A 50-Year Study Sheds New Light around the Outcomes Of Exercise and Depression


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Judith Campisi, Ph.D. on Cellular Senescence, Mitochondrial Dysfunction, Cancer & Aging

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Many Benefits of Exercise: Mayo Clinic Radio

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Exercise as a Treatment for Depression [Scientific Review]

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According to a new 50-year study published in JAMA Psychiatry, people who exercise exhibit fewer depressive symptoms over the course of their lives. Researchers from the UK and Canada. According to a new 50-year study published in JAMA Psychiatry, people who exercise exhibit fewer depressive symptoms over the course of their lives. Researchers from the UK and Canada looked at 11,000 people born in the same week in 1958, tracking them for the next 50 years. Light Shed on Link Between Depression, Dementia A new study published online July 30 in the journal Neurology sheds more light on the mystery. just like exercise or eating right, will lead.

But new research out of the University of Adelaide has shed light on the mental health impacts of stopping a regular workout routine. In a review of relevant studies, researchers analysed the impact of pausing a regular workout routine in active adults who exercised at least 30 minutes, three times a week for three months. Study in ‘split brain’ patients sheds new light on sleep slow waves The animals won’t be forced or even encouraged to hit the running wheel.

Rather, frequency and duration of exercise. In fact, a newly conducted meta-analysis about dietary inflammatory index (DII) and depression shed new light on what to eat to fight against depression and why a MD is a better choice than WD during this situation. In this study, four prospective cohorts and two cross-sectional studies enrolling a total of 49,584 subjects have been analyzed. The association of depression with prevalent MCI and with progression from MCI to The epigenetic findings will shed new light on the link between exercise and gene activation of relevant genes in the biochemical pathways underlying cognitive decline. An important consideration of this study is the isolated aerobic exercise intervention.

The link between BDNF and hippocampal impairment in humans is more tenuous, but two recent studies have shed some light on the associations. In one study, BDNF was measured in cerebrospinal fluid (CSF) and cognitive function assessed by a comprehensive neuropsychological battery (Li and others 2009). CSF BDNF levels were reduced in older adults.

Study sheds light on link between PCOS and mental health such as anxiety and depression. Now, a new study suggests this may be down to hormonal imbalances before birth that affect the brain. Relationship between personality, health: Study sheds new light on link Date: December 11, 2014 Source: University of Nottingham Summary: New.

List of related literature:

One of the studies by Penninx and colleagues (2002) demonstrated that aerobic exercise had a more beneficial clinical effect on depression than did resistance exercise.

“A Clinical Guide to the Treatment of the Human Stress Response” by George S. Everly, Jr., Jeffrey M. Lating
from A Clinical Guide to the Treatment of the Human Stress Response
by George S. Everly, Jr., Jeffrey M. Lating
Springer New York, 2012

Beginning in the 1920s, researchers began studying exercise as a low-cost, effective alternative to medication or psychotherapy for the treatment of depression – and one that does not have negative side effects.

“Routledge Handbook of Applied Sport Psychology: A Comprehensive Guide for Students and Practitioners” by Stephanie J. Hanrahan, Mark B. Andersen
from Routledge Handbook of Applied Sport Psychology: A Comprehensive Guide for Students and Practitioners
by Stephanie J. Hanrahan, Mark B. Andersen
Taylor & Francis, 2010

As the researchers stated, this “reaffirms that depression is very sensitive to exercise and helps firm up a biochemical link between physical activity and depression.”33 At least 100 clinical studies have now evaluated the efficacy of an exercise program in the treatment of depression.

“Textbook of Natural Medicine E-Book” by Joseph E. Pizzorno, Michael T. Murray
from Textbook of Natural Medicine E-Book
by Joseph E. Pizzorno, Michael T. Murray
Elsevier Health Sciences, 2012

Patients with depression should also be informed that exercise training has been shown to reduce depressive symptoms in both healthy and medically ill populations.

“Clinical Exercise Physiology” by Jonathan K. Ehrman, Paul M. Gordon, Paul S. Visich, Steven Keteyian
from Clinical Exercise Physiology
by Jonathan K. Ehrman, Paul M. Gordon, et. al.
Human Kinetics, 2009

Exercise is such a powerful treatment for depression that older studies may actually have underestimated its effects.

“Exercise Is Medicine: How Physical Activity Boosts Health and Slows Aging” by Judy Foreman
from Exercise Is Medicine: How Physical Activity Boosts Health and Slows Aging
by Judy Foreman
Oxford University Press, Incorporated, 2020

The results showed that exercise resulted in big improvements in depression.

“Exercise for Mood and Anxiety: Proven Strategies for Overcoming Depression and Enhancing Well-Being” by Michael Otto, Jasper A.J. Smits
from Exercise for Mood and Anxiety: Proven Strategies for Overcoming Depression and Enhancing Well-Being
by Michael Otto, Jasper A.J. Smits
Oxford University Press, USA, 2011

The immediate effects of exercise in treating depression were comparable to those of antidepressant medication, with a significantly lower likelihood of depression relapse over time (Babyak et al., 2000).

“The Handbook of Health Behavior Change, Third Edition” by Sally A. Shumaker, PhD, Judith K. Ockene, PhD, MEd, MA, Kristin A. Riekert, PhD
from The Handbook of Health Behavior Change, Third Edition
by Sally A. Shumaker, PhD, Judith K. Ockene, PhD, MEd, MA, Kristin A. Riekert, PhD
Springer Publishing Company, 2008

Although the higher-intensity exercise training resulted in a greater reduction of depressive symptoms, this change was unrelated to changes in fitness.

“The Psychology of Exercise: Integrating Theory and Practice” by Curt L. Lox, Kathleen A. Martin Ginis, Steven J. Petruzzello
from The Psychology of Exercise: Integrating Theory and Practice
by Curt L. Lox, Kathleen A. Martin Ginis, Steven J. Petruzzello
Taylor & Francis, 2016

Other studies, looking specifically at the effects of exercise on depression in patients with cancer, have shown similar results.

