Durability – 3 Supplements Everybody Ought To Be Taking

 

Life Expectancy with Prostate Cancer Diagnosis

Video taken from the channel: Prostate Cancer Research Institute


 

Cracking the Longevity Code: J. Craig Venter PhD #182

Video taken from the channel: StartUp Health


 

Approaching the Second Half: The Latest Research on Longevity and Aging; By Anne Brunet, PhD

Video taken from the channel: Stanford Medicine


 

Sulfur for a Long Life

Video taken from the channel: Cell Press


 

The IGF-1 Trade-Off: Performance vs. Longevity

Video taken from the channel: FoundMyFitness


 

Taking These 3 Supplements Daily Can Change Your Life For Good

Video taken from the channel: Natural Solution


 

Dr David Sinclair Describes His Entire Longevity Routine

Video taken from the channel: Modern Wisdom


 

Live Healthy Longer: Healthspan vs. Lifespan: Brian Kennedy at TEDxMaui 2013

Video taken from the channel: TEDx Talks


 

Life Expectancy with Prostate Cancer Diagnosis

Video taken from the channel: Prostate Cancer Research Institute


 

Cracking the Longevity Code: J. Craig Venter PhD #182

Video taken from the channel: StartUp Health


 

Approaching the Second Half: The Latest Research on Longevity and Aging; By Anne Brunet, PhD

Video taken from the channel: Stanford Medicine


 

Sulfur for a Long Life

Video taken from the channel: Cell Press


 

Taking These 3 Supplements Daily Can Change Your Life For Good

Video taken from the channel: Natural Solution


 

Dr David Sinclair Describes His Entire Longevity Routine

Video taken from the channel: Modern Wisdom


3 Top Longevity Supplements #1 Fish Oil. Click hereto order fish oil now. Funny, yes, but there is plenty of truth hidden in this gem. Barbell #2 Vitamin D. Click hereto order vitamin D now. Most of us don’t see enough sun.

We grind away at our jobs and work #3 Niagen. Omega-3 fatty acids should be added to your diet for its brain-boosting, heart-healthy, and inflammation-fighting superpowers, Dr. Taz advises. But for anyone who might treat this buzzy supplement. 11 Longevity Vitamins.

The 11 nutrients identified by Ames as crucial for a long, healthy life, plus where to find them. Pyrroloquinoline quinone (PQQ): Available in energy and brain formulas and in standalone supplements, but not in multivitamins. Taurine: In some protein powders and standalone supplements.

Lutein and zeaxanthin: In eye-health formulas and standalone supplements. But some of the vitamins and supplements we take may do more harm than good, Barber warns. Here are five vitamins and supplements Barber believes post 50s should reconsider. (Be sure to consult with your doctor before making any individual changes to your supplement regimen and to check for any possible counter interactions with medicines you. Over-the-counter dietary supplements are big business — more than 90,000 products generate about $30 billion every year in the United States. Older adults make up a big part of these sales, too.

A survey of almost 3,500 adults ages 60 and older published Oct. 1, 2017, in The Journal of Nutrition found that 70% use a daily supplement (either a. The rationale for taking supplements in the first place is as insurance against nutritional gaps in the diet and as added defense against increasing toxic pressures from the environment. Ideally, your diet should provide most of your nutritional needs, and it can if it is the right diet for you, richly varied, and abundant in fresh vegetables. “Don’t take supplements with that expectation.” Evidence does suggest that some supplements can enhance health in different ways.

The most popular nutrient supplements are multivitamins, calcium and vitamins B, C and D. Calcium supports bone health, and vitamin D helps the body absorb calcium. These Are the Best Supplements to Take at Every Age Plus, here are 3 rules to follow for a long life—and the exercise that’ll increase your longevity. Healthy Body.

Supplements. Herbal Medicine. Aromatherapy & Essential Oils. Massage Therapy. Omega-3 fatty acid supplements are widely available at many grocery stores and pharmacies and have many health benefits including reducing inflammation and lowering your triglyceride levels.

Flaxseed is a source of omega-3 that is suitable for vegetarians and vegans. If a person cannot get enough omega-3 in their diet, they might consider taking a supplement. Speak to a doctor before.

List of related literature:

Why would you need to take supplements for health, fitness, and longevity?

“Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging” by Ben Greenfield
from Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging
by Ben Greenfield
Victory Belt Publishing, 2020

There has never been a single supplement that has survived the test of time.

“Quantum Eating: The Ultimate Elixir of Youth” by Tonya Zavasta
from Quantum Eating: The Ultimate Elixir of Youth
by Tonya Zavasta
BR Publishing, 2007

Supplements are quite useful in persons older than 65 years.

“The Clinician's Handbook of Natural Medicine E-Book” by Joseph E. Pizzorno, Michael T. Murray, Herb Joiner-Bey
from The Clinician’s Handbook of Natural Medicine E-Book
by Joseph E. Pizzorno, Michael T. Murray, Herb Joiner-Bey
Elsevier Health Sciences, 2008

Supplements may include essential nutrients, e.g. minerals, vitamins and fatty acids, that may usually be in the diet and/or have well-established functions in the body, e.g. creatine.

“Manual of Dietetic Practice” by Joan Gandy
from Manual of Dietetic Practice
by Joan Gandy
Wiley, 2019

According to Manore and Thompson (2000), exercise increases the need for the B-complex vitamins in athletes perhaps up to twice the current RDAs.

“Textbook of Work Physiology: Physiological Bases of Exercise” by Per-Olof Åstrand, Kaare Rodahl, Hans A. Dahl, Sigmund B. Strømme
from Textbook of Work Physiology: Physiological Bases of Exercise
by Per-Olof Åstrand, Kaare Rodahl, et. al.
Human Kinetics, 2003

Although people can gain small amounts of body weight while taking creatine supplements, scientific studies do not support claims that the amino acid improves endurance or performance; indeed, such supplements may have negative health effects (Terjung et al., 2000).

“Essential Concepts for Healthy Living” by Sandra Alters, Wendy Schiff
from Essential Concepts for Healthy Living
by Sandra Alters, Wendy Schiff
Jones and Bartlett Publishers, 2005

SUPPLEMENTS AREN’T nearly as important as some people would have you believe.

“Bigger Leaner Stronger: The Simple Science of Building the Ultimate Male Body” by Michael Matthews
from Bigger Leaner Stronger: The Simple Science of Building the Ultimate Male Body
by Michael Matthews
Waterbury Publishers, Incorporated, 2019

For example, vitamin A, beta-carotene, and vitamin E—while all healthy when consumed in food—have been shown to significantly increase death when consumed as supplements.29 The problems with supplements shouldn’t come as a surprise.

“The Forks Over Knives Plan: How to Transition to the Life-Saving, Whole-Food, Plant-Based Diet” by Alona Pulde, Matthew Lederman, Marah Stets, Brian Wendel, Darshana Thacker
from The Forks Over Knives Plan: How to Transition to the Life-Saving, Whole-Food, Plant-Based Diet
by Alona Pulde, Matthew Lederman, et. al.
Atria Books, 2017

For easier supplement use, refer to Longevity Capsules in the Supplements section of this book.

“Reference Guide for Essential Oils” by Connie Higley, Alan Higley
from Reference Guide for Essential Oils
by Connie Higley, Alan Higley
Abundant Health, 1998

Unless you live in a pristine environment, eat a perfectly balanced organic diet, get just the right amount of exercise and rest, and are under no stress, then the answer is yes—supplements are a good idea.

“User's Guide to Nutritional Supplements” by Jack Challem
from User’s Guide to Nutritional Supplements
by Jack Challem
Basic Health Publications, Incorporated, 2003

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

[email protected]

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212 comments

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  • It’s all how you take care of yourself, I’m 64 and feel and look younger than people my age. I work hard and eat healthy foods. I’m still waiting for my hair to turn gray, and my skin Glows. I’m not on any medicine. I love me.��❤️

  • Sir,
    I am a 31 year old male and I’ve been suffering from Keratoconus (eyes), Plantar Fascitis (feet), Degenerative Disk (lower back), along with occasional muscular pain (esp. in neck, shoulders and back).
    Although I’ve been taking care of these by regular follow up with respective professionals, prescribed medications and daily exercises. Further, i take sufficient healthy diet too.
    Iv recently started taking a couple of supplements on daily basis:
    * Vitamin C with Zinc tablets
    * Fit eye plus tablets
    * Bilberry extract tablets
    * Vitamin D3 tablets
    * Supradyn tablets
    * Collagen Peptides powder (taken along with honey & lemon in warm water)
    * Vitamin B12 tablets
    * Magnesium Oxide Tablets

    I take half of these in the morning, and the remaining in the afternoon. I haven’t experienced any visible side effects in the past 3 weeks since I’ve been consuming them. However, I’m not very sure if I’m taking them properly or if I should be consuming them at all.

    Sir, please suggest me the most effective way to consume these supplements in order to get maximum benefits. Im ready to give them a further try for the next 2-3 months to see any changes in my condition.

    Thanks

  • https://www.youtube.com/channel/UCwDHVTaHw6XzYfj_wSgfbiw/featured?view_as=public
    Be part of our Growing Family,
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  • Does this guy understand that most of us are not Doctors nor do we have a personal drug dealer. So unless you got diabetes no doctor will give you metformin.

  • No matter what you do to improve your chances of long life medicinally, you can’t stop fate, if it’s your turn to get hit by a bus.

  • You take statin drug, and baby aspirin? You are a very questionable Dr. It seems you got or little, or no that much knowledge about natural medicine, and health. ��

  • Dr. Sinclair takes statin drugs? This is surprising. Statin drugs are very bad for you. A “high cholesterol” reading isn’t necessarily bad, because cholesterol is an integral part of cells. It’s not cholesterol that destroys your cardiovascular system but calcium deposits in arteries, which cholesterol tries to smooth over. I’m surprised that Dr. Sinclair doesn’t take vitamin K2, which gets the calcium out of your circulatory system and back into your bones, where it belongs. Also, what about vitamin D3 and magnesium, which are both essential and in which most Americans are deficient? And rather than taking aspirin, which is bad for you, why doesn’t he just take ginger, a blood thinner? And it’s been proven that giving blood at least once every two years has been proven to prevent heart attacks.

  • My testimony is I used to have very frail and nails that break so easily! After a month of taking multivitamins, my nail started growing very strong!

