Bring Your Fitness Info Past the Application with this New Premium Feature


Why My Macros+ is better than My Fitness Pal

Video taken from the channel: Alessandra and Josh


SPOTIFY APP ON FITBIT CHARGE 4 How To Setup, Music Controls, Playlists, Overview!

Video taken from the channel: Tinker Forward



Video taken from the channel: wiredtech


Strava’s New Local Legends: How it works!

Video taken from the channel: DC Rainmaker


Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

Video taken from the channel: FoundMyFitness


The Baby2Body app Your fitness & wellbeing coach for pregnancy & beyond

Video taken from the channel: Baby2Body

Take Your Fitness Info Beyond the App with Our New Premium Feature. by Glennis Coursey. June 24, 2016. No Comments. Over the next few months, we’ll be releasing multiple new features that will be available as part of our MyFitnessPal Premium subscription.

Download Beyond Fitness and enjoy it on your iPhone, iPad, and iPod touch. ‎• Notification: Club are able to send messages to member regarding Daily workouts, Announcements or even specific message. member can set reminder against each notification they receive. club is also able to send attachments like document, excel, image, PDF etc. From the mind of former Olympian turned Personal Trainer, Glen Smith, comes Your Fitness App – The Simple Way to Fitness! Your Fitness App is designed with you in mind, meaning that whatever your goal or fitness level, we have a workout for you. Choose from our selection of workouts, or create your own from our library of instructional videos – there are 100’s for you to choose from!

The market for the fitness tracking app is really booming all over the world. With many existing fitness apps, it is very important to include vital features which will make your app a unique one. Here we have listed all the features which your app must along. It includes both the usual ones as well as some new ideas which haven’t been tries before.

Fiitizens is a new start up app that allows you to record your workouts for up to 60 seconds and then post them to a community of fitness enthusiasts. However it doesn’t stop there, Fiitizens has created a gamification system around this where the video viewers will then rate your video out of 5 stars, giving you stars to collect to level up. But, if you want 2020 to be different, there is no reason to wait for the new year, and to help your fitness mission take off, we have listed some of the best workout apps for Android and iOS. These workout apps will inspire you to lose those extra kilos that you have put on binging on sugary delights.

Your users receive basic app features for free but should pay for the premium feature set. Such a business model is also known as a premium subscription model. It means that basic features are free, and advanced fitness plans or personal coaching services are paid. New Year’s resolution time has arrived, and the gym is going to be packed more than ever. Instead of fighting for equipment and spending money on expensive memberships, stick with these fitness apps that can go wherever you go during our No-Gym January Challenge.All of these fitness apps are cheaper than a gym membership but just as effective while working out in the comfort of your own home.

One of the best parts of the app is it pairs with most devices, like the new Garmin Forerunner 245, so once you have the app, you can take it with you just about anywhere you can take your. With over 1.6 million apps in the Google Play Store and 1.5 million in the App Store, there’s a lot of noise in any category you choose you have your app in. Due to that noise, many people choose to take interest in apps, only when the app icon entices them.

List of related literature:

Similar in strategy to Smule’s I Am T-Pain, the magazine’s fitness app, Men’s Health Workouts, includes an extensive collection of workouts and exercises for the initial $1.99 app price.

“The Business of iPhone App Development: Making and Marketing Apps that Succeed” by Dave Wooldridge, Michael Schneider
from The Business of iPhone App Development: Making and Marketing Apps that Succeed
by Dave Wooldridge, Michael Schneider
Apress, 2010

On top of that, the In-App Purchase items offered in Men’s Health Workouts are presented in the same design theme as the rest of the app’s custom interface, providing a seamless user experience.

“The Business of iOS App Development: For iPhone, iPad and iPod touch” by Dave Wooldridge, Taylor Pierce
from The Business of iOS App Development: For iPhone, iPad and iPod touch
by Dave Wooldridge, Taylor Pierce
Apress, 2014

Finally, exercise mode should match the client’s ultimate goals for specificity of training.

“NSCA's Essentials of Personal Training” by NSCA -National Strength & Conditioning Association
from NSCA’s Essentials of Personal Training
by NSCA -National Strength & Conditioning Association
Human Kinetics, Incorporated, 2011

As discussed in chapter 7, new digital marketing methods are available that enable fitness managers or marketers to use search engines, websites, social media, email, blogging, and mobile apps for target-specific promotional messaging.