“Cancer Rehabilitation: Principles and Practice” by Michael O'Dell, MD, Michael Stubblefield, MD
from Cancer Rehabilitation: Principles and Practice
by Michael O’Dell, MD, Michael Stubblefield, MD
Springer Publishing Company, 2009

Although exercise is valuable in reducing depression in mentally healthy individuals, greater decreases in depression through exercise occur in those requiring psychological care.

“Biophysical Foundations of Human Movement” by Bruce Abernethy, Vaughan Kippers, Marcus G. Pandy, Stephanie J. Hanrahan
from Biophysical Foundations of Human Movement
by Bruce Abernethy, Vaughan Kippers, et. al.
Human Kinetics, 2013

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

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  • Hey, guys! The most important thing to do after watching this video is to go check out the brand new FoundMyFitness depression topic page. More than just digging into this topic of exercise and depression, we also discuss many diverse and interconnected topics like the role of inflammation, circadian rhythm disruption, nutrition, and gut microbes in depression, and much more. There’s nearly 100 peer-reviewed references and growing. A truly fabulous resource. foundmyfitness.com/topics/depression

    Big thanks to members that continue to give us the opportunity to make great resource like this. To learn how to become a paying member of the FoundMyFitness community and thereby support resources like this video and the pages on the website, visit the crowdsponsor page on our website at foundmyfitness.com/crowdsponsor.

    If you suffer from a clinical mental health condition like depression, it’s important to note that this video isn’t meant to be a substitute for the proper diagnosis or treatment of any mental health disorder. Please seek out proper clinical treatment and listen to the advice of a mental health care professional.

  • Thanks Dr. Patrick, a fan,… but this all sounds like Quorum Sensing, as a fan of Dr. Bonnie Bassler also. This is the mechanism that I have theorized for Metastasis Once a quorum is formed we see Antagonistic Pleiotropic responses… [Williams GC 1957] and Dr. Campisi is describing the same Quorum Sensing function that we see for cancers (Metastasis)… but following a different evolutionary path… seems that all this can be regulated by blocking the “Cellular Communications” or more interesting… “Redirect”.
    ps… the “unknowns” mentioned points right at your “Buddy” Dr. Ames’ Triage Theory….

    70 Going On 100… or maybe 70 Going On 128… the Hayflick Limit… or if a fan of Ray Kurzweil… then this is all a Moot Point…

  • Thank you so much Rhonda. You should win a nobel prize or something for distributing this information so readily. Taking your notes word for word.

  • @ 2:51 “exercise improved depression” allow me to request that the presenter restructure their semantics “studies show that exercises reduces depression not improves it.”

    What would you rather do? reduce your depression or improve your depression?

  • Most people won’t understand this video. It is far too technical and I understand it because I understand anatomy and physiology. Ask someone on the street if the know what dopamine and serotonine Etc is.

  • Big picture observation.
    I say this with kindness but objective assertiveness.
    I’m 2 minutes into this video The video started out reasonably simple however at about a minute the jargon used to communicate was unnecessary complicating the subject. All this complicated jargon makes following the message delivery impossible.

    Refer to Thomas Jefferson’s famous quote “never use two words when one word will do. “

    A couple tidbits and observations about addiction treatment and applying vigorous outdoor exercise as a therapeutic healing component;

    1. My psychiatrist techniques and protocols kept me unhealthy and dependent on psych meds. Furthermore, none of the treatment team that I was under care for carried out Any sort of self-care practice where exercise and high quality nutrition were a part of their daily regimen -they were all physically unhealthy.
    2. I fired my addiction treatment clinicians. I hired a sober coach. We spent two years getting physically healthy and changing my lifestyle to a self-care first practice.

    3. Because I became physically healthy from exercise and high quality nutrition My brain healed and my paws post acute withdrawal symptoms evaporated.

    4. Being healthy in the body allowed exponential healing of my emotional wounds subsequently I shed my emotional baggage.

    Summary; My healthy body and my healthy mind are now working cohesively together in synergy.

    Modern medicine for the most part is failing; prescribing psych meds in lieu of getting physically healthy with vigorous outdoor exercise and high quality nutrition.

    I was diagnosed as bipolar, severe ADD, manic depressive, depressed my psych my psychiatrist and addiction treatment professionals that I hired they’re prescribed methods and practices were mediocre and incompetent.

    Back to initial point about complicated jargon. Addiction treatment and human rehabilitation is a complicated subject… A video such as this covers and macro subjects when it should be breaking down the subjects into micro subjects / lessons.

    This video is 16 minutes almost nobody is going to be able to follow this unnecessarily complicated presentation. Deer presenter with kindness and tenderness I plead to you to rehearse your presentation with a typical target audience…. The idea being they can critique your presentation effectiveness and usefulness.

  • Its go job i exercise 5 days a week, with boxing spinning and weights. With the fact i have a w8fe who shouts all the time and doesnt let me near her and just makes excuses like im tired, or yoh gave coffee breath or even ive have to get the washing out of the machine. Exercice only keeps me from fucking topping myslef. Exercise follwed by a wank in the shower then its all down hill until i sleep

  • Hey Seniors! This man called you all “elderly” and feels facing death shouldn’t naturally lead to depression ���� Listen to your friendly artist: try weed (sativa) and know we’re out here seeking the Grail.