  • It’s so sad that we are replacing healthy eating with pills to stay healthy nowadays. I eat homemade yogurt every day. I always add fresh fruit, Chia seeds and almonds that I grind myself. It’s healthier and a nicer experience than swallowing pills. Plus, that’s probiotics, vitamins, Omega 3, antioxidants and fibre right there! And it’s delicious! Can all be mixed into a delicious smoothie to take to work if in a hurry, or whatever. Salmon is also a great source of Omega 3; once or twice a week is enough. If you have a garden or even a patio, nothing beats eating your own fresh greens that you know haven’t been sprayed to death. I don’t bother growing lettuce because they have no nutritional value whatsoever. But things like perpetual spinach, beet, kale, etc. are so easy to grow even in containers, gives you continuous supply so is cheaper; and so good for you and no chemicals have been added. I use them raw in salads rather than cook them to death and destroy the nutrients. I’m in my 60’s and I’m healthy. Eating right has always been the key to good health; that’s the “natural solution” and that will never change.

  • 100-1000 percent? Who the fuck wants to live past 75?you can’t do anything. Who is going to take 100IU a day of GH? This is informative but I see a lot of holes.

  • Sir,
    I am a 31 year old male and I’ve been suffering from Keratoconus (eyes), Plantar Fascitis (feet), Degenerative Disk (lower back), along with occasional muscular pain (esp. in neck, shoulders and back).
    Although I’ve been taking care of these by regular follow up with respective professionals, prescribed medications and daily exercises. Further, i take sufficient healthy diet too.
    Iv recently started taking a couple of supplements on daily basis:
    * Vitamin C with Zinc tablets
    * Fit eye plus tablets
    * Bilberry extract tablets
    * Vitamin D3 tablets
    * Supradyn tablets
    * Collagen Peptides powder (taken along with honey & lemon in warm water)
    * Vitamin B12 tablets
    * Magnesium Oxide Tablets

    I take half of these in the morning, and the remaining in the afternoon. I haven’t experienced any visible side effects in the past 3 weeks since I’ve been consuming them. However, I’m not very sure if I’m taking them properly or if I should be consuming them at all.

    Sir, please suggest me the most effective way to consume these supplements in order to get maximum benefits. Im ready to give them a further try for the next 2-3 months to see any changes in my condition.

    Thanks

  • Just bought the most amazing bottle of multi Vitamins, it’s got….ABCDEFGHIJKLMNOPQRSTUVWXYZ………man I’m gonna live forever….now where’s my beer.������������������������

  • Dr David Sinclair it’s a world changer
    Certainly the molecules discover NMN-NAD-resveratrol, boost sirt 1 and for better endothelial function also will help these regenerative
    Processes.

    Regenerative treatments

    Páncreas regeneration

    https://www.facebook.com/cientificomarioncamacho/videos/2073447296004983?sfns=mo

    Neuronal refresh

    https://www.facebook.com/cientificomarioncamacho/videos/1902015503148164/

    Múltiple sclerosis

    https://www.facebook.com/cientificomarioncamacho/videos/1911795905503457/

    Macular degeneration

    https://www.facebook.com/cientificomarioncamacho/videos/1615588898457494?sfns=mo

    Retinitis pigmentosa

    https://www.facebook.com/896399837043074/posts/2755316424484730?sfns=mo

    https://www.facebook.com/cientificomarioncamacho/videos/1997767016906345/

    Retinitis pigmentosa

    https://www.facebook.com/cientificomarioncamacho/videos/329687151057184?

    https://www.facebook.com/kary.camacho.52831

    T cells vs cancer

    https://www.facebook.com/896399837043074/posts/2674198802596493/?d=n

    Stem cell implantation

    https://www.facebook.com/cientificomarioncamacho/videos/1767590836590632?vh=e&d=n&sfns=mo

    Regenerative processes for retina
    brain, and other organs

    https://www.facebook.com/cientificomarioncamacho/videos/1762653680417681?vh=e&d=n&sfns=mo

  • The major things are still: food, sport, fasting and livestyle in general
    The things mention in this video are more supplementing the points above.

  • Some say that probiotics are useless damaged by stomach acids. If I was going to take any probiotic it would be and is sometimes apple cider videgar. Being liquid some of it may just bypass the stomach and go into the intestines to be absorbed

  • People who are criticizing David Sinclaire for taking metformin, it looks, like you are unfamiliar with research that shows that low doses of metformin can potentially extend the lifespan by protecting against such diseases as cancer, heart disease, and Alzheimer’s. I am sure that it does have side effects especially for people with compromised health.
    Check out the following research articles:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772077/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943638/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052468/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898468/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066537/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892694/
    https://pubmed.ncbi.nlm.nih.gov/21882902/
    https://pubmed.ncbi.nlm.nih.gov/30255224/
    https://pubmed.ncbi.nlm.nih.gov/18728386/
    https://pubmed.ncbi.nlm.nih.gov/21084729/

  • Tropical islands are not conducive to a healthy lifestyle, especially if one is born and raised there. ☯️ Sugars and carbohydrates are likewise. ��‍♂️ LXX �� XXL ��

  • what brand of resveratrol do you use. i see Trans-Resveratrol, combinations of blueberry, acai, and other with japanese knotweed. and what strength.

  • ITS EPA AND DHA NOT DPA ITS EMBARRASSING TO GET THAT WRONG IN A VIDEO YOU MAKE CLAIMING TO EDUCATE. SHAMEFUL PITIFUL THUS CHANNEL IS NOTHING MORE THAN SOMEONE JUST LOOKING FOR MONEY THERES OBVIOUSLY ZERO PASSION INTO HEALTH! Horrible channel

  • Omega 3 has helped me with depression. Tumeric has given me energy aswell as broccoli. Probiotics helped me with anxiety and depression. Those are my main foods I eat.

  • LXX �� XXL ��
    My hair colour is returning. �� ��‍♂️ My body has returned. None of the above have been used, except for the Fasting.

  • For multivitamins and minerals and omega 3 capsules. And EPA AND DHA FATS. SUPPLY ALL OVER INDIA.by NUTRITIONIST. CONTACT:8121703060

  • Igf 1 increase due to diet will not increase performance.

    Igf 1 raise due to diet will not protect neurons.

    Increasing muscle mass and whatnot is better attained through weightlifting and cardio.

    You increase IGF-1 solely through diet (or worse, drugs) and stay sedentary and I’ll lift weights and we’ll see who is stronger in a year.

    These are cool hypotheses.

    Diminished muscle mass and libido and whatnot through igf-1 reduction via diet is not a thing.

    This os a load of horseshit. No wonder joe rogan, the self proclaimed idiot, has you on his show constantly.

    “Healthy balanced diet” doesn’t mean anything because it’s too vague.

    I’m pretty sure igf-1 increase through non.dietary means without a doctor’s prescription is illegal.

  • In another video I recall he took the Merformin at night and in the off-days training… maybe morning / evening makes no difference, just saying

  • For a super smart man like Dr Sinclair.. I would have guessed that he would stay away from full fat milk. He states that he has high cholesterol and is on statins.. Would staying away from animal proteins and saturated fats be the obvious choice as opposed to Statins?

  • I love my Chinese and Korean serums with IGF1 and IGF2. Also, for the fat and sugar avoiders pertaining to the chocolate. I reccomend using cacao powder it is chocolate minus the fat, and sugar.

  • The properties that make the Bravo yogurt mentioned by Dr. Sinclair unique are described in detail in this article https://www.biorxiv.org/content/10.1101/714154v3 where its GcMAF and anti nagalase activities were evaluated by an independent laboratory. This article already is in the top 25% of all research outputs scored by Altmetric (attention score), see https://biorxiv.altmetric.com/details/63993873

  • For very different reasons, NAD+ has also attracted a wave of attention from cancer researchers. Recent studies suggest that cancer cells of many types depend on NAD+ to sustain their rapid growth and that cutting off the NAD+ supply could be an effective strategy for killing certain cancers. The data from these studies paint a more complicated picture of NAD+ and raise new questions about the diverse ways taking an NAD+-boosting supplement might influence health. “It might still slow down the aging part, but it might fuel the cancer part,” says Versha Banerji, a clinician-scientist at the University of Manitoba. “We just need to figure out more about the biology of both of those processes, to figure out how we can make people age well and also not get cancer.” This is just a fellow up to my previous post. Interesting that most sites are ignoring the possibilities of its effects on cancer.

  • I was on Statin and it was causing muscular damage my doctor said and he switch me on Crestor and I had a few bad side effects like chest pain and I quit them and I take only one aspirin a day and I am strict on my diet, lost 37 lb, I avoid process food and hardly no sugar now, I take Moringa leaf powder for arthritis and turmeric every day and I am. in lot better shape. in the long run sugar was my worst enemy. I eat wild meat that I hunt and fish that I catch myself only

  • It’s interesting how type 2 diabetes is now considered a part of aging. Before the 1970s, it wasn’t even acknowledged as existing.

  • It’s a myth that balanced diets give you all vitamins. They give you up to 80%. But please don’t take vitamin E with other vitamins. It blocks their absorptions.

  • Always when i go to doctors for ask wht the best supplement for me, they just like, ah you wont to buy extra vitamins and minerals, food gave u enough! Dont buy anything ��

  • Diagnosed with Gleason 7 but nobody will tell me if it is aggressive. Makes me think it is but they are afraid to get me upset. Upset anyway. Getting radiation treatment with Cyberknife. Maybe if it works, then they will tell me. But I doubt it.

  • I periodically take TA-165 to boost HGH. I feel and look 100% better. What are your thoughts about cancer with taking HGH or HGH boosters?

  • He may actually have a heart attack on statins, they are lethal, I am very surprised at that. Love his research on nad but that makes no logical sense to me.

  • He should know aspirin is not good daily from what it does to stomach. Hawthorne is a natural blood thinner. Metformin is good in some ways bad in others on what it does

  • Longevity in regards to not going into a heavier state of repair as much and causing less oxidative stress within the body but what use is that when GH and igf1 are release periodically in times of need as we recover, in reality you’re just saying those who’s bodies spend more time healing/recovering are going to shorten their life span which makes some sense but to lower igf1 also comes with alot more of its own risks due to its synergism with other hormones and it’s knocking affect on health and recovery. If I’m lying in a cage or glass box permanently in a lab environment then yes of course lower igf1 levels would mean a longer life but in the real world where there is risk and reward I’m gonna want the correct GH and igf1 response in any situation to get me trough life and help me sleep, repair and completely recover in shorter time. I would no doubt assume that keeping that low igf1 mouse in with a standard group of mice outside a lab environment would drastically shorten its life due to its hormonal handicap. Not all avenues of repair will be affected but some clearly important ones will be no doubt.