“Health Fitness Management” by Mike Bates, Mike Spezzano, Guy Danhoff
from Health Fitness Management
by Mike Bates, Mike Spezzano, Guy Danhoff
Human Kinetics, Incorporated, 2019

Finally, the total fitness function score constrained by each attribute is obtained.

“Advanced Information Networking and Applications: Proceedings of the 33rd International Conference on Advanced Information Networking and Applications (AINA-2019)” by Leonard Barolli, Makoto Takizawa, Fatos Xhafa, Tomoya Enokido
from Advanced Information Networking and Applications: Proceedings of the 33rd International Conference on Advanced Information Networking and Applications (AINA-2019)
by Leonard Barolli, Makoto Takizawa, et. al.
Springer International Publishing, 2019

It also includes software that allows you to build a personal fitness report by entering your data into a computer.

“Health Opportunities Through Physical Education” by Corbin, Charles B, McConnell, Karen, Le Masurier, Guy, Corbin, David, Farrar, Terri
from Health Opportunities Through Physical Education
by Corbin, Charles B, McConnell, Karen, et. al.
Human Kinetics, 2014

The Health & Fitness app appears.

“Windows 10 Simplified” by Paul McFedries
from Windows 10 Simplified
by Paul McFedries
Wiley, 2015

A 2013 review coded 30 of the top free and paid iTunes and Google Play mHealth weightloss apps (that at minimum included weight, diet, and physical activity self-monitoring) in January 2012 for the presence of 20 BCTs, based on the Diabetes Prevention Program (see Table 13.4 for a list of the BCTs) [24].

“Quality in Obesity Treatment” by John M. Morton, Stacy A. Brethauer, Eric J. DeMaria, Scott Kahan, Matthew M. Hutter
from Quality in Obesity Treatment
by John M. Morton, Stacy A. Brethauer, et. al.
Springer International Publishing, 2019

The health and fitness app allows users to set achievable health goals, monitor one’s health plans, and develop training plans without having a personal trainer and even getting a gym membership (Rhea & Feldsbeg 2018).

“ECKM 2019 20th European Conference on Knowledge Management 2 VOLS”
from ECKM 2019 20th European Conference on Knowledge Management 2 VOLS
Academic Conferences and publishing limited, 2019

As I am writing now, a simple fitness app popped into my head.

“Migrating to Android for iOS Developers” by Sean Liao
from Migrating to Android for iOS Developers
by Sean Liao
Apress, 2014

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

[email protected]

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  • Dr Rhonda, Would it be relatively low risk/potentially beneficial to supplement 3-6 grams a day of NMN if one had chronic and acute muscle strains to heal. I am learning of the angiogenic nature of NMN..and it seems to be helping reduce pain in a bad strain.

  • Any way to opt out of this pathetic feature? I know if you don’t go public it won’t register, but why do strava come up with a feature like this, when they ruined the downhill segment feature with the 0.25% gradient limit? No need for live segments any more, just some pathetic bush if you ride up the road each day!

  • Could you please talk bit slower!!! As an international viewer to understand you, I need to watch your videos 3-4 times,If you don’t want international viewers then ignore me and carry on talking like a machine gun.Thank you

  • thank you for acknowledging you do torture these little creatures I think you should test on the worst of the worst human beings after all isnt their DNA closer to ours thank you for practicing on yourself

  • i could see this for Lock & Damn #1 in Mpls… decent short climb lot of people repeat over and over for hill work. (cause we’re pretty flat terrain overall)

  • Isaiah 65:20 No child will die in infancy; everyone will live a very long life. Anyone a hundred years old will be considered young, and to die younger than that will be considered a curse. Also John @, 1John 5: 11,13, John17;3 all promise ETERNAL LIFE for believers in Jesus.
    Acts 2: 38 Repent & be water baptized for the forgiveness of sins ( in thought, word and deed ) and for the gift of Holy Spirit.
    Mark @ The person who believes and is baptized is saved ; the person who believes not is condemned.

  • 1. Stress kills, 2. Get lots sleep. 3. Keep strong libido practice. 4.’Love thy self & others. 5. Do lot’s of what gives you happiness. 6.Try to hurt others as less as possible, 4. Good deeds will out-weight the corrupt. Plus-> Many more positive things, in relation to ones own specific nature. So watz good 4 da goose isn’t always a;right 4 za gandoor.

  • You and Dr. David Sinclair are AWESOME! I’m glad that I’ve found your channel Dr. Patrick! I love what you two are doing. I hope you two keep up the great work with your studies/research. I’d like to see more videos of you and Sinclair and showing the latest studies.

