Study States More And More People Should Use Anti-Depressants

 

Do Antidepressants Work or What?

Video taken from the channel: Healthcare Triage


 

How Long Should You Take Antidepressants For?

Video taken from the channel: The Doctors


 

The ‘extreme’ side-effects of antidepressants BBC News

Video taken from the channel: BBC News


 

Study shows antidepressants are effective

Video taken from the channel: 5 News


 

Pharmacology ANTIDEPRESSANTS SSRIs, SNRIs, TCAs, MAOIs, Lithium ( MADE EASY)

Video taken from the channel: Speed Pharmacology


 

Study shows that antidepressants are more effective than a placebo

Video taken from the channel: OxfordHealth


 

How Long Should You Use Antidepressants?

Video taken from the channel: Wall Street Journal


Millions MORE of us should be taking antidepressants: Largest-ever study claims the pills DO work and GPs should be dishing them out Study examined 120,000 people in more than 500 trials across three decades Experts at Oxford University declared anti-depressants are helpful to the ill They hope. More Americans are using prescriptions for anti-anxiety and other mental health medications as the country struggles to cope with the COVID-19 pandemic. Between mid-February and mid-March, use of. Scientists say they have settled one of medicine’s biggest debates after a huge study found that anti-depressants work.

The study, which analysed data from 522 trials involving 116,477 peopl. A study calling for a million more patients to be prescribed antidepressants on the NHS has sparked a backlash by experts who say it ignores the dangers. Prescriptions of the drugs have soared in.

On Wednesday, a large new study provides evidence that antidepressants are more effective than placebo at treating acute depression in adults. The study. The study, published in JAMA, looks at nearly 10 years of medical records that include more than 100,000 prescriptions written by about 160 primary care.

Doctors should prescribe more antidepressants for people with mental health problems, study finds Data from 522 trials, involving 116,000 patients found that every one of the 21 antidepressants. Millions more people around the world should be prescribed pills or offered talking therapies, which work equally well for moderate to severe depression, say. The current focus on long-term use is troubling, and he says, “I think the field doesn’t have as good answers as we would like.” But Kramer believes in antidepressants when used correctly.

“People who respond to antidepressants find that their sadness is more subject to logic—they can talk themselves out of it,” says George I. Papakostas, MD, an assistant professor of psychiatry.

List of related literature:

Indeed, this study too showed that most persons with moderate or low levels of depression gained nothing by adding medications to the psychotherapy provided.

“The Heroic Client: A Revolutionary Way to Improve Effectiveness Through Client-Directed, Outcome-Informed Therapy” by Barry L. Duncan, Scott D. Miller, Jacqueline A. Sparks
from The Heroic Client: A Revolutionary Way to Improve Effectiveness Through Client-Directed, Outcome-Informed Therapy
by Barry L. Duncan, Scott D. Miller, Jacqueline A. Sparks
Wiley, 2011

Again, few studies have looked at this population for a sufficient time, but what studies exist do support the efficacy of antidepressants in this population.

“Psychiatry” by Allan Tasman, Jerald Kay, Jeffrey A. Lieberman, Michael B. First, Mario Maj
from Psychiatry
by Allan Tasman, Jerald Kay, et. al.
Wiley, 2011

Other studies have also reported significant reductions in outcome with depression.

“Scientific Foundations of Cognitive Theory and Therapy of Depression” by David A. Clak, Aaron T. Beck, Brad A. Alford
from Scientific Foundations of Cognitive Theory and Therapy of Depression
by David A. Clak, Aaron T. Beck, Brad A. Alford
Wiley, 1999

Since there probably are many more people who are depressed than those taking antidepressants, these figures are astounding.

“Calm Energy: How People Regulate Mood with Food and Exercise” by Robert E. Thayer
from Calm Energy: How People Regulate Mood with Food and Exercise
by Robert E. Thayer
Oxford University Press, 2003

By way of background, the researchers cited several prior studies, all of which should have told the regulators that their warnings to discourage antidepressant use lacked empirical support and that it could indeed be harmful to the mental health and well-being of depressed children and adolescents.