  • Research online Scientifically Proven as Our Lord Jesus blood type discovered in the Holy Eucharist as part of the Catholic Faith it’s so amazing plus many more great Miracles in the Catholic God Bless Take Care ������☘

  • DO YOU KNOW ASCORBIC ACID IS NOT VITAMIN C? (NOT EVEN CLOSE).
    https://m.youtube.com/watch?v=paIFO9g5TLw&list=PLpTTF6wMDLR5tjNfMLc-5RpRzxK5D0yqH&index=20&t=0s

  • Sinclair lost all credibility as soon as he admitted he uses a statin as well as Metformin. The baby aspirin does nothing good for him either.

  • You should never let this slowing growing cancer bother you. And you should never accept any prostate cancer treatments because they are all toxic poisons to your bodies. What kind of sick minded urologists, medical and radiation oncologists, would tell their patients to get rid of their prostates to avoid prostate cancers later? We now know that there are basically two types of prostate cancer: one that would kill you no matter what cancer treatment or combination of treatments you receive; the other one grows ever so slowly that you will die with something else and not of it. Wake up and take charge of your own health, men! Do what your bodies tell you to you, and don’t pay any attention to this bunch of so-called cancer specialists who tell you that your PSA “seems elevated” which lead you to unnecessary biopsies and overtreatments that, for sure and without a doubt, will ruin your quality of life.

  • Statins and metformin? Lol
    I would not listen to anything this man say..
    The WORST meds ive ever had in my life are TAMIFLU, STATINS AND PREDNISONE.
    I shifted to magnesium glycinate, vitamin C, fish oils, coconut oil and turmeric

  • DO YOU KNOW ASCORBIC ACID IS NOT VITAMIN C? (NOT EVEN CLOSE).
    https://m.youtube.com/watch?v=paIFO9g5TLw&list=PLpTTF6wMDLR5tjNfMLc-5RpRzxK5D0yqH&index=20&t=0s

  • Similar to the way people process caffeine differently, some people need to increase IGF-1 and others should focus on reduction. One problem is the further down the rabbit hole one exploresmuch of the available data is contradictory. In other words one study reports a substance increases IGF-1 while another study reports the same substance has no discernible impact on IGF-1. For example it’s said that meat increases levels of IGF-1 in the body. We often read that over consumption of red meat is detrimental to health. It follows that articles on the internet state red meat increases IGF-1. But then researching the subject in depth you’ll find contradictory information stating that all meat except red meat increase IGF-1. Someone is right who? I suspect many of the conclusions reported are based on who funds the study.

  • https://www.youtube.com/channel/UCwDHVTaHw6XzYfj_wSgfbiw/featured?view_as=public
    Be part of our Growing Family,
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  • Diagnosed with Gleason 7 but nobody will tell me if it is aggressive. Makes me think it is but they are afraid to get me upset. Upset anyway. Getting radiation treatment with Cyberknife. Maybe if it works, then they will tell me. But I doubt it.

  • I, being a health professional, don’t agree with this. If you have a balanced diet, you’ll get the nutrition. If you regularly detox your body, all the nutrition you eat, will get absorbed in the body. Nature has a solution to everything. Moreover, nutritional supplements is multi billion market. Take it if and when prescribed, that to for short period of time.

  • We have best evidence of food supplements in health problems. We are promoting only Nutrilite brand to all our customers. If you need any more details cal me +919885872144 srinivas

  • No matter what you do to improve your chances of long life medicinally, you can’t stop fate, if it’s your turn to get hit by a bus.

  • Actually the isolation of Alpha tocopherol (Vitamin E)was the biggest mistake in nutritional history. The following video explains the entire history as well as why it failed as an antioxidant and causes higher mortality rates. https://youtu.be/V9zHfSIPdSo

  • Are you made do not take probiotics supplements daily Guys don’t take plz it’s harmful.. You can take vitamin D supplement and omega 3 and can take natural sorce for vitamins and minerals okk

  • While vitamin D is good for you…the supplements can cause hypercalcemia (too much calcium). Please do some research before taking 5000 iu daily.

  • best dietary supplement for 2020
    https://www.amazon.ae/gp/product/B07M9J2JDN/ref=as_li_tl?ie=UTF8&camp=247&creative=1211&creativeASIN=B07M9J2JDN&linkCode=as2&tag=yh17shope-21&linkId=c1f4da74afc521cf4beb5b7bec652f68

  • Yeah, the young mouse contributes to rejuvenation in the old mouse while the old mouse contributes to aging in the young mouse. It’s like thermodynamics. Life is a form of reverse entropy where order and complexity is increased over time.

  • Baby aspirin over a long period of time is rough on kidneys. The funny thing is people will actually try and do what this guy does. Get old gracefully folks and enjoy your life.

  • All of this assuming you are only taking IGF-1 and GH Ubiquinol, Alpha GPC, and many other supplements have protective antioxidant effects. Make your stack DEEP ladies and gentlemen.

  • Multi vit (with food)A,B,C,D,K,E, zinc {teracoting}
    Probiotic (before sleep)
    Omega 3 (EPA and DPA)( with food)
    Lean meat with healthy fats and raindow of foods.

  • Not everyone needs a multivitamin. If we consume a reasonably balanced diet our bodies get most of what is needed. Some supplements can be quite useful like turmeric, zinc, and magnesium among others depending on individual deficiencies.

  • If you eat a lot of eggs, choose Eggland’s Best for the added Omega-3. I eat 3-4 a day which takes care of my Omega-3 needs. 125 mg of Omega-3 per egg.

  • If you eat a lot of eggs, choose Eggland’s Best for the added Omega-3. I eat 3-4 a day which takes care of my Omega-3 needs. 125 mg of Omega-3 per egg.

  • Dr. Rhonda Patrick is like that cool teacher everyone wishes to have.
    I started drinking green tea daily and eating the leaves for 2 weeks now. Really feel better now! I can even focus more when studying!

  • My grandma is 102 years old and perfectly healthy. She tells me it’s because she has drank a bucket of her sterilized diarrhea every day for 60 years. She has great skin too.

  • Diagnosed in November with “quite aggressive” Gleason 7 I’m 71 and wondering how long I would have if I didn’t so anything (?) As it is I am due to start Hormone Therepy in a few days Followed by Radio Therepy in a couple of months I’m frightened am I doing the right thing?

  • It’s a myth that balanced diets give you all vitamins. They give you up to 80%. But please don’t take vitamin E with other vitamins. It blocks their absorptions.

  • Dr. Ruggiero is the inventor of Bravo Yogurt and is deeply interested in studying anti-aging.  He believes that we as people should have more capacity to endure.  He has studied lobsters who don’t die of old age and cancer which can stay alive in a petri dish for 60 years.  He thinks that we can change our fates and has put his ideas to work in a product of longevity along with products that do a great job cleaning up issues like diseases.  

    I am quite sure that this book by Dr. David A. Sinclair, PhD, Professor at Harvard Medical School is a book worth reading and practices worth noting.  For example, I use  Bravo yogurt every morning for 5 years.  Very often I gain more capacity and efficient.  I make it a daily part of my amazingly healthy life!  I get it here.   www.bravocoop.com

  • Just bought the most amazing bottle of multi Vitamins, it’s got….ABCDEFGHIJKLMNOPQRSTUVWXYZ………man I’m gonna live forever….now where’s my beer.������������������������

  • since 2012 singapore doctors complaint NO sales…WHY… cos 18hrs fasting + low carbs cure tons of sickness, always empty our stomach, fully digest n NO piling foods in stomach is key….. from SG

  • Leave caloric restriction for the mice? What about all her talks with Dr. Longo? This is 2013 video. I see her visits with Dr. Longo is in 2016

  • You would need a very big tablet to get all the multivitamins and minerals, the amounts in the tablets are so small to make any difference. Best to sort your diet out first, do some research.

  • Please, what excactly is an NAD supplement? what does contain it? I dont know all the stuff he is talking about except the resveratrol

  • My PSA went from 10 to 14 in three months. Going for my third MRI since diagnosed with prostate CA three years ago. Been doing active surveillance because my doctor is against over treatment. It’s stressful to live with cancer and never knowing if it will spread outside the prostate between scans. An MRI is too expensive to do more than once a year.

  • He takes statins and he microwaves food which he eats for the Probiotics… And this is why you have to be intelligent and CHERRY-PICK all of the available information out there… Even ppl with great knowledge and insights in one thing completely suck at another… Also their Ego might come into play and they could push false information because they too proud to actually do a deep research… Just remember to CHERRY-PICK!!!

  • These comments are hilarious, the ignorance and arrogance of the YouTube masses is truly appalling.

    But funny in a dark humor sort of way.

  • Should I cycle MSM? I am taking MSM for 2 years now, 12 grams a day. REcently I was told to cycle my supplements (like acetyl-l-carnitine), but I dont know wether MSM should be cycled too, like d3 you dont cylce, so I dont know wether MSM is a supplement to cycle or not.

  • Does this guy understand that most of us are not Doctors nor do we have a personal drug dealer. So unless you got diabetes no doctor will give you metformin.

  • The only practical solution for aging is with replacing the body cells in a controlled fashion. The final roadblock would be the brain, unless someone finds a way to transfer consciousness.
    Either way, that luxury will be very unlikely to be affordable for the 99%

  • Please, what excactly is an NAD supplement? what does contain it? I dont know all the stuff he is talking about except the resveratrol

  • Yeah, the young mouse contributes to rejuvenation in the old mouse while the old mouse contributes to aging in the young mouse. It’s like thermodynamics. Life is a form of reverse entropy where order and complexity is increased over time.

  • If I have a choice between looking like Arnold and dying at 90 or looking normal and dying at 120, that’s not really a hard choice. Let’s get to the gym and pump up. I’m actually all about anti-aging but that’s where I draw the line.