  • I was panhandling 1 day, & a lady who was kind, told me I was beautiful inside, she had a large chunk of her face amputated, & a paralyzed eye, that hurt & watered in spring breeze. She explained to me she thought she’d be young 4-ever like most do, grew organic veggies, long before trendy, never smoked, lived in nice cozy house by beach, here in lovely Victoria BC, & ended up with cancer. I told her all my street family die young, usually of fentanyl overdose. A woman died the other day cause someone slipped it in her cocaine, or accident, (Sorry Ranting Off Encounter). She said I was her therapist now, & blessed to have met me. I told her overdose on purpose is only for incurable suffering, & sadly she said that was her. I think maybe talking to me she decided to buy heroin maybe to die. What went wrong??? She told me she did everything she could, to incite a long healthy happy existence, only to be turned into something, that is not only physically shocking, but a complete treachery of ones own body on themselves.

  • How come it’s available for you in Holland then? You’re not even a paid user in either of those states, are you? Just curious. This by the way is kinda like Mayorship in Foursquare or Swarm. A bit childish but fun.

  • Here is why we the people should boycott Hyatt Hotels.

    Look up ” ” National & Global Day of Prayer & Repentance on Sept 26. God will heal our land if we Repent & Pray. Believe and trust in the bl o o d that was shed by J e s u s C h r i s t for your sins; being born again/saved.
    Humble yourself before the LORD and S A V I O U R J e s u s C h r i s t and pray. Pray by lying prostrate on the floor with your face to the ground. The ultimate humility before Jesus Christ is you on your face. Read 1 Corinthians 15:1-4.

    Watch; ” BELLY OF THE BEAST” and learn of the l u c i f e r i a n worship created by the founding fathers in Rome, Maryland. Watch B i b l e teacher R o b e r t B r e a k e r’s videos, “Understanding The Times.” & “Can You See in 2020?”

    You can make a difference! We can’t lose with J e s u s C h r i s t. Give Him your heart today!

  • I got one because I did grocery errands for my grandmum once a week… I don’t know if this feature is really necessary but whatever.

  • Hello i bought this cheap weight scale… And I weight myself in kg it 80.50 kg but when i weight in pound it said 160.1 pound..
    Tell me if im wrong but isn’t 160.1 pound = 72kg..please tell me im not wrong ahhahahahhaha im in tremendous shock right now

  • The studies on NMN with mice show between 400mg and 500mg/kg/day. That is 35,000 mg per day for a 70 kg (154

    lb) person. He takes only 1000 mg per day. Can anyone explain why?

  • Very interesting as usual, but can you talk about the cancer risk of NMN sometime? I read about that more and more, which made me quit NMN. That’s not what we are looking for right? Thanks for all the great video’s.

  • Have any studies been done on nebulizing nicotinamide mononucleotide? Glutathione is commonly nebulized. I wonder if NMN could also safely be nebulized.

  • So how do you delete it. Can’t find that information. Why don’t they introduce private messaging to assist communication between club members and also age group related KOM’s. Something useful. I despair.

  • I don’t get it. You take NR or NMN, you have more NAD+ in the blood, but it shows no effect on energy demanding exercise or other parameters. Seems like a waste of time and money.

  • For me, this explanation and the instructions from Strava have the same issue. that is: My segment explorer screen is different to that shown. Looking at the screen as shown at 4:00, what I see is the same for the first two lines (ie. the “Explore” heading and the tab strip i.e. “For You, Challenges…” etc. but below that it’s different. Crucially I don’t have the Settings icon. The Search option is actually at the top tot he right of the ‘people’ icon. I get that this change may be due to an update but the Settings icon just seems to be gone so I can’t view Local Legend Segments only.

  • C-vitamin does same thing as Metformin, activates AMPK and inhibits MTOR. Humans have broken gulo gene which would have given us internal c-vitamin production like many animals.

  • They should make a similar award to this, but count who has done the biggest number of different segments in a given area/region/radius/whatever over the last 90 days, might get people exploring new trails and routes

  • I immediately went to a segment where i do most of efforts to see if I had it. Turns out some guy has done my favorite segment 190 times in the past 90 days…

  • I have been doing the 16:8 intermittent fasting regiment every single day, and I love it. It makes my life much easier, I don’t have to worry about eating 3 meals a day, I just eat 1-2 meals a day, and I’m good. It’s not just calorie restriction that slows down aging guys, it’s also about keeping stress levels down and getting good sleep, invest your money into a very good bed. Eating right and getting some exercise is also a must. I do low carbs high fat diet, and I run and do some weight training.