  • Numerous things have improved in my own life since I applied this fibroids procedure. I have implemented the directions conscientiously and had never stop ever since. I am completely happy that I am seeing the final results now. This procedure had made my severe and terrifying experience into a blessing in disguise. Fibroids are all gone right now. I remembered I got this plan on Google, it calls Hαmjot Sυnu
    good luck

  • Very interesting! It had me wondering whether Hyperbaric Oxygen therapy could be effective in regenerating the Senescent cells…Interesting to me, as I am a technical diver, and can easily do dives in 20 to 30 feet of water breathing pure O2….and combine that with my ketogenic diet….If you think there is anything to this, I may start doing this a couple of times each month:-)
    Closest article I found almost on point with this follows:
    ” Cell cycle synchronization of tumor cells by exposure to hyperbaric oxygenation (HBO) may increase the efficacy of chemotherapy or radiation by placing cells into a chemosensitive portion of the cycle. The purpose of the current study was to examine oxygen pressure-dependent relationships with respect to the cell cycle in prostate tumor cells in vitro. LNCaP cells were grown in an incubator at 21% O2 and then exposed to 100% oxygen at pressures up to 6 atmospheres (atm) for 1.5 h. Cells were then returned to the incubator and evaluated for DNA content by propidium iodide and new DNA synthesis with a pulse-chase experiment. Cell cycle effects were evaluated by flow cytometry. Exposure to HBO increased the percentage of cells synthesizing new DNA in a dose-dependent fashion: 0 atm, 44%; 6 atm, 65%. Cells that synthesize new DNA accumulate in G2/M as a function of partial pressure of oxygen. These results suggest that HBO induces cells to enter the cell cycle and accumulate in G2/M. Cell cycle synchronization and entry of senescent cells into the cell cycle suggest that HBO may be a useful adjuvant to chemotherapy or radiation in the treatment of prostate cancer. There are two potential mechanisms of action that may make HBO efficacious in the treatment of prostate cancer. HBO may potentiate cancer chemotherapeutic agents that cause damage to DNA during DNA synthesis or HBO may inhibit cell division causing accumulation in G2/M.”

  • In the discussion around mice and people’s mortality for unknown reasons, “heart just stopped” makes me think of stem cells. AFAIK that is quite common towards the end of life, the heart cells are not replaced fast enough, or at all. I believe this is where stem cell therapy needs further research. I understand that we can not make stem cells from skin and fat cells. In regards to rapamycin, that may be risky to use for the sole purpose of dampening mTor. There are other molecules that are safer that also target mTor/p53 such as Berberine which I use daily.

  • And a ratio of less that 1/1000 dislikes shows you the content of your videos ��. And the dislikers probably need to listen the most.

  • I’m depressed and the only thing I still make myself do is exercise… if I let that go I’d be gone. It doesn’t make me feel better because my reward system is f-Ed up from being on drugs. I’m quitting but I have to put up with everything being a chore for another 6-12 months… yay! I beg all of you that are dealing with crazy pain to stay away from drugs. 2 weeks tops then surgery. I was bed ridden for 4 months in insane pain. Would NEVER do that again. Straight to the surgeon next time (bulging disc, sciatic nerve pain). And I’ve had sciatica before but not like that time… anyway. When I had a normal brain I was riding bikes 10+ hours a week and 5-8 hours in the gym. I felt amazing!!! So yes, if you have a normal functioning brain I couldn’t imagine something better..��❤️

  • I have suffered from treatment resistant GAD and comorbid depression for over 20 years. Symptoms include low testosterone and adrenal fatigue which make exercise difficult. Took up jogging recently and so far after each short jog I don’t feel any better (no endorphins or runners high) I just seem to develop post exercise headaches instead. It is disheartening but I will persevere.

  • Seeing fat, obese people motivates me to hit the gym. If not I slack off and get fat myself. It’s called a workout for a reason. Leaving the gym clean and showered is worth it. Balance is good for the brain. I stand on a 15 lbs medicine ball (basketball size) for a minute squat down a bit and raise up. I took a while to do. Also walk backwards 5 min (on my 30 min am wake up walk). I get “looks” and dogs trip sometimes but agility, even a small amount is good. It took you tube 3 weeks to suggest this to me! There slacking. Dr Rhonda should be in every You Tube users suggestion list.

  • As a fellowship holder of different specialty I can clearly see knowledge reason and quality. Instant subscribed and will follow keep the good work.

  • I don’t do shit all day. But I practice classical guitar, draw, write, clean…etc. I feel upbeat and happy most times.
    I wonder if internal monolog has a larger influence on depression than anything external. I love my life and creative outlets. Mirror time is usually goofy faces, fart sounds and laughing. How strong can ‘mind over matter’ be?

  • Can you please do a review of fluoxetine (prozac) induced BDNF response? Here’s the relevant study: https://www.ncbi.nlm.nih.gov/pubmed/15381288

    “BDNF protein levels remained unaltered until 21 days of fluoxetine treatment, when the numbers of BDNF immunoreactive cells were increased, reaching significance in the pyramidal cell layer of CA1 and CA3 regions of Ammon’s horn (CA1 and CA3) but not in the other sub-regions of the hippocampus”

  • I know my Vo2 max can stay high well into my 70’s. I primarily focused on HIT calisthenics training in order to maintain my high vo2 levels. I have just turned 40 and will be dropping weight for the next ten years. I don’t want to carry too much muscle into my 50’s and beyond. I’m rowing now and will soon be back in the pool but I don’t feel the intensity of calisthenics hit training with either exercise. The after effects of complete exhaustion and overall exertion are similar but the intensity wanes. Is endurance training as effective at maintaining vo2 levels as hit training?

  • Fabulous interview, confirmed my theory on cell life. Listened to this multiple times. Aging is a bitch, but there are things we can do about it. Rhonda, please do a vid on antiinflammatory diet and lifestyle, in addition to fasting. I could certainly fast 1 day/week.

  • I love how informative and clear these videos are. I, without any prior knowledge about this stuff, can actually follow and find it very interesting. Incredible work and interesting findings! Thanks.

  • Easier said than done and I think it really depends on the level of depression you have.

    I had severe chronic depression where I was bed ridden for 22-23 hours of the day. I woke up once a day to eat dinner my husband made. Exercise wasn’t going to save me from my depression.

    However, it would have been much better used to prevent some of my depression in the first place.

  • I find weight training or calisthenics with only a minor amount of aerobic exercise most beneficial. I use to do a lot of endurance cycling and couldn’t figure out why I was always anxious. The excess cortisol from overtraining the aerobic system can have negative results, especially in the anxiety prone. YMMV.

  • Nick Lane has a chapter in The Vital Question about the trade off in age and reproductive rate between, for example, rats and pigeons, and that the two are reciprocally related.

