Study States More And More People Should Use Anti-Depressants

 

Do Antidepressants Work or What?

Video taken from the channel: Healthcare Triage


 

How Long Should You Take Antidepressants For?

Video taken from the channel: The Doctors


 

The ‘extreme’ side-effects of antidepressants BBC News

Video taken from the channel: BBC News


 

Study shows antidepressants are effective

Video taken from the channel: 5 News


 

Pharmacology ANTIDEPRESSANTS SSRIs, SNRIs, TCAs, MAOIs, Lithium ( MADE EASY)

Video taken from the channel: Speed Pharmacology


 

Study shows that antidepressants are more effective than a placebo

Video taken from the channel: OxfordHealth


 

How Long Should You Use Antidepressants?

Video taken from the channel: Wall Street Journal


Millions MORE of us should be taking antidepressants: Largest-ever study claims the pills DO work and GPs should be dishing them out Study examined 120,000 people in more than 500 trials across three decades Experts at Oxford University declared anti-depressants are helpful to the ill They hope. More Americans are using prescriptions for anti-anxiety and other mental health medications as the country struggles to cope with the COVID-19 pandemic. Between mid-February and mid-March, use of. Scientists say they have settled one of medicine’s biggest debates after a huge study found that anti-depressants work.

The study, which analysed data from 522 trials involving 116,477 peopl. A study calling for a million more patients to be prescribed antidepressants on the NHS has sparked a backlash by experts who say it ignores the dangers. Prescriptions of the drugs have soared in.

On Wednesday, a large new study provides evidence that antidepressants are more effective than placebo at treating acute depression in adults. The study. The study, published in JAMA, looks at nearly 10 years of medical records that include more than 100,000 prescriptions written by about 160 primary care.

Doctors should prescribe more antidepressants for people with mental health problems, study finds Data from 522 trials, involving 116,000 patients found that every one of the 21 antidepressants. Millions more people around the world should be prescribed pills or offered talking therapies, which work equally well for moderate to severe depression, say. The current focus on long-term use is troubling, and he says, “I think the field doesn’t have as good answers as we would like.” But Kramer believes in antidepressants when used correctly.

“People who respond to antidepressants find that their sadness is more subject to logic—they can talk themselves out of it,” says George I. Papakostas, MD, an assistant professor of psychiatry.

List of related literature:

Indeed, this study too showed that most persons with moderate or low levels of depression gained nothing by adding medications to the psychotherapy provided.

“The Heroic Client: A Revolutionary Way to Improve Effectiveness Through Client-Directed, Outcome-Informed Therapy” by Barry L. Duncan, Scott D. Miller, Jacqueline A. Sparks
from The Heroic Client: A Revolutionary Way to Improve Effectiveness Through Client-Directed, Outcome-Informed Therapy
by Barry L. Duncan, Scott D. Miller, Jacqueline A. Sparks
Wiley, 2011

Again, few studies have looked at this population for a sufficient time, but what studies exist do support the efficacy of antidepressants in this population.

“Psychiatry” by Allan Tasman, Jerald Kay, Jeffrey A. Lieberman, Michael B. First, Mario Maj
from Psychiatry
by Allan Tasman, Jerald Kay, et. al.
Wiley, 2011

Other studies have also reported significant reductions in outcome with depression.

“Scientific Foundations of Cognitive Theory and Therapy of Depression” by David A. Clak, Aaron T. Beck, Brad A. Alford
from Scientific Foundations of Cognitive Theory and Therapy of Depression
by David A. Clak, Aaron T. Beck, Brad A. Alford
Wiley, 1999

Since there probably are many more people who are depressed than those taking antidepressants, these figures are astounding.

“Calm Energy: How People Regulate Mood with Food and Exercise” by Robert E. Thayer
from Calm Energy: How People Regulate Mood with Food and Exercise
by Robert E. Thayer
Oxford University Press, 2003

By way of background, the researchers cited several prior studies, all of which should have told the regulators that their warnings to discourage antidepressant use lacked empirical support and that it could indeed be harmful to the mental health and well-being of depressed children and adolescents.

“Research Methods in Psychology: Investigating Human Behavior” by Paul G. Nestor, Russell K. Schutt
from Research Methods in Psychology: Investigating Human Behavior
by Paul G. Nestor, Russell K. Schutt
SAGE Publications, 2011

This is often the case with antidepressant medications: some of the world’s best-selling antidepressant drugs have been regarded as useless because new evidence has shown that most of their ability is due to the placebo effect.

“How Your Mind Can Heal Your Body: 10th Anniversary Edition” by David R. Hamilton, PHD
from How Your Mind Can Heal Your Body: 10th Anniversary Edition
by David R. Hamilton, PHD
Hay House, 2010

This seems surprising given that drugs are the most common treatment for depression in the UK, and it is also surprising that so few studies have been conducted in the UK.

“Psychology of Physical Activity: Determinants, Well-being, and Interventions” by Stuart Biddle, Nanette Mutrie
from Psychology of Physical Activity: Determinants, Well-being, and Interventions
by Stuart Biddle, Nanette Mutrie
Routledge, 2001

indeed, in many of the unpublished studies, ssris have failed to outperform placebos.

“Crazy Like Us: The Globalization of the American Psyche” by Ethan Watters
from Crazy Like Us: The Globalization of the American Psyche
by Ethan Watters
Free Press, 2010

But the study was not designed to examine how MBCT would fare against antidepressants alone.

“Mindfulness-Based Cognitive Therapy for Depression, Second Edition” by Zindel V. Segal, John Teasdale, Jon Kabat-Zinn
from Mindfulness-Based Cognitive Therapy for Depression, Second Edition
by Zindel V. Segal, John Teasdale, Jon Kabat-Zinn
Guilford Publications, 2018

However, they also noted that 40% of depressed individuals respond to placebo over a 3to 4-week period.

“New Directions in Affective Disorders” by Bernard Lerer, Samuel Gershon
from New Directions in Affective Disorders
by Bernard Lerer, Samuel Gershon
Springer New York, 2012

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

[email protected]

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135 comments

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  • about the last point of the pharmaceutical companies not having much incentive to get more data, wouldn’t competitive advantage over other potential therapies be one reason for them to gather this sort of higher quality data? Or is the competition between different drugs not yet high enough to impact companies’ decisions in this way?