  • Rhonda excellent super informative, “keep it simple “ interview, very relaxed yet specific. Dovetails with your detail breakdown video of NR/NMN.

    So, it would appear NMN IS a bit more effective predictively in humans, but the
    baseline threshold floor has to be broken through? Not ENTIRELY clear on average
    NMN dose for a 180lb person the math
    titration is kinda buried in the conversation. What’s the gram number?!

  • I basically used this thoery while on Keto for the last 4 years. My conclusions were based on my own reading/research as the keto benefits unfolded. My research helped to feed my detox and repair of my metabolism, helped my make specific choices and formulate certain regiments of what I call treatments. Physiological effects were my main compass. Long story short, I used Cottonseed Oil, Castor Oil and a 2 week Molasses process. Cottonseed Oil fats, specifically the Beta nature of the fat I feel is very important for keeping DNA reflexes alive while detoxing, perhaps rapidly on a something like the Ketogenic Diet. Castor oil mimics and is a direct replacement of cellular wall material. Molasses helps the cell release its stored waste which aids the cell in its uptake of nutriments. I also have done what I call a Keto Molasses treatment. Basically 1 tbsp of molasses is your days worth of 20g of carbs, taken for 4-5 days, followed by 2-3 zero carb days, then back to full 20g carb meals. The process took 12 days for results. The result was a massive release of energy day 12. Where did the energy come from? The energy was from long long chain hydrogen bonds being broken and released, no doubt many long waiting toxins with them. The physiological effect was the desire to RUN. Run I did and it helped spurn a time period of regular physical walking, jogging in addition to a workout routine. A universal conclusion that I have made based on my results is that: many of the nutriments that are found in these fat sources are supposed to be found within crop soils. Farm soils are not so organic anymore with the over farmed, chemical fertilizer, pesticides conditions. These modern over farming mechanisms also hinder, in my opinion, specific hormone exchanges needed to help a plant have a robust immunity code. Down to the details, pollinating with some kind of bee is not enough, the crop may need a specific bee in its exchange, in its hormonal exchange. The trickle effect is that the consumers, the eaters of crops don’t get the full immunity code needed to feed our own immune systems.

  • Yes, I take resveratrol in biogel form in a sachet it’s gone through cap-E test as well… showing the high percentage of antioxidants as well in the superfruit product:)

  • I look forward to some of my mates collecting these so that I can hammer them about participation awards. Ray brings the quality as always, Strava not so much.

  • The award symbol shouldn’t be a gold wreath but a little troll with the message from Strava “you’re a Local Legend! No one trolls this segment [name] as hard as you do!”

  • This explanation of the local legends feature was very thorough and helpful! I don’t think I would have understood the feature without viewing this video first.

  • This is a much less awkward interview than the one she had with Aubrey de Grey on the same subject. It helps a lot that David Sinclair is apparently genuinely as concerned with healthspan as lifespan and actually looks after himself, instead of just drinking and doing nothing else like de Grey. (And de Grey is brilliant, don’t get me wrong.)

  • I purchased this app after watching this video today. The very first food item that I barcode-scanned was off by 20 grams of protein and 60 calories! Yikes! The product is Body Fortress Whey Protein-Vanilla. There are 30 grams of protein per scoop and 190 calories, My Macros + has the protein content per scoop at 10 grams and 130 calories. I don’t have the time to fight this app by having to change the macros that are incorrect. I will see if I can get a refund. You did a good job explaining things though…

  • Very good video as usual. But yeah, Strava’s loosing a lot of its previous appeal to me by going wide/social. I can see where they’re going though, might be a good strategy (for them).

  • So this is aimed at commuters?

    Should take pros off the segments and have separate listing for them.

    How about listing the steepest incline on climbs as well, average incline is often very deceiving

  • Speaking of strava: Anyone else having issues getting PB:s showing up on your activities in the feed the last couple of days? Got 3 PB:s today but none of them showed up on the activity, had to go into every single segment to look up if i got a PB or not

  • It looks like I’m the only person that likes this idea then… Whilst I’m not reasonably fast, I don’t have a single KOM. I do ride a lot though, so when this comes to the UK, I can at least chase some awards based on effort and commitment, not performance ����‍♂️

  • What a dumb feature. Who asked for this? We still can analyse Cycling Dynamics on Strava or get a notification when a bike component have reached a certain distance. I don’t know, maybe notify me when I should change my chain…

  • Not what I was expecting at all. Was thinking it was going to rank top riders based on number of KOMs / top 10s. Would have been way cooler

  • Is this feature still full of bugs? When I click on some segments where the Local Legend has 1 attempt, I look at my attempts in the last 90 days and I have five or more. Do you know a reason why I wouldn’t be the segment legend? I also tried searching for Legend segments on the map like you show in the video, only to find that there is no Local Legend time available.. kind of like it’s not one of the chosen segments for legendary status. As always, thorough and entertaining video. Thanks!

