Do BCAAs Cause Cancer and Diabetes

 

Are BCAA (Branched Chain Amino Acids) Healthy?

Video taken from the channel: NutritionFacts.org


 

How diabetes can increase cancer risk

Video taken from the channel: American Chemical Society


 

The Big Fat EAA Lie NOT Better Than BCAA | Tiger Fitness

Video taken from the channel: Tiger Fitness


 

How Diabetes Increases Cancer Risks

Video taken from the channel: Health Professional Radio


 

Can BCAA have a link to Diabetes?

Video taken from the channel: bios3training


 

5 BCAA Side Effects

Video taken from the channel: UltimateFatBurner.com


 

New Research on Glucose and Cancer

Video taken from the channel: Roswell Park Comprehensive Cancer Center


There is a distinct lack of evidence in the present body of research proving that BCAA or BCAA supplements cause cancer or diabetes. To promote the idea that three amino acids are the cause for these chronic diseases, is nothing but pure fear mongering. Again, remember that correlation is not the same as causation.

There is increasing evidence that diabetes leads to a significantly higher risk for certain types of cancer. Both diabetes and cancer are characterized by severe metabolic perturbations and the branched chain amino acids (BCAAs) appear to play a significant role in both of these diseases. BCAAs may also benefit people with liver disease. However, some research links increased BCAA levels to conditions such as diabetes, cancer, liver.

Moreover, the taking of BCAA supplements also can possibly lead to diabetes. Studies from the Duke University medical center showed that too Much Protein allegedly from taking BCAA supplements along with eating, can lead to insulin resistance in the long run. And developing insulin resistance is a precursor to diabetes.

Branched‐chain amino acids (BCAA) have increasingly been studied as playing a role in diabetes, with the PubMed search string “diabetes” AND “branched chain amino acids” showing particular growth in studies of the topic over the past decade (Fig. 1). Nagata C, Nakamura K, Wada K, Tsuji M, Tamai Y, Kawachi T. Branched-chain amino acid intake and the risk of diabetes in a Japanese community: the Takayama study. Am J Epidemiol.

2013;178(8):1226. It is too early to prove whether BCAAs are helpful for diabetes or an inherited form of autism spectrum disorder, two other reported uses. Dosages of BCAAs vary, depending upon the reason for use. However, knowledge about the potential of BCAAs and their pathways of metabolism affecting α-cell function is lacking. It needs to be clarified whether BCAAs could over time contribute to the progressive α-cell dysfunction, and play a pathogenic role in the formation and progressive development of type 2 diabetes – like lipoand glucotoxicity.

There has been increased study into the correlation of breast cancer and diabetes. The connection has been made as a result of improvements in diagnosis and treatment of. Diabetes or insulin resistance causes removal of magnesium along with other minerals from your body due to excess removal of water through urination.

Research in the 90s found that there was a link between low magnesium levels in the blood and type 2 diabetes.

List of related literature:

Therefore additional studies that examine the metabolic and clinical effects of including BCAAs in diets for dogs with cancer are needed before recommendations can be made.

“Canine and Feline Nutrition E-Book: A Resource for Companion Animal Professionals” by Linda P. Case, Leighann Daristotle, Michael G. Hayek, Melody Foess Raasch
from Canine and Feline Nutrition E-Book: A Resource for Companion Animal Professionals
by Linda P. Case, Leighann Daristotle, et. al.
Elsevier Health Sciences, 2010

Since then, additional studies have shown that in humans, BCAAs have no effect on muscle growth and may cause a spike in blood glucose or insulin, along with an imbalance of the more important EAAs.

“Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging” by Ben Greenfield
from Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging
by Ben Greenfield
Victory Belt Publishing, 2020

Research has found that levels of BCAAs were higher in some individuals with obesity and have been associated with worse metabolic health and future insulin resistance or type 2 diabetes mellitus (T2DM).

“Integrative and Functional Medical Nutrition Therapy: Principles and Practices” by Diana Noland, Jeanne A. Drisko, Leigh Wagner
from Integrative and Functional Medical Nutrition Therapy: Principles and Practices
by Diana Noland, Jeanne A. Drisko, Leigh Wagner
Springer International Publishing, 2020

Epidemiologic studies have suggested that nutritional factors such as reduced fat intake and increased soy protein may have a protective effect against the development of prostate cancer.