  • I’ve been suicidal my entire life and frankly still am, but let me tell you this it’s difficult to feel depressed when you look like a greek statue, and people loving it as well. I feel like confidence and depression are on the same gradient sort of plane, so they are mutually exclusive. So my anecdotal evidence confirms this.

  • Now produce as a tie in the topic glyphosate. Hear MIT Ph.D Stephanie Seneff. Also see her interview with Dr. Mercola Aug. 4, 2019. Let’s crush Monsanto Roundup this time. Formerly PCB, agent orange, GMO if you eat food that interferes with the gut and your breathing in air that is CUMULATIVELY insidious then watch autism, auto immune diseases, Alzeyhemers, food allergies, obesity, diabetes all rise. Roundup is loosing in court for cancer. Heart diseasewell glyphosate causes sulfate deficiency. Your going to have systematic inflammation.

    I have a Masters in Kinesology from 1980. We never talked about the mechanisms you reveal and Dr. Raison and Dr. Seneff. Thank you for making us all a global community of informed citizens. So my best activity is to put what they call puts on Monsanto. So it all must move together personal health and industry.

  • Hi, Can you PLEASE do a video on the antinutrients in plant food, this is a big topic at the moment and one I find very confusing…Are plants good or bad?

  • Sounds lovely, however many of the meds you mention are absolutely contraindicated for people who have inconveniences like epilepsy. Remeron can exacerbate depression, confusion, weakness, liver problems… and cause seizures. Just a few of the side-effects. RESEARCH, people. ��

  • Not certain about the points made but,if anyone else wants to discover curing depression try Nevolly Depression Remover Nerd (do a google search )? Ive heard some great things about it and my cousin got amazing success with it.

  • I think if we got away from calling it depression to toxic induced brain injury from prolonged periods of stress will help change the paradigm in therapy and life changes. We began looking at this in Special forces opertertors in order to preserves the force. Sleep, nutrition and brain health, you my lady are in to something

  • My name is Lindo and I just started my channel talking about my depression, getting through life on a daily basis. please join me in my journey and hopefully we can help each other and support through out.
    Thank you.

  • 5 years ago when I quit alcohol I could barely work a 2 hour shift

    My depression was at about 8.5 level.

    Today I’m riding my bike 200 to 300 miles a month out on the mountain or the road bike.

    I noticed that when I spent too much time indoors at home on the internet and social media I was chronically in the state of discontent and depression –

    Too much internet and too much mobile device use had my brain foggy

    Great video by the way

  • Just discovered Kyle Kittleson’s past vocal support for Trump, which while now revoked is pretty damn disappointing given the reality of who Trump always has been, and it kinda ruined this channel for me. So that sucks.

  • After Leg Day work out doing lots of squats and then my morning double espresso, I feel sooo good and at peace. Hurts when you work hard, but I believe the pain makes you a happier person.

  • I love Rhonda, ever since I discovered her on Joe Rogan podcast. She always gives so detailed description of everything and has a pleasant personality.

  • If you don’t have the motivation to exercise then you will have the motivation for chemotherapy. Because obesity ultimately leads to cancer, especially in women. The cancer will take the pounds of of you fast. That’s how it happened in my family.

  • I’ve exercised by jogging for the last 25 years and I now have non-reversible arthritis in my knees and can’t walk or jog more than about 5 blocks w/o quite alot of pain. Some days are better than others. My cardio these days can easily take me 20 kms plus, but the knees won’t let me. Did 20 kms last year and couldn’t walk by the end. This year I went to the doctor and he said there is no cure, prescribed some cream, a physiotherapist that may help in slowing down the severity of the arthritis, and a check up in 3 months. I can jog uphill w/o much problem, but the walk or careful jog back down is most always tough and pain enduring. Feeling good about what exercise is doing for my cardio, but facing possible cortisone shots, which only work temporarily, or possibly getting knee replacements were not in mind so much when starting to jog. Miss being able to jog and walk w/o pain. I’m 55.

  • Hey Rhonda! Not sure if you’ll even reply to this, but what is your opinion on seres therapeutics microbiome drug they are trying to get to market? Will this method be effective? Or is it a dead end? Your reply would be amazing! Thanks

  • Cheers for the Video! Excuse me for the intrusion, I would appreciate your initial thoughts. Have you tried Lammywalness Erase Depression Guide (erm, check it on google should be there)? It is a great one of a kind product for beating depression fast minus the headache. Ive heard some super things about it and my buddy after many years got great success with it.

  • I got diagnosed 17 years ago. Somethings to bear in mind: if you are severely depressed, none of the above applies because you literally have neither the will, nor the energy to do anything. Again, depending on severity, or the stage of your recovery, you may be able and willing to exercise, but if you got at it too vigorously, it may set you back. I used to find that it would leave me feeling bereft. Looking back, I suspect that having unstable blood sugar played a part. I think the key is to build up intensity very, very slowly, especially if you were unfit prior to diagnosis. Also, it may take some time to find an exercise system that suits you, i.e. that you look forward to doing. So the message is, aim for it if you can, don’t beat yourself up if you can’t and don’t force it.

  • Depressioncareproducts.com
    Has things to help you fight Anxiety & Depression.

    Its an alternative to prescription drugs. Take a look and buy something for yourself or a loved one struggling with the symptoms of Anxiety or Depression

    Thank you for this great video.


  • my brother took medicine for depression and started seeing things, hearing voices that weren’t there, and almost tried to kill himself. i would never take medicine for my depression because it won’t help.

  • @ 2:31 SAID IN A SARCASTIC TONE exercise is not a stand alone component to human rehabilitation note: unequivocably with total certainty you absolutely have to combine high quality nutrition, with moderate vigorous exercise.

    Without the combination of the two the desired exponential healing of the mind of body will be stifled / lowered.

    Repeat after me: exercise and diet combined work together.

    Repeat again: exercise and diet combined work together.

    We’re at @ 2:31 did jargon is so complicated it’s impossible to follow I don’t care if your doctor and understand this physician’s lingo speak.

    Note: AA program is a derivative of the oxford group CBT protocol. My AA 12-step sponsor is a orthopedic surgeon he uses the 12 steps in lieu of CBT therapy for me it’s actually more effective cuz my sponsor is not making money.

