Live Forever NAD Booster NMN May Repair DNA, Fight Aging

 

The Edge of Medicine and Ageing David Sinclair

Video taken from the channel: AMPAMPLIFY


 

Can Niacinamide and Metformin Reverse Aging? Update February 2019

Video taken from the channel: E O


 

CeraGen Niagen & Cera-Q for Enhanced Memory and Heathy Aging | Tiger Fitness

Video taken from the channel: Tiger Fitness


 

4.1 Prof David Sinclair

Video taken from the channel: RACP


 

NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide

Video taken from the channel: FoundMyFitness


 

Anti-Aging Compound in Human Clinical Trial: Will Boosting NMN Slow Aging?

Video taken from the channel: HEC Science & Technology


 

Rewinding the clock on aging blood vessels

Video taken from the channel: Harvard Medical School


Accelerated aging is the culprit. While the body has an innate ability to repair DNA, this ability weakens as we age. The team from the University of South Wales have identified an NAD+ signaling molecul. The new drug they found, NMN, which converts to NAD+ in the body, helps to activate all seven of the SIRT enzymes (SIRT1-7) which are used during DNA repair.

In mice, this resulted in an increased. Treating mice with an NAD+ ‘booster’ called NMN improved their cells’ ability to repair DNA damage caused by radiation exposure or ageing For the past four years, Professor Sinclair and Dr Wu. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions.

However, the safety of NMN in humans have remained unclear. We, therefore, conducted. Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are two supplements that have taken the longevity and anti-aging world by storm. With animal studies showing.

Experiments conducted on mice show that treatment with the NAD+ precursor NMN mitigates age-related DNA damage and wards off DNA damage from radiation exposure. If affirmed in further. The cells in the human body are programmed to repair DNA damage. Yet the cells can’t repair such damage as effectively after years of aging.

The UNSW researchers have determined the. Anti-Aging Mechanisms of NAD+ NAD+ promotes longevity through multiple mechanisms including DNA repair. Restoration of NAD+ has been shown to increase lifespan in mice by the human equivalent of 4.

When researchers treated young mice and older mice with a NAD+ “booster” called Nicotinamide mononucleotide (NMN) it improved the animals’ ability to repair DNA damaged by exposure to radiation. Live Forever Manual Accident and Emergency Diet Exercise Mental Wellbeing Mind Upload Quantified Self Sleep Technological Study reviews NMN as a therapy for NAD+ metabolism disorders. Fight Aging! 29-May-2020.

500 mg shown safe in clinical trials lots more research underway Genflow Seeks Investors for Novel SIRT6 DNA Repair.

List of related literature:

The ‘double-agent’ theory may explain why antioxidant supplements have had so little effect on lifespan: they cannot halt mitochondrial leakage, and cells are refractory to overloading with antioxidants, lest they smother the powerful genetic response to injury.

“Oxygen: The molecule that made the world” by Nick Lane
from Oxygen: The molecule that made the world
by Nick Lane
OUP Oxford, 2002

In Drosophila, mutations like methuselah, and overexpression of Cu/Zn super oxide dismutase, can extend the maximum lifespan (Lin et al., 1998; Parkes et al., 1998).

“Handbook of Models for Human Aging” by P. Michael Conn
from Handbook of Models for Human Aging
by P. Michael Conn
Elsevier Science, 2011

Like the DNA in the nucleus, mitochondrial DNA can become damaged and fail to be repