Somatopause – The Decline of Growth Hormones and IGF-1 Levels With Aging


Insulin, carbohydrates and the IGF-1 pathway’s role in cancer and aging | Peter Attia

Video taken from the channel: FMF Clips


The longevity advantage of genetic deficiencies in growth hormone/IGF-1 signaling | Valter Longo

Video taken from the channel: FMF Clips


Specific Hormones | Functions of Growth Hormone (hGH)

Video taken from the channel: Catalyst University


GF-1 Therapy: More Potent Than Growth Hormone Therapy To Reverse Aging? Thierry Hertoghe, M.D.

Video taken from the channel: AMMG CME Conferences & Certification


Clemens: The Growth Hormone/IGF-1 Axis in Bone and Muscle

Video taken from the channel: ASBMR


The IGF-1 Trade-Off: Performance vs. Longevity

Video taken from the channel: FoundMyFitness


The Dreadful Duo: Uncontrolled GH and IGF-1

Video taken from the channel: Novartis

Somatopause is characterized by declining or deficient growth hormone (GH) and Insulin-like growth factor 1 (IGF-1) levels as you age. Growth hormone levels peak in adolescence and somatopause usually begins between the ages of 25 and 50, with growth hormone levels decreasing by 14% every 10 years of adult life. Age-related decline in the activity of the somatotropic axis (GHRH, GH and IGF-1) has been termed “somatopause” in analogy to the menopause and andropause, the age-related decline in gonadal function and plasma levels of sex steroids in women and men. Researchers show that the somatopause is related directly to the decline of growth hormone (a natural substance produced by the body) during aging.

In fact, biomedical research shows that increasing growth hormone can produce an average response of a 14 percent loss in body fat and an 8 percent gain in muscle. Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-1), declines over time until only low levels can be detected in individuals aged ≥60 years. Treatment with growth hormone (GH) has long been considered as a possible “fountain of youth” to promote improved function during aging.

Growth hormone production and secretion, GH binding protein, and insulin-like growth factor-1 (IGF-1) levels decline with aging, which is. Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-1), declines over time until only low levels can be detected in individuals aged ≥60 years. This phenomenon, which is known as the ‘somatopause’, has led to recombinant human GH being widely promoted and abused as an antiageing drug, despite lack of. Based on the decreases in GH and IGF-1 with age in both rodents and humans and their association with clinical conditions associated with aging, the concept of a “somatopause” (decreases in GH and IGF-1 with age) that leads to functional changes normally associated with age became prevalent in the clinical literature. The area of cellular metabolism surrounding growth hormone, IGF-1, and insulin is arguably the most studied set of mechanisms linking the operation of metabolism and the pace of aging.

It is impacted by calorie restriction, an intervention that reliably slows aging.The longest lived engineered mice are those in which growth hormone signaling is disabled, and there is an equivalent human. As HGH levels decline with age, so, too, do IGF-1 levels. Not only does IGF-1 production occur in the liver, but also on various target tissues regulated by paracrine/autocrine actions.

The relationship between IGF-1 and growth hormone regulates the level of insulin growth factor 1. IGF-1 has been shown to play a role in bone formation and can help prevent bone loss in older age (especially in post-menopausal women who are at the highest risk of bone-related disorders like osteoporosis). Researchers believe that IGF1 stimulates bone formation by having a.

List of related literature:

Although agerelated decreases in circulating IGF-I levels and/or the activity of the IGF system may contribute to impaired bone formation with aging, these changes may also explain, at least in part, the age-related increase in circulating sex hormone binding globulin (SHBG) levels [37].

“Osteoporosis in Men: The Effects of Gender on Skeletal Health” by Eric S. Orwoll, John P. Bilezikian, Dirk Vanderschueren
from Osteoporosis in Men: The Effects of Gender on Skeletal Health
by Eric S. Orwoll, John P. Bilezikian, Dirk Vanderschueren
Elsevier Science, 2009

Growth hormone (GH) levels can also decline with aging, and there has been interest in the effects of declining GH levels in the elderly (described as somatopause).

“Porth's Pathophysiology: Concepts of Altered Health States” by Sheila Grossman
from Porth’s Pathophysiology: Concepts of Altered Health States
by Sheila Grossman
Wolters Kluwer Health, 2013

Circulating levels of growth hormone (GH), and of insulin-like growth factor-1 (IGF-1), decline with aging.