  • “David Sinclair is one of the most accomplished fraudsters of modern time, and he most certainly belongs in Harvard.
    He was the main person behind the resveratrol scam of the early 2000s, which resulted in him forming a company to sell a patented version of resveratrol, and that company was bought by GSK for $700mil. The company quickly went under when several clinical trials with the “miracle” patented resveratrol were cancelled due to deaths in the active group.
    Needless to say Mr. Sinclair emerged unscathed and kept all of the money he got from the company sale. Now he peddles other sirtuin (SIRT) activators similar to resveratrol, and of course intermittent fasting as it also activates those genes.
    The fact that proven fraudsters like him not only get rich from killing others but keep coming back with the same idea in a new wrap (and successfully so) gives me serious doubts about the future of humanity.” Haidut

  • My grandma is 102 years old and perfectly healthy. She tells me it’s because she has drank a bucket of her sterilized diarrhea every day for 60 years. She has great skin too.

  • what brand of resveratrol do you use. i see Trans-Resveratrol, combinations of blueberry, acai, and other with japanese knotweed. and what strength.

  • These comments are hilarious, the ignorance and arrogance of the YouTube masses is truly appalling.

    But funny in a dark humor sort of way.

  • David Sinclair tested how resveratrol was most effectively absorbed and found (I saw a lot of his podcasts) that when it is taken with fat it is 5x more bio available. I suppose 2 spoons of yogurt would be enough fat, but when I check my full fat yogurts, they are only 3 or 4% fat so I’m interested in how yogurt can help the resveratrol absorb?? (maybe his yogurt is 30 or 50% fat). The other thing that makes resveratrol more bio available is piperine. I personally take it with fat and curcumin supplements, which also have piperine in them, so I’m guessing they work well together. Like Sinclair (who’s book is fabulous by the way) I’m also having a 1000mg XR metformin tablet with these two but will stop from now since I saw this from Rhonda Patrick https://www.youtube.com/watch?v=2Bsk7qZ8888 (spoiler: if you exercise, don’t take Metformin like David Sinclair)

  • Acromegaly and people with genetically low HGH (likely igf 1 as well but i would want to do more research on that) are fairly well studied. People with acromegaly arent performance and cognitive powerhouses nor do they have super awesome lives that we would all envy with a super high quality if life or ultra high subjective well being. And people with HGH deficiencies aren’t infertile or don’t have extremely atrophied musculature nor are they demented and stupid nor.do they have super low quality of life and constantly fight depression and bad.feelongs, but they are highly resistant or even immune to cancer.

    This is horseshit.

    Don’t trust the hypotheses in this video to be conclusions.

  • Diagnosed in November with “quite aggressive” Gleason 7 I’m 71 and wondering how long I would have if I didn’t so anything (?) As it is I am due to start Hormone Therepy in a few days Followed by Radio Therepy in a couple of months I’m frightened am I doing the right thing?

  • For all those who care, we have this Healthspan | Longevity discord at https://discord.gg/ftSbffu. Feel free to join in at anytime, for an engaging discussion or to share the latest about developments in this field of life extension.

  • Great information to find out if you have cancer they need to do a biopsy that means sticking needle in walnut size prostate if psa test is high which is sc inaccurate take a look a Richard Ablin on you tube scary

  • I use Berberine instead of Metformin. Nicotinomide Riboside and resveratrol. Also broccoli sprouts. I use intermittent fasting as well. NAD should be taken with a methyl-donor such as N-acetyl cysteine because it will deplete you, especially if you are taking niacin.

  • “David Sinclair is one of the most accomplished fraudsters of modern time, and he most certainly belongs in Harvard.
    He was the main person behind the resveratrol scam of the early 2000s, which resulted in him forming a company to sell a patented version of resveratrol, and that company was bought by GSK for $700mil. The company quickly went under when several clinical trials with the “miracle” patented resveratrol were cancelled due to deaths in the active group.
    Needless to say Mr. Sinclair emerged unscathed and kept all of the money he got from the company sale. Now he peddles other sirtuin (SIRT) activators similar to resveratrol, and of course intermittent fasting as it also activates those genes.
    The fact that proven fraudsters like him not only get rich from killing others but keep coming back with the same idea in a new wrap (and successfully so) gives me serious doubts about the future of humanity.” Haidut

  • fallacy #1 The assumption that what the US spends on health care correlates with our level of caring about healthcare,
    mostly what we pay for health care is due to a corrupt health system that is designed to support the financial interests of health insurance companies and big pharma.
    What do we get from our inflated spend on healthcare? Ridiculously Healthy profits for insurance companies.

  • I say this with the utmost respect if there is one woman I would want to make sweet sweet love to, it’s Dr. Patrick. In the whole world. Include everyone. For me, she’s the one. No other mouth has looked sexier saying the word “polyphenols’ as Dr. Patrick, in the annals of human history.

  • For multivitamins and minerals and omega 3 capsules. And EPA AND DHA FATS. SUPPLY ALL OVER INDIA.by NUTRITIONIST. CONTACT:8121703060

  • Its approx. $5 per gram of NAD Booster (NMN) so if he takes 2 grams per day for 30 days that’s around $300 per month but on his Harvard salary, he can afford it!

    PS Alot of the NMN products are Fake! Buyer beware! He probably has access to labs and fellow colleagues to test the purity of the products he buys!

  • Rodent models, almost like a human model but not even close. Actually using a rodent model to make meds or anything for humans is just terrible science and doesn’t work. Just look at how dangerous most of human medicine is. Humans are the Guinea pigs for the pharmaceutical industry. But humans are to stupid to see this issue. So keep taking all the meds they keep telling you you need ������������������������

  • Just found out from my MRI that I have 2 suspect areas of cancer. One rated 4, and the other rated 5 on a 1 to 5 scale… 5 being worst.
    I have important shit on my mind. What’s my Wife going to do when/if I’m gone before her… and why did you wear that tie? MAX cynical.

  • If it takes 100 times the doss to reduce life by 50% but only a modest dose to make aging bearable I think it’s a decent trade off. How much does production decrease by age 80? To 1/4? So you’d really not even be getting a “larger” dose, just maintaining a youthful amount

  • Dr. Sinclair takes statin drugs? This is surprising. Statin drugs are very bad for you. A “high cholesterol” reading isn’t necessarily bad, because cholesterol is an integral part of cells. It’s not cholesterol that destroys your cardiovascular system but calcium deposits in arteries, which cholesterol tries to smooth over. I’m surprised that Dr. Sinclair doesn’t take vitamin K2, which gets the calcium out of your circulatory system and back into your bones, where it belongs. Also, what about vitamin D3 and magnesium, which are both essential and in which most Americans are deficient? And rather than taking aspirin, which is bad for you, why doesn’t he just take ginger, a blood thinner? And it’s been proven that giving blood at least once every two years has been proven to prevent heart attacks.

  • Supplements are so unregulated that it would be very useful to know where he purchases things like resveratrol, since I assume he tests everything he takes.

  • In another video I recall he took the Merformin at night and in the off-days training… maybe morning / evening makes no difference, just saying

  • Thank Gawd for the comment section hear, I almost listened to the 50 year old scientist who looks 35 and has been studying this for 30 years in the leading edge of science. Thank

  • Yes, calory restriction is not the same thing as eating less often. �� I’m 70 and an very pleased with how things are going. #growingyoung

  • why would you listen to this guy…it’s not like he has a PhD in molecular genetics or was promoted as a tenured professor at Harvard Medical School, amirte…youtube geniuses?

  • A little fast-paced, but insanely useful and great video. Great to see some scientific applicability to increasing fitness, coming from a source that’s not a gym-bro

  • Its approx. $5 per gram of NAD Booster (NMN) so if he takes 2 grams per day for 30 days that’s around $300 per month but on his Harvard salary, he can afford it!

    PS Alot of the NMN products are Fake! Buyer beware! He probably has access to labs and fellow colleagues to test the purity of the products he buys!

  • He takes statins and he microwaves food which he eats for the Probiotics… And this is why you have to be intelligent and CHERRY-PICK all of the available information out there… Even ppl with great knowledge and insights in one thing completely suck at another… Also their Ego might come into play and they could push false information because they too proud to actually do a deep research… Just remember to CHERRY-PICK!!!

  • So what is metformin anyway? He said it originally was a natural molecule, then tweeked. Kind of how St. John’s wort was tweeked into Prozac? What is it?

  • I use Berberine instead of Metformin. Nicotinomide Riboside and resveratrol. Also broccoli sprouts. I use intermittent fasting as well. NAD should be taken with a methyl-donor such as N-acetyl cysteine because it will deplete you, especially if you are taking niacin.

  • “Cancer” is caused by sugar, fructose, fungus, yeasts, molds,toxic diets,pesticides, dairy, hormones,” prions “, virus in meat,chlorinated water,, high oxalate crystals, high uric acid,, Stress, UV radiation exposure, G5 towers, electric magnetic radiation-damaged, heated fats, fried foods, high protein diets, processed food, refine carbohydrates.

    “Eat a low “”lectin”” ” low “oxalate” ” diet “…no spinach, no wheat!.no bread, no pasta!
    American cuisine is poison, cosmic UV radiation exposure (sun), mercury in Fish.

    If you keep you blood sugar below 85 and you eat organic plant base diet you will never get Cancer.

    Many people feel tired and depressed they exercise they eat healthy..They forget that Candida fungus and yeast in the body cause chronic fatigue, brain fog, chronic depression and many diseases in the brain and body ; Fungus, candida and yeast love fructose -> Fruit and high refined carbohydrates.

    Fructose causes a “fatty liver”…damages the liver, weight gain, and feeds parasites, Candida, yeast in the body..

    all bacteria, virus fungus love “fruit sugar “.__ Fruit is poison and addictive! > (fructose)

    Read the Book called ; “”The Yeast connection handbook “”By Williams G Crook, M.D.

    “Cats claw” is a an amazing herb it good for Amyloid in Alzheimer’s great to kill candida and virus also taking oregano oils, MSM sulfur, coconut oils are good for fungus and yeast or you can go to your doctor and get a prescription for anti-fungal medication called “NYSTATIN”

    Watch what you put in your mouth.

    Don’t dig your grave with your teeth.

    Coffee is another drug (caffeine ) makes the liver to release sugar to the blood and this causes ” insulin” surge to be released by the pancreas..the result is hunger and weight gain!

    you want to lose weight? no coffee, no tea….no caffeine!….coffee and teas are a drug > ( caffeine )

    Liver Detoxification –. L-Ornithine is truly special, because it helps your body eliminate extra nitrogen amonia from high protein diets and other types of waste.

    The liver hates fat, fried food, heated damaged fats, sugar, fructose, chemicals,pesticides -> Detox!