  • I’m losing some hair on my forehead and a lot of my hair is turning white.I think I’m aging faster than most people my age because not too many people my age have white hair. my age is 68….I noticed you don’t monetize your videos…you can make some extra money by monetizing them..looks like i need to do more fasting also.after watching your video

  • same thing you can see in dogs. dogs that get regular excersize (playing, walking, etc) daily are way more relaxed and controlled than dogs that dont.

  • If elevated innate inflammation may drive aging, does this mean that inducing stress via hormesis (egcg, tumeric, sulforaphane, exercise etc) is activating acute inflammation rather than innate?

    So high levels of IGF1 in the brain is good, but ideally low everywhere else?

    Also, can anyone explain why for the non-super athlete, Peter Attia recommends exercises that work the fast type2 twitch fibers?! He also supplements with leucine during his workouts as a boost to mtor1. What’s the mechanism?

  • I have found that before I started exercising, I was always stressed sad and angry. Now that I have started running running daily, I have felt happier and no longer feel that way.

  • I find that exercise doesn’t really help because achieving my ultimate goal seems impossible given lm not genetically structured. It frustrates and depresses me.

  • I’m depressed, I don’t have friends, I don’t talk to anyone except my family, I don’t use Facebook, WhatsApp and other social networking shit.. it’s been almost a year!
    Before all this happened I was a very different person, I was quite and calm but I was happy, now I’m frustrated and trapped!
    Depression struck me after my girlfriend broke up with me and stopped talking to me..
    I hate the way my life is right now!

  • First of all, there is no such thing as “depression” as that’s a pseudomedical condition. Secondly, no exercise fitness does NOT make everyone less stressed. In my case, exercise and fitness raises and causes additional stress and also makes me angrier and bad tempered and no, no steroids are used and I try to vary up the types. I realized the hard way that I didn’t need to focus on exercise and fitness and just carry on with regular life and since moving on from fitness/exercise, my stress has dropped and I do feel better. No regrets moving on from exercise/fitness.

  • Great to hear the scientific reasons why I think exercise helps me cope with bipolar. Diabetes and obesity is common in people with bipolar.

  • Secret Counselling is a ONLINE Counselling platform for psychological issues such as Depression, OCD, Anxiety, Fear, Schizophrenia etc.., Meet Secret Counselor from http://www.mysecretcounselor.com

  • Wow. Very good film. My uncle was formerly a fat. He remodeled his body from 285lbs of pure fat into 204lbs of real lean muscle. I couldn’t believe it! I just subscribed myself as I’m seeking to get heftier muscles. He made use of the Muscle Building Bible (Look in Google)…

  • In this 1-hour long conversation, we discuss….
    00:00:52 The concept of antagonistic pleiotropy, which is an important evolutionary biological explanation for aging whereby a gene may be understood to exhibit more than one trait where at least one of these traits is beneficial to the organism’s fitness while yet another trait may be detrimental to that same organism’s fitness.
    00:01:32 What the fundamental molecular processes of aging are and some of the on-going research and general thought is surrounding these processes.
    00:04:05 The essential differences that a pathologist would observe if they looked at and compared the tissues of a young person with a much older person… even beyond structural differences.
    00:05:00 The qualities of the two major immune responses and how our innate immune response is both our best friend when it comes to keeping us alive but may be our worst enemy when it comes to keeping aging at bay.
    00:05:27 The infiltration of immune cells into our tissues that occurs as a function of aging and the role of damaged or senescent cells in attracting these immune cells.
    00:07:16 The changes in gut permeability that happen with age and how that may increase our susceptibility to chronic, low-level inflammation.
    00:08:36 The evolutionary biology explanation for why we have the mechanism of cellular senescence in the first place.
    00:11:46 The problem of senescent cells and the characteristics they possess that ultimately drive their ability to further their own accumulation. This is done through a feedback loop whereby the burden of senescent cells itself further increases their accumulation and, thus, associated pathologies.
    00:12:29 The role of senescent cells in an “epithelial to mesenchymal transition,” which facilitate loss of appropriate tissue function and even cancer metastasis and progression.
    00:13:36 Why diseases of aging, despite occurring in vary diverse tissue types, all begin to crop up simultaneously after 50 or 60 years of life.
    00:16:30 The clearance of senescent cells as a valid life extension strategy, where some animal research has shown a median lifespan increase by as much as nearly 25% in a mouse model of accelerated aging.
    00:17:50 Why it might be a bad idea to kill off senescent cells just before surgery or when you might need acute tissue repair.
    00:18:55 Why tackling cellular senescence may be a strategy that is best employed at strategic intervals rather than every single day.
    00:22:53 Preservation of brain function and how supporting brain cells called astrocytes seem to be simultaneously the most likely type of brain cells to become senescent and also, perhaps unsurprisingly, to be the ones to give rise to brain cancer.
    00:26:04 How mitochondrial dysfunction, even in the absence of DNA damage, can cause cells to undergo senescence.
    00:26:34 The interesting observation that senescence from damage versus energy crisis (failed mitochondria) demonstrates a markedly different and uniquely identifiable phenotype of cellular senescence.
    00:28:41 The change in immune strategies that occur as a result of aging and how that’s reflected by a change in our number of lymphoid versus myeloid lineage cells.
    00:29:09 Some of the current thought surrounding why we build up senescent cells as we age in spite of the fact that our immune system actually actively plays a role in clearing these cells.
    00:30:40 The effects of prolonged fasting on the activation of hematopoietic stem cell self-renewal (Dr. Valter Longo’s work) and the role this may play in rebalancing lymphoid and myeloid lineage cells.
    00:34:34 The diverging approaches towards improving healthspan by taking action against senescent cells: use of senolytic drugs (which kill the cells) versus the use of drugs that dampen mTOR, such as rapamycin, which leave the cells alive but ultimately suppress the inflammatory aspects of their secretory phenotype.
    00:35:34 How periodic prolonged fasts might mimic some of these effects associated with an mTOR dampening drug like rapamycin since fasting is itself a way to temporarily reduce mTOR activity and rodent research suggests it may clear these cells as well.
    00:37:33 How the secretions of senescent cells can affect the regenerative capabilities of stem cells.
    00:38:14 Some of the complexities behind scenarios in which cellular senescence may play a positive role in skin health, especially through the secretion of growth factors involved in repair as part of the senescence-associated secretory phenotype (SASP).
    00:41:29 The open questions regarding the potentially differing origins of senescent cells between various tissue types (e.g. muscles vs. heart) and whether these cells are tied to the type of senescence associated with mitochondrial dysfunction… or… the other phenotype which is more commonly associated with various types of cellular damage.
    00:44:14 The reason why telomeres are disproportionately the recipients of damage when nuclear DNA damage occurs.
    00:45:26 The surprisingly large effect of exercise on lifespan that can occur in spite of (sustained) obesity.
    00:47:47 The benefits of exercise in mitigating some of the side effects of chemotherapy.
    00:48:51 The practicality of a consumer available clinical assays for DNA damage and the challenge of assessing tissue-specific senescence without the use of invasive biopsy.
    00:54:45 Some of the interesting studies showing that nicotinamide riboside (a form of Vitamin B3) may improve tissue aging and mitochondrial function and whether this might be associated with reductions in cellular senescence or not.
    00:55:55 The effect of so-called fasting mimetic compounds (e.g. hydroxycitrate, resveratrol & spermidine) on senescent cells.
    00:57:15 The interesting capacity for cancer resistance in elephants, possibly conferred, in part, by extra copies of the tumor suppressor gene TP53.
    00:58:11 The possible existence of cellular senescence as a conserved mechanism in some lower organisms.
    00:59:20 How some rapidly dividing cells, such as keratinocytes in the basal layer of our skin, tend to undergo senescence more often whereas other rapidly dividing cells, such as those in the gut, tend to undergo programmed cell death as an alternative to senescence.