“Handbook of Models for Human Aging” by P. Michael Conn
from Handbook of Models for Human Aging
by P. Michael Conn
Elsevier Science, 2011

A decrease in growth hormone (GH) release by the pituitary gland causes a decrease in the production of insulin-like growth factor 1 (IGF1) by the liver and other organs (somatopause).

“Williams Textbook of Endocrinology E-Book” by Shlomo Melmed, Ronald Koenig, Clifford Rosen, Richard Auchus, Allison Goldfine
from Williams Textbook of Endocrinology E-Book
by Shlomo Melmed, Ronald Koenig, et. al.
Elsevier Health Sciences, 2019

The decline in levels of IGFBP-3 with age is not as great as that of IGF-I, resulting in a relative excess of IGFBP-3.

“Principles of Orthomolecularism” by R. A. S. Hemat
from Principles of Orthomolecularism
by R. A. S. Hemat
Urotext, 2004

(Left) A decrease in growth hormone (GH) release by the pituitary gland causes a decrease in the production of insulin-like growth factor-1 (IGF-1) by the liver and other organs (somatopause).

“Endocrinology: Basic and Clinical Principles” by Shlomo Melmed, P. Michael Conn
from Endocrinology: Basic and Clinical Principles
by Shlomo Melmed, P. Michael Conn
Humana Press, 2007

Leal-Cerro A, Garcia E, Astorga R, et al: Growth hormone (GH) responses to the combined administration of GH-releasing hormone plus GH-releasing peptide 6 in adults with GH deficiency, Eur J Endocrinol 132(6):712–715, 1995 Jun.

“Endocrinology E-Book: Adult and Pediatric” by J. Larry Jameson, Leslie J. De Groot
from Endocrinology E-Book: Adult and Pediatric
by J. Larry Jameson, Leslie J. De Groot
Elsevier Health Sciences, 2010

Decreased growth hormone (GH) release by the anterior pituitary depresses production of IGF-1 by the liver and other tissues, which inhibits cellular growth (a condition of aging termed somatopause).

“Exercise Physiology: Nutrition, Energy, and Human Performance” by William D. McArdle, Frank I. Katch, Victor L. Katch
from Exercise Physiology: Nutrition, Energy, and Human Performance
by William D. McArdle, Frank I. Katch, Victor L. Katch
Lippincott Williams & Wilkins, 2010

Trials with patients have shown that responses to growth hormone or growth hormone secretagogues, as measured by serum IGF-1 levels, persist in the elderly.

“Principles and Practice of Geriatric Medicine” by M.S. John Pathy, Alan J. Sinclair, John E. Morley
from Principles and Practice of Geriatric Medicine
by M.S. John Pathy, Alan J. Sinclair, John E. Morley
Wiley, 2006

Because the growth centers have not closed, increased levels of growth hormone in skeletally immature patients result in giantism.2,68,76 Giantism patients with persistent increases in growth hormone also demonstrate acromegalic features.

“Clinical Imaging E-Book: With Skeletal, Chest and Abdomen Pattern Differentials” by Dennis Marchiori
from Clinical Imaging E-Book: With Skeletal, Chest and Abdomen Pattern Differentials
by Dennis Marchiori
Elsevier Health Sciences, 2004

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

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  • A video on IGF-1 that does not mentioned anything related to its effects on cancer in humans, neither the foods that causes it production to increase… could you please comment on that?

  • I periodically take TA-165 to boost HGH. I feel and look 100% better. What are your thoughts about cancer with taking HGH or HGH boosters?

  • Yes, calory restriction is not the same thing as eating less often. �� I’m 70 and an very pleased with how things are going. #growingyoung

  • All of this assuming you are only taking IGF-1 and GH Ubiquinol, Alpha GPC, and many other supplements have protective antioxidant effects. Make your stack DEEP ladies and gentlemen.

  • I say this with the utmost respect if there is one woman I would want to make sweet sweet love to, it’s Dr. Patrick. In the whole world. Include everyone. For me, she’s the one. No other mouth has looked sexier saying the word “polyphenols’ as Dr. Patrick, in the annals of human history.

  • Longevity in regards to not going into a heavier state of repair as much and causing less oxidative stress within the body but what use is that when GH and igf1 are release periodically in times of need as we recover, in reality you’re just saying those who’s bodies spend more time healing/recovering are going to shorten their life span which makes some sense but to lower igf1 also comes with alot more of its own risks due to its synergism with other hormones and it’s knocking affect on health and recovery. If I’m lying in a cage or glass box permanently in a lab environment then yes of course lower igf1 levels would mean a longer life but in the real world where there is risk and reward I’m gonna want the correct GH and igf1 response in any situation to get me trough life and help me sleep, repair and completely recover in shorter time. I would no doubt assume that keeping that low igf1 mouse in with a standard group of mice outside a lab environment would drastically shorten its life due to its hormonal handicap. Not all avenues of repair will be affected but some clearly important ones will be no doubt.

