of the intestinal lining may lead to “leaky gut syndrome,” which allows microbes, metabolites and toxins to pass from the digestive system into the bloodstream. Learn how new gut bacteria test kits from microbiome testing companies offer a convenient way to conduct gut testing at home. This innovative way to measure digestive health and gut. The key, experts say, may lie in the microbiome —the makeup of bacteria and other microorganisms in the stomach and intestines, or, informally, the gut.

Research on the microbiome is. Some chalk up this link to intestinal bacteria’s ability to make small molecules (called metabolites) that can reach the brain and impact how it works. Continued Care and Feeding of Your Microbiome.

We’re back again with another edition of Gut Check, our series on the relationship between food and the gut microbiome.So far, we’ve taken a closer look at how whole grains and fiber affect our gut.

List of related literature:

If the gut microbiome is involved in the proper development of our immune system, proper digestion and nutrient absorption, and also plays a role in proper brain functioning, it stands to reason that abnormal microbiomes can cause improper functioning.

“Visualizing Human Biology” by Kathleen A. Ireland
from Visualizing Human Biology
by Kathleen A. Ireland
Wiley, 2017

Although we don’t know exactly how having a healthy gut microbiome might reduce the risk of each of these conditions, researchers are anxious to figure it out, because understanding it could lead to new treatment options.

“The Lose Your Belly Diet: Change Your Gut, Change Your Life” by Travis Stork, M.D.
from The Lose Your Belly Diet: Change Your Gut, Change Your Life
by Travis Stork, M.D.
Bird Street Books, 2016

An alternative explanation is that the observed alteration in the gut microbiome of patients with IBD is simply a consequence of the intestinal inflammatory response without consequence to the host.

“Pediatric Inflammatory Bowel Disease” by Petar Mamula, Jonathan E. Markowitz, Robert N. Baldassano
from Pediatric Inflammatory Bowel Disease
by Petar Mamula, Jonathan E. Markowitz, Robert N. Baldassano
Springer New York, 2012

Other evidence comes from the implication of the gut microbiome in the degradation of dietary proteins through the release of tryptophan, which is converted into various catabolites by the gut microbiome (Roager & Licht, 2018).

“Microbiomes of Soils, Plants and Animals: An Integrated Approach” by Rachael E. Antwis, Xavier A. Harrison, Michael J. Cox
from Microbiomes of Soils, Plants and Animals: An Integrated Approach
by Rachael E. Antwis, Xavier A. Harrison, Michael J. Cox
Cambridge University Press, 2020

Much of the early research on the gut microbiome focused on the impact of particular bacteria on human health, but researchers are now examining the role of other types of microbes found in our colons, such as viruses, fungi, protists, and archaea.

“Future Foods: How Modern Science Is Transforming the Way We Eat” by David Julian McClements
from Future Foods: How Modern Science Is Transforming the Way We Eat
by David Julian McClements
Springer International Publishing, 2019

While the body of evidence is not entirely developed at this time, there is some literature to support the positive effects on the gut microbiome that this lifestyle intervention modulates.

“Integrative Gastroenterology” by Gerard E. Mullin, Marvin Singh
from Integrative Gastroenterology
by Gerard E. Mullin, Marvin Singh
Oxford University Press, 2019

Another outstanding question is whether the metabolic effects of the altered gut microbiota (“dysbiosis”) is due to the change in bacterial species per se, or rather due to functional changes within the collective microbiota genome, known as the microbiome.

“Endocrinology: Adult and Pediatric E-Book” by J. Larry Jameson, Leslie J. De Groot
from Endocrinology: Adult and Pediatric E-Book
by J. Larry Jameson, Leslie J. De Groot
Elsevier Health Sciences, 2015

To evaluate the effect of dynamics of the gut microbiome, a single-center study prospectively analyzed 12 ICU patients and showed that changes in the gut microbiota can be associated with patient prognosis [18].

“Annual Update in Intensive Care and Emergency Medicine 2020” by Jean-Louis Vincent
from Annual Update in Intensive Care and Emergency Medicine 2020
by Jean-Louis Vincent
Springer International Publishing, 2020

Studies in humans and other mammals have implicated the microbiome in a range of physiological processes that are vital to host health including energy homeostasis, metabolism, gut epithelial health, immunological activity, and neurobehavioral development.

“Nutraceuticals in Veterinary Medicine” by Ramesh C. Gupta, Ajay Srivastava, Rajiv Lall
from Nutraceuticals in Veterinary Medicine
by Ramesh C. Gupta, Ajay Srivastava, Rajiv Lall
Springer International Publishing, 2019

Gut microbiomes vary by geographic location, and thus results from microbiome studies may not be relevant to all IBD populations.

“The ASCRS Textbook of Colon and Rectal Surgery” by Scott R. Steele, Tracy L. Hull, Thomas E. Read, Theodore J. Saclarides, Anthony J. Senagore, Charles B. Whitlow
from The ASCRS Textbook of Colon and Rectal Surgery
by Scott R. Steele, Tracy L. Hull, et. al.
Springer International Publishing, 2016

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

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  • Interesting research topic. Another line of research off of this one would be the difference that you see in European populations that don’t have as high rates of obesity as the US. Unpasteurized cheeses, fresh fruits/vegetables, and unpasteurized alcoholic beverages would all add in different microbes. The use of different preservatives in foods could also be a factor.