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  • Probably the best podcast i ever watch in 20 years. There are few things (more specific) i learn today but..there is another way if you understand ancient civilizations (it imply electricity and not chemistry communication of the cells, removing the “good bacteria” from the body, slower cell multiply ).

  • Larger things tend to live longer. See also the book WHY BAD THINGS HAPPEN TO GOOD PEOPLE which is about unfair “progeria” disease (rapid aging). Figure out the weight/size thing; figure out the fast-aging. Hit reverse. Live longer. See also Dr Magda Havas research into wifi / microwaves / rf / dirty electricity as causal to rapid aging syndrome. T O X I… C OM

  • I’m already on a NATURAL senolytic product, formulated by a world renowned scientist and biochemist who also formulated a stem cell regeneration product that I took, to support my journey to completely eliminate my Fibromyalgia and MS! He also sits on the board of the world Stem Cell Congress. Feel free to get in touch

  • You see the design and still believe in evolution!?!? “Cells evolve” because they just thought so!!! Just go to Yahweh and ask to be saved.
    fasting eats senescent cells.

  • Superb! Focused, indepth, informative,
    Dr R, P style of targeting questions
    To extract easy explanation for the benefit of all viewers, Top of all admitting, “no one really knows exactly why that is actually happening “!

  • I LOVE YOUUUU I’m your biggest fan ♥️♥️ your knowledge and videos have always been there for me when I give up on my goals and fall off track. I just listen to you and I’m back to pushing to be the healthiest I can be. Thank you Dr. Rhonda you are the MVP

  • Incredible interview. Thank you Dr. Rhonda Patrick!! Sounds like everyone should incorporate a 4 day fast into their lives. How often do you think they should do this? Every year maybe?

  • I wonder if it is possible that the immine system becomes cytokine resistant over time with years of signaling from an ever increasing number of senescent cells… And in doing so requires more and more pro-inflammatory molecules before it is targeted for death by the immune cells… Thereby increasing systemic inflammation and cancer risks?

  • Great interview. Re: her comment that it might be best to rid of senescent cells every once in a while, (instead of constantly worrying about it), I’ve been doing a four to five day fasting mimicking diet once a month to get rid of senescent cells. It’s nice to have confirmation that this is likely a helpful thing to do.

  • Wow, at 33:00 where she mentions mTOR and rapamycin it’s almost as if Dr. Peter Attia presented this word for word in his video ‘Peter Attia Reverse engineered approach to human longevity’. In that video at 40:30 he literally writes out her words “yeast flies worms mice(mammals)” on the chalkboard and goes on to rave about rapamycin.

  • 24 hour fast
    vigorious excercise
    feeling heart pumping strong

    its sunny
    I close my eyes
    I see a flow with in my eye fluid
    sun through my eye lid (its redish)

    i feel a vigor
    its like feeling high
    in stillness

  • Hey Rhonda, thanks for your informative videos, I’m currently studying nutritional science in Germany and I have to say that your Podcast were one of the main reasons to go into this area:). I was wondering if there isn’t also a sociological viewpoint from which you could look onto diseases such as depression. What I’m suggesting is that although such neurological diseases as depression and Alzheimer’s have neurophysiological/biological consequences, might there not also be contributing factors found more in the epigenetic terrain which is leading to the physiological changes in the human brain and body in general, such as the loss of social activity/ community in old age? Do you have information on the way experiential stimulus is influencing body physiology? For example the loss of a loved one will certainly influence the brains physiology.

    Best Regards,
    Jakob Bühner

  • Next to lifestyle factors radiation (EMF) could play a big role that senescent cells accumulate in the body. EMF is a silent killer which is not directly visible but with lab tests could be a proven fact.

  • Just because aging isn’t well-understood so far doesn’t mean it will remain this way in the immediate future. As long as the current anti-aging experimental treatments such as stem-cell and gene therapy keep working and improving, understanding everything isn’t essential.

  • Learn to fast. It’s an acquired skill. That serves us better and faster than any drug treatment, no matter the diet. Next, get a glucometer and eat to keep blood glucose low. You’ll need it when you become diabetic anyway, so may as well learn to use one. Fasting cures all the stuff Dr. Patrick gave great info about. How can she not know about that?