“Goldman's Cecil Medicine,Expert Consult Premium Edition Enhanced Online Features and Print, Single Volume,24: Goldman's Cecil Medicine” by Russell La Fayette Cecil, Lee Goldman, Andrew I. Schafer
from Goldman’s Cecil Medicine,Expert Consult Premium Edition Enhanced Online Features and Print, Single Volume,24: Goldman’s Cecil Medicine
by Russell La Fayette Cecil, Lee Goldman, Andrew I. Schafer
Elsevier/Saunders, 2012

The BCAAs are found in high concentrations in association with obesity and type 2 diabetes and it has been suggested that they may contribute to these conditions.

“Human Metabolism: A Regulatory Perspective” by Keith N. Frayn, Rhys Evans
from Human Metabolism: A Regulatory Perspective
by Keith N. Frayn, Rhys Evans
Wiley, 2019

β-Sitosterol, the major component in peanut sterols, has been shown to inhibit cancer growth (Awad et al. 2000) and may offer protection from colon, prostate, and breast cancer.

“Vegetable Oils in Food Technology: Composition, Properties and Uses” by Frank Gunstone
from Vegetable Oils in Food Technology: Composition, Properties and Uses
by Frank Gunstone
Wiley, 2011

Thus, a key mechanism driving cancer cell lethality involves BCAAs as crucial metabolites under the critical regulation of the mitochondrial MEs.

“AACR 2018 Proceedings: Abstracts 1-3027” by American Association for Cancer Research
from AACR 2018 Proceedings: Abstracts 1-3027
by American Association for Cancer Research
CTI Meeting Technology, 2018

It is believed that IGF-1 acts as a mitogen (stimulates cell division) for prostate cancer cells; thus, downregulation of IGF-1 by lycopene will reduce growth and proliferation of the cancer cells.

“Functional Foods and Nutraceuticals” by Rotimi E. Aluko
from Functional Foods and Nutraceuticals
by Rotimi E. Aluko
Springer New York, 2012

polyunsaturated fats, shows a strong positive correlation with prostate cancer incidence and mortality, perhaps resulting from fat-induced alterations in hormonal profiles, the effect of fat metabolites as protein or DNA-reactive intermediates, or fat-induced elevation of oxidative stress.

“Urologic Surgical Pathology” by David G. Bostwick, Liang Cheng
from Urologic Surgical Pathology
by David G. Bostwick, Liang Cheng
Mosby/Elsevier, 2008

Blocking ASCT2 to prevent glutamine uptake and glutaminolysis has been shown to successfully prevent tumor cell proliferation in melanoma, non-small cell lung cancer, prostate cancer and acute myeloid leukaemia.

“AACR 2016: Abstracts 1-2696” by American Association for Cancer Research (AACR)
from AACR 2016: Abstracts 1-2696
by American Association for Cancer Research (AACR)
CTI Meeting Technology, 2016

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

[email protected]

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97 comments

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  • sounds like a bunch of bullshit. Only 22 bucks no biggie guys cmon itll do nothing for you but ill continue to lie with my straight face.

  • your right Jerry,and egg whites spike insulin as well when eating without the yolks,but bcaa is far from the only reason ones health is bad

  • A man selling a BCAA product telling you that all the studies showing the hype about BCAAs’ are not legit. Only what he says is legit now go and buy his product.

  • Concerning nausea also, another problem seems to be that manufactures add vitamin B6 to every supplement, as it helps the body absorb the other nutrients within the supplement. Thus, if you take different supplements the B6 adds up and may cause nausea and gastrointestinal issues.

  • But people were not eating protein in isolation, they were eating food. I think this entire video, and its title is misleading at best. In fact, I think it falls into one of Dr G’s biggest criticisms, reductionist thinking.

  • Dr. Gregor! I love your videos and book. The video intro is very loud compared to the audio of the rest of the video. It’s a little abrasive. Just thought I’d let you know! Thanks for the facts!!!

  • this study is trash, only 74 participants, not lab controlled, so we have no way of verifying if anyone actually followed the diet. no defintion of a “high protein” diet. no real control group (balanced omnivorous diet) no isolating bcaa’s, i don’t even like bcaa’s as a supplement, but this is just pure cherry picking, typical vegan.