  • Strava: “Its too expensive for us to track segments, we need to make it premium”
    Also Strava: “Hey, lets add extra complexity that no-one asked for to segment tracking!”

  • You will only have it for the next 88 days if Jos Van Beurden doesn’t decide he wants to regain his Local Legend status. After all he did it 22 times when there was no Local Legend status. In fact, if he doesn’t regain it, it’s just because he is giving it to you ��

  • Activate brown fat to lose weight >> Consider a low-fat, high-carb diet ( plant-based diet and fasting )
    Although there’s no firm evidence that any specific foods or nutrients can activate brown fat, it’s interesting to note that radiologists—who want to decrease brown fat activity when doing scans of cancer patients, because the heat generated by activated brown fat

    makes it harder to see tumor-related activity—routinely recommend that patients eat a high-fat, low-carb diet before scans, on the grounds that this reduces brown fat activation. This suggests that a low-fat, high-carb diet will boost brown fat activity.
    Activate brown fat to lose weight >> Consider a low-fat, high-carb diet ( Eat a plant-based diet and fasting )

  • In this video Dr Sinclair says that smoking damage is irreversible, yet this article says they magically heal:

  • off topic but what do u think of this alzheimers/keto study Rhonda? Would love to know your thoughts study says saturated fat REDUCES beta amyloid!

  • Strava still making lame features. Its another quantity over quality KOM. I wish they would bring back the annual KOM, but restrict it to popular segments. A 10 year old KOM is meaningless. Also, they still haven’t fixed their auto flag of suspicious rides. Ebikes are going up and down grades at impossible speeds and Strava can’t figure this out but are focused on giving out meritless awards.

  • Dr. Rhonda Patrick is the Hermione Granger of the longevity world. Good thing she’s on our side. �� Best interview of Dr. Sinclair. So much info packed into this interview, way more than his book. (still get his book). The posting of the research articles is unlike anyone else…”How does she do that?!” ��

  • Strava should concentrate to fixing bugs that are all over basic data like avg runs per week and shoe mileage. Also data is not consistent between app and web page.

  • Pointless feature that’ll take up valuable real estate on the screen. Strava: there must be tons of legitimate feature requests made from your subscription base over recent months and years. Please work on those. If you’re struggling, I have some ideas.

  • What about Jiaogulan vs. Metformin?
    Traditional Chinese herb (绞股蓝), Gynostemma pentaphyllum, “southern ginseng”, deemed the king of all Oriental medicines, “immortality herb”. In one study, it improved both fasting glucose levels and (more important) tolerance. ANti-inflammatory (reduces TNF-a and NFkB) supresses insulin, increases AMPK, promotes mitochondria

  • This is pretty okay. I think it’s nice to have participation badges/statuses. However, why not expand the KOM/QOM with regional kings and queens and create a “court” of sorts. Strava could do it by county, and could have separate leaderboards for it, so the top 10 people in each county would be that county’s “royalty”, and each number could be given a name, such as the Duchess or Duke, etc. I think this would actually help get more people more interested by providing the ability to maybe get in on another type of status even if maybe they can’t pull KOM’s on everything, they might still be able to be the “Duke of Multnomah County”.

  • I tried another food item that I had today and the actual calories are 230 with 29 grams of protein for a small can of Starkist Selects Tuna in Extra Virgin Olive Oil (4 oz can). I scanned the barcode with My Macros+ and it said the the calories were 580 and the that the protein was 58 grams for this 4oz can! Wow! I also scanned some Kontos mini-Flatbread that I ate today and the macros were pretty close though… Probably not going to use this appI see why there is no free version, because nobody would purchase it after dealing with all of the bad data.

  • Ok great, I commute regularly and there are segments that I’ve passed about 500 times. My last 90 days would have 60-70 logs of same segments. And I guess there are a few segments that don’t have many alternatives(like on bridges) where there would be quite a few people with similar score.

  • Gen Zs have been saving so much money on avo toast with all the cafes closed, they can afford Strava subscriptions now; the participation award generation needs validation regardless of achievement.