“Research Methods in Psychology: Investigating Human Behavior” by Paul G. Nestor, Russell K. Schutt
from Research Methods in Psychology: Investigating Human Behavior
by Paul G. Nestor, Russell K. Schutt
SAGE Publications, 2011

This is often the case with antidepressant medications: some of the world’s best-selling antidepressant drugs have been regarded as useless because new evidence has shown that most of their ability is due to the placebo effect.

“How Your Mind Can Heal Your Body: 10th Anniversary Edition” by David R. Hamilton, PHD
from How Your Mind Can Heal Your Body: 10th Anniversary Edition
by David R. Hamilton, PHD
Hay House, 2010

This seems surprising given that drugs are the most common treatment for depression in the UK, and it is also surprising that so few studies have been conducted in the UK.

“Psychology of Physical Activity: Determinants, Well-being, and Interventions” by Stuart Biddle, Nanette Mutrie
from Psychology of Physical Activity: Determinants, Well-being, and Interventions
by Stuart Biddle, Nanette Mutrie
Routledge, 2001

indeed, in many of the unpublished studies, ssris have failed to outperform placebos.

“Crazy Like Us: The Globalization of the American Psyche” by Ethan Watters
from Crazy Like Us: The Globalization of the American Psyche
by Ethan Watters
Free Press, 2010

But the study was not designed to examine how MBCT would fare against antidepressants alone.

“Mindfulness-Based Cognitive Therapy for Depression, Second Edition” by Zindel V. Segal, John Teasdale, Jon Kabat-Zinn
from Mindfulness-Based Cognitive Therapy for Depression, Second Edition
by Zindel V. Segal, John Teasdale, Jon Kabat-Zinn
Guilford Publications, 2018

However, they also noted that 40% of depressed individuals respond to placebo over a 3to 4-week period.

“New Directions in Affective Disorders” by Bernard Lerer, Samuel Gershon
from New Directions in Affective Disorders
by Bernard Lerer, Samuel Gershon
Springer New York, 2012

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

[email protected]

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81 comments

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  • about the last point of the pharmaceutical companies not having much incentive to get more data, wouldn’t competitive advantage over other potential therapies be one reason for them to gather this sort of higher quality data? Or is the competition between different drugs not yet high enough to impact companies’ decisions in this way?

  • Wow! So much the good doc does not mention here. How about how these medications are dependency forming. Not addictiveyou don’t crave them. But once you start taking them you become dependent on them, meaning you need to keep taking them just to stay normal. And how about when the doc says there is no evidence that long-term use of these meds are bad for youhas there been much research? There would likely not be much official evidence if there hasn’t been any official research. I’m sure the meds help some people. I’m sure there is depression that is purely chemically based, but very often depression is a symptom of a problem in your life. When you deal with the problem, your depression will lift. The right anti-depressant is often not a pill but a lifestyle change or just getting through a bump in the road and having a great support system. And if you start taking anti-depressants, of course you chances of relapse are highbecause these meds are dependency forming. As for getting off the meds, you can’t do it cold turkey. You have to find a doc who is down with getting you off the meds and then do it slowly and incrementally. And by the way, they talk here about the likelihood of having a second major depressive episode if you have had a first, but is that second episode most likely to happen if you have been on meds and go off? What does the research say about the likelihood of having a second major depressive episode if you got through the first one without chemical intervention. Just so much not discussed in this clip. Conveniently left out. Wonder how many of the people in this clip are on the drug company’s payroll.

  • this mustache is a liar and a crook psychiatrist. There is way too much evidence of long term use being harmful to ignore. How much is he getting paid by pharma to say otherwise?

  • Antidepressants cause side effects when in use and causes withdrawal syndrome when you leave them. They make problems even worser. Worthless anti-depressants are worthless.