  • EAAs include BCAAs. It’s not one vs the other. 3 BCAAs will not do their job properly without the other 5 EAAs along with them… and vise versa.

  • and another thing most of these people don’t even have there blood work done so they’re not for sure if they have diabetes or not, people are dumb

  • This video presentation ignores the elephant in the room for obesity, insulin resistance and type 2 diabetes by omitting to mention mTOR.

  • BCAA are missing like 2 or 3 build stones? right, so it’s basically not giving any effect what so ever. Our normal food we eat create those building stones, and you need all of them for it to be complete and actually give effect. EAA got that….not BCAA
    TBH i don’t know what the fuck i’m talking about, but that’s what i got told. It’s a damn supplement war out there….
    Using EAA tho…

  • https://builtwithscience.com/bcaas-benefits/
    Here’s an article with a half a dozen studies that prove BCAAs are useless, and can actually be catabolic if taken at the wrong time. He’ll probably delete this comment though. I can’t believe we’re still talking about this. The science is done. ��‍♂️

  • 5:35 this is dumb. The group that ate more calories lost more weight only if they burned more calories or if they lost more water weight and the study didn’t account for that or if they lost muscle mass and the control group lost fat (because the same amount of calories from protein would weigh more than from fat). So the higher protein diet is actually better for fat loss by preserving/building muscle instead of fat, and that’s without mentioning that protein is more satiating so it makes it easier to eat less.

  • You are way off base. The Wolfe studies were over a 20 year period on burn victims and elderly muscle wasting patients and tinkered with the exact ratios to support and preserve muscle mass. All studies can be found on the AminoAuthority.com. Over 10 million in research. Wolfe is also a published author on Amino Acids research. He’s spent his life’s work studying Aminos. It was licenced to the supplement community under a patent and definitively shows that BCAAs can somewhat help preserve muscle but do NOT build muscle. BCAAs DO NOT creat anabolism. The ratios and other supporting EAAs have to be correct.

  • Hello Dr. Greger
    I watched a lot of your videos and i am still reading about eating meat
    I found this research that supports eating meat
    Could you please make a video addressing the background of the research
    Thanks
    https://youtu.be/1rz-8H_i1wA

  • Again, nothing to back this claim other than saying it’s seince. Oh and name dropping. And a study says…. and since people now know doctors are paid to say certain things ( fact) ( Dr Oz) I don’t believe any of this. Simply saying studies show… Think for yourself people!

  • Yes, great improvement in the way the video is made. Seeing Dr Greger talking with excitement throughout whole video. Good job Dr Greger!

  • Your going abit overboard on this stuff. Quite frankly you keep going,your gonna lose subscribers not to mention lose respect because alot of what your saying is BS,sorry dude.

  • I love it when they compare a healthy versus of a vegan diet vs a non healthy omnivore diet. Lol geez i wonder what the outcome will be. Why don’t you compare two healthy diets for once?

  • That sounds quite reasonable but for certain people or for people who are involved in alot of exercise or who need increased high percentage protein food may need animal protein so the thing is to come back to self-awareness and not use it all the time we are omnivores by evolution not carnivores, it is balance between anabolic and catabolic and FG 21 is the bodies way of upregulating this in favour of body cell life I guess. This subject IS very controversial you would rarely see a really top level athlete being vegan in fact the amount of food need to replenish muscle breakdown and the faster metabolism would probably make it impossible, protein intake then is crucial, we can live without carbs even on low levels of fat but no protein for a lengthy period the body will first use up muscle which may have taken months and months of hard training to build first, but for the regular or mid range the above video is probably correct limit animal protein or know when to eat it ie high growth phase.

  • BCAA are saffest supplements…..none of your so called side effects hold any element of truth coz even taking paracetamol causes serious side effects in 1 in million peoples

  • I don’t buy either one. Both are completely unnecessary. I get enough of these since they comprise the protein I eat daily. Plus the one whey shake I drink post workout definitely has these aminos covered. I love you and all Marc but come on, EAA’s are and always will be superior to BCAA’s. EAA’s are biologically able to produce new muscle tissue. BCAA’s CANNOT, NEVER HAVE, AND NEVER WILL BE ABLE TO BUILD NEW TISSUE.  The body needs ALL the amino acids to build new tissue, not just the 3 BCAA’s.  You can’t argue basic biology facts.