  • Chris Masterjohn says this much Niacin Riboside bad because it depletes Trimethyl groups: He recommends trimethylglycine (and gets a commission) byJarrow Formulas, I heard no mention of this from you, but Dr Brad Stanfield says it is niacinamide that depletes the methyl groups, but not Nicotinic Acid What say you?

  • what about nadh as a subilingual supplement. It’s Nad+ reduced by a hydrogen and its awaiable as stabelized supplement going over to bloodstream over mouth.

    Why nobody talks about this?

  • I have been taking NR for about 2-3 months and now I have to hear that the NR on my desk has most likely become NAM again. And that it blocks my DNA repair.
    Anyone a good source for NR? Or an info how long it will take until NR becomes NAM again?
    Rhonda do you have any further Info about that?

  • Was looking at this today and I wonder if segments require a minimum number of different users to run it before the local legend thing kicks in. Looked in my local area and only a very few of my local segments turned up, even though there are many segments in the area that are public and have many attempts. Unless they are slowly rolling out the data or something…

  • This is a fun feature there are a few segments I would have to guess I’m the local hero on. Can’t wait till this gets turned on in Ohio. (Also it’s K. O. M. ��)

  • Good video. Niacin has been proven to lower methyl donors in the body. Does increasing NAD do the same thing? If so….. that’s a HUGE problem for a lot of people who have low methylation already.

  • You don’t mention any negatives associated with any of the scales…

    How is one scale better than another if you have nothing but great things to say about each one?

  • I am one of the “losers” who find this new feature to be very motivational. I think the term “Local Legend” is intended to be tongue-in-cheek, and not taken too seriously. But for those of us who have no possible chance of ever getting a KOM, the “golden laurels” can add some interest to the currently required solo rides. Admittedly, it works much better in a rural area such as mine where there are no commuters. I do wonder about the algorithm Strava uses to determine which segments qualify, but as I said, this is not serious stuff so I have no complaints.

  • Resveratrol supplementation did not show any benefits in humans:, then NMN does not have proper trials in Humans yet or long-term efficacy and safety guarantees. Long-living parents is your best bet for longevity.
    Intermittent fasting + exercise + proper nutrition are far safer and harmless alternatives worth trying over expensive ‘miracle’ pills.