  • Really annoys me that doctors never look into the nutition of a patient which I beleive is one of the main reasons for mental illnesses. So of course if you’re coming off your meds but still eating badly you won’t be supplying your neurotransmitters with the right nutrition. Secondly most people come off antidepressants much too quickly and what doctors say is the mental illness coming back could very well be simply withdrawal symptoms. Best not to ever start these drugs and look into your lifestyle and nutrition first. Stresses cause nutritional deficiencies..

  • Been researching this for 15 years, for me antidepressants actually do more harm than good. Ssris and snris feel like a shitty version of amphetamine. Ssris narrow your emotional “bandwidth” so you don’t get sad but you dont get giddy or joyful either

  • When I was young, I developed a minor tick disorder. As a result, the doctors put me on powerful antidepressants, because after all, in their minds, any drug is better than no drug. The antidepressants made me completely withdrawn socially. Today I am forced to be on welfare because I have zero ability to make friends, and of course because I failed college.

  • Once you have clinical depression & especially if you have been hospitalized then I recommend you taking It lifelong. If you stop it you may relapse & end up in a hospital.

  • I used to suffer and share my story on my channel here and now I’m going al carnivore and learning that diet causes mental disorders and also cures it! I read a testimony the other day of a son who helped cure his mom of schizophrenia in 3 days with a water fast. I don’t use any pharmaceutical drugs!! There’s NO pharma drug where benefits outweighs the risk! They add these things so people will have suicidal ideation otherwise they’d pay for things such as the gym memebership, massage therapy, acupuncture and prescribe a healthy diet like all carnivore! Just found out USDA and WHO have been lying to us all these years about food and specifically meat!! Check out Dr. Paul Saladino on here. He’s a Psychiatrist and he concurs along with many other Fundamental Doctors!

  • Could you please make a video covering the PACE trial that falsely claimed GET and CBT are effective treatments for Myalgic Encephalomyelitis?

  • Moral of the story: Big pharma says take your meds the rest of your natural born life.
    It’s good for you and we make tons of money. Don’t worry that is what the meds are for. Besides if you have a side affect no problem we have a pill

  • Further Research List: (I keep thinking dysthymia)
    1) How well do antidepressants work for milder symptoms that fall short of major depression?
    2) How well do antidepressants work longer than 2 months, especially for mild symptoms?
    3) Does long term antidepressant use outperform placebo?

  • This was great, been searching for “what does chronic fatigue feel like” for a while now, and I think this has helped. Ever heard of Diyadelyn Ziyily Idea (do a google search )?

    It is a smashing one off guide for getting rid of chronic fatigue syndrome (CFS Also known as myalgic encephalomyelitis or ME) without the hard work. Ive heard some decent things about it and my neighbour got excellent results with it.

  • https://en.m.wikipedia.org/wiki/Akathisia

    If you or someone you know is taking a psychiatric medication, you owe them this information. Psychiatrists are informed by the FDA and drug companies which have provided untruthful and fraudulent information regarding akathisia for 50+ years. Once this is triggered there is no help.

  • Oh no, antidepressants are god’s gift to Earth and never have any negative outcomes for the people thrust onto them.

    Or so I’ve been told by some SciShow viewers, despite the real experiences on myself and other people. The flaws in the system aren’t hard to see when you’re willing to view them objectively. I can tell you right out you’re lucky if your prescriber bothers to tell you the advantages and disadvantages of each medication.

    I take umbrage with the whole “chemicals” assumption in the first place, but it’s the practice that’s most alarming, and all the money swirling around it. And it’s really annoying when you know you’ve had numerous negative experiences, but everyone keeps trying to sell you on the same idea, the idea of insanity. And who knows what these things have done to me long-term?

    I don’t want more pills! I want a different situation.

  • PSEUDO SCIENCE BS. YOU HAVE A CHEMICAL IMBALANCE REALLY, HOW DO YOU KNOW DOCTOR? DID YOU TEST MY SEROTONIN LEVELS WHEN I BLINKED. LYING BASTARDS!!! CORRUPT MEDICINE!!!