  • Someone once tested that just by changing gut microbes animals (lab rats) can actually loose A LOT of weight “naturally”.
    In a World with obesity so much on the rise, it is a research I would like to see more developed.

  • This is really interesting! I’m Hmong-American and I’m first generation, born in the U.S when my parents came over. There are photos of my parents who looked very young and skinnier back in their prime. However, as time has passed, they’ve become different because of the foods they eat. My guess was because of their micro biomes and ours. With the introduction of many processed foods and such, it makes me wonder exactly the same question, Does the food we eat change our micro biomes? Or does the micro biome change because of the food we eat?

  • Are antibiotics found in food killing the good bacteria and then the gut is invaded by the other bacteria? Or does the invaders kill off the normal fauna? Does more radiation found in cities affect the equilibrium? Are micro particles influencing this war? We have tests for all those factors, let’s combine those with machine learning and solve this.

  • But what is it about the USA that changes it? What can we do to get our gut microbiome back to what it is supposed to be! Chemicals? Toxins?

  • It’s the amount of Msg we use in our food. Fast food and processed food has loads of it. Glutamates from MSG attach to glutamate receptors along GI tract nerves and brain. Glutamates triggers nervous system to trigger smooth muscle around intestines. Persistals happens too fast then sops. At the same time Entero endocrine cells release serotonin to signal each nerve to fire. Food passes to fast from stomach to small intestine. Then the small intestine become stagnant once it depletes levels of Serotonin which then cause depression.. Food stops moving and gets fermented by bacteria. Bacteria multiply then immune system gets triggered and sends white blood cells to the intestine which then cause inflammation and sometumes auto immune diseases like Crohn’s or ulcerative colitis. The constant triggerr of immune system will destroy the good Gut Flora in the GI tract. From then on you have bacteria over growth which cause gas and heartburn. The problem then is the amount of MSG that food manufacturers are adding into the food to enhance flavor and increase sales. They use various fifferent names for MSG to confuse the consumer.

  • This information about gut research is so very promising. Wouldn’t it be nice if we had optimal financial sourcing to make sure this research was optimized.

  • Listen to this episode of Plant Proof Podcast for further information if this tickles your interest. So much to learn!

  • Is it the incorporation of modern day antibiotics in our foodchain, especially the US one, leading to more sensitive microbes dying off? Or is it more stress related or is it that those bacteria in the first world are hyper aggressive now?

  • It’s not just diet. Antibiotics are prescribed at basically the maximum possible level which destroys your entire microbiome. We grow monocrops rather than rotating crops, which means the soil becomes devoid of nutrients and becomes like a desert. We spray everything with glyphosate and other pesticides, which is water soluble so it’s everywhere. It’s on the food we eat. We even breathe it in when it rains. This chemical can disrupt the extremely delicate 1 cell thick lining of your gut. It creates a permeability in the lining of your digestive tract and allows microorganisms that would normally be blocked out by your gut lining to enter your body. When this happens, your immune system gets alerted and you get chronic inflammation. I think this is just the beginning of what I think is one of the biggest issues facing society right now.

  • I think at the end, he miss the principal point: feeling and thinking (human *being*). It’s directly connected to your guts, collect data from a wise man in USA, I’m sure he would be as the non-western people, and even better!

    Plus, try meditation + yoga + gratitude during a month to compare before/after on the bacteria. (And not only food)

    I’m sure the best and beautiful solution is here if you wanna help / save western human (it’s like 80% depressed people in America, no?). 
    Philosophy, Psychology, Spirituality, Wisdom…
    Knowing yourself then others then the world / universe ��.

  • I love this ted talk. I deeply recommend Missing Microbes By Doctor Martin J. Blaser! He goes much more in detail. It’s truly amazing.

  • You can change the predominance of your microbiome from bacteroides to prevotella in just a couple weeks eating a whole foods, plant based diet.

  • Eating healthy just means getting the processed foods out of your system. What diseases you are predestined to have are genetic based and not much you can do about it besides try to halt it for a few years. I have known healthy eating, active people drop dead of common diseases even after doing everything correctly. There is no genetic or health perfection. Do the best you can and deal with real life.

  • The heathiest gut bacteria come from eating a diverse diet of homegrown unwashed organic vegetables and fruits. This is because they have elevated microbiotics on their surface which will diversify your gut and keep you healthy. You can test this yourself. Test your gut before and after and you will see an enormous positive change as well as much better digestion. It is common for people from small villages in other countries to grow their own food but once they come to America, they eat processed food and lose their gut diversity.

  • Not telling us how to replace the current gut microbes we have living in our guts with what should be there was a big fail on the part of this speaker. He really missed a big opportunity in this talk which I am not used to in a TED talk.

  • Animals live far longer and older in zoos compared to their wild peers. Thanks to the good and abundant food, and to the medical care provided by the zoo staff and vet doctors.

  • Hypothesis: if you investigate the microbiome of Italians in Sardinia (or vegetarians) you’ll find a healthy diverse microbiome.
    The USA is in grave danger with a large part of the population being overfed yet undernourished. (It affect the ability to think clearly…)