  • 00:00:36 Landmark moments in longevity research with the discovery of genes that control the aging process and how these genes can be activated by lifestyle factors such as fasting and exercise.
    00:01:06 Altering the insulin/IGF-1 signaling pathway in earthworms can extend their lifespan by 100%.
    00:01:45 Slowly ageing by design: the rise of NAD+ and sirtuin-activating compounds.
    00:05:02 How resveratrol may delay aging by activating a class of enzymes called sirtuins.
    00:06:15 How the addition of an extra copy of the SIR2 gene in S. cerevisiae (yeast) can extend yeast lifespan by 30%.
    00:06:40 How having high levels of sirtuins may give organisms the benefit of caloric restriction or other stressors such as heat stress or amino acid restriction without actually engaging in those activities.
    00:07:50 How fasting for one or two days per week, a type of intermittent fasting, may activate sirtuins sufficiently to recapitulate the benefits of long-term caloric restriction. Review on caloric restriction and sirtuin biology.
    00:08:15 How the metabolic switch into ketosis may be an important differentiator between ongoing caloric restriction and finite periodic fasts.
    00:08:50 How caloric restriction potently increases sirtuins, as measured by SIRT1 levels, by as much as 5to 10-fold in the liver and muscle of rats, but this beneficial activity is immediately dampened by the introduction of IGF-1 and insulin.
    00:10:13 How several pathways, including those involving sirtuins, insulin/IGF-1, and mTOR, all interact as components of a highly conserved holistic network to create the benefits of caloric restriction.
    00:10:56 Caloric restriction, fasting, and exercise increase levels of NAD+, and this activates sirtuins.
    00:12:20 NAD+ may regulate circadian rhythm though its control of sirtuins, which in turn regulate both the circadian clock in the brain as well as peripheral clocks, such as the liver.
    00:13:00 In addition to activating sirtuins, NAD+ is essential for mitochondrial metabolism and function but it is also required for repairing damage to DNA by activating an enzyme called PARP.
    00:13:30 How organisms have developed nutrient-sensing genetic pathways such as sirtuins, AMPK, and mTOR in order to understand what is going on in the environment.
    00:14:44 Although NAD+ levels and sirtuin activities decrease with age, animal studies suggest that raising cellular NAD+ levels can trick the body into thinking it is younger.
    00:16:00 Resveratrol enhances the binding of sirtuins to NAD+ thus making sirtuins more easily activated for a longer period.
    00:17:28 How DNA damage consumes NAD+ through the activation of PARP, a major DNA repair protein, leaving less NAD+ available to activate sirtuins and distracting sirtuins from fulfilling their other roles.
    00:20:00 Dr. Sinclair’s informational theory of aging posits that aging is due to a loss of cellular identity, a type of epigenetic signal noise, that has parallels in biology with the signal correction capabilities of the TCP/IP protocol.
    00:20:33 Steve Horvath’s epigenetic aging clock, which measures DNA methylation groups, may play a role in widespread gene regulation, including sirtuin genes, and how NAD+ may participate in resetting the clock.
    00:22:56 How the epigenetic clock can predict your chronological age and how long you have to live.
    00:23:47 How epigenetic reprogramming in old mice can restore youthful gene activity patterns, reverse the DNA methylation aging clock, and restore the function and regenerative capacity of the aging retina.
    00:24:51 The signal that resets the epigenetic clock in mice involves Yamanaka factors a group of four transcription factors that can reprogram an adult cell to become a pluripotent stem cell that can form any cell type.
    00:26:24 How short term treatment with the Yamanaka factors can reverse cellular and physiological hallmarks of aging and prolong lifespan in mice with a premature aging phenotype.
    00:27:45 Dr. Sinclair’s hope that we may eventually find a way to induce Yamanaka factors in a way that is more safe and applicable to humans than current genetic engineering and viral techniques used in animal research.
    00:28:25 How fasting, exercise, and other lifestyle factors may slow the rate of epigenetic aging but may not be sufficient to reverse it like some of the powerful Yamanka factors may be able to.
    00:29:51 How Dr. Sinclair’s lab and others are trying to find safe ways to reset the epigenetic aging clock with Yamanaka factors without causing tumors and other safety issues.
    00:32:46 How Dr. Sinclair thinks Claude Shannon’s theory on mathematical theory communication may also explain the aging process.
    00:34:02 Dr. Sinclair’s take on who some of the top scientists to follow in the field of aging epigenetics are, which includes Drs. Juan Carlos Izpisua Belmonte, Steve Horvath, Manuel Serrano, Anne Brunet, Shelley Berger, and Jessica Tyler.
    00:36:00 How nobel-prize winning biologist John Gurdon put an adult cell nucleus from a tadpole into a frog’s egg, producing a new tadpole, suggesting that the genome can be reset to a very early stage in an organism’s lifespan. Review on nuclear reprogramming.
    00:36:22 How cellular NAD+ is made from a variety of precursors including tryptophan, nicotinic acid, nicotinamide riboside, nicotinamide mononucleotide, and nicotinamide. Nicotinamide riboside gets converted into nicotinamide mononucleotide, which is then converted to NAD+.
    00:37:33 How NAD+ is a large molecule that does not get taken up in animals as efficiently as the NAD+ boosters nicotinamide riboside and nicotinamide mononucleotide, the latter of which is transported by a recently discovered transporter.
    00:38:18 How NAMPT, an enzyme in yeast that is activated by exercise and calorie restriction, is key for NAD+ production and longevity benefits.
    00:39:45 Plants produce compounds that activate sirtuin pathways in plants in response to stress and, in turn, the compounds activate beneficial pathways like the sirtuin pathway in humans, a phenomenon called xenohormesis. Resveratrol is one such compound and is produced when grape plants are stressed either in response to fungus or a lack of water.
    00:41:11 How small stressors such as exercise, calorie restriction, and ingestion of plant polyphenol compounds activate various stress response pathways in the body that help slow aging, but calorie excess and a sedentary lifestyle have the opposite effect, signaling the body to reproduce and continue aging, a concept known as the disposable soma theory of aging.
    00:41:56 When rhesus monkeys were fed a diet high in refined sugar (sucrose) and fat for two years, they experienced a 40% increase in arterial stiffness and inflammation but this was completely reversed if they were given 80 mg of resveratrol per day for one year then 480 mg/day for a second year.
    00:44:26 How resveratrol is a very insoluble molecule but its bioavailability can be increased if it is taken with food that contains a moderate amount of fat.
    00:45:38 Mice that were fed an obesogenic diet but were also given a low dose of resveratrol lived longer and had organs that were healthier and younger looking compared to mice fed the obesogenic diet alone.
    00:48:32 How a phase 2 clinical trial involving people with Alzheimer’s disease showed resveratrol improved mental examination status scores, induced marker changes that might suggest reduced accumulation of amyloid-beta in the brain, lowered markers of activated microglia, and more.
    00:49:28 How resveratrol has been shown to induce autophagy by directly inhibiting mTOR through ATP competition in mice.
    00:51:00 How both nicotinamide riboside and nicotinamide mononucleotide have been shown to improve cognitive function and brain pathology in mice that have been engineered to get a disease similar to Alzheimer’s disease.
    0:51:29 How treating mice with nicotinamide mononucleotide can prevent age-related endurance losses by promoting new blood vessel growth.
    00:52:30 How an NAD+ isotope tracer study revealed that orally administered precursors of NAD+ such as nicotinamide riboside and nicotinamide mononucleotide do not form NAD+ in any other tissues other than the liver, but that dose was half the amount used in animal studies that showed benefits in the brain and muscle.
    00:53:37 How there may be a threshold dose of nicotinamide riboside and nicotinamide mononucleotide that needs to be crossed in order to override the liver’s first pass clearance mechanisms so that nicotinamide riboside and nicotinamide mononucleotide NAD+ levels rise in other tissues like skeletal muscle, and this is why almost all animal studies use very high doses.
    00:54:13 How there may be challenges in translating animal studies on nicotinamide riboside and nicotinamide mononucleotide to humans particularly due to the need to determine the dose required to promote health benefits.
    00:56:33 How a couple of clinical trials are underway to test safety with a molecule called MIB-626, which is a potential strong NAD+ booster.
    00:59:16 Older mice that were given NMN (300 mg/kg/day) experienced delayed aging in the liver, muscle, immune cells, eyes, and bones, but those that took a lower dose of NMN (100mg/kg/day or human equivalent of 8mg/kg/day) had improved mitochondrial function and enhanced physical performance.
    01:00:05 How fragmented sleep consistently leads to higher fasting and postprandial blood glucose levels.

