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Video taken from the channel: FMF Clips
Specific Hormones | Functions of Growth Hormone (hGH)
Video taken from the channel: Catalyst University
GF-1 Therapy: More Potent Than Growth Hormone Therapy To Reverse Aging? Thierry Hertoghe, M.D.
Video taken from the channel: AMMG CME Conferences & Certification
Clemens: The Growth Hormone/IGF-1 Axis in Bone and Muscle
Video taken from the channel: ASBMR
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The Dreadful Duo: Uncontrolled GH and IGF-1
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Somatopause is characterized by declining or deficient growth hormone (GH) and Insulin-like growth factor 1 (IGF-1) levels as you age. Growth hormone levels peak in adolescence and somatopause usually begins between the ages of 25 and 50, with growth hormone levels decreasing by 14% every 10 years of adult life. Age-related decline in the activity of the somatotropic axis (GHRH, GH and IGF-1) has been termed “somatopause” in analogy to the menopause and andropause, the age-related decline in gonadal function and plasma levels of sex steroids in women and men. Researchers show that the somatopause is related directly to the decline of growth hormone (a natural substance produced by the body) during aging.
In fact, biomedical research shows that increasing growth hormone can produce an average response of a 14 percent loss in body fat and an 8 percent gain in muscle. Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-1), declines over time until only low levels can be detected in individuals aged ≥60 years. Treatment with growth hormone (GH) has long been considered as a possible “fountain of youth” to promote improved function during aging.
Growth hormone production and secretion, GH binding protein, and insulin-like growth factor-1 (IGF-1) levels decline with aging, which is. Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-1), declines over time until only low levels can be detected in individuals aged ≥60 years. This phenomenon, which is known as the ‘somatopause’, has led to recombinant human GH being widely promoted and abused as an antiageing drug, despite lack of. Based on the decreases in GH and IGF-1 with age in both rodents and humans and their association with clinical conditions associated with aging, the concept of a “somatopause” (decreases in GH and IGF-1 with age) that leads to functional changes normally associated with age became prevalent in the clinical literature. The area of cellular metabolism surrounding growth hormone, IGF-1, and insulin is arguably the most studied set of mechanisms linking the operation of metabolism and the pace of aging.
It is impacted by calorie restriction, an intervention that reliably slows aging.The longest lived engineered mice are those in which growth hormone signaling is disabled, and there is an equivalent human. As HGH levels decline with age, so, too, do IGF-1 levels. Not only does IGF-1 production occur in the liver, but also on various target tissues regulated by paracrine/autocrine actions.
The relationship between IGF-1 and growth hormone regulates the level of insulin growth factor 1. IGF-1 has been shown to play a role in bone formation and can help prevent bone loss in older age (especially in post-menopausal women who are at the highest risk of bone-related disorders like osteoporosis). Researchers believe that IGF1 stimulates bone formation by having a.
List of related literature:
|from Osteoporosis in Men: The Effects of Gender on Skeletal Health|
|from Porth’s Pathophysiology: Concepts of Altered Health States|
|from Handbook of Models for Human Aging|
|from Williams Textbook of Endocrinology E-Book|
|from Principles of Orthomolecularism|
|from Endocrinology: Basic and Clinical Principles|
|from Endocrinology E-Book: Adult and Pediatric|
|from Exercise Physiology: Nutrition, Energy, and Human Performance|
|from Principles and Practice of Geriatric Medicine|
|from Clinical Imaging E-Book: With Skeletal, Chest and Abdomen Pattern Differentials|