    I LOVE chromium GTF by NOW. I have been using this for years. I’d been having a lot of difficulty with low blood sugarwith hand tremors & a foggy head. When I take this supplement daily, I feel steady all day even if I’m late eating a meal. appetite control & sugar cravings along with eating lower carbs. help keep my blood sugar in line.

    -If you’re trying to losing weight the solution is “Fasting ” and eating a plant base diet..the less you eat the longer you will live.

    great book ; The Obesity Code: Unlocking the Secrets of Weight Loss by DR. Jason Fung

    A “mycotoxin ” is a toxic secondary metabolite produced by organisms of the fungus kingdom and is capable of causing disease and death in both humans and other animals. The term ‘mycotoxin’ is usually reserved for the toxic chemical products produced by fungi that readily colonize crops

    = Mycotoxins are toxic compounds that are naturally produced by certain types of moulds (fungi). Moulds that can produce mycotoxins grow on numerous foodstuffs such as cereals, dried fruits, nuts and spices.

    -Aflatoxins are amongst the most poisonous mycotoxins and are produced by certain moulds (Aspergillus flavus and Aspergillus parasiticus) which grow in soil, decaying vegetation, hay, and grains. Crops that are frequently affected by Aspergillus spp. include cereals (corn, sorghum, wheat and rice), oilseeds (soybean, peanut, sunflower and cotton seeds), spices (chili peppers, black pepper, coriander, turmeric and ginger) and tree nuts (pistachio, almond, walnut, coconut and Brazil nut).

    The toxins can also be found in the milk of animals that are fed contaminated feed, in the form of aflatoxin M1. Large doses of aflatoxins can lead to acute poisoning (aflatoxicosis) and can be life threatening, usually through damage to the liver. Aflatoxins have also been shown to be genotoxic, meaning they can damage DNA and cause cancer in animal species. There is also evidence that they can cause liver cancer in humans.

    Ochratoxin A is produced by several species of Aspergillus and Penicillium and is a common food-contaminating mycotoxin. Contamination of food commodities, such as cereals and cereal products, coffee beans, dry vine fruits, wine and grape juice, spices and liquorice, occurs worldwide.

    https://www.who.int/news-room/fact-sheets/detail/mycotoxins

  • I was on Statin and it was causing muscular damage my doctor said and he switch me on Crestor and I had a few bad side effects like chest pain and I quit them and I take only one aspirin a day and I am strict on my diet, lost 37 lb, I avoid process food and hardly no sugar now, I take Moringa leaf powder for arthritis and turmeric every day and I am. in lot better shape. in the long run sugar was my worst enemy. I eat wild meat that I hunt and fish that I catch myself only

  • Hey guys great video! I do love short videos that get to the point and put out the information without all of the filler! Thank you! I do have a question: NAD booster seems to be a more or less generic term. Can you tell to us, your audience, the name of the specific NAD booster that you use, Mr. Sinclair? Many thanks guys!

  • ITS EPA AND DHA NOT DPA ITS EMBARRASSING TO GET THAT WRONG IN A VIDEO YOU MAKE CLAIMING TO EDUCATE. SHAMEFUL PITIFUL THUS CHANNEL IS NOTHING MORE THAN SOMEONE JUST LOOKING FOR MONEY THERES OBVIOUSLY ZERO PASSION INTO HEALTH! Horrible channel

  • I, being a health professional, don’t agree with this. If you have a balanced diet, you’ll get the nutrition. If you regularly detox your body, all the nutrition you eat, will get absorbed in the body. Nature has a solution to everything. Moreover, nutritional supplements is multi billion market. Take it if and when prescribed, that to for short period of time.

  • The problem I have here,is that he takes statins? You can get clean genuine plant sterols on line from the same sites you would get resveratrol from,which reduce cholesterol and are naturally occurring and harmless,so why take statins which are dangerous and have tons of negative side effects?? Considering he’s a brain box scientist from Harvard,this makes no sense.

  • Was discussing vitamin use with my former physician and he said they’re all nonsense, and absolutely useless, a waste of money. You get all the vitamins and minerals you need from the food you eat. I did mention he is my EX doctor.

  • Just found out from my MRI that I have 2 suspect areas of cancer. One rated 4, and the other rated 5 on a 1 to 5 scale… 5 being worst.
    I have important shit on my mind. What’s my Wife going to do when/if I’m gone before her… and why did you wear that tie? MAX cynical.

  • This guy wants to live forever. I dont give a damn what he takes or does. We all gotta go folks. Pack your bags. Were going bye bye. He may live an extra month.

  • It’s all how you take care of yourself, I’m 64 and feel and look younger than people my age. I work hard and eat healthy foods. I’m still waiting for my hair to turn gray, and my skin Glows. I’m not on any medicine. I love me.��❤️

  • Plant based diets can significantly increase survival rate. “When applied to a petri dish of cancer cells, the blood of those who ate a plant based diet for a year had 8x the stopping power when it came to cancer cell growth (for prostate specifically).” https://www.youtube.com/watch?v=0VX_oZBMSd4

  • I’ll do it… I’m ready for a free biomedical test. Feel free to study my body for research. �� ��
    I’ll be part of your studies!! ��

  • Pycnogenol and CBD aid in the conversion of white adipose tissue into brown adipose tissue. FACT. Something you should check out: http://www.ProjectCBD.org/guidance/conditions
    https://www.hindawi.com/journals/jdr/2018/9713259/  Journal of Diabetes Research

    Volume 2018, Article ID 9713259, 11 pages

    https://doi.org/10.1155/2018/9713259

    Research Article

    Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice

    Huiying Cong,1,2 Wenxia Zhong,1,2 Yiying Wang,1,2 Shoichiro Ikuyama

    ,3 Bin Fan

    ,4 and Jianqiu Gu

    1,2

    1Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, China

    2The Endocrine Institute and the Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, China

    3Department of Clinical Investigation, Department of Diabetes, Endocrine and Rheumatic Diseases, Oita San-ai Medical Center, 1213 Ichi, Oita 870-1151, Japan

    4Department of Neurology, Shengjing Hospital, China Medical University, No. 39 Huaxiang Road, Shenyang 110022, China

    Correspondence should be addressed to Bin Fan; [email protected] hotmail.co.jp and Jianqiu Gu; [email protected] 163.com

    Received 27 June 2017; Revised 2 October 2017; Accepted 26 October 2017; Published 17 January 2018

    Academic Editor: Hiroshi Okamoto

    Copyright © 2018 Huiying Cong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Beige adipocytes in white adipose tissue (WAT) have received considerable recognition because of their potential protective effect against obesity. Pycnogenol (PYC), extracted from French maritime pine bark, has anti-inflammatory and antioxidant properties and can improve lipid profiles. However, the effect of PYC on obesity has never been explored. In this study, we investigated the effects of PYC on obesity and WAT browning in apolipoprotein E(ApoE-) deficient mice. The results showed that PYC treatment clearly reversed body weight and the mass of eWAT gain resulting from a high-cholesterol and high-fat diet (HCD), but no difference in food intake.

    The morphology results showed that the size of the adipocytes in the PYC-treated mice was obviously smaller than that in the HCD-fed mice. Next, we found that PYC upregulated the expression of genes related to lipolysis (ATGL and HSL), while it decreased the mRNA level of PLIN1. PYC significantly increased the expression of UCP1 and other genes related to beige adipogenesis. Additionally, PYC increased the expression of proteins related to the protein kinase A (PKA) signaling pathway. The findings suggested that PYC decreased obesity by promoting lipolysis and WAT browning. Thus, PYC may be a novel therapeutic target for obesity.

    https://www.ncbi.nlm.nih.gov/pubmed/27067870 

    Mol Cell Biochem. 2016 May;416(1-2):131-9. doi: 10.1007/s11010-016-2702-5. Epub 2016 Apr 11.

    Cannabidiol promotes browning in 3T3-L1 adipocytes.

    Parray HA1, Yun JW2.

    Author information

    Abstract

    Recruitment of the brown-like phenotype in white adipocytes (browning) and activation of existing brown adipocytes are currently being investigated as a means to combat obesity. Thus, a wide variety of dietary agents that contribute to browning of white adipocytes have been identified. The present study was designed to investigate the effects of cannabidiol (CBD), a major nonpsychotropic phytocannabinoid of Cannabis sativa, on induction of browning in 3T3-L1 adipocytes. 

    CBD enhanced expression of a core set of brown fat-specific marker genes (Ucp1, Cited1, Tmem26, Prdm16, Cidea, Tbx1, Fgf21, and Pgc-1α) and proteins (UCP1, PRDM16, and PGC-1α). Increased expression of UCP1 and other brown fat-specific markers contributed to the browning of 3T3-L1 adipocytes possibly via activation of PPARγ and PI3K. In addition, CBD increased protein expression levels of CPT1, ACSL, SIRT1, and PLIN while down-regulating JNK2, SREBP1, and LPL. 

    These data suggest possible roles for CBD in browning of white adipocytes, augmentation of lipolysis, thermogenesis, and reduction of lipogenesis. In conclusion, the current data suggest that CBD plays dual modulatory roles in the form of inducing the brown-like phenotype as well as promoting lipid metabolism. Thus, CBD may be explored as a potentially promising therapeutic agent for the prevention of obesity.

    KEYWORDS:

    Browning; Cannabidiol; Lipogenesis; Thermogenesis

  • Please don’t take iron-supplements with tea or coffee. Coffee has tannic acid, which binds to iron and thus reduces its absorptions.

  • Hello! My dad is 62 his PSA is 473 and his prostate has spread to the bone. Can you do a video on that please? We were told if the cancer has spread to the bones this means its in stage 4. How bad is this? Is it curable? Anyone else has gone through the same situation?

  • David Sinclair tested how resveratrol was most effectively absorbed and found (I saw a lot of his podcasts) that when it is taken with fat it is 5x more bio available. I suppose 2 spoons of yogurt would be enough fat, but when I check my full fat yogurts, they are only 3 or 4% fat so I’m interested in how yogurt can help the resveratrol absorb?? (maybe his yogurt is 30 or 50% fat). The other thing that makes resveratrol more bio available is piperine. I personally take it with fat and curcumin supplements, which also have piperine in them, so I’m guessing they work well together. Like Sinclair (who’s book is fabulous by the way) I’m also having a 1000mg XR metformin tablet with these two but will stop from now since I saw this from Rhonda Patrick https://www.youtube.com/watch?v=2Bsk7qZ8888 (spoiler: if you exercise, don’t take Metformin like David Sinclair)

  • I make my own yogurt using Lactobacillus reuteri from BioGaia (Sweden), take a NAD booster and resveratrol but Metaformin caused a tasty metallic taste after several weeks that made food taste revolting. I simply abandoned it. But the above combined is a very potent age reversal combination in the areas of physical vitality, physical appearance and mental clarity, I have observed personally. Starting TRT only because my ‘free’ testosterone remains stubbornly very low although my total testosterone is well over 700 ng/dl at 62 yo. I have been lifting weights since the age of 25, but as men age sex binding hormone globuline (SHBG) increases steadily which strongly bings to testosterone reducing the ‘free’ testosterone percentage.