  • The biggest gripe I have with the anti BCAA crowd is how much they exaggerate how big of a waste of money it is. BCAAs cost me about $1 per workout. I like the taste of them and they help me to stay hydrated by sipping on them throughout. It’s not that big of a deal.

  • Cancer patients have lower vitamin c it dosent mean vitamin c deficiency causes cancer if you have insulin resistance of corse bcaa will be higher in your plasma because your insulin dosent store it well it dosent mean bcaa causes diabetes lol diabetes is an auto immune illness lol if bcaa causes diabetes then proteins alone causes diabetes plant or animal makes no sence all the diabetics i know never toke bcaa

  • So you say you only take in during your workout and make that super clear then in the same paragraph you say you take it during the day aswell yh i call bs

  • Yes lets use a study of menopausal women and just fail to mention this and apply this logic to everyone. Nothing said about their diet intake other than the protein part, not even what source they got it from. Looking forwards to Barts rebuttal of this nonsense. Know what improves and puts T2D in remission? Keto and carnivore, that’s a fact. Would love to see a plant based diet vs keto/carni in a metabolic ward for say 6 months with T2D patients. My guess is, most if not all in the carni/keto group will have a reduction in medicine or complete remission of T2D.

  • Did u see those P-vaules. Yea, this isn’t sloppy at all. lol. The layers of complexity make these types of experiments extremely difficult to control. Furthermore, not a single mention of the exact population that was studied was given other than diabetics. Were they young, old, male, female, how long had they been suffering from diabetes? This video is NOT scientific, it is scientism. Propaganda. Quite frankly, it is very sloppy science communication.

  • Here’s a fun fact Rich Piana enlightened me on: Eat real food and you’ll get more results than taking BCAAs, tits out, pants down, right babe?

  • I believe Dr. Greger is misrepresenting data in the study presented at 3:45.

    I just got done reading the study presented at 3:45. In that study the authors specifically state “Although we found that HP intake during weight loss attenu
    ates the beneficial effect of moderate weight loss on muscle insulin action, this does not mean that an HP weight loss diet necessarily results in a diminished improvement in plasma glucose homeostasis”. They also state “The decline
    in basal plasma insulin concentration after weight loss without a

    change in plasma glucose concentration and a slight reduction in
    basal glucose Ra, suggests that weight loss in both the WL and WL-HP groups may have improved hepatic insulin sensitivity”. They continue to say, ” our data demonstrate that HP intake prevented the WL-induced improvement in muscle insulin sensitivity.

    Dietary protein is a potent insulin secretagogue (Floyd
    et al., 1966; Ang et al., 2012; Manders et al., 2014), which may overcome the adverse effect of protein on insulin sensitivity by increasing the secretion of insulin. In addition, protein causes greater satiation and has a greater thermogenic effect of feeding than carbohydrate and fat, which can lead to greater weight loss with an HP than a standard protein diet (Wycherley et al., 2012; Leidy et al., 2015). Therefore, the adverse effect of dietary protein on muscle insulin action could be offset by its effect on hepatic insulin sensitivity, insulin secretion, and energy balance.”

  • If your natty and training for 60 minutes then that is the stimulus for MPS. Eat optimal protein x 3-4 each day (also stimulates MPS) and you dont need either EAA or BCAA intraworkout. ��

  • Big question here: Wondering if people who lift/workout regularly who increase protein intake also can see similar amounts of negative effects over a long period of time, or if most if these studies focus on groups of people who are generally less active?

  • Interesting video. But its really missing the influence of strength training on protein needs. The stresses we put on our bodies can, as far as I know, heavily influence our dietary needs.

  • I seriously thought for a second you weren’t going to say “put it to the test”. I was this close to packing up shop and never watching again….jk

  • Hi bro, i started taking 3:1:1 bcaa intra workout for the last week. im noticing that im having huge heart palpitations. in your experience could bcaa’s be causing this?

  • I find it very ironic you drive home he has financial ties and he has a motive to say eaa is better but didn’t you as well? You were involved with xtend studies to show it works to drive sales you had financial motives as well

  • Hold on…
    This is a 100% diet based study.
    What about the OUTPUT. What about the exercise and physical/ mental calorie consumption? Are these sedentary subjects? Are any of these individuals active, athletes, Male/ female, age? Stress factors, other food categories consumed?