  • Wow! So much the good doc does not mention here. How about how these medications are dependency forming. Not addictiveyou don’t crave them. But once you start taking them you become dependent on them, meaning you need to keep taking them just to stay normal. And how about when the doc says there is no evidence that long-term use of these meds are bad for youhas there been much research? There would likely not be much official evidence if there hasn’t been any official research. I’m sure the meds help some people. I’m sure there is depression that is purely chemically based, but very often depression is a symptom of a problem in your life. When you deal with the problem, your depression will lift. The right anti-depressant is often not a pill but a lifestyle change or just getting through a bump in the road and having a great support system. And if you start taking anti-depressants, of course you chances of relapse are highbecause these meds are dependency forming. As for getting off the meds, you can’t do it cold turkey. You have to find a doc who is down with getting you off the meds and then do it slowly and incrementally. And by the way, they talk here about the likelihood of having a second major depressive episode if you have had a first, but is that second episode most likely to happen if you have been on meds and go off? What does the research say about the likelihood of having a second major depressive episode if you got through the first one without chemical intervention. Just so much not discussed in this clip. Conveniently left out. Wonder how many of the people in this clip are on the drug company’s payroll.

  • this mustache is a liar and a crook psychiatrist. There is way too much evidence of long term use being harmful to ignore. How much is he getting paid by pharma to say otherwise?

  • Antidepressants cause side effects when in use and causes withdrawal syndrome when you leave them. They make problems even worser. Worthless anti-depressants are worthless.

  • Really annoys me that doctors never look into the nutition of a patient which I beleive is one of the main reasons for mental illnesses. So of course if you’re coming off your meds but still eating badly you won’t be supplying your neurotransmitters with the right nutrition. Secondly most people come off antidepressants much too quickly and what doctors say is the mental illness coming back could very well be simply withdrawal symptoms. Best not to ever start these drugs and look into your lifestyle and nutrition first. Stresses cause nutritional deficiencies..

  • Been researching this for 15 years, for me antidepressants actually do more harm than good. Ssris and snris feel like a shitty version of amphetamine. Ssris narrow your emotional “bandwidth” so you don’t get sad but you dont get giddy or joyful either

  • When I was young, I developed a minor tick disorder. As a result, the doctors put me on powerful antidepressants, because after all, in their minds, any drug is better than no drug. The antidepressants made me completely withdrawn socially. Today I am forced to be on welfare because I have zero ability to make friends, and of course because I failed college.

  • Once you have clinical depression & especially if you have been hospitalized then I recommend you taking It lifelong. If you stop it you may relapse & end up in a hospital.

  • I used to suffer and share my story on my channel here and now I’m going al carnivore and learning that diet causes mental disorders and also cures it! I read a testimony the other day of a son who helped cure his mom of schizophrenia in 3 days with a water fast. I don’t use any pharmaceutical drugs!! There’s NO pharma drug where benefits outweighs the risk! They add these things so people will have suicidal ideation otherwise they’d pay for things such as the gym memebership, massage therapy, acupuncture and prescribe a healthy diet like all carnivore! Just found out USDA and WHO have been lying to us all these years about food and specifically meat!! Check out Dr. Paul Saladino on here. He’s a Psychiatrist and he concurs along with many other Fundamental Doctors!

  • Could you please make a video covering the PACE trial that falsely claimed GET and CBT are effective treatments for Myalgic Encephalomyelitis?

  • Moral of the story: Big pharma says take your meds the rest of your natural born life.
    It’s good for you and we make tons of money. Don’t worry that is what the meds are for. Besides if you have a side affect no problem we have a pill

  • Further Research List: (I keep thinking dysthymia)
    1) How well do antidepressants work for milder symptoms that fall short of major depression?
    2) How well do antidepressants work longer than 2 months, especially for mild symptoms?
    3) Does long term antidepressant use outperform placebo?

  • This was great, been searching for “what does chronic fatigue feel like” for a while now, and I think this has helped. Ever heard of Diyadelyn Ziyily Idea (do a google search )?

    It is a smashing one off guide for getting rid of chronic fatigue syndrome (CFS Also known as myalgic encephalomyelitis or ME) without the hard work. Ive heard some decent things about it and my neighbour got excellent results with it.

  • https://en.m.wikipedia.org/wiki/Akathisia

    If you or someone you know is taking a psychiatric medication, you owe them this information. Psychiatrists are informed by the FDA and drug companies which have provided untruthful and fraudulent information regarding akathisia for 50+ years. Once this is triggered there is no help.

  • Oh no, antidepressants are god’s gift to Earth and never have any negative outcomes for the people thrust onto them.

    Or so I’ve been told by some SciShow viewers, despite the real experiences on myself and other people. The flaws in the system aren’t hard to see when you’re willing to view them objectively. I can tell you right out you’re lucky if your prescriber bothers to tell you the advantages and disadvantages of each medication.

    I take umbrage with the whole “chemicals” assumption in the first place, but it’s the practice that’s most alarming, and all the money swirling around it. And it’s really annoying when you know you’ve had numerous negative experiences, but everyone keeps trying to sell you on the same idea, the idea of insanity. And who knows what these things have done to me long-term?

    I don’t want more pills! I want a different situation.

  • PSEUDO SCIENCE BS. YOU HAVE A CHEMICAL IMBALANCE REALLY, HOW DO YOU KNOW DOCTOR? DID YOU TEST MY SEROTONIN LEVELS WHEN I BLINKED. LYING BASTARDS!!! CORRUPT MEDICINE!!!

  • They’re not just used for depression but people who have panic attacks and severe anxiety. They probably do something since it’s hard to orgasm when you’re on them

  • they feel better on meds and want to come off.If they get depressed off the medication, has the medication done any good. or is it just doing good while its in the system. it just shows BIG pharma,s plan comfort not cure.

  • Don’t ever stop taking antidepressants. Once you start, your on for life and if you stop you’ll be suicidal anyway so the question becomes moot. That’s why that pill pusher won’t give a straight answer. It is interesting that these bozo’s are using the addiction term “relapse” for depressive episodes. Depression is not a choice, it comes on when your the most venerable all by itself and without your knowledge. It’s not falling off the wagon, there is no wagon save taking pills for the rest of your life. Don’t trust psychologists, they are shills for the big pharma, making a ton of money hooking you on a drug that you will be addicted to for many, many years to come.

  • I’ve been on lexapro for 14 years..I only take one 10mg pill once a week for the past year. Its the pick me up I need..Dr’s still write the Rx…

  • When you say “depression” are you just referring to clinical depression or are other diagnosis included in that spectrum? Like anxiety disorders and panic disorders?

  • I was diagnosed with General anxiety disorder and doctor gave me the SSRIS pills. I took one pill like told and my anxiety gone, i feel calm and everything, but i feel the whole day like im gonna puke. does anyone know is this normal? (first day ever of using this antidepressants)

  • Of course people are at a high chance of relapse. Antidepressants don’t treat or cure depression or anxiety, they are only for symptom management. If you’re not actually treating the cause (emotional/spiritual injury), you will be at high risk of those problems resurfacing.

  • took lexapro for three months, zoloft after that + lamictal… 11 months after starting meds…. i’m still here, stressors come and go, but that’s life. I believe that antidepressants work… but added therapy works wonders.