    We are hyper-carnivores. Dr. Salisbury did experiments on human diets and published in 1888. Anyone making diet recommendations needs to know that research upside down and backwards.

  • Thanks for your videos on such interesting topics and the way you make them comprehensible for the public!:-) I really enjoy your videos!

  • 47:00: Other than the hormetic effect exercise, aerobic exercise also moves the lymph, and nourishes the cells with fresh oxygenated blood. Can’t just look at the sub-cellular level!

  • Any thoughts on what the minimum-effective-dose is or how it differs across the 3 exercise types (strength training, aerobic, anaerobic)? For example, for anaerobic, on a recent Bulletproof podcast episode, they mention the CAR.O.L FIT AI cycling machine only requires two 20-second periods at “maximum-intensity” to get the full benefit?!
    Ben Greenfield had an episode on the X3 Isokinetic Bar (bone compression) which supposedly only requires 10 min/day! Or thoughts on using Blood-Flow-Restriction/Occlusion techniques for strength-training? Ken Ford for example, recommends GoBstrong and KAATSU.
    Are there benefits of stacking exercise mimetics (ex. Aceytl L-Carnitine (Thorne), beta alanine, etc).. or, like antioxidants, can they potentially undo some of the positive signaling of the physical exercise? On a recent HumanOS podcast episode, Ben Miller suggests this is the case with metformin!

  • i hear a lot about how certain things are as a result of evolution, I just never hear how they know that to be so. It’s just always assumed from the start, but never actually discussed. Like we have no idea why things age, or why certain organisms age differently than others, but we’re 100% sure that it’s a result of evolution for some reason

  • Loved Judith Campisi’s insight here! So interesting and she did a great job of conveying highly technical information simply enough for me to grasp.

  • Notice that fasting works without scientists knowing how it works. If I had waited for permission from scientists to fast I would have either died or become a basketcase.

  • Why senescence just don’t die? That is evolutionary point beyond senescence cells? Why immune system just don’t kill them? Here we don’t understand something.

  • Part of the problem of obesity is there is no sidewalks! Either you drive ride a bike hopping you won’t get run over or walk on dirt/grass.

  • • Great interview! Lots of good information, much appreciated.
    • Re: five-day fasts, I’ve done a couple of them, followed by re-feeds, since learning about them in the interview with Dr. Longo, and love how they leave me feeling. I’m planning on doing one fast a month for a while, and keeping an eye on the results.
    • I found the passing reference to spermidine supplements interesting. I haven’t found a supplement, but have been eating foods high in spermidine (but very low in protein), like mushrooms and corn, during the fasts.
    • As a side note, I read recently that the supplement Quercetin also appears capable of targeting and killing senescent cells, and may make resveratrol more effective when they’re taken together. PQQ, found in green tea, also appears to kill senescent cells. And caloric restriction (particularly a low calorie/high fat diet) appears to slow aging in both laboratory animals and, some evidence suggests, human beings.
    • Re: brain cells senescence, it is perhaps related to the accumulation of amyloid plaque, which can be removed by some nutrients, including folate and the sugar Trehalose.
    • Finally, a suggestion: It would be fun to see an interview with Dave Fisher, the man who’s been living on 1600 calories a day for the past twenty years. Fisher was born in 1957, and looks maybe like he’s in his mid-thirties. Unlikely I suppose, as he’s not a scientist. But it would be interesting to learn more about his protocol, and the dramatic results.

  • I am very appreciate it and grateful for the Information you provide on your podcast. But my problem is finding a qualified mental health professional. That would recommend alternative ways which you describe all they wanna do is give me drugs for your depression and collect your co-pay. Been through several psychologists and psychiatrists with very little help for my depression and insomnia for over 20 years. So it has force me to do my own research and experiment on myself through trial and error. I have had some positive experience but it’s still a work in progress but I wish I could find a competent mental health professional to advise them to verify the approaches I’ve been taking. Thank you for all your advice and God bless you �������� Glenn

  • Fascinating as always. Thank you so much for the work on your interview technique also (I know it’s tempting to jump in as you often have amazing insights) but this interview where you allowed to her to speak fully was so much easier to watch. Best health show on Youtube!

  • The key is getting enough, but not too much. I personally exercise 5 times a week 40 minutes a day.
    Monday: 10 minutes cardio, 30 minutes legs/abs.
    Tuesday: 10 minutes cardio, 30 minutes chest/triceps/anterior delts
    Wednesday: off
    Thursday: 10 minutes cardio, 30 minutes back/biceps/posterior delts/forearms
    Friday: 30 40 minutes cardio, 10 minutes stretching
    Saturday: Boxing and some mixed exercise such as tire flipping, farmers walk, climbing etc.
    sunday: off

  • This is one of the best videos that I have ever watched. It would have remained completely engaging had it lasted for many more hours. Thank you so much I plan to become a sponsor of your show now.

  • What I get from this is there is a need for a balance for the proper amount of senescent cells.
    Once there are too many of them, then we need to get rid of them.

    Easy to know, hard to do:-)

  • fascinating discussion Dr. Campisi’s work is impressive, as are her knowledge & communication skills. a 6 hr interview would have flown by. thanks for choosing her Rhonda one of your best to date. now I feel obliged to give you some money.:-)

  • Thank you for the informal video! I just posted a fitness video where my guest discusses how fitness influences her mental health. Would love if you could check it out! Thanks!

  • I love riding my bike outdoors. This along with other cardio at the gym has been my go to treatment for depression/ brain fog for over 20 years. I recently had 13 mercury filled dental amalgam fillings removed safely by a holistic dentist. I’m hoping in time as I detox the mercury stored in my body and brain that my depression, brain fog will resolve. If you have dental amalgams, please consider removing them safely. I recommend watching “Smoking teeth” on YouTube and also watch chemist Boyd Haley PHD lecture on mercury on the IAOMT YouTube channel. Blessings and health to you.

  • Happiness is obeying Christ. Forget loneliness too! You get to see his Omnipresent bearded face. I prove it on my channel. I suffered from depression until I started obeying Christ. It makes sense. Christ loves us = He wants to see us happy. His doctrine is the divine path to happiness and eternal life. Don’t forget you cannot obey Christ’s divine doctrine without his help.