    This is probably misleading garbage, isolated micro study. Who are you fishing for grants from?

    Looking through the comments most who are praising your information obviously don’t think. You could sell them anything. YOU are the intromyocellular fat.

  • I have some spirulina superfood powder, I did some research but i’m real uncertain on whether or not algae superfoods are safe, though they are rich in all the vital minerals and nutrients including essential proteins the human body needs

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  • I experienced diarrhea next day after taking BCAA.. So should i totally avoid BCAA? and will that affect or limit my muscle gain if i don’t take BCAA??

  • Then why is it I see a chick on this in the local gym with an enlarged head and all buffed out and she is openly
    using BCAAs? ( has the bottle out and mixes it in front of everyone )
    Is there something else perhaps she’s using along with this that’s a steroid?
    Also saw a personal trainer acquaintance blow up unnaturally in 90 days and he said he uses Creatine….
    I know people say neither are steroids,
    But the growth I’ve seen in a few people I know is steroid like.
    Can’t just be a placebo… either they are selling it what it is and they mix in steroids regardless to an ignorant public or the people I know are shooting up in the dark…

  • this is very interesting, I take a….well, a known trademarked supplement with BCAAs and pregnanelone and somethings that happened when I was younger when I took BCAAs occurred and this is making a bit more sense. Thank you for making this and clarifying.

  • Спасибо за русские субтитры ��
    Thanks for making russian subtitles ��
    PS: I wish we had more doctors like Mr. Michael Greger everywere in the world ��

  • Here is a research study showing the difference. BCAAs are effective but the other aminos are a limiting factor. EAAs are superior.

    https://www.frontiersin.org/articles/10.3389/fphys.2017.00390/full

  • I’ve been at this for 20 years and when they said essential amino acids beat Branch chains I knew that was a biggest bunch of shit I have ever heard I seen the research for over 30 years and use them myself I’m glad you know what you’re doing Mark cuz a lot of people don’t keep it up my friend

  • Ball of confusion tired of these dorks and their goddamn studies you need protien to build muscle no matter what form be your on genie pig see what works for you

  • BCAA’s have no evidence of causing cancer, diabetes or anything else harmful. However there is extremely strong evidence that they plain just don’t do jack $hit.

  • Ok I bought a protein powder from. now sports pea protein with BCAAs included in the protein has a lot of BCAAs in it. Is that safe to take. Or should I just take a whey isolate protein instead.

  • Thank you for sharing this video marc lobliner i like your energy telling the truth im looking forward meeting you in person when you visit Columbus Ohio next year for Arnold sports expo we have lunch and cut of coffee catch up some things i been watching your YouTube channel for little while bro

  • I know this is an old post, but if the argument is that BCAAs do nothing then I can see why Marc is upset. I’ve used BCAAs for years, but have recently purchased some EAAs. It makes sense, since you are getting all 9 AAs instead of the 3 so you can’t lose either way. Now, like with all supplements, you need to do your homework on the brand in which you purchase and read those labels. If the labels have no real portions or ingredients listed then I would be hesitant in buying them.

  • U better stop Marc someone is going to make a video that u are bullying him waaaa. when u said that u challenge anyone in a debate and no one responded that’s it, it’s over.

  • Did that last study indicate that animal proteins were worse? Or do animal proteins contain more BCAAs? Or ARE animal proteins also known as BCAAs?
    If not, I don’t see a link between the last two studies.
    Also, in the second last study you said it showed we can eat lots of plant protein, but in the last one you said that more than the RDI is bad; but didn’t say whether that includes plant protein.
    Can you please clarify?

  • Hello sir,
    IAM from India,
    And I have fatty liver with minor alivated sgpt and sgot level, so can I take BCAA or not,
    Actually I already taken sample of BCAA and it’s really helps me for my weight training in good way,
    Hence request u to plz advise can I take in this liver condition
    Plz sir reply me,

    I’m also taking Iso pure zero carb is it safe in fatty liver or not
    Plz reply about this also

  • Just passed my gestational diabetes test eating a whole foods plant based diet. I tracked my own glucose levels for 2 weeks. There were some days where my blood sugar spiked quite high after eating a large meal of refined carbohydrates. However, I eat lower protein and lower fat, so I wasn’t that worried about it. The midwife still suggested I eat more protein ��

  • Great video, how do you feel about taking algae superfood supplements like chlorella and spirulina, think they are safe for consumption??