  • “Cancer” is caused by sugar, fructose, fungus, yeasts, molds,toxic diets,pesticides, dairy, hormones,” prions “, virus in meat,chlorinated water,, high oxalate crystals, high uric acid,, Stress, UV radiation exposure, G5 towers, electric magnetic radiation-damaged, heated fats, fried foods, high protein diets, processed food, refine carbohydrates.

    “Eat a low “”lectin”” ” low “oxalate” ” diet “…no spinach, no wheat!.no bread, no pasta!
    American cuisine is poison, cosmic UV radiation exposure (sun), mercury in Fish.

    If you keep you blood sugar below 85 and you eat organic plant base diet you will never get Cancer.

    Many people feel tired and depressed they exercise they eat healthy..They forget that Candida fungus and yeast in the body cause chronic fatigue, brain fog, chronic depression and many diseases in the brain and body ; Fungus, candida and yeast love fructose -> Fruit and high refined carbohydrates.

    Fructose causes a “fatty liver”…damages the liver, weight gain, and feeds parasites, Candida, yeast in the body..

    all bacteria, virus fungus love “fruit sugar “.__ Fruit is poison and addictive! > (fructose)

    Read the Book called ; “”The Yeast connection handbook “”By Williams G Crook, M.D.

    “Cats claw” is a an amazing herb it good for Amyloid in Alzheimer’s great to kill candida and virus also taking oregano oils, MSM sulfur, coconut oils are good for fungus and yeast or you can go to your doctor and get a prescription for anti-fungal medication called “NYSTATIN”

    Watch what you put in your mouth.

    Don’t dig your grave with your teeth.

    Coffee is another drug (caffeine ) makes the liver to release sugar to the blood and this causes ” insulin” surge to be released by the pancreas..the result is hunger and weight gain!

    you want to lose weight? no coffee, no tea….no caffeine!….coffee and teas are a drug > ( caffeine )

    Liver Detoxification –. L-Ornithine is truly special, because it helps your body eliminate extra nitrogen amonia from high protein diets and other types of waste.

    The liver hates fat, fried food, heated damaged fats, sugar, fructose, chemicals,pesticides -> Detox!

    I LOVE chromium GTF by NOW. I have been using this for years. I’d been having a lot of difficulty with low blood sugarwith hand tremors & a foggy head. When I take this supplement daily, I feel steady all day even if I’m late eating a meal. appetite control & sugar cravings along with eating lower carbs. help keep my blood sugar in line.

    -If you’re trying to losing weight the solution is “Fasting ” and eating a plant base diet..the less you eat the longer you will live.

    great book ; The Obesity Code: Unlocking the Secrets of Weight Loss by DR. Jason Fung

    A “mycotoxin ” is a toxic secondary metabolite produced by organisms of the fungus kingdom and is capable of causing disease and death in both humans and other animals. The term ‘mycotoxin’ is usually reserved for the toxic chemical products produced by fungi that readily colonize crops

    = Mycotoxins are toxic compounds that are naturally produced by certain types of moulds (fungi). Moulds that can produce mycotoxins grow on numerous foodstuffs such as cereals, dried fruits, nuts and spices.

    -Aflatoxins are amongst the most poisonous mycotoxins and are produced by certain moulds (Aspergillus flavus and Aspergillus parasiticus) which grow in soil, decaying vegetation, hay, and grains. Crops that are frequently affected by Aspergillus spp. include cereals (corn, sorghum, wheat and rice), oilseeds (soybean, peanut, sunflower and cotton seeds), spices (chili peppers, black pepper, coriander, turmeric and ginger) and tree nuts (pistachio, almond, walnut, coconut and Brazil nut).

    The toxins can also be found in the milk of animals that are fed contaminated feed, in the form of aflatoxin M1. Large doses of aflatoxins can lead to acute poisoning (aflatoxicosis) and can be life threatening, usually through damage to the liver. Aflatoxins have also been shown to be genotoxic, meaning they can damage DNA and cause cancer in animal species. There is also evidence that they can cause liver cancer in humans.

    Ochratoxin A is produced by several species of Aspergillus and Penicillium and is a common food-contaminating mycotoxin. Contamination of food commodities, such as cereals and cereal products, coffee beans, dry vine fruits, wine and grape juice, spices and liquorice, occurs worldwide.

  • Yes, Dr. Hertoghe has an accent because he is from Antwerp and is a physician with an office in Brussels, Belgium.

    Dr. Thierry Hertoghe devotes his life to the promotion of a better, patient-oriented and evidence-based medicine.

    Thanks for liking our channel…
    Check out our latest videos from the the AMMG 2012 Conferences

  • I wouldn’t say the relationship between longevity, performance, growth factors is super straightforward. There are lots of animal models that don’t follow the expected path (I think there are a couple reviews that cover growth hormone/igf-1 manipulations), and there are plenty of other chemicals that affect performance and longevity, making context important.

  • Fasting and intense exercises like HIIT increases growth hormone and thus IGF. So does that means they accelerate ageing? But there are numerous studies showing the benefit of exercise and fasting in slowing down ageing by boosting NAD+. So if increased IGF can be equated to increased ageing, how can this be true?

  • “When you increase the expression of growth hormone by 100 or 1000 fold, that reduces the life span of mine by 50%.”

    Bruh NOBODY is taking growth hormone at anywhere near those doses lmfao. Taking a couple IUs of growth hormone every day will double or triple your natural IGF levels. Not increase them even remotely near 100 times lmao

  • I realize this is an old video but her latest podcast (last 2 years) would seem to contradict this. Not the science, that seems consistence. But her stance on how to approach this seems to have changed. She seems very much in favor of intermitting fasting. Almost all her guest are pro-intermitting fasting. Which is not caloric restriction per se but it has similar affects on IGF1. At least according to people she has had on he podcasts like Dr. Longo

  • I say go ahead and boost GH and IGF-1, just don’t take 100 1000x the amount. Take the same amount you would have likely had at your peak. And by all means go ahead and take the polyphenols/catechins too. Hopefully there is a way to get the best of both worlds.

  • Im on 4th day of dividing dry fast with water fast and I have a question…Is it ok to do moderate exercise when you fast like this, will that increase IGF1?

  • There is no trade-off. Doctors need to understand the holistic nature of the human body and not hone in on a specific chemical and it’s effects. People who eat right and exercise and have high IGF-I levels don’t get cancer, those who have bad diet, improper sleep and lots of stress and high IGF-I levels may get cancer. The body is holistic, stop picking it apart and analyzing it in a way that it doesn’t actually work.

  • 100-1000 percent? Who the fuck wants to live past 75?you can’t do anything. Who is going to take 100IU a day of GH? This is informative but I see a lot of holes.

  • Watch the full episode:

    FoundMyFitness episode page:

    More clips from this guest:

  • Leave caloric restriction for the mice? What about all her talks with Dr. Longo? This is 2013 video. I see her visits with Dr. Longo is in 2016

  • Why not inform people yay if they off animal proteins they will have. Significantly low IGF levels? Why not suggest they iNclude more plant foods and less animal proteins in their daily diet

  • Similar to the way people process caffeine differently, some people need to increase IGF-1 and others should focus on reduction. One problem is the further down the rabbit hole one exploresmuch of the available data is contradictory. In other words one study reports a substance increases IGF-1 while another study reports the same substance has no discernible impact on IGF-1. For example it’s said that meat increases levels of IGF-1 in the body. We often read that over consumption of red meat is detrimental to health. It follows that articles on the internet state red meat increases IGF-1. But then researching the subject in depth you’ll find contradictory information stating that all meat except red meat increase IGF-1. Someone is right who? I suspect many of the conclusions reported are based on who funds the study.

  • Acromegaly and people with genetically low HGH (likely igf 1 as well but i would want to do more research on that) are fairly well studied. People with acromegaly arent performance and cognitive powerhouses nor do they have super awesome lives that we would all envy with a super high quality if life or ultra high subjective well being. And people with HGH deficiencies aren’t infertile or don’t have extremely atrophied musculature nor are they demented and stupid they have super low quality of life and constantly fight depression and bad.feelongs, but they are highly resistant or even immune to cancer.

    This is horseshit.

    Don’t trust the hypotheses in this video to be conclusions.

  • I have to ask what your opinion is on the carnivore lifestyle?? they have so many healthy people who live this way and honestly they look very very young and look healthier then any group of people i’ve ever seen….and from what i see they live long and stay strong and young looking well into elderly years. I just wanted to hear your opinion on this??