  • Virtually none of the Resveratrol or NAD that he takes makes it through the gut and into the bloodstream. Unless you inject the stuff, taking it orally is mostly a waste of time. And if he’s fasting and staying away from too many carbs and too much sugar, he shouldn’t need metaformin.

  • I’ll do it… I’m ready for a free biomedical test. Feel free to study my body for research. �� ��
    I’ll be part of your studies!! ��

  • Statins and metformin? Lol
    I would not listen to anything this man say..
    The WORST meds ive ever had in my life are TAMIFLU, STATINS AND PREDNISONE.
    I shifted to magnesium glycinate, vitamin C, fish oils, coconut oil and turmeric

  • Baby aspirin over a long period of time is rough on kidneys. The funny thing is people will actually try and do what this guy does. Get old gracefully folks and enjoy your life.

  • Supplements are so unregulated that it would be very useful to know where he purchases things like resveratrol, since I assume he tests everything he takes.

  • The only practical solution for aging is with replacing the body cells in a controlled fashion. The final roadblock would be the brain, unless someone finds a way to transfer consciousness.
    Either way, that luxury will be very unlikely to be affordable for the 99%

  • NAD booster?.. reco pls and/or what would be one to avoid? AMZN: NAD+ >> https://www.amazon.com/HPN-Supplements-Nicotinamide-Metabolic-Longevity/dp/B00L5Q951S/ref=sr_1_1_sspa?keywords=NAD+booster&qid=1581901013&sr=8-1-spons&psc=1&spLa=ZW5jcnlwdGVkUXVhbGlmaWVyPUEzTUNYTk4wWlhHTE1DJmVuY3J5cHRlZElkPUEwNTc3NzI4MTNVRzA3UzdLVTdHQSZlbmNyeXB0ZWRBZElkPUEwODQ1ODU5TkNTOFBBMzM0OUZJJndpZGdldE5hbWU9c3BfYXRmJmFjdGlvbj1jbGlja1JlZGlyZWN0JmRvTm90TG9nQ2xpY2s9dHJ1ZQ=

  • The properties that make the Bravo yogurt mentioned by Dr. Sinclair unique are described in detail in this article https://www.biorxiv.org/content/10.1101/714154v3 where its GcMAF and anti nagalase activities were evaluated by an independent laboratory. This article already is in the top 25% of all research outputs scored by Altmetric (attention score), see https://biorxiv.altmetric.com/details/63993873

  • Berberine instead of Metformin. Berberine

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/ 

    Efficacy of Berberine in Patients with Type 2 Diabetes

    Jun Yin, Huili Xing, and Jianping Ye

    Additional article information

    Abstract

    Berberine has been shown to regulate glucose and lipid metabolism in vitro and in vivo. This pilot study was to determine the efficacy and safety of berberine in the treatment of type 2 diabetic patients. In study A, 36 adults with newly diagnosed type 2 diabetes were randomly assigned to treatment with berberine or metformin (0.5 g t.i.d.) in a 3-month trial. The hypoglycemic effect of berberine was similar to that of metformin. 

    Significant decreases in hemoglobin A1c (HbA1c; from 9.5% ± 0.5% to 7.5% ± 0.4%, P<0.01), fasting blood glucose (FBG; from 10.6 ± 0.9 mmol/L to 6.9 ± 0.5 mmol/L, P<0.01), postprandial blood glucose (PBG; from 19.8 ± 1.7 to 11.1 ± 0.9 mmol/L, P<0.01) and plasma triglycerides (from 1.13 ± 0.13 mmol/L to 0.89 ± 0.03 mmol/L, P<0.05) were observed in the berberine group. 

    In study B, 48 adults with poorly controlled type 2 diabetes were treated supplemented with berberine in a 3-month trial. Berberine acted by lowering FBG and PBG from one week to the end of the trial. HbA1c decreased from 8.1% ± 0.2% to 7.3% ± 0.3% (P<0.001). Fasting plasma insulin and HOMA-IR were reduced by 28.1% and 44.7% (P<0.001), respectively. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) were decreased significantly as well. 

    During the trial, 20 (34.5%) patients suffered from transient gastrointestinal adverse effects. Functional liver or kidney damages were not observed for all patients. In conclusion, this pilot study indicates that berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism.

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  • Some say that probiotics are useless damaged by stomach acids. If I was going to take any probiotic it would be and is sometimes apple cider videgar. Being liquid some of it may just bypass the stomach and go into the intestines to be absorbed

  • You would need a very big tablet to get all the multivitamins and minerals, the amounts in the tablets are so small to make any difference. Best to sort your diet out first, do some research.

  • For very different reasons, NAD+ has also attracted a wave of attention from cancer researchers. Recent studies suggest that cancer cells of many types depend on NAD+ to sustain their rapid growth and that cutting off the NAD+ supply could be an effective strategy for killing certain cancers. The data from these studies paint a more complicated picture of NAD+ and raise new questions about the diverse ways taking an NAD+-boosting supplement might influence health. “It might still slow down the aging part, but it might fuel the cancer part,” says Versha Banerji, a clinician-scientist at the University of Manitoba. “We just need to figure out more about the biology of both of those processes, to figure out how we can make people age well and also not get cancer.” This is just a fellow up to my previous post. Interesting that most sites are ignoring the possibilities of its effects on cancer.

  • Great information to find out if you have cancer they need to do a biopsy that means sticking needle in walnut size prostate if psa test is high which is sc inaccurate take a look a Richard Ablin on you tube scary

  • We have best evidence of food supplements in health problems. We are promoting only Nutrilite brand to all our customers. If you need any more details cal me +919885872144 srinivas

  • Cheers for the video content! Excuse me for chiming in, I would love your initial thoughts. Have you thought about Mackorny Long Body Blueprint (Have a quick look on google cant remember the place now)? It is a great exclusive product for Increasing your penis size minus the headache. Ive heard some incredible things about it and my cousin at very last got great success with it.

  • Berberine instead of Metformin. Berberine

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/ 

    Efficacy of Berberine in Patients with Type 2 Diabetes

    Jun Yin, Huili Xing, and Jianping Ye

    Additional article information

    Abstract

    Berberine has been shown to regulate glucose and lipid metabolism in vitro and in vivo. This pilot study was to determine the efficacy and safety of berberine in the treatment of type 2 diabetic patients. In study A, 36 adults with newly diagnosed type 2 diabetes were randomly assigned to treatment with berberine or metformin (0.5 g t.i.d.) in a 3-month trial. The hypoglycemic effect of berberine was similar to that of metformin. 

    Significant decreases in hemoglobin A1c (HbA1c; from 9.5% ± 0.5% to 7.5% ± 0.4%, P<0.01), fasting blood glucose (FBG; from 10.6 ± 0.9 mmol/L to 6.9 ± 0.5 mmol/L, P<0.01), postprandial blood glucose (PBG; from 19.8 ± 1.7 to 11.1 ± 0.9 mmol/L, P<0.01) and plasma triglycerides (from 1.13 ± 0.13 mmol/L to 0.89 ± 0.03 mmol/L, P<0.05) were observed in the berberine group. 

    In study B, 48 adults with poorly controlled type 2 diabetes were treated supplemented with berberine in a 3-month trial. Berberine acted by lowering FBG and PBG from one week to the end of the trial. HbA1c decreased from 8.1% ± 0.2% to 7.3% ± 0.3% (P<0.001). Fasting plasma insulin and HOMA-IR were reduced by 28.1% and 44.7% (P<0.001), respectively. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) were decreased significantly as well. 

    During the trial, 20 (34.5%) patients suffered from transient gastrointestinal adverse effects. Functional liver or kidney damages were not observed for all patients. In conclusion, this pilot study indicates that berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism.

  • Hey guys great video! I do love short videos that get to the point and put out the information without all of the filler! Thank you! I do have a question: NAD booster seems to be a more or less generic term. Can you tell to us, your audience, the name of the specific NAD booster that you use, Mr. Sinclair? Many thanks guys!

  • The major things are still: food, sport, fasting and livestyle in general
    The things mention in this video are more supplementing the points above.

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  • Thank Gawd for the comment section hear, I almost listened to the 50 year old scientist who looks 35 and has been studying this for 30 years in the leading edge of science. Thank

  • The problem I have here,is that he takes statins? You can get clean genuine plant sterols on line from the same sites you would get resveratrol from,which reduce cholesterol and are naturally occurring and harmless,so why take statins which are dangerous and have tons of negative side effects?? Considering he’s a brain box scientist from Harvard,this makes no sense.

  • “When you increase the expression of growth hormone by 100 or 1000 fold, that reduces the life span of mine by 50%.”

    Bruh NOBODY is taking growth hormone at anywhere near those doses lmfao. Taking a couple IUs of growth hormone every day will double or triple your natural IGF levels. Not increase them even remotely near 100 times lmao

  • You take statin drug, and baby aspirin? You are a very questionable Dr. It seems you got or little, or no that much knowledge about natural medicine, and health. ��

  • Dr David Sinclair it’s a world changer
    Certainly the molecules discover NMN-NAD-resveratrol, boost sirt 1 and for better endothelial function also will help these regenerative
    Processes.

    Regenerative treatments

    Páncreas regeneration

    https://www.facebook.com/cientificomarioncamacho/videos/2073447296004983?sfns=mo

    Neuronal refresh

    https://www.facebook.com/cientificomarioncamacho/videos/1902015503148164/

    Múltiple sclerosis

    https://www.facebook.com/cientificomarioncamacho/videos/1911795905503457/

    Macular degeneration

    https://www.facebook.com/cientificomarioncamacho/videos/1615588898457494?sfns=mo

    Retinitis pigmentosa

    https://www.facebook.com/896399837043074/posts/2755316424484730?sfns=mo

    https://www.facebook.com/cientificomarioncamacho/videos/1997767016906345/

    Retinitis pigmentosa

    https://www.facebook.com/cientificomarioncamacho/videos/329687151057184?

    https://www.facebook.com/kary.camacho.52831

    T cells vs cancer

    https://www.facebook.com/896399837043074/posts/2674198802596493/?d=n

    Stem cell implantation

    https://www.facebook.com/cientificomarioncamacho/videos/1767590836590632?vh=e&d=n&sfns=mo

    Regenerative processes for retina
    brain, and other organs

    https://www.facebook.com/cientificomarioncamacho/videos/1762653680417681?vh=e&d=n&sfns=mo

  • He should know aspirin is not good daily from what it does to stomach. Hawthorne is a natural blood thinner. Metformin is good in some ways bad in others on what it does

  • LXX �� XXL ��
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  • Please don’t take iron-supplements with tea or coffee. Coffee has tannic acid, which binds to iron and thus reduces its absorptions.

  • Plant based diets can significantly increase survival rate. “When applied to a petri dish of cancer cells, the blood of those who ate a plant based diet for a year had 8x the stopping power when it came to cancer cell growth (for prostate specifically).” https://www.youtube.com/watch?v=0VX_oZBMSd4

  • Hi Dr. Patrick! Great video thank you for sharing. I was hoping you would elaborate on possible effects of changing facial bones as a possibility of taking growth hormone or any of the variations being marketed to people today such as MK677, Sermorelin or Ipamorelin? I’ve heard that there are certain growth plates in the face or jaw that don’t fully close and if this is true what are the chances any of the above named growth hormone inhibitors or carriers will cause changes in growth plates that may be open? No medical professional or clinic or nutritional guru have ever done a video or discussed this aspect.

  • ok nice theory. Now did You tested it on Yourself?… i think no.
    So You are not credible person.
    Yes i know many idiots like such a bullshit talking..theory… it is sounds so nice and elegance and hard dictionary for most… but this is still a theory.
    Pin IGF Yourself and make some Vlog then You will be reliable person, but for this it has to be a warrior not a anther scientific looser.

  • since 2012 singapore doctors complaint NO sales…WHY… cos 18hrs fasting + low carbs cure tons of sickness, always empty our stomach, fully digest n NO piling foods in stomach is key….. from SG

  • Are you made do not take probiotics supplements daily Guys don’t take plz it’s harmful.. You can take vitamin D supplement and omega 3 and can take natural sorce for vitamins and minerals okk

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  • He may actually have a heart attack on statins, they are lethal, I am very surprised at that. Love his research on nad but that makes no logical sense to me.

  • While vitamin D is good for you…the supplements can cause hypercalcemia (too much calcium). Please do some research before taking 5000 iu daily.

  • Omega 3 has helped me with depression. Tumeric has given me energy aswell as broccoli. Probiotics helped me with anxiety and depression. Those are my main foods I eat.

  • Before you ask your doctor for his advice ask him how much training he got in med school on vitamins and supplements. Most doctors get about 3 or 4 hours and thats about it. Some doctors know more but its because they did there own research. Those are the good doctors. Good doctors are only as good as the training they get or they search for the answers on there own. A lot of there training is paid for by drug companies so why would a drug company want doctors to even know about something they cant make money on?

  • Lactose intolerant here so I just take prebiotic for my bowel and probiotic for my gut. I also take L glutamine to repair my intestines from years of alcohol. Beetroot is good for high cholesterol as is garlic etc

  • This guy wants to live forever. I dont give a damn what he takes or does. We all gotta go folks. Pack your bags. Were going bye bye. He may live an extra month.

  • I realize this is an old video but her latest podcast (last 2 years) would seem to contradict this. Not the science, that seems consistence. But her stance on how to approach this seems to have changed. She seems very much in favor of intermitting fasting. Almost all her guest are pro-intermitting fasting. Which is not caloric restriction per se but it has similar affects on IGF1. At least according to people she has had on he podcasts like Dr. Longo

  • For a super smart man like Dr Sinclair.. I would have guessed that he would stay away from full fat milk. He states that he has high cholesterol and is on statins.. Would staying away from animal proteins and saturated fats be the obvious choice as opposed to Statins?

  • Cheers for the video content! Excuse me for chiming in, I would love your initial thoughts. Have you thought about Mackorny Long Body Blueprint (Have a quick look on google cant remember the place now)? It is a great exclusive product for Increasing your penis size minus the headache. Ive heard some incredible things about it and my cousin at very last got great success with it.

  • Was discussing vitamin use with my former physician and he said they’re all nonsense, and absolutely useless, a waste of money. You get all the vitamins and minerals you need from the food you eat. I did mention he is my EX doctor.

  • NAD booster?.. reco pls and/or what would be one to avoid? AMZN: NAD+ >> https://www.amazon.com/HPN-Supplements-Nicotinamide-Metabolic-Longevity/dp/B00L5Q951S/ref=sr_1_1_sspa?keywords=NAD+booster&qid=1581901013&sr=8-1-spons&psc=1&spLa=ZW5jcnlwdGVkUXVhbGlmaWVyPUEzTUNYTk4wWlhHTE1DJmVuY3J5cHRlZElkPUEwNTc3NzI4MTNVRzA3UzdLVTdHQSZlbmNyeXB0ZWRBZElkPUEwODQ1ODU5TkNTOFBBMzM0OUZJJndpZGdldE5hbWU9c3BfYXRmJmFjdGlvbj1jbGlja1JlZGlyZWN0JmRvTm90TG9nQ2xpY2s9dHJ1ZQ=

  • Always when i go to doctors for ask wht the best supplement for me, they just like, ah you wont to buy extra vitamins and minerals, food gave u enough! Dont buy anything ��

  • Im on 4th day of dividing dry fast with water fast and I have a question…Is it ok to do moderate exercise when you fast like this, will that increase IGF1?

  • My testimony is I used to have very frail and nails that break so easily! After a month of taking multivitamins, my nail started growing very strong!

  • why would you listen to this guy…it’s not like he has a PhD in molecular genetics or was promoted as a tenured professor at Harvard Medical School, amirte…youtube geniuses?

  • Not everyone needs a multivitamin. If we consume a reasonably balanced diet our bodies get most of what is needed. Some supplements can be quite useful like turmeric, zinc, and magnesium among others depending on individual deficiencies.

  • I say go ahead and boost GH and IGF-1, just don’t take 100 1000x the amount. Take the same amount you would have likely had at your peak. And by all means go ahead and take the polyphenols/catechins too. Hopefully there is a way to get the best of both worlds.

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  • Why not inform people yay if they off animal proteins they will have. Significantly low IGF levels? Why not suggest they iNclude more plant foods and less animal proteins in their daily diet

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  • My PSA went from 10 to 14 in three months. Going for my third MRI since diagnosed with prostate CA three years ago. Been doing active surveillance because my doctor is against over treatment. It’s stressful to live with cancer and never knowing if it will spread outside the prostate between scans. An MRI is too expensive to do more than once a year.

  • There is no trade-off. Doctors need to understand the holistic nature of the human body and not hone in on a specific chemical and it’s effects. People who eat right and exercise and have high IGF-I levels don’t get cancer, those who have bad diet, improper sleep and lots of stress and high IGF-I levels may get cancer. The body is holistic, stop picking it apart and analyzing it in a way that it doesn’t actually work.

  • Sinclair lost all credibility as soon as he admitted he uses a statin as well as Metformin. The baby aspirin does nothing good for him either.

  • You should never let this slowing growing cancer bother you. And you should never accept any prostate cancer treatments because they are all toxic poisons to your bodies. What kind of sick minded urologists, medical and radiation oncologists, would tell their patients to get rid of their prostates to avoid prostate cancers later? We now know that there are basically two types of prostate cancer: one that would kill you no matter what cancer treatment or combination of treatments you receive; the other one grows ever so slowly that you will die with something else and not of it. Wake up and take charge of your own health, men! Do what your bodies tell you to you, and don’t pay any attention to this bunch of so-called cancer specialists who tell you that your PSA “seems elevated” which lead you to unnecessary biopsies and overtreatments that, for sure and without a doubt, will ruin your quality of life.

  • Dr. Rhonda Patrick congratulates you for the excellent video.
    Do you know this product: Pro igf-1 Hi-Tech pharmaceuticals? thank you…

  • In my late 20’s but have the IGF-1 levels of a 70 year old. I look 15 but feel 65. I have an amazing metabolism, I can eat whatever I want and don’t get fat. Very lean. I have elevated SHBG. And it’s very hard for me to put on weight. The downsides are I get fatigued very easy. I can’t tolerate long exercise sessions. I feel weak. And let’s just say everyone wants to look younger, but when you look 15 it sucks. Trust me, the “benefits” don’t outweigh the negatives. I’m starting on growth hormone asap.

  • Virtually none of the Resveratrol or NAD that he takes makes it through the gut and into the bloodstream. Unless you inject the stuff, taking it orally is mostly a waste of time. And if he’s fasting and staying away from too many carbs and too much sugar, he shouldn’t need metaformin.

  • People who are criticizing David Sinclaire for taking metformin, it looks, like you are unfamiliar with research that shows that low doses of metformin can potentially extend the lifespan by protecting against such diseases as cancer, heart disease, and Alzheimer’s. I am sure that it does have side effects especially for people with compromised health.
    Check out the following research articles:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772077/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943638/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052468/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898468/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066537/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892694/
    https://pubmed.ncbi.nlm.nih.gov/21882902/
    https://pubmed.ncbi.nlm.nih.gov/30255224/
    https://pubmed.ncbi.nlm.nih.gov/18728386/
    https://pubmed.ncbi.nlm.nih.gov/21084729/

  • I wouldn’t say the relationship between longevity, performance, growth factors is super straightforward. There are lots of animal models that don’t follow the expected path (I think there are a couple reviews that cover growth hormone/igf-1 manipulations), and there are plenty of other chemicals that affect performance and longevity, making context important.

  • Fasting and intense exercises like HIIT increases growth hormone and thus IGF. So does that means they accelerate ageing? But there are numerous studies showing the benefit of exercise and fasting in slowing down ageing by boosting NAD+. So if increased IGF can be equated to increased ageing, how can this be true?

  • So what is metformin anyway? He said it originally was a natural molecule, then tweeked. Kind of how St. John’s wort was tweeked into Prozac? What is it?