  • go back into the golden age of body building they had no pre-workout, post-workout or gimmicky protein powders they had “Food”. Everything is about making $$$$ now a days simple equation train correctly, eat correctly, rest correctly and you will get Gainz…

  • Credit where credit is due but you need the EEA’s to act on all neurotransmitters and trigger protein synthesis enough for it to havew an effect. You juice, so the difference is insignificant for you. You have all 3 + 6 others ( histadine not needed) you need all 8 to make protein. This cannot be made with 3! BCAA’s work, EAA’s work better. Quite simple! Also, a Meta Analysis is more than just a study….it’s an analysis of multiple studies on the same subject. Poor performance!

  • Some comments asking about BCAA Supplementation, exercise and muscle gain. Dr Greger won’t take about it as long as there’s no negative research about it. If the research says it is good for him it’s not excite.

  • BCAA is like having a baseball team and only have a pitcher and catcher it’s not complete team! Yes, any supplements could have junk and fillers, even in EAA supplements.

  • This is a biased review. These studies do not account for people that do cardio and resistance training, which helps fight insulin resistance. Is this study on sedentary individuals? Again this Dr. is showing bias study’s, to prove his narrative. Why would I take advice from a 125 lb male that looks like golem from lord of the rings.

  • I wish they ran a study like this on athletes who weight lifted or played contact sports because the recommendation for protein intake is higher for them. I wonder if its the BCAA type that’s making the difference between the two groups ( such as leucine ).

  • this sport is going to shit from this supplement crap storm these guys are pushing! Dude you call your self a bodybuilder why the fuck do you thind red meat and eggs are fucking superior protien sources dude!?Because they have Bcaa!? For the love of god shut the fuck up with your supplement studies and eat fucking! da faq

  • Stop with the click bait titles and maybe you won’t have this backlash. Seriously, mix in some other topics before you piss off your base with this stuff. That wasn’t even a study with a set methodology with control groups.

  • Man I remember when you pushed bcaa megadosing and gaining crazy amount of weight in no time. I used to argue with you and others about that actually. It’s hard to trust ‘anyone’ selling supplements so I’ll just say use whey. It digests just fine and fast enough around workouts and is superior in multiple mechanisms to all those amino acid products.

  • Were those studies done on people that weight lift though or not, i feel if you’re exercising and weight training the results would change

  • Marc is a certified scrotum tickle.

    Here’s what Alan Aragon said on the matter of BCAAs:

    “Let me also add that whey protein has a stronger anabolic/anticatabolic effect than its equivalent in supplemental EAA or BCAA [2]. It’s no surprise that supplemental BCAA has an equivocal track record in the research [3,4]. For those concerned about “going catabolic” doing fasted cardio without AA supplementation, my colleagues and I found no difference in body comp effects between fed vs fasted cardio when total protein is sufficient (both groups retained their LBM) [5]. As for the ability of BCAA to inhibit muscle soreness, note that this is always compared to a non-protein placebo.

    It’s LOL to supp with BCAA to begin with (instead of an intact, high-quality protein such as whey, which provides the rest of the EAAs as well as other co-factors for anabolism – but it’s all moot if you’re getting enough total daily protein anyway). Here’s a salient quote from a recent review [6]:

    “Thus, as we speculated, consumption of crystalline BCAA resulted in competitive antagonism for uptake from the gut and into the muscle and was actually not as effective as leucine alone in stimulating MPS. Despite the popularity of BCAA supplements we find shockingly little evidence for their efficacy in promoting MPS or lean mass gains and would advise the use of intact proteins as opposed to a purified combination of BCAA that appear to antagonize each other in terms of transport both into circulation and likely in to the muscle.”

    The only people who are not wasting time & money on supplemental BCAA are those who must maintain a low-protein diet, or a diet with restricted amounts of high-quality protein. With that all said, if your total daily protein is optimized, and you don’t mind consuming the functional equivalent of really expensive flavored water, then be my guest.”