  • As a college student going into health science, I show your awesome videos to many of my peers for that extra dose of wonderful information.

  • I have been to 5 psychiatrists and none of them told me about how exercising could have a serious positive impact on depression. Instead, they have doubled my dosage and sent me home.

  • I am 65 and I have been depressed for as long as I remember myself. My life was not easy. Right now I just want to die because I am in poor health, overweight and have no motivation to live. Tomorrow will not be better. I wish someone would start a site how to commit suicide without pain.

  • But What if the telomere length is the cause of inflammation? People never seem to think the oter way around. They always go for inflammation, mitochondria etc, but they never consider the idea that telomeres are the reason we get inflammation, mitochondrial dysfunction etc. These things seemed to reverse in mice as well as brain size and cognitive function when they induced telomerase.

  • How can a person who knows they are seriously depressed (again) come forward to get (properly) treated? I am 59, and have had depression in varying degrees since I was 12. In 1995, I was initially dx with Dysthymia and put on SSRIs. Within 2 months, my dx was changed to: major depression, then psychotic depression, and I was 5150’d. Over the next 10 years, my dx changed to: Bipolar, PTSD, Schizophrenia, OCD, DID, Borderline personality, and finally; Schizoaffective D/O, OCD, PTSD. I was involuntarily hospitalized 20 times in 6 years. I was given 25 different meds:SSRIs, Lithium, mood stabilizers (anti-convulsants) and anti-psychotics. Finally, in hospital, I was given 12 ECT treatments, that I did not consent to (I don’t know who did). In 2005, I took myself off all the meds, as I was not sure if I was even alive. I got a job, and have not been seriously depressed (except holidays) since then; until now. In December 2019, I was evaluated for ASD, and told I met the DSM5 diagnostic criteria for ASD 1. Now I am struggling to accept that diagnosis, though I know that it is the most accurate ( Psych px from age 4). I know at present I am severly depressed (not actively suicidal), but am terrified to tell my therapist for fear that that 10 year journey to HELL will start again. I am not willing to go through that again!!!!!! How do I get treated without this catastrophic snowballing? I do not trust mental health professionals who almost “helped” me to death?

  • Kicked all meds a long time ago for diet and exercise to reduce my depression, almost eliminated it all together. I love seeing some science behind this.

  • I loved listening to this doctor talk about psychotropic medications. It made me gain better understanding. I took care of a lady with dementia who would have benefited from being better evaluated and treated. When in the presence of others, she would be the life of the party but, when she thought she was left alone, she would cry frequently and she would never eat. I think she was depressed and would hide by acting like life was a bawl of cherries. Sad. Remeron would have helped her eat and gain weight that she was losing. And Wellbutrin might have helped her depresion. Just because they have dementia doesn’t meant they don’t know something is wrong with them. Plus all the anxiety that ensues, anxiety is a major cause for depression. One lady I looked after used to ask: “what’s wrong with me”. Once in a while they might say: “how do I get over what I have?” meaning they know something is wrong with their mind. Depression is something common in the elderly who lose their independence.

  • It’s completely MedCircle’s decision if they want to require people to pay to watch their videos, but justifying it by saying it’s cheaper than seeing a professional is NOT cool coming from a channel that purports to be all about mental health awareness. Watching professionals and people with mental illnesses talk about different mental health topics is NOT a substitute for receiving mental health care and should not be compared to as such.

    I just went to the MedCircle Facebook page to see if others were having the same issue with no longer being able to see full series and was very disappointed to see that “It’s cheaper per day than seeing a professional,” was the reasoning MedCircle was giving. Please be careful not to give people the impression that subscribing to your videos is a cheaper alternative to receiving mental health care. I’m not trying to be confrontational; I just am really passionate about mental health as someone who has struggled with it (as well as with being able to afford it) and think it’s a really dangerous message to put out there.

  • The way you guys are sitting makes it hard to watch this. And it’s a good subject. I live in a Senior Care facility, 7 years now. But I’m only 63. Yeah, I have ME/CFS. They screwed my windows shut because 2 fellows in another facility jumped out their windows, I think it was the same night, and died. It was Royal something, Birmingham, AL. I’m fighting to get one window unscrewed so I can open it for my dog. This place is something else. It is NOT A PSYCHIATRIC FACILITY. But I am busy with my channel, so they think I stay in my room because I’m depressed. Sheesh!!

  • Another reason why such people may not speak of their depression is because they have spent a lifetime with nobody giving a damn, and now are coming closer to their end and figure nobody is going to give a damn now. Another thing about depression is a feeling of pointlessness and not wanting to put the work into changing things; this gets even more so in an older age and are burned out from a rubbish life. Apathy indeed.

  • Dear Dr. Rhonda, please if you have any influence on studies, or at least the studies you quote, we need to see studies that have an equal number of females to males. The differences could be significant. It’s only the equitable thing to do.

  • It’s difficult to feel sympathy for older adults that have spent a lifetime manipulating family & friends to suit their own needs… �� Including lying to Doctors about physical & mental issues…

  • If i didn’t keep up with my excercise routine i’d probably off myself already tbh, being fit and healthy is definitely beneficial to your health people.

  • Remeron; worst medication I have ever been on. Soooooo much weight gain! There doesn’t seem to be an off switch to ‘wanting’ food.

  • Maybe they do not want to take any more pills. Or have heard what all the pills do in the long run that is not conducive to life. What is missing is the natural B vitamins, stem cells, minerals etc so most times they need nutrition instead of treating the symptoms only. 1000mg of flush free niacin, add same dosage with 3 6 9 oil and calcium works wonders. Also take into account what the Sun is or is not emitting recently that effects everyone’s health. What about the harmful effects of EMF’s and start including the 5 G killer microwaves. I swear doctors are so far behind in what is really going on and more gullible with biased research to boot.

  • Oh ya I am caring for an 89 year old woman who would not admit she was depressed. She thinks it is something she needs to snap out of.