  • I’d like to hear more from yourself and Dr. Sinclair on Oleic Acid (using Olive Oil) causing Gene activation using the same pathways as Resveratrol uses only being more effective!

  • Myfitnesspal you can change it to gain weight, maintain weight, or lose weight and the exercise section still stays there but it lowers the amount of calories you actually need and I’ve tried it and it’s way less confusing and actually helpful. I’m trying to gain muscle and add a little weight so it’s helpful to have it, I’d rather have it the.n not and be able to change a setting.

  • This is an amazing video..!! Really great weighing scales BTW I have a created a list of some of the best selling weight scale.!! Could be helpful for the audience as well

  • This interview is excellent. I’m only half way through and I’m having a brain orgasm. I have weeks of reading ahead of me. Thanks for including time stamp show notes, and adding in visuals during the conversation.
    ” I have to interrupt because I get excited” I feel the same way David. Thanks Rhonda for such an information packed video. The video editing ( visuals) sets this interview apart from any other. It turns passive audio input into visual stimuli; creating additional memorization hooks. Great work all around!

  • I love the feature on the Renpho scales. But they don’t last. I can’t get them to work more then a month before it breaks. At least the company replaces without hassel.

  • Curious to know why the Garmin rated #1 as it appears to be the only one that works with just one app from Garmin. No IOS, no Fitbit, no Google Fit, etc.

  • They should spend the money on making the platform more social friendly. Such as private messaging.
    Seems like it’s a half baked idea to try and please all the subscription uproar. No reason to roll it out slowly unless it’s not ready yet in my opinion.

  • Thanks For Watching! What are your thoughts on using Spotify on the Fitbit Charge 4? Let me know in the comments!


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  • At a first glance one might think that Rhonda and Dr.Sinclair are relatives. The facial features share some similarity. Even the way they give that humble smile. I wish all the scientists could explain what they are doing with the same ease as these two.

  • this looks like a very easy feature to game for wannabe geurilla marketers. Just upload the same super long manual ‘commute’ activity every day for eternity.

  • propaganda much??? This is clearly a commercial… Besides, All the KOM winners are on ebikes. There’s like middle aged women ascending 12% grades at 18mph…. Strava spent too much time figuring out how to get money out of their user base and not enough time with ride type authentication.

  • You convinced me to switch! I’ve been using mfp premium for about a year and didnt love it. It took about a week to get used to mm+ and I’m still learning but I really like it!