    In other words, invest in a high quality whey protein supplement.

    And eat real food.

  • I’m not overweight, and I use BCAA’s with my training regime. Should I rather not? Not sure if the video refers to any BCAA’s or specifically if they come from an animal source.

  • Wait what. I shouldn’t even be eating the recommended daily protein amount? I workout 4 days a week (nothing crazy but for an hour at the gym) and I should be eating LESS protein than even the recommended amount?

  • What’s up brah I love you channel love your content!!! I won’t get tired of telling you that you are my YouTube hero my friend!!! One day once my fitness journey channel gets big enough I want to do a collab with u somehow!!! Even though we on diff parts of the country!!! I’ll fly to u, that’s how much I love yo shit!!!! Keep telling it like it is homie!!!

  • As a counterpoint, it should be noted that the conclusions here may only apply to prediabetic or metabolically-challenged (not trying to be funny) individuals and NOT athletes. Actually -and unfortunately, since it jumbles and mixes up a lot of messages the same can be said for a lot of studies: what you can conclude in patients with declared symptoms may not apply to healthy or “active +” individuals. Case in point: the foundational study by Pendergast et al. in 96 clearly shows that while athletes also display higher intramyocellular lipids, these are actually beneficial to their activity. And it’s not just because the study is old and flawed. Savage et al. mid 2019 have shown in the J. Lipid Res that the nature (saturated or not) of the lipids accumulated would be the key point, not the presence/quantity. So concluding that BCAAs could have indirect adverse consequences as a whole based on that is tricky, in particular for athletes known to rely on them and who have demonstrably higher needs for them. Like many things in science, that may be turned on its head in the future, but this certainty remains: you always have to be very cautious trying to transpose the conclusions of a study based on patients with declared clinical signs to a healthy population and even more when you deal with individuals who are particularly active and thus have specific adaptations to the imposed demands of what they do…

  • The study presented at 5:12 is extremely misleading and wrong. LOOK AT THE DATA PRESENTED!!!

    First, the baseline of the protein restricted group was 2621 up or down by 410. That’s between 3,031 and 2211. The followup was 2856 up or down by approximately 200. That’s between 3056 and 2656. That’s still in the approximate range they started! The control group started at 2464 plus or minus 611. That’s between 3075 and 1853. They ended at 2367 plus or minus 445. That’s between 2811 and 1922.

    The protein restricted group should have been eating more calories than the control group because they started off with a 18 pound higher body weight than the control group. Their calorie needs will be different from control group that is lighter. Even after the study they ended with more weight and more fat mass than the control group started or ended with. The protein restricted group also started at baseline with far less FGF21 than the control group and barely surpassed the control group levels at follow up. The results of any study can be skewed when your starting sample of your test group starts off highly divergent from your control. I wouldn’t trust any of the conclusions Dr. Greger is coming to from the information cited. This is garbage.

  • @Nutritionfacts what about protein for athletes? I lift and I am still trying to lose weight but I struggle to get to 100 grams of protein? Would that be a problem in my body recomposition goals??

  • My local Gold’s was giving out free samples provided by the fitness supplement store next door. I did try some Muscle Sport caffeine infused BCAA. I loved it. However, I am concerned about list of ingredients which reads like a Physicians Desk Reference, and the product is expensive.
    Yours is the only source I have found that doesn’t sound like brand hyperbole (hype & BS). Furthermore, the guy here criticizing you cannot spell or construct a coherent sentence. So, who would I believe?

  • Well BCAAs stimulate muscle protein synthesis. What if the high protein diet is taken by individuals who excercise quite regularly? Would these findings be consistent under those conditions?

  • I go by what helps me recover…bcaa by themselves didnt do much,eaa didnt do much..but take either one in a carb/electrolyte drink help a fuck load. As long as ur body has a good supply of the building blocks of life who gives a fuck on either

  • You do realize a Meta-Analysis is an amalgam of multiple studies. A Meta-Analysis is quite literally, the “end-all be-all” of scientific research literature.