  • hallo kann mir bitte jemand helfen unsere medikamente sind essitaloprama 10 mg, paliperidon 6 mg, aripiprazol 5 mg und ketiapine 200 mg wir leiden unter sehr hohe Gewichtszunahme nebivolol 5 mg ist für Herz da die anderen medikamente einen Herzrythmus herzschläge erhöhen… wir haben jetzt den ketiapine weggelassen und nexivol also nebivolol nun halbiert.. bitte kann mir jemand rat geben wiesoo Gewichtszunahme so stark ist bitte bitte

  • Can someone tell me what over the counter drugs i can take. I’ve been suffering from anxiety worse than usual, my chest feels heavier than usual and i often get nauseous.

  • I have been on different antidepressants for 22 years
    Yes 22 years!
    My doctor keep giving me
    I want to stop theme
    But I’m so scared
    I lost my friends, family work…

    My life is ruined
    Any help here?

  • Would you consider doing a video on bipolar depression, and how it’s different from major/minor depression? I’ve only been able to gather vague and/or limited info so far on the topic and I really want to understand it better

  • how horrible ‘relapse ‘ is disingenuous most people do not relapse but for most they are experiencing drug withdrawal and possibly brain harm from having an artificial agent mess with receptor sites long term causing an imbalance to an organ our brains that try to keep balance

  • Someone is lying here.  If 2/3 of people on anti-depressants are depressed then an increase in depression following “quitting” has to do with rebounding.  If there is no physical stimulation to produce the serotonin, then the receptors will have nothing to “catch”!  However, if the patient is getting adequate sunlight, “vigorous” exercise, practice at laughing it’s unlikely that he/she will fall back into depression.  Come on people this is not an absence of neurochemicals it’s an absence of physical stimuli which produces the neurolo-chemical deficiency!!!! Also, if more people are prone to suicide while taking ADs, then why in the hell would they be prescribed!?  I now that the correct answer has$ in it.  I also know that the re-imbursement form Pharma to Dr.’s directly can be as much as a quarter of a Million dollars annually!!! (SF Chronicle report and the highest reimbursements directly to doctors for prescribing 2016)

  • I took them 4 yrs but so suck of the regular check ups on how they were working after I’d taken it 4 8 yrs I stopped. Don’t wanna miss work 4 stupid doc apps that I didn’t need

  • I think those who are going through difficult times in their life, should just avoid medication. If their case of depression was caused by a problem, they really don’t need it because the depression will stop upon resolution. They’re basically only throwing money away and unnecessarily suffering the side effects.

    Of course, the problems are: 1. People may not know they have a problem or don’t know how to deal with the problem. 2. Something may be a problem for them which nobody else regards as a problem (I see jobs as a problem-For various reasons). 3. People don’t know how to communicate, or don’t know depression is a matter of communication. 4. People don’t realize that A. Solutions may take awhile to achieve or B. People have to figure out how to live around the problem because they can’t solve it.

    People say depression is a chemical imbalance. I don’t know if it is, but, if it is: I say the depression itself is the imbalance, but, it’s only temporary is the depression is caused by some hardship in life.

  • I’ve been taking Celexa for 10 years and I’m petrified to stop taking them but I’m concerned about the affects of long term use. I’ve had triple bypass surgery. Anyone have any relevant experiences?

  • Even as a person with severe chronic depression, antidepressants are risky and their effects highly variable. I’ve been prescribed some that have made my symptoms much worse, caused me great pain, and the like. Finding the right balance of psychiatric medication is a moving target-my needs change over the years, as do the effects I experience from some medications or combinations. I do wish psychiatric medicine had more of a grounding in science than it currently does.

  • For some reason, this video entirely omits long-term severe depression. It mentions long-term mild, and acute major, but those aren’t exclusive.

  • As someone who’s been in and out of psych hospitals for the past few years, I can say with certainty that antidepressants work. Just not for everyone. Unfortunately I’ve been unable to find a medication that works for me, but that doesn’t mean that they shouldn’t be tried by people. A modest amount of relief from symptoms is better than no relief at all.

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  • I have been taking AD for 6 years. I have several depressive episodes a year. I do get suicidal and I self harm. I have changed AD about 4 times. Now I’m on sertraline and mirtazapine.

  • Antidepressants can permanently remove your sexuality. See this site about Post-SSRI/SNRI Sexual Dysfunction. We have personal stories, professional letters and resources: @t​

  • https://en.m.wikipedia.org/wiki/Akathisia

    If you or someone you know is taking a psychiatric medication, you owe them this information. Psychiatrists are informed by the FDA and drug companies which have provided untruthful and fraudulent information regarding akathisia for 50+ years. Once this is triggered there is no help.

  • I have tried anti depressants in the past and disagree that they work with everyone as the longer I took them the worse I became! All I was being told by doctors is after so many weeks they will definitely start to work but eventually after months of taking antidepressants I stopped and eventually got better naturally

  • Took Effexor/Pristiq for the better part of 20 years and recently stopped cold turkey. The nightmares have returned but other than that I still haven’t seen an increase in sadness. However the risk/reward while taking this drug was kind of expensive. Several side effects made it barely worth it.

  • mianserine, the minimal dose gave me joints and muscle pain. i started using it 4 weeks ago for anxiety and insomnia. it is hard to find anything about this topic in the literature. also i expected to find more shared experiences on the Net.

  • The video states that activating “the bad” serotonin receptor, 5-HT2A, actually induces depression, yet research on Psilocibin (magic mushrooms) microdosing suggests the contrary. Any neuroscience/psychopharmacology grad students got any input on this? ��

  • anti-depressents
    they should just call them Depression killers
    they just make your brain IGNORE the drepssed feeling

    dosn’t CURE the cause of the depression

    which can mean you end up getting worse.

  • Dr Jarvis said they can find a medicine that will work for you eventually. Well, how can they find the right one when they don’t even know why the drugs work on the few that they do? They used to think it was a serotonin deficiency, but we know now that isn’t the case. So this fraud doctor thinks we should just keep trying other ones until we find one that works? The data from their own studies show they work no better than a placebo for most people, while having terrible side effects. The healthcare industry is one big ripoff for the patient.

  • ALL antidepressants are neuro toxin drugs. DO NOT ever take them and leave any doctor who prescribes them. People like us are the only people to stop these doctors and companies. DO NOT spend your hard earned money to let an idiot doctor poison your brain and body. These drugs often cause irreversible side effects. I took antidepressants for not even 2 weeks and my body and emotions are still numb (over a year ago). These drugs will ruin your life and eventually your families life when they don’t understand what happened to you and why your like this.

  • Who else is on a TCA? I can’t find many experiences with them (clomipramine) and want to meet someone who’s had success with one. SSRI and SNRI are not very helpful

  • Believe in yourself. You’ll get better! I promise. As long as you think you can get better you will… Just be yourself, That’s all you need to do ��

  • Depression/the need for antidepressant use should be reassessed at least every 2 years, and that assessment can involve trying lower doses or tapering off of the medications. This is recommended in the guidelines, but is rarely actually done. Why risk your patient falling back into depression when they are now used to taking the drug? There’s a benefit to taking fewer medications, but doctors are reluctant to take the risk.