  • They’re not just used for depression but people who have panic attacks and severe anxiety. They probably do something since it’s hard to orgasm when you’re on them

  • they feel better on meds and want to come off.If they get depressed off the medication, has the medication done any good. or is it just doing good while its in the system. it just shows BIG pharma,s plan comfort not cure.

  • Don’t ever stop taking antidepressants. Once you start, your on for life and if you stop you’ll be suicidal anyway so the question becomes moot. That’s why that pill pusher won’t give a straight answer. It is interesting that these bozo’s are using the addiction term “relapse” for depressive episodes. Depression is not a choice, it comes on when your the most venerable all by itself and without your knowledge. It’s not falling off the wagon, there is no wagon save taking pills for the rest of your life. Don’t trust psychologists, they are shills for the big pharma, making a ton of money hooking you on a drug that you will be addicted to for many, many years to come.

  • I’ve been on lexapro for 14 years..I only take one 10mg pill once a week for the past year. Its the pick me up I need..Dr’s still write the Rx…

  • When you say “depression” are you just referring to clinical depression or are other diagnosis included in that spectrum? Like anxiety disorders and panic disorders?

  • I was diagnosed with General anxiety disorder and doctor gave me the SSRIS pills. I took one pill like told and my anxiety gone, i feel calm and everything, but i feel the whole day like im gonna puke. does anyone know is this normal? (first day ever of using this antidepressants)

  • Of course people are at a high chance of relapse. Antidepressants don’t treat or cure depression or anxiety, they are only for symptom management. If you’re not actually treating the cause (emotional/spiritual injury), you will be at high risk of those problems resurfacing.

  • took lexapro for three months, zoloft after that + lamictal… 11 months after starting meds…. i’m still here, stressors come and go, but that’s life. I believe that antidepressants work… but added therapy works wonders.

  • hallo kann mir bitte jemand helfen unsere medikamente sind essitaloprama 10 mg, paliperidon 6 mg, aripiprazol 5 mg und ketiapine 200 mg wir leiden unter sehr hohe Gewichtszunahme nebivolol 5 mg ist für Herz da die anderen medikamente einen Herzrythmus herzschläge erhöhen… wir haben jetzt den ketiapine weggelassen und nexivol also nebivolol nun halbiert.. bitte kann mir jemand rat geben wiesoo Gewichtszunahme so stark ist bitte bitte

  • Can someone tell me what over the counter drugs i can take. I’ve been suffering from anxiety worse than usual, my chest feels heavier than usual and i often get nauseous.

  • I have been on different antidepressants for 22 years
    Yes 22 years!
    My doctor keep giving me
    I want to stop theme
    But I’m so scared
    I lost my friends, family work…

    My life is ruined
    Any help here?

  • Would you consider doing a video on bipolar depression, and how it’s different from major/minor depression? I’ve only been able to gather vague and/or limited info so far on the topic and I really want to understand it better

  • how horrible ‘relapse ‘ is disingenuous most people do not relapse but for most they are experiencing drug withdrawal and possibly brain harm from having an artificial agent mess with receptor sites long term causing an imbalance to an organ our brains that try to keep balance

  • Someone is lying here.  If 2/3 of people on anti-depressants are depressed then an increase in depression following “quitting” has to do with rebounding.  If there is no physical stimulation to produce the serotonin, then the receptors will have nothing to “catch”!  However, if the patient is getting adequate sunlight, “vigorous” exercise, practice at laughing it’s unlikely that he/she will fall back into depression.  Come on people this is not an absence of neurochemicals it’s an absence of physical stimuli which produces the neurolo-chemical deficiency!!!! Also, if more people are prone to suicide while taking ADs, then why in the hell would they be prescribed!?  I now that the correct answer has$ in it.  I also know that the re-imbursement form Pharma to Dr.’s directly can be as much as a quarter of a Million dollars annually!!! (SF Chronicle report and the highest reimbursements directly to doctors for prescribing 2016)

  • I took them 4 yrs but so suck of the regular check ups on how they were working after I’d taken it 4 8 yrs I stopped. Don’t wanna miss work 4 stupid doc apps that I didn’t need

  • I think those who are going through difficult times in their life, should just avoid medication. If their case of depression was caused by a problem, they really don’t need it because the depression will stop upon resolution. They’re basically only throwing money away and unnecessarily suffering the side effects.