  • I get it jerry. I got it last time. people just don’t listen to what is being said. they just hear what they want. keep the raw tv coming. I appreciate your content

  • This is clear manipulation of data from A plant biased doctor.
    If anyone wants to understand protein and muscle,then look up someone that has studied it for over 25 years and is a professor emeritus on the subject.
    Dr Donald Layman on youtube.
    Dr Gregor is NOT either a protein expert or muscle expert therefore he is cherry picking small epidemic studies that actually mean nothing,furthermore he us totally biased towards plant based diets and that kind of Dr with that biased mentality cannot be trusted for true independent advice.

  • I am on caloric deficit I only use protein aftr my workout only I want to lose extreme fat I there any safest thing to use which may not affect my heaklth?please must reply

  • Right. They lost weight, they lost 50% fat 50% muscle mass. How about if you are an athlete? Should you just make your life a hell by restricting protein. Let all serious athletes consume at least a freaking 2g of protein per KG of body weight.

  • Really dislike this new presentation format. Can’t see the text at all. I guess now that he’s rich he only knows what it’s like having a giant monitor.

  • hi mate I really need yuour help I’m skinny I want to put on so I’ve bought critical mass and bacca is becca good for me or bad I don’t want risk it plz let me kw if I should take becca tablet or no thank u plz get back to me

  • If the more you activate mtor causes diabetes then exercising would cause diabetes has it incresses mtor you guys are total nut jobs sugar dosent cause diabetes but essential amino acids do lol hahaha its not a fact bcaa plasma levels are associated with insulin resistance thats all their is no data that says dietary bcaa causes insulin resistance diabetes is hereditary and of course any food will feed cancer cancer uses bcaa and protein synthesis to grow lol but it dosent cause cancer

  • BCAA OR EAA is bad news for people that are already diabetic! I’m a diabetic and prior to taking BCAA my sugar levels were under 100 in fasted state, now they are over 145 in fasted state. WTF lucky I realize the problam

  • how about for those already healthy and advanced in weightlifting? I have heard the opposite effects of going on a completely ketogenic diet in terms of insulin resistance…?

  • Well that doctor sells BCAA/EAA supplement the only thing different about it compared to others is it seems its 3 Grams ish total of all so i guess his point is less is better? its a prop blend but just by looking at it you can see 3 grams about with all 9 aminos so i would guess around 500mg to 1 gram of leucine?

  • Bioavaliability… Talking a lot about getting healthier when you are obese, but what about people who want yo gain mass and muscle?

  • Sorry but why you say that a meta analysis is worse than a study?I thought that a meta analysis is a “conclusion” of many studies..

  • Just lace the gloves back up fellas, step back into the ring and throw some hands and hash this shit out then dap it up and keep it moving.

  • Vegans have been spreading the word that high amounts of leucine is linked to health issues. Beef pork chicken cheese all have large amounts. This is not new news.

  • I’ve done the low protein, plant-based diet twice. If you don’t mind becoming weak as hell, then I’d say go for it. You will definitely lose weight and maybe improve certain health factors.

  • I would like to know how the results might differ if the participants in that study were consuming only vegan protein sources. Like, I use a BCAA from an entirely vegan company since I’m very active and could use the extra AA’s. I don’t think this is making me obese though…

  • well I’m glad you talking about BCAAs, if these dumb ass want to die for taking too much of that s*** let him die f*** them J, I appreciate the knowledge thank you

  • So these studies were all on obese individuals or diabetics? Seems like a big difference compared to a lean athlete who gets a little extra protein to support adaptations.

  • I’m really skeptical with him outright saying the fat person thigh was healthier than the muscular person thigh… The image seems to be taken from an entirely separate study, so I don’t understand how he can make that conclusion.

  • Some researches on BCAAs and mental health:) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973973/ just google “BCAA” + any thing in your mind and you will get something bad about BCAA.

  • Thank you for responding. However the pea protein has a list of all 17 BCAA in the protein. It seems to me there is a lot of BCAAs, like arginine has 2246 mg in it and others are a good amount or seems high to me. I’m not sure if this is high or just fine. Is this safe as for the amounts. Can I take to much or overdose on BCAA in a protein. Also Can I gain muscle with pea or is whey better for building muscle? Thanks

  • I am a whole foods plant based vegan, no oil, no gluten. My A1C is 4.5 and I’m 8lbs overweight. I eat a lot of plant protein, and tons of carbs. I have perfect blood work. I’m 53 and med free.