  • Why would anyone tell you how to get off them? It’s pouring money when people are addicted to meds, drugs, alcohol, smoking or whatever, big corporations don’t really want that to stop..

  • I’ve never tried to kill myself not on antidepressants, yet every time I’ve taken antidepressants, I have tried to kill myself… Almost always within the first month of use, I have severe bipolar, and yet, I still try to kill myself. Some of the antidepressants I’ve taken, have caused other side effects like withdraws and panic attacks.

  • Hey everybody taking antidepressants! If the medication isn’t working for you,
    1. talk to your doctor (psychiatrist)
    2. Remember you aren’t depending on the antidepressants
    3. If you believe that it works, it will work.
    Believe in it. Believe in yourself. You’ll get better! I promise. As long as you think you can get better you will.

    I’m here to talk to so if any of you are going through anything, reply to this comment. You’re anonymous and I am too. You’re safe. There’s always someone there.

  • The question is, are these processes observable or merely theoretical? Darwinism, a theory is decompiling faster than I can type this comment. However, smug scientists were and some still yet are dogmatic about darwinism. Scientist can be some of the most lying and dishonest mother fuckers known to man……Prove me wrong.

  • Depression is not caused because of “imbalance of chemical”. Drugs do that to your brain. Ssris make your depression chronic. Drug business is shit and the research scores are manipulated and made by drug companies. Google More, for example http://www.ssristories.org, http://www.madinamerica.com

  • Thanks a lot! First I thought it’s quiet a bit too sketchy biology-wise, and you barely mentioned practical (medical) details.
    But now I see this is a very good basis for further medical study of the antidepressants!

    Also I wish it would be a bit about dopamine as well, particularly DRIs, NDRIs, SNDRIs (TRIs).

  • Since the 90s I’ve been on nearly all the available anti-depressants at one time or another (except tricyclics, not a good idea for someone with major depressive disorder too easy to use to commit suicide with) they all have side affects and some work better than others. But, and this is a big but, they help me function but they don’t “fix” me. Drugs may dampen the blackness but talk therapy brings back the sunlight and gives me the tools to deal deal with the cloudy days.

  • Antidepressants are not the cure of depression. Instead the correct diet which does not inflame the gut can stop it. As various inflammatory mediators are directly linked to brain to pass inflammation to the brain.

  • Hi Aaron. Love the series. However do feel like you could have mentioned the Lancet study published in February 2018 comparing efficacy of antidepressants. It was another paper that got a lot of coverage, here in the UK and I felt like it would have been relevant. Also mentioning how researchers distinguish between ‘limited’ or ‘small’ efficacy would have been interesting
    Regards
    Lily

  • Hi doctor speed pharmacology, hopefully u will be healthy s super fine, how i can get your notes ( pdf), please humble request to you Sir. I need your pdf notes. Must reply me sir thanks.

  • Yes, they work. The problem is some work great for some people and do absolutely nothing for others (or sometimes bad things). It’s frustrating. I have crippling OCD and it took 31 different medications to find one that worked. Once I got on a good dose it changed my life. I without a doubt still have OCD and some days are better than others but the drug gave me my life back.

  • “Severe depression”? The majority of people prescribed antidepressants do not have severe depression. The “benefits” do not outweigh the risks… given that the meta analyses show that SSRI medications do not outperform the placebo effect. These drugs represent criminal negligence in institutional medicine.

  • When antidepressants start to work, they make you feel like it’s not all that bad, really they can cause more damage when trying to come off them. Had problem? Now, you have a bigger problem. I have been antidepressants for 15 years, but now I really see how dangerous they are. Almost died due to withdrawal problems, and nobody was around, I myself wasn’t “around”.

  • Why do soooo many American women, that is white women, have these dipped gravelly rough half-swallowed voice speaking habits? Are they emotionally 2 years old?

  • Society wants everyone to feel like shit. Anything that makes you feel good is immediately branded as illicit. Yet antidepressants that make many people feel shit, especially at the start which they call “adjustment period” are allowed despite practically every antidepressant saying that we don’t understand how they work. The antidepressants not as thoroughly researched as illicit drugs, and they are never researched with the view that they should be considered illicit drugs always with the view they are legitimate and necessary forms of treatment. So we don’t know how they work (search Wikipedia for most antidepressants and in many places it will say something is unknown about every single one), we don’t know what the long term effects are, etc. Big pharma is not interested in your health with these tablets.

  • Scans for depressions???? They are wasting government funds on such works and in the end make us consume more of these AD’s than is necessary. They do not want to address the root cause.

  • I previously had very serious depression and anxiety and took medication for years. I did eventually begin to feel better and am now able to manage my symptoms and mindset, but I should note that I spent a lot of time in therapy and that the majority of the things that permit me to control my reactions now and helped me cope with things then were breakthroughs in therapy sessions. I am now off of medication entirely and, although I still have some issues, they are far from as bad as they used to be. I didn’t really notice any differences while I was on the medication alone (before going to therapy) but I can definitely say I noticed a difference when I was decreasing dosage and when they were no longer present. Thank you for bringing this information to light. It helps me think about my previous use and how, althought it seemed to work with me (in conjunction to other forms of treatment), it mat not work well with others

  • All I know is that Wellbutrin has lifted that depression negative energy that kept me from doing anything and replaced it with what I hope is normal.

  • Give that poison to that ‚doctor‘ who said,let them take some different ones!
    Why?.cause there is no real difference in ssri!they are all poison!

    if not,you‘re a lucky one that could try something else to get that done
    ,cause there‘re not that much!

    With Snri i don‘t know,but i pressume they‘re equal in that matter!
    Never take these poison,nothing what works like ssri!

    The big pharma studies wich ‚justified’ their claims for everybody,are all based on guesses n now u know everything what everybody have been guessed,hä?!!!

  • I remember I just abruptly stopped taking my antidepressants and I felt like I was going to die for the next couple of weeks. It was like withdrawal

  • For anyone people suffering with a debilitating mental illness, I implore you try a MAOI inhibitor. MAOI INHIBITORS, such as PHENELZINE, are the most powerful antidepressants in EXISTENCE.

    Psychiatrists don’t prescribe them often because of outdated and incorrect dietary restrictions, and because they are not profitable to corrupt pharmaceutical companies.