    Of course, the problems are: 1. People may not know they have a problem or don’t know how to deal with the problem. 2. Something may be a problem for them which nobody else regards as a problem (I see jobs as a problem-For various reasons). 3. People don’t know how to communicate, or don’t know depression is a matter of communication. 4. People don’t realize that A. Solutions may take awhile to achieve or B. People have to figure out how to live around the problem because they can’t solve it.

    People say depression is a chemical imbalance. I don’t know if it is, but, if it is: I say the depression itself is the imbalance, but, it’s only temporary is the depression is caused by some hardship in life.

  • I’ve been taking Celexa for 10 years and I’m petrified to stop taking them but I’m concerned about the affects of long term use. I’ve had triple bypass surgery. Anyone have any relevant experiences?

  • Even as a person with severe chronic depression, antidepressants are risky and their effects highly variable. I’ve been prescribed some that have made my symptoms much worse, caused me great pain, and the like. Finding the right balance of psychiatric medication is a moving target-my needs change over the years, as do the effects I experience from some medications or combinations. I do wish psychiatric medicine had more of a grounding in science than it currently does.

  • For some reason, this video entirely omits long-term severe depression. It mentions long-term mild, and acute major, but those aren’t exclusive.

  • As someone who’s been in and out of psych hospitals for the past few years, I can say with certainty that antidepressants work. Just not for everyone. Unfortunately I’ve been unable to find a medication that works for me, but that doesn’t mean that they shouldn’t be tried by people. A modest amount of relief from symptoms is better than no relief at all.

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  • I have been taking AD for 6 years. I have several depressive episodes a year. I do get suicidal and I self harm. I have changed AD about 4 times. Now I’m on sertraline and mirtazapine.

  • Antidepressants can permanently remove your sexuality. See this site about Post-SSRI/SNRI Sexual Dysfunction. We have personal stories, professional letters and resources: @t​

  • https://en.m.wikipedia.org/wiki/Akathisia

    If you or someone you know is taking a psychiatric medication, you owe them this information. Psychiatrists are informed by the FDA and drug companies which have provided untruthful and fraudulent information regarding akathisia for 50+ years. Once this is triggered there is no help.

  • I have tried anti depressants in the past and disagree that they work with everyone as the longer I took them the worse I became! All I was being told by doctors is after so many weeks they will definitely start to work but eventually after months of taking antidepressants I stopped and eventually got better naturally

  • Took Effexor/Pristiq for the better part of 20 years and recently stopped cold turkey. The nightmares have returned but other than that I still haven’t seen an increase in sadness. However the risk/reward while taking this drug was kind of expensive. Several side effects made it barely worth it.

  • mianserine, the minimal dose gave me joints and muscle pain. i started using it 4 weeks ago for anxiety and insomnia. it is hard to find anything about this topic in the literature. also i expected to find more shared experiences on the Net.

  • The video states that activating “the bad” serotonin receptor, 5-HT2A, actually induces depression, yet research on Psilocibin (magic mushrooms) microdosing suggests the contrary. Any neuroscience/psychopharmacology grad students got any input on this? ��

  • anti-depressents
    they should just call them Depression killers
    they just make your brain IGNORE the drepssed feeling

    dosn’t CURE the cause of the depression

    which can mean you end up getting worse.