  • I’m so glad I rewatched this as the first time I listened to it I heard caloric restriction causes brain atrophy. But then I saw that it wasn’t specifically the case. Which is good because I’ve been on 600 calories a day for 30 days

  • I make my own yogurt using Lactobacillus reuteri from BioGaia (Sweden), take a NAD booster and resveratrol but Metaformin caused a tasty metallic taste after several weeks that made food taste revolting. I simply abandoned it. But the above combined is a very potent age reversal combination in the areas of physical vitality, physical appearance and mental clarity, I have observed personally. Starting TRT only because my ‘free’ testosterone remains stubbornly very low although my total testosterone is well over 700 ng/dl at 62 yo. I have been lifting weights since the age of 25, but as men age sex binding hormone globuline (SHBG) increases steadily which strongly bings to testosterone reducing the ‘free’ testosterone percentage.

  • The question is. Did the mice live longer because they ate less. And what was the quality of their food… A person with high GH because they are more active eat more. Salad, hq produce & fasting, instead of cheeseburgers, may neutralize the difference. I dont know, but that would be one of my questions.

  • Hello! My dad is 62 his PSA is 473 and his prostate has spread to the bone. Can you do a video on that please? We were told if the cancer has spread to the bones this means its in stage 4. How bad is this? Is it curable? Anyone else has gone through the same situation?

  • Dr. Ruggiero is the inventor of Bravo Yogurt and is deeply interested in studying anti-aging.  He believes that we as people should have more capacity to endure.  He has studied lobsters who don’t die of old age and cancer which can stay alive in a petri dish for 60 years.  He thinks that we can change our fates and has put his ideas to work in a product of longevity along with products that do a great job cleaning up issues like diseases.  

    I am quite sure that this book by Dr. David A. Sinclair, PhD, Professor at Harvard Medical School is a book worth reading and practices worth noting.  For example, I use  Bravo yogurt every morning for 5 years.  Very often I gain more capacity and efficient.  I make it a daily part of my amazingly healthy life!  I get it here.   www.bravocoop.com

  • Should I cycle MSM? I am taking MSM for 2 years now, 12 grams a day. REcently I was told to cycle my supplements (like acetyl-l-carnitine), but I dont know wether MSM should be cycled too, like d3 you dont cylce, so I dont know wether MSM is a supplement to cycle or not.

  • Rodent models, almost like a human model but not even close. Actually using a rodent model to make meds or anything for humans is just terrible science and doesn’t work. Just look at how dangerous most of human medicine is. Humans are the Guinea pigs for the pharmaceutical industry. But humans are to stupid to see this issue. So keep taking all the meds they keep telling you you need ������������������������

  • It’s interesting how type 2 diabetes is now considered a part of aging. Before the 1970s, it wasn’t even acknowledged as existing.

  • For all those who care, we have this Healthspan | Longevity discord at https://discord.gg/ftSbffu. Feel free to join in at anytime, for an engaging discussion or to share the latest about developments in this field of life extension.

  • Multi vit (with food)A,B,C,D,K,E, zinc {teracoting}
    Probiotic (before sleep)
    Omega 3 (EPA and DPA)( with food)
    Lean meat with healthy fats and raindow of foods.

  • Pycnogenol and CBD aid in the conversion of white adipose tissue into brown adipose tissue. FACT. Something you should check out: http://www.ProjectCBD.org/guidance/conditions
    https://www.hindawi.com/journals/jdr/2018/9713259/  Journal of Diabetes Research

    Volume 2018, Article ID 9713259, 11 pages

    https://doi.org/10.1155/2018/9713259

    Research Article

    Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice

    Huiying Cong,1,2 Wenxia Zhong,1,2 Yiying Wang,1,2 Shoichiro Ikuyama

    ,3 Bin Fan

    ,4 and Jianqiu Gu

    1,2

    1Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, China

    2The Endocrine Institute and the Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, China

    3Department of Clinical Investigation, Department of Diabetes, Endocrine and Rheumatic Diseases, Oita San-ai Medical Center, 1213 Ichi, Oita 870-1151, Japan

    4Department of Neurology, Shengjing Hospital, China Medical University, No. 39 Huaxiang Road, Shenyang 110022, China

    Correspondence should be addressed to Bin Fan; [email protected] hotmail.co.jp and Jianqiu Gu; [email protected] 163.com

    Received 27 June 2017; Revised 2 October 2017; Accepted 26 October 2017; Published 17 January 2018

    Academic Editor: Hiroshi Okamoto

    Copyright © 2018 Huiying Cong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Beige adipocytes in white adipose tissue (WAT) have received considerable recognition because of their potential protective effect against obesity. Pycnogenol (PYC), extracted from French maritime pine bark, has anti-inflammatory and antioxidant properties and can improve lipid profiles. However, the effect of PYC on obesity has never been explored. In this study, we investigated the effects of PYC on obesity and WAT browning in apolipoprotein E(ApoE-) deficient mice. The results showed that PYC treatment clearly reversed body weight and the mass of eWAT gain resulting from a high-cholesterol and high-fat diet (HCD), but no difference in food intake.

    The morphology results showed that the size of the adipocytes in the PYC-treated mice was obviously smaller than that in the HCD-fed mice. Next, we found that PYC upregulated the expression of genes related to lipolysis (ATGL and HSL), while it decreased the mRNA level of PLIN1. PYC significantly increased the expression of UCP1 and other genes related to beige adipogenesis. Additionally, PYC increased the expression of proteins related to the protein kinase A (PKA) signaling pathway. The findings suggested that PYC decreased obesity by promoting lipolysis and WAT browning. Thus, PYC may be a novel therapeutic target for obesity.

    https://www.ncbi.nlm.nih.gov/pubmed/27067870 

    Mol Cell Biochem. 2016 May;416(1-2):131-9. doi: 10.1007/s11010-016-2702-5. Epub 2016 Apr 11.

    Cannabidiol promotes browning in 3T3-L1 adipocytes.

    Parray HA1, Yun JW2.

    Author information

    Abstract

    Recruitment of the brown-like phenotype in white adipocytes (browning) and activation of existing brown adipocytes are currently being investigated as a means to combat obesity. Thus, a wide variety of dietary agents that contribute to browning of white adipocytes have been identified. The present study was designed to investigate the effects of cannabidiol (CBD), a major nonpsychotropic phytocannabinoid of Cannabis sativa, on induction of browning in 3T3-L1 adipocytes. 

    CBD enhanced expression of a core set of brown fat-specific marker genes (Ucp1, Cited1, Tmem26, Prdm16, Cidea, Tbx1, Fgf21, and Pgc-1α) and proteins (UCP1, PRDM16, and PGC-1α). Increased expression of UCP1 and other brown fat-specific markers contributed to the browning of 3T3-L1 adipocytes possibly via activation of PPARγ and PI3K. In addition, CBD increased protein expression levels of CPT1, ACSL, SIRT1, and PLIN while down-regulating JNK2, SREBP1, and LPL. 

    These data suggest possible roles for CBD in browning of white adipocytes, augmentation of lipolysis, thermogenesis, and reduction of lipogenesis. In conclusion, the current data suggest that CBD plays dual modulatory roles in the form of inducing the brown-like phenotype as well as promoting lipid metabolism. Thus, CBD may be explored as a potentially promising therapeutic agent for the prevention of obesity.

    KEYWORDS:

    Browning; Cannabidiol; Lipogenesis; Thermogenesis

  • Before you ask your doctor for his advice ask him how much training he got in med school on vitamins and supplements. Most doctors get about 3 or 4 hours and thats about it. Some doctors know more but its because they did there own research. Those are the good doctors. Good doctors are only as good as the training they get or they search for the answers on there own. A lot of there training is paid for by drug companies so why would a drug company want doctors to even know about something they cant make money on?

  • A video on IGF-1 that does not mentioned anything related to its effects on cancer in humans, neither the foods that causes it production to increase… could you please comment on that?

  • Hi!☺️

    I am SAIKIRAN WELLNESS COACH
    & we support people with good nutrition

    The categories which we deal with

    weight GAIN
    Weight Management
    Digestive Health
    Heart Health
    Energy & Fitness
    Children Nutrition
    Sports Nutrition
    Bone & Joint Health!
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  • So… intermittent fasting could potentially be making my brain weaker over time by lowering IGF-1? I thought I.F. was the be-all and end-all (it’s touted as such all over YouTube). God, every video I watch says something different this stuff is so confusing for a layperson.

  • It’s so sad that we are replacing healthy eating with pills to stay healthy nowadays. I eat homemade yogurt every day. I always add fresh fruit, Chia seeds and almonds that I grind myself. It’s healthier and a nicer experience than swallowing pills. Plus, that’s probiotics, vitamins, Omega 3, antioxidants and fibre right there! And it’s delicious! Can all be mixed into a delicious smoothie to take to work if in a hurry, or whatever. Salmon is also a great source of Omega 3; once or twice a week is enough. If you have a garden or even a patio, nothing beats eating your own fresh greens that you know haven’t been sprayed to death. I don’t bother growing lettuce because they have no nutritional value whatsoever. But things like perpetual spinach, beet, kale, etc. are so easy to grow even in containers, gives you continuous supply so is cheaper; and so good for you and no chemicals have been added. I use them raw in salads rather than cook them to death and destroy the nutrients. I’m in my 60’s and I’m healthy. Eating right has always been the key to good health; that’s the “natural solution” and that will never change.

  • Actually the isolation of Alpha tocopherol (Vitamin E)was the biggest mistake in nutritional history. The following video explains the entire history as well as why it failed as an antioxidant and causes higher mortality rates. https://youtu.be/V9zHfSIPdSo

  • Excellent point about new technologies emerging in the next 15-20 years. I receive Google Alerts concerning the latest news about “prostate cancer research” which is very informing. I suspect I know about the new advances well before most urologists do, and certainly mine. In my lay opinion the advances are beginning to snowball downhill as the technology improves. Following Moore’s Law the advances will only happen faster as time goes on.

  • Lactose intolerant here so I just take prebiotic for my bowel and probiotic for my gut. I also take L glutamine to repair my intestines from years of alcohol. Beetroot is good for high cholesterol as is garlic etc

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  • Excellent point about new technologies emerging in the next 15-20 years. I receive Google Alerts concerning the latest news about “prostate cancer research” which is very informing. I suspect I know about the new advances well before most urologists do, and certainly mine. In my lay opinion the advances are beginning to snowball downhill as the technology improves. Following Moore’s Law the advances will only happen faster as time goes on.