    For more information look at highly respected psychopharmacologist Dr Ken Gillman’s website https://psychotropical.com/

  • selegiline is the stuff and i can only imagine what tranylcypromine is like
    SSRIS dont actually describe the action of these drugs.
    Fluoxetine for example is unique because it upregulates 5ht2a and also inhibits 5ht2c,this translates to increased dopamine and norepinephrine.It will also, long term upregulate dopamine receptors as well as a1adrenergic receptors.Other ssris snris atypical and tricyclics,
    which also have a distinct pharmacology, will also have similar(long term due to receptor regulation) effects except 5ht2a upregulation.
    i think that 5ht2a activation is as good as its inactivation in terms of antidepressant properties.Saint johns wort for example produces a 50% increase in 5ht2a and 5ht1a density,while also being actually more potent as a norepinephrine and dopamine reuptake inhibitor.Considering serotonin affinities for receptors and competition for receptors between serotonin and the newest antidepressant, vortioxetine basically chugs serotonin into 5ht2 and doesnt produce downregulation like other agents.5ht2a activation has been linked to a bdnf increase.The other “SSRIs”stray from the description,as well.A study found that serotonin “hijacks” the dopamine transporter,resulting in co-signalling.Dopamine has a lot to do with antidepressant response overall.
    Dopamine transporter isnt present in the prefrontalcortex and the reuptake is done by the norepinephrine transporter,which is blocked by snris.This equals to increased dopamine levels on site specific parts of the brain like the pfc.Besides venlafaxine and desvenlafaxine have a not unreachable(dose wise)affinity for the dopatransport.
    <3

  • antidepressants ruined my life, this is a painfully honest comment. the problem in my case is the DISHONESTY!!! psychiatrists lie all the time

  • There really isn’t much evidence!? There is plenty of evidence that long term use of antidepressants can be problematic! LISTEN TO YOUR FRICK’N PATIENTS! You’re putting a neurotoxin into your body. You don’t need evidence, it’s common sense.

  • Fun fact: the overall effect size of the ‘these things work’ study was SMALLER than the effect of the first ‘these things don’t work study’ XD

  • For the gentleman with the shaking hand, I had a similar response to benzodiazepines and SSRI’s. Have you had your DNA checked? It was found with me that I am a rapid and ultra rapid metabolizer of many anxiety, depression, and opioid medications. I had seizures, speech problems, and involuntary movements such as yours. I am still trying to withdrawal from these drugs, as the withdrawal symptoms are horrible and in the beginning were like the side effects, only worse. It may be worth looking into. Thank you all for fighting this fight.

  • You just can’t stop taking any medication right away you could end up int the hospital! I’m an antidepressants and I love them and I’ve been on them since 5 years ago

  • As someone who’s been on and off anti depressants for 7 years doctor sportelli is talking bullshit about them not being addictive and have no side effects which are dangerous
    Serotonin Syndrome happens in people dependent on antidepressants more often than someone who go on Chinese medicine (or herbal medicine) because they take a substance ontop of their medication without realising it can increase the serotonin in their body which triggers serotonin Syndrome which can be easily mistaken as an overdose
    Not saying all his information is wrong but the addictiveness of antidepressants is being so badly underplayed here it pisses me off he can call himself an “expert” and not know that they are just as if not more addictive than illegal narcotics

  • Been taking antidepressants for 6 years. For the first almost 5 years my psychiatrist had to keep raising the doses consistently before I finally reached a good level. Last year I stopped taking one of them (under my doctor’s directions) and I didn’t feel a thing. Now I’m only taking three pills and they are working good. My mom keeps telling me I should finally stop taking them all, that I’m addicted, that they aren’t good for me etc. But I know I’m not an addict, I hate having to take my meds. I know I need them though and I really don’t wanna mess this balance up.

  • Me. Getting beautiful depression and its symptoms….
    Also me. A beginner jus finishing my second week of fluoxetine…lemme introduce to a lil longer affect of balancing everything out….
    Also me again… trying to write a comment trying to b funny but my lack of some chemicals in my brain cant tell the certain part of my brain to think if something funny and put it in the comment section…oh not blimen fair me not able to sleep when I really want too!!!

  • so medications that are indicated for major depression are likely not clinically effective when people don’t have major depression… go figure?

  • I’ve been on Xanax since 1994. I was told I would not have to worry about getting them since my anxiety was so extreme. I also have sleep narcolepsy and the Xanax affected me wonderfully. At one time I was given 6 a day! As I’m getting older and now have issues with pain. Here in Florida I’m told I can’t have them both. So they are wanting to give me antidepressants in place of the Xanax. Black box relabled medications. It makes no sense to me what so ever when the side effects from the antidepressants are much worse than the Xanax. I’m 58 so I feel at my age I should be able to make my own choices. I’ve had a horrible reaction to the meds I was prescribed this first go round. A panic attack from hell. My left eye felt like it had a thread running through the lid and was being tugged on. And then the vomiting. We are told to take these medications for 6 to 8 weeks for the full affect. I would much rather taper off the Xanax with nothing than add an antidepressant. Yet my Dr will only help me taper if I take the antidepressants and mood stabilizer. I’m not depressed and not having any issue with mood. Why must we be forced and used to only be a profit for money? My psychiatric is actually quite nice. Yet my soul is feeling terrorized. I’m shaking so badly I just want to climb into my closet but I wouldn’t look very stable would I lol. Life is life. Thank God I have God during this controlled persecution or as I call it Natzi America. I chose my pain meds over the Xanax because I have pancreatitis. It’s severe and so is the pain. Since I can’t take both meds I am not feeling quite myself. It’s hard trying to keep doing for my family when I nearly drop or make a mess out of everything I touch. Please everyone. Don’t think you must take these meds to become better. Try a psychologist instead. These medications change you. There is no such thing as a chemical imbalance. That’s been proven. And if these meds are so wonderful why must they relabled them. Why are they black box warning you? If you take them for the 6 to 8 week period you are already setting yourself up for withdrawal. And who’s to say now that they are finding such bad side effects that these drugs too won’t be taken from you. Do your research. Dr Peter Bregan is wonderful. Watch the history of psychiatric medication. Trust and believe in yourselves. Follow your gut. In pregnancy our brain and gut are attached for a period of time. This is why eating healthy affects your brain health and so much more. This is why what your brain and gut have effects on each other as they are made up of the same tissue. Love to all. I wish you peace and I wish you joy.

  • The problem is that psychiatry is on the whole is still at “humour” levels of understanding. The four main neurotransmitters (dopamine, serotonin, norepinephrine, and GABA interact in ways that aren’t well understood and while manipulating them is effective for some people they aren’t reliable predictors of who will get better and who won’t

  • Usually I never comment on videos. But this shirt and tie totally not fitting together just is asking to be pointed out. That being said amazing content. Reminds me a lot of the book missed connections.

  • Nah. Just gives you more energy, similar to caffeine. Which is enough to trick some people into thinking they’re motivated to do stuff.
    The idea of a drug curing depression is ridiculous.