  • Dr Jarvis said they can find a medicine that will work for you eventually. Well, how can they find the right one when they don’t even know why the drugs work on the few that they do? They used to think it was a serotonin deficiency, but we know now that isn’t the case. So this fraud doctor thinks we should just keep trying other ones until we find one that works? The data from their own studies show they work no better than a placebo for most people, while having terrible side effects. The healthcare industry is one big ripoff for the patient.

  • ALL antidepressants are neuro toxin drugs. DO NOT ever take them and leave any doctor who prescribes them. People like us are the only people to stop these doctors and companies. DO NOT spend your hard earned money to let an idiot doctor poison your brain and body. These drugs often cause irreversible side effects. I took antidepressants for not even 2 weeks and my body and emotions are still numb (over a year ago). These drugs will ruin your life and eventually your families life when they don’t understand what happened to you and why your like this.

  • Who else is on a TCA? I can’t find many experiences with them (clomipramine) and want to meet someone who’s had success with one. SSRI and SNRI are not very helpful

  • Believe in yourself. You’ll get better! I promise. As long as you think you can get better you will… Just be yourself, That’s all you need to do ��

  • Depression/the need for antidepressant use should be reassessed at least every 2 years, and that assessment can involve trying lower doses or tapering off of the medications. This is recommended in the guidelines, but is rarely actually done. Why risk your patient falling back into depression when they are now used to taking the drug? There’s a benefit to taking fewer medications, but doctors are reluctant to take the risk.

  • Why would anyone tell you how to get off them? It’s pouring money when people are addicted to meds, drugs, alcohol, smoking or whatever, big corporations don’t really want that to stop..

  • I’ve never tried to kill myself not on antidepressants, yet every time I’ve taken antidepressants, I have tried to kill myself… Almost always within the first month of use, I have severe bipolar, and yet, I still try to kill myself. Some of the antidepressants I’ve taken, have caused other side effects like withdraws and panic attacks.

  • Hey everybody taking antidepressants! If the medication isn’t working for you,
    1. talk to your doctor (psychiatrist)
    2. Remember you aren’t depending on the antidepressants
    3. If you believe that it works, it will work.
    Believe in it. Believe in yourself. You’ll get better! I promise. As long as you think you can get better you will.

    I’m here to talk to so if any of you are going through anything, reply to this comment. You’re anonymous and I am too. You’re safe. There’s always someone there.

  • The question is, are these processes observable or merely theoretical? Darwinism, a theory is decompiling faster than I can type this comment. However, smug scientists were and some still yet are dogmatic about darwinism. Scientist can be some of the most lying and dishonest mother fuckers known to man……Prove me wrong.

  • Depression is not caused because of “imbalance of chemical”. Drugs do that to your brain. Ssris make your depression chronic. Drug business is shit and the research scores are manipulated and made by drug companies. Google More, for example http://www.ssristories.org, http://www.madinamerica.com

  • Thanks a lot! First I thought it’s quiet a bit too sketchy biology-wise, and you barely mentioned practical (medical) details.
    But now I see this is a very good basis for further medical study of the antidepressants!

    Also I wish it would be a bit about dopamine as well, particularly DRIs, NDRIs, SNDRIs (TRIs).

  • Since the 90s I’ve been on nearly all the available anti-depressants at one time or another (except tricyclics, not a good idea for someone with major depressive disorder too easy to use to commit suicide with) they all have side affects and some work better than others. But, and this is a big but, they help me function but they don’t “fix” me. Drugs may dampen the blackness but talk therapy brings back the sunlight and gives me the tools to deal deal with the cloudy days.

  • Antidepressants are not the cure of depression. Instead the correct diet which does not inflame the gut can stop it. As various inflammatory mediators are directly linked to brain to pass inflammation to the brain.

  • Hi Aaron. Love the series. However do feel like you could have mentioned the Lancet study published in February 2018 comparing efficacy of antidepressants. It was another paper that got a lot of coverage, here in the UK and I felt like it would have been relevant. Also mentioning how researchers distinguish between ‘limited’ or ‘small’ efficacy would have been interesting
    Regards
    Lily

  • Hi doctor speed pharmacology, hopefully u will be healthy s super fine, how i can get your notes ( pdf), please humble request to you Sir. I need your pdf notes. Must reply me sir thanks.