  • Watch the full episode:

    FoundMyFitness episode page:

    More clips from this guest:

  • The question is. Did the mice live longer because they ate less. And what was the quality of their food… A person with high GH because they are more active eat more. Salad, hq produce & fasting, instead of cheeseburgers, may neutralize the difference. I dont know, but that would be one of my questions.

  • If it takes 100 times the doss to reduce life by 50% but only a modest dose to make aging bearable I think it’s a decent trade off. How much does production decrease by age 80? To 1/4? So you’d really not even be getting a “larger” dose, just maintaining a youthful amount

  • ok nice theory. Now did You tested it on Yourself?… i think no.
    So You are not credible person.
    Yes i know many idiots like such a bullshit talking..theory… it is sounds so nice and elegance and hard dictionary for most… but this is still a theory.
    Pin IGF Yourself and make some Vlog then You will be reliable person, but for this it has to be a warrior not a anther scientific looser.

  • I tried many products to grow taller in the past 2 years, but with no luck. When I saw on youtube Growth Sinerama Wmx for the first time it was easy to notice that this one was different from the rest.

  • I’m so glad I rewatched this as the first time I listened to it I heard caloric restriction causes brain atrophy. But then I saw that it wasn’t specifically the case. Which is good because I’ve been on 600 calories a day for 30 days

  • Hi Dr. Patrick! Great video thank you for sharing. I was hoping you would elaborate on possible effects of changing facial bones as a possibility of taking growth hormone or any of the variations being marketed to people today such as MK677, Sermorelin or Ipamorelin? I’ve heard that there are certain growth plates in the face or jaw that don’t fully close and if this is true what are the chances any of the above named growth hormone inhibitors or carriers will cause changes in growth plates that may be open? No medical professional or clinic or nutritional guru have ever done a video or discussed this aspect.

  • In my late 20’s but have the IGF-1 levels of a 70 year old. I look 15 but feel 65. I have an amazing metabolism, I can eat whatever I want and don’t get fat. Very lean. I have elevated SHBG. And it’s very hard for me to put on weight. The downsides are I get fatigued very easy. I can’t tolerate long exercise sessions. I feel weak. And let’s just say everyone wants to look younger, but when you look 15 it sucks. Trust me, the “benefits” don’t outweigh the negatives. I’m starting on growth hormone asap.

  • So… intermittent fasting could potentially be making my brain weaker over time by lowering IGF-1? I thought I.F. was the be-all and end-all (it’s touted as such all over YouTube). God, every video I watch says something different this stuff is so confusing for a layperson.

  • Dr. Rhonda Patrick is like that cool teacher everyone wishes to have.
    I started drinking green tea daily and eating the leaves for 2 weeks now. Really feel better now! I can even focus more when studying!

  • A little fast-paced, but insanely useful and great video. Great to see some scientific applicability to increasing fitness, coming from a source that’s not a gym-bro

  • Igf 1 increase due to diet will not increase performance.

    Igf 1 raise due to diet will not protect neurons.

    Increasing muscle mass and whatnot is better attained through weightlifting and cardio.

    You increase IGF-1 solely through diet (or worse, drugs) and stay sedentary and I’ll lift weights and we’ll see who is stronger in a year.

    These are cool hypotheses.

    Diminished muscle mass and libido and whatnot through igf-1 reduction via diet is not a thing.

    This os a load of horseshit. No wonder joe rogan, the self proclaimed idiot, has you on his show constantly.

    “Healthy balanced diet” doesn’t mean anything because it’s too vague.

    I’m pretty sure igf-1 increase through non.dietary means without a doctor’s prescription is illegal.

  • I love my Chinese and Korean serums with IGF1 and IGF2. Also, for the fat and sugar avoiders pertaining to the chocolate. I reccomend using cacao powder it is chocolate minus the fat, and sugar.

  • If I have a choice between looking like Arnold and dying at 90 or looking normal and dying at 120, that’s not really a hard choice. Let’s get to the gym and pump up. I’m actually all about anti-aging but that’s where I draw the line.

  • Dr. Rhonda Patrick congratulates you for the excellent video.
    Do you know this product: Pro igf-1 Hi-Tech pharmaceuticals? thank you…

  • Great, I just came Here.. It is such a nice Information. In Indonesia I just sell the IGF-1 product for 3 years, AND here I am Learning again about it. Learning for whole LIFE is a MUST. Success Dr. Rhonda Patrick