  • This is the most pathetic interview I’ve ever seen. Holy shit the wall street journal? Psychiatrists are not real doctors and its not a real branch of medicine. They have absolutely no idea what they are talking about. Your brain is not supposed to be pounded every single day for 10 years with sereotinin. Antidepressants do permanent damage to your brain. Everybody who watched this video should be immediately shocked that the doctor isn’t warning people of the dangers of being on a extremely powerful and mind altering drug for 40 years, instead hes like “well no there isn’t any evidence”. REALLY? Horse shit. Plenty of studies show these medications are dangerous.

  • Also, there’s very minimal research on withdrawal from many of these drugs, take Effexor for instance. Its withdrawal is extremely strong and hits just like PCP. I’ve seen a close relative go only a day and a half without it a couple times, and they become a completely different person. it’s about the worst thing I have seen them go through.

  • The effectiveness of anti-depressants has to do with the person. Everyone is different. I have dealt with major depressicw depression for a long time and anti-depressants has helped me cope and control it. For me, most of my medications worked while I was on them one in particular did not. Just because it is not effective for one person, it doesn’t mean that it works for everyone. And for some people, medications don’t help, which is also fine. We need to stop looking at it as a one size fits all and look at it more individually

  • I noticed this effect with Zoloft anecdotally myself. When I was so depressed I couldn’t get out of bed, it was like a stepping stool that made it possible for me to make it to therapy appointments and get out of my house, and all the other things that I needed to do to get better.

    But once I had my life back on track, even though I still suffered from moderate depression, the Zoloft felt like it did nothing. I switched to Prozac, which helped a lot, but I’ve since learned that it’s treating another disorder I have.

  • Let me give everybody in the world a friendly factual warning, my personal experience about what antidepressants and all related meds do to people. It does cause autism if you use it while pregnant, it will destroy the person you are, it damages your brain and body, and it doesnt work for anything. It is a money making racket and it will destroy your life, never ever take it. I write the absolute truth, dont fall for the media propaganda, dont destroy yourself.!!!!!!

  • The diagnosis is subjective and money is not… if psychiatrists treated broken arms they would put on a cast and leave it on forever.. if you take the cast off even though your arm is better you could break your arm again.. better leave the cast on just in case… after 5 years people who have taken off their casts are twice as likely to break their arm again… I wonder why?? Oh well… come back.. I’ll put a new cast on your arm every month and get a free trip to Hawaii from the cast makers plus I get to charge you for an office visit… maybe you should see a cast psychologist and join a cast decorating class

  • Damn pills will kill you and y’all taking these damn pills are a bunch of sheep and with vax your killing your self and your kids by giving them these worthless injections

  • Bupropion is an Amphetamine (a Cathinone, to be more precise), and it acts as other Amphetamines do: by releasing norepinephrine/noradrenaline and dopamine, and also by blocking the reuptake of those compounds. This means that it should be classified as a stimulant, but it is such a bad stimulant that it can be mislabeled an antidepressant.

    I was prescribed Bupropion once to increase my avolition. I took it for around two weeks and developed signs of an amphetamine psychosis needless to say I immediately stopped taking it. I hypothetize that the reason for this effect was that I belong to the about 10% of the European population that are CYP2D6 slow metabolizers, as I react differently to all kinds of medication that are metabolized b CYP2D6.

  • I’m fully convinced that the drug that saved me from my depression was not an antidepressant. It was a mood stabilizer. I’m on it and an atypical antidepressant now. The antidepressant seems help some but the mood stabilizer does the heavy lifting. I’d really like to know why that is. Also I’d like to note that what we know about neuroscience suggests that all psychoactive medications wear off eventually. Neuroadaptation is really wonderful. Someone should look into getting them to last longer.

  • So what does this mean for people with chronic depression? I am unclear whether the data says anything conclusive. If not, other than non-pharmacological treatments such as talk therapy, are there treatment recommendations?

  • They only work for one thing, i graduated hs last year and there are alot of kids taking antidepressents, mostly getting them illegally and i live in a suburban neighborhood, kids forget who they are when theyre on those, and most act out when they forgot to take the pill that day (withdrawls)not to mention none of the kids that take them all the time even know what day it is, 80’s had crack, 2000’s are the years of benzos and opiates

  • (I’m not a doctor, but you should research this and find out for yourself) L-Tryptophan works great to fight depression on demand. It is a natural amino acid our body consumes and uses anyway, and does not have the dependency (AKA addiction) that industrial anti depression drugs have. It works by naturally increasing Serotonin production by supplying the material to make more. A process the body regulates so overdose is impossible. While industrial drugs break body processes to keep Serotonin from metabolizing, which can have bad side effect on your mental abilities restful sleep and procreation. It Works withing minutes and is mild, unlike the industrial drugs that may take weeks to have an effect and must be taken regularly. Be warned that people on commercial anti-depressants needs to detox before using Tryptophan as the mixture of the two can lead to too much Serotonin in your system which is bad. There was an incident where poisoned Tryptophan caused some damage, some conspiracy theory regarding the debut of Prozac which happened at the same time exists, but to this day internet articles discussing Tryptophan mention that case, so draw your own conclusions.

  • Lexapro works as a miracle for my severe depression. Years later i developed peripheral neuropathy in my feet due to other reasons. Neurontin works as a miracle for that too. Since I have essential hypertension, I would think that Cymbalta even though it is supposed to help with neuropathic pain, since it may increase my heart rate and blood pressure it would probably not be advisable to switch to Cymbalta. The Neurontin works wonders for the neuropathy so why should I switch from Lexapro to Cymbalta. This was very informative indeed.

  • I have quite a few criticisms of many aspects of psychology, mental illness and psychiatry specifically. Let me first state that I do believe there are useful aspects of psychology, the mind exists, people have behaviors, these things can be observed and studied, however, the claims often put forward by psychiatry are often dubious at best and pseudoscience at worst.

    In truth, there is no such thing as mental illness. So-called “Mental illnesses” cannot be literally diseases since they merely refer to the undesirable thoughts, feelings, and behaviors of persons. Classifying thoughts, feelings, and behaviors as diseases is a logical and semantic error, like classifying the whale as a fish. As the whale is not a fish, mental illness is not a disease. Individuals with brain diseases (bad brains, example: tumor, epilepsy, Alzheimer’s) or kidney diseases (bad kidneys) are literally sick. Individuals with mental diseases (bad thoughts or behaviors), like societies with economic diseases (bad fiscal policies), are metaphorically sick. The serious and dangerous consequences of the misclassification of (mis)behavior as illness are that it provides an ideological justification for state-sponsored discrimination under the guise of medical treatment.