  • Yes, they work. The problem is some work great for some people and do absolutely nothing for others (or sometimes bad things). It’s frustrating. I have crippling OCD and it took 31 different medications to find one that worked. Once I got on a good dose it changed my life. I without a doubt still have OCD and some days are better than others but the drug gave me my life back.

  • “Severe depression”? The majority of people prescribed antidepressants do not have severe depression. The “benefits” do not outweigh the risks… given that the meta analyses show that SSRI medications do not outperform the placebo effect. These drugs represent criminal negligence in institutional medicine.

  • When antidepressants start to work, they make you feel like it’s not all that bad, really they can cause more damage when trying to come off them. Had problem? Now, you have a bigger problem. I have been antidepressants for 15 years, but now I really see how dangerous they are. Almost died due to withdrawal problems, and nobody was around, I myself wasn’t “around”.

  • Why do soooo many American women, that is white women, have these dipped gravelly rough half-swallowed voice speaking habits? Are they emotionally 2 years old?

  • Society wants everyone to feel like shit. Anything that makes you feel good is immediately branded as illicit. Yet antidepressants that make many people feel shit, especially at the start which they call “adjustment period” are allowed despite practically every antidepressant saying that we don’t understand how they work. The antidepressants not as thoroughly researched as illicit drugs, and they are never researched with the view that they should be considered illicit drugs always with the view they are legitimate and necessary forms of treatment. So we don’t know how they work (search Wikipedia for most antidepressants and in many places it will say something is unknown about every single one), we don’t know what the long term effects are, etc. Big pharma is not interested in your health with these tablets.

  • Scans for depressions???? They are wasting government funds on such works and in the end make us consume more of these AD’s than is necessary. They do not want to address the root cause.

  • I previously had very serious depression and anxiety and took medication for years. I did eventually begin to feel better and am now able to manage my symptoms and mindset, but I should note that I spent a lot of time in therapy and that the majority of the things that permit me to control my reactions now and helped me cope with things then were breakthroughs in therapy sessions. I am now off of medication entirely and, although I still have some issues, they are far from as bad as they used to be. I didn’t really notice any differences while I was on the medication alone (before going to therapy) but I can definitely say I noticed a difference when I was decreasing dosage and when they were no longer present. Thank you for bringing this information to light. It helps me think about my previous use and how, althought it seemed to work with me (in conjunction to other forms of treatment), it mat not work well with others

  • All I know is that Wellbutrin has lifted that depression negative energy that kept me from doing anything and replaced it with what I hope is normal.

  • Give that poison to that ‚doctor‘ who said,let them take some different ones!
    Why?.cause there is no real difference in ssri!they are all poison!

    if not,you‘re a lucky one that could try something else to get that done
    ,cause there‘re not that much!

    With Snri i don‘t know,but i pressume they‘re equal in that matter!
    Never take these poison,nothing what works like ssri!

    The big pharma studies wich ‚justified’ their claims for everybody,are all based on guesses n now u know everything what everybody have been guessed,hä?!!!

  • I remember I just abruptly stopped taking my antidepressants and I felt like I was going to die for the next couple of weeks. It was like withdrawal

  • For anyone people suffering with a debilitating mental illness, I implore you try a MAOI inhibitor. MAOI INHIBITORS, such as PHENELZINE, are the most powerful antidepressants in EXISTENCE.

    Psychiatrists don’t prescribe them often because of outdated and incorrect dietary restrictions, and because they are not profitable to corrupt pharmaceutical companies.