    Psychiatry is not a legitimate field of empirical scientific observation, like say neurology. Rather, psychiatry is merely modern prescribed moral philosophy masquerading as science. So-called mental illnesses do not have biological evidence of disease, and no physical empirical objective observations of someone’s brain or “brain chemicals” are made to diagnose these “illnesses”; simply the moral judgment by a psychiatrist that a person’s thoughts feelings or behaviors are wrong. Until 1974 psychiatry classified homosexuality as a mental illness, up until then Homosexuality was listed in the DSM and considered a disease, not because there was any objective way to biologically measure that someone was homosexual and that homosexuality was a result of some sort of brain damage, homosexuality was, like all mental illnesses, merely a behavior that was judged as wrong. Homosexuality was eventually cured of its disease status, not because someone made some breakthrough discovery that being gay wasn’t some sort of mental disease, neurological or otherwise, but because the would-be LGBT movement of the time protested this classification and psychiatry bowed to the political pressure. Psychiatry is medicalized bigotry, it is a weapon in the toolbox of state-sponsored oppression. “Mental illnesses” are not real diseases of the body or brain, they are the thoughts feelings and behaviors our unelected moral arbitrators deem as disruptive to social order.

    Science is a method, a set of steps used to make empirical inferences about the universe. It is making testable, repeatable, and falsifiable observation and concluding some logically necessary truth or law based on those observations. However, psychiatry and its claims of mental illness actually fail this method, “mental illnesses” are not based on observation simply assertion that fundamentally fail to be falsifiable. Read about the Rosenhan experiment, a person pretending the be mentally ill is indistinguishable from a person who allegedly is mentally ill. I could go to a doctor and claim I have all the symptoms of lung cancer, but one scan and they would tell me to get the fuck out, a real disease can’t be faked for long because it can be shown objectively to be absent, mental illness, on the other hand, could just be an Oscar award winning performance in disguise and there is no way to prove otherwise. The claim that certain thoughts, feelings, or (mis)behaviors are not only just wrong, but literally some kind of disease like cancer or the flu, can not only not be proven right, it’s Not Even Wrong.

    To be clear, I am not saying mental suffering is not real, I am not saying people don’t engage in disadvantageous thoughts feelings and behaviors that they would like to change and would be in their best interest to do so, there is simply no evidence that such things are literally illness like diabetes or the flu since there is no evidence of objective measurable damage or infection, only at best differences, but differences aren’t diseases. My position is that so-called mental illnesses are the natural human reaction to loss or to ongoing hardship/drudgery and that severe mental illnesses are the normal reaction to a major loss or to ongoing hardship/drudgery that is particularly arduous. It is not something that needs to be “treated” as a medical condition; rather, it can be alleviated, either by supporting individuals through their loss or actively helping them identify and extricate themselves from the harmful circumstances. Many people point to effectiveness of drugs as proof mental illness is real and that it is being treated by those drugs, but what drugs do, in some cases, is provide an altered mental state, which some people find preferable to disadvantageous mental states, this doesn’t demonstrate a correction of a “Chemical imbalance” rather all this demonstrates is that doing mind-altering drugs is fun and useful which is not something I disagree with. Personally I am pro-drug, if drugs can help, whether it be some smoka da ganja or antidepressants, if it improves your life then I am in favor of you having safe access to it. However I am critical of the current paradigm of psychiatry framing often dangerous psychoactive drugs as treating an underlying illness for which there is no evidence of existing, and can potentially do a great deal more harm than good. The issue here is not whether people should or shouldn’t take these pills. That’s each person’s individual choice. The issue is psychiatry pushing these dangerous brain-disruptive chemicals on people, under the religious farce that they have an illness, for which the pills are the necessary, effective, and safe treatment.

    So in summary, I do believe people suffer greatly as a result of undesirable and disadvantages thoughts, feelings, and behaviors, such as depression, however viewing this through the lens of “disease” is incorrect and dangerous and psychiatry lacks legitimacy as a field of science. So-called mental illness are just the result of problems with living, life is hard, people have struggles, biases, funky beliefs, etc. Humans are complex and fallible, but none of that is disease, those are simply the symptoms of our terminal humanity.

  • The source card for the main study is incorrect. The card looks to be recycled from the first Ioannidis paper, not updated for the more recent network meta-analysis. Would it be possible to add a link to the meta-analysis in the description? I got really excited and was hoping to read it.

  • What’s weird is people talk about lithium causing weight gain, whenever I took it for three months I lost over 35 pounds. Not sure if it was the lithium or what. Worked tho for my depression.

  • Thank you so much for this lecture! It really helped. Question: Trazodone and nefazodone has similar effects as SSRI’s? If we had to classify, is it closer to a SSRI?

  • For me personally, antidepressants make it so I can function. They don’t make it so I don’t have off days, but they make it so I can make more progress in my mental health.

  • Clinical best practice indicates that people have best outcomes with combined pharmaceutical and psychotherapeutic support. Could you review this evidence as well?

  • Why get off them. They save lives. It’s like telling a diabetic to stop taking insulin. Depression is not just environmental it’s chemical and genetic.

  • I’m 63 yo been on Prozac 4 yrs. It changed my life.I intend to NEVER stop taking it. On and off I tried to selfmedicate all my life. I liked the pills,could never drink alcohol. PROZAC SAVED MY LIFE!

  • I am taking sertraline and I am really worried it will mess up my serotonin and after a few months the serotonin wont be produced by the brain without the substance. Am I right on thinking that? Can sertraline damage the brain permanently?

  • Where are the links to the meta-analysis reports? Also please don’t wear stripes and checks It looks terrible in general, but worse in a digital format

  • I really believe antidepressants work, but how to fix dying communities, loss of social interaction, alienation at work and hopelessness?? You could mitigate the feelings, but you will need more to forget.

  • Why do doctors prescribed antidepressants for people with fibromyalgia and other chronic pain conditions as the first medicines to try even when depression isn’t a big factor in the diagnosis at the time?

  • I understand that an individual instance does NOT represent a trend, butI have depression ans have tried a bunch of kinds of medications over the years. I am on one and seem to be doing SO much better, and I can assure you my life situation has not improved. It makes it far more manageable. I am pretty sure I would be dead without them. (I am a strong advocate for using them along side therapy, though!!! It isn’t some miracle pill and I understand that.)

  • After being depressed and anxious since I was a kid, that eventually progressed into me not being able to leave my house for almost a year, I started an antidepressant and antianxiety 6 months ago. Already I am able to leave my house every single day and interact with people without sweating, my heart racing, and scratching myself to the point of bleeding. Other methods have helped but not this much. Though obviously this is not the case for everyone (I had a horrible reaction to prozac) it does work for some people, and for those people it can 100% change their life. I finally have the ability to seek out and try other treatments. This medication may just be an aid to get to a slightly better place, just enough to be able to go from there.

  • I’m so glad this is a source I can go to that looks at medication critically without throwing it all under the “big pharma” and “natural resources are better” bus. (Not saying big pharma doesn’t exist, but as someone who grew up with no medicine whatsoever, I have no trust in those who say all, or even most, medication is bad.)

  • This is the most evil and detached mechanical disempowered view on the issue. The drugs create classical physical dependence! The treatment is prescribed addiction! And for a recovering addict, it a moral conondrum and a compromise of ethics to subject oneself to the opaque glass eye of the psychiatry industry

  • Based on vast personal experience with family and friends, antidepressants should be outlawed forever!

    They destroy lives, extremely addictive, they make drug companies rich, wealthy and powerful.

  • Problem with one size fits all health generalization and stereotypes is in reality not everyone can react the same way. I can see why anti Baxter’s are paranoid about health care because of such bullshit.

  • Antidepressants increase depression and anxiety in kids and are known to cause a permanently depressed/anxious state, yet prescriptions to minors are still allowed. Why didn’t you mention this?

  • take at least 6-12 Months after you`re free of symptoms.. after 2nd relaps think about taking a low dose for the rest of your live… funnier things to do but it´s a cronic disease… it´s not just the mental side, it´s also a disorder in your brain, you brain is not working right…… and that can only be treated with meds… others have to take meds all their life for heart diseases etc…  don`t think about it all the time.. if you want, compensate by a healthy lifestyle

  • http://www.TheAntiDepressionStore.COM

    Products that can help to significantly reduce and even eliminate symptoms of Anxiety & Depression.

    Thank you for this helpful video
    TheDepressionDr.com

  • I understand the usuuefulness of meta analysis studies and other forms of data collection and examination for professionals who know what they are doing to be better at their job, but considering how often and how easily studies can be manipulated to show certain results they didn’t receive. 11 major studies on anti depressants repackaged to give conflicting outcomes? If someone says “here’s some data and research” nowadays are they really saying anything at all?

  • Apparently, Dr. Harriet Hall disagrees with you.

    “This new evidence is impressive. Only the most perversely recalcitrant antidepressant denialists will continue to say that the drugs are no more effective than placebo. The debate is over. Questions remain about effect size and prescription guidelines, but it has been satisfactorily established that antidepressants (all of them) work better than placebo. Depression kills; antidepressants can help prevent suicides, relieve suffering, and improve quality of life and functioning. Thanks for that, Big Pharma.”

  • Awesome and highly informational. I was looking for the reasons for the side effects for desvenlafaxin, in both areas were explained. Spinal, and gastrointestinal.

  • My guess as to why this is so hard to fix is the fact that depression is a normal feeling that people should feel from time to times and not necessarily a chemical problem, if you work long hours, have no partner and live alone I would argue you should feel depressed, you are living so far from what humans did 20,000 years ago. We should look to curing our life styles that are lonely and lacking family. Look at rat park, social improvements can cure drug addiction, I’m sure they can help cure depression.

  • This is purely speculative, but if people are prescribed a drug that’s been on the market long enough to start picking up detractors and anecdata saying it doesn’t work or has some strong negative side effects, a newly released medication wouldn’t have that same history to overcome as far as a negative bias possibly influencing perceived patient benefit. An established but possibly negatively “reviewed” drug would bias patients against it while a new one would not yet have those expected weaknesses or questioned (not questionable) efficacy.

    Just a thought. The brain is weird like that.

  • If I may paraphrase a joke from Craig Ferguson:
    “Yes, these pills are a crutch… Who cares?!
    You don’t kick a crutch out from under a one legged person and tell him to hop!”

  • All psy drugs can induce anhedonia (not only ssri, even if they are more likely to cause it), which is an intolerable condition. Anhedonia induced by psy drugs means: the total inhability to feel pleasure. It’s not just that mild depression where you have less interests or feeling very anxious, it’s just that you can’t “feel” anything. You can’t have sex because you don’t enjoy it physically. You don’t eat, and you are not hungry, because you don’t have any pleasure in eating even the most delicious meal. You can’t feel love, even for your partner. You don’t feel love for your children, or your parents, your pet, or anything like that. You don’t have any interests left. You can’t feel any pleasurable sensation. You don’t react to external stimulus. Someone can menace you or your loved ones, you don’t feel anything. You will only react because you know that if your emotions weren’t numb you would react, the rationality is the only thing left, but you are suffering so much you end losing all rationality. You are in this zombie-state, chemically induced, sometimes with only 5 or 6 pills, you never know how you will react and after how many pills since it’s due to your metabolism of the cytochrome P450 (mainly CYP2D6 for psy drugs). You never know when it will end. When you tell to your psychiatrist, he tell you it’s your disease. You was consulting for chronic tiredness and lack of confidence? Too bad, it’s your disease if you feel nothing!

  • I am looking for info on
    Anti depressant side effect symptoms and tips for dealing with it

    current side effects include

    jaw clench urge
    talkative
    continuous bliss regardless of situation for example being able to find negative situations amusing rather than negative
    missed sleep cycles

    extreme negative side effects include

    megalomania
    rage
    rage caused by minor events or occurrences or previously known and processed information

    most annoying side effect is
    realization of medication side effects
    and their negative effect on behavior
    yet

    still not caring about negative side effects
    due to

    megalomania
    bliss
    rage

    combination

    my assumption is some sort of combination of
    ssri
    and
    Ritalin or dex

  • I see a lot of people keep on talking about Erectodom Secrets. But I’m uncertain if it’s good. Have you ever tried this popular erectile dysfunction treatment?

  • https://en.m.wikipedia.org/wiki/Akathisia

    If you or someone you know is taking a psychiatric medication, you owe them this information. Psychiatrists are informed by the FDA and drug companies which have provided untruthful and fraudulent information regarding akathisia for 50+ years. Once this is triggered there is no help

  • When being prescribed anti-depressants, my doctor wrote out an x/y graph. X being effectiveness, and Y being acceptability. Based on this graph he let me choose.

    What do you think of doctors having a tool like this? His was made on his interpretation of research he’s read, but wouldn’t something based on clinical research and measured values, that’s standardized be better?

  • medical school must teach integrative medicine environmental medicine lifestyle medicine these modalities are a minority in th emedical profession which is defacto whiteman medicine a related matter from socrates WHO head is non white staywithme but he is ignoring non white medicine ayur veda TCM traditional chinese medicine which WHO knows as traditional and complimentery medicine they should use it
    maharishi ayur veda is most complete leading edge of integrative medicine

    also test Dr fred Klenner protocol [[[ JAMA 1949 ]]] high dose intravenous vitamin C
    and test real licorice found effective against SARS western master herbalism MH degree NH degree which have been treated as heresy

  • Antidepressants work very well for me(ive been on the same one for almost two years. The only negative side effect ive had is a lowered metabolism, and therefore weight gain. And I have severe major depression, anxiety, and anorexia nervosa as a result of ASD. I’ve recovered from all 3 too

  • Please please do an episode on the new FDA approved migraine medicine coming out soon! It’s the first time in over 20 years a migraine medicine was put on the market and all us chronic migraine suffers are kinda freaking out about it! ��