    For more information look at highly respected psychopharmacologist Dr Ken Gillman’s website https://psychotropical.com/

  • selegiline is the stuff and i can only imagine what tranylcypromine is like
    SSRIS dont actually describe the action of these drugs.
    Fluoxetine for example is unique because it upregulates 5ht2a and also inhibits 5ht2c,this translates to increased dopamine and norepinephrine.It will also, long term upregulate dopamine receptors as well as a1adrenergic receptors.Other ssris snris atypical and tricyclics,
    which also have a distinct pharmacology, will also have similar(long term due to receptor regulation) effects except 5ht2a upregulation.
    i think that 5ht2a activation is as good as its inactivation in terms of antidepressant properties.Saint johns wort for example produces a 50% increase in 5ht2a and 5ht1a density,while also being actually more potent as a norepinephrine and dopamine reuptake inhibitor.Considering serotonin affinities for receptors and competition for receptors between serotonin and the newest antidepressant, vortioxetine basically chugs serotonin into 5ht2 and doesnt produce downregulation like other agents.5ht2a activation has been linked to a bdnf increase.The other “SSRIs”stray from the description,as well.A study found that serotonin “hijacks” the dopamine transporter,resulting in co-signalling.Dopamine has a lot to do with antidepressant response overall.
    Dopamine transporter isnt present in the prefrontalcortex and the reuptake is done by the norepinephrine transporter,which is blocked by snris.This equals to increased dopamine levels on site specific parts of the brain like the pfc.Besides venlafaxine and desvenlafaxine have a not unreachable(dose wise)affinity for the dopatransport.
    <3

  • antidepressants ruined my life, this is a painfully honest comment. the problem in my case is the DISHONESTY!!! psychiatrists lie all the time

  • There really isn’t much evidence!? There is plenty of evidence that long term use of antidepressants can be problematic! LISTEN TO YOUR FRICK’N PATIENTS! You’re putting a neurotoxin into your body. You don’t need evidence, it’s common sense.

  • Fun fact: the overall effect size of the ‘these things work’ study was SMALLER than the effect of the first ‘these things don’t work study’ XD

  • For the gentleman with the shaking hand, I had a similar response to benzodiazepines and SSRI’s. Have you had your DNA checked? It was found with me that I am a rapid and ultra rapid metabolizer of many anxiety, depression, and opioid medications. I had seizures, speech problems, and involuntary movements such as yours. I am still trying to withdrawal from these drugs, as the withdrawal symptoms are horrible and in the beginning were like the side effects, only worse. It may be worth looking into. Thank you all for fighting this fight.

  • You just can’t stop taking any medication right away you could end up int the hospital! I’m an antidepressants and I love them and I’ve been on them since 5 years ago

  • As someone who’s been on and off anti depressants for 7 years doctor sportelli is talking bullshit about them not being addictive and have no side effects which are dangerous
    Serotonin Syndrome happens in people dependent on antidepressants more often than someone who go on Chinese medicine (or herbal medicine) because they take a substance ontop of their medication without realising it can increase the serotonin in their body which triggers serotonin Syndrome which can be easily mistaken as an overdose
    Not saying all his information is wrong but the addictiveness of antidepressants is being so badly underplayed here it pisses me off he can call himself an “expert” and not know that they are just as if not more addictive than illegal narcotics

  • Been taking antidepressants for 6 years. For the first almost 5 years my psychiatrist had to keep raising the doses consistently before I finally reached a good level. Last year I stopped taking one of them (under my doctor’s directions) and I didn’t feel a thing. Now I’m only taking three pills and they are working good. My mom keeps telling me I should finally stop taking them all, that I’m addicted, that they aren’t good for me etc. But I know I’m not an addict, I hate having to take my meds. I know I need them though and I really don’t wanna mess this balance up.

  • Me. Getting beautiful depression and its symptoms….
    Also me. A beginner jus finishing my second week of fluoxetine…lemme introduce to a lil longer affect of balancing everything out….
    Also me again… trying to write a comment trying to b funny but my lack of some chemicals in my brain cant tell the certain part of my brain to think if something funny and put it in the comment section…oh not blimen fair me not able to sleep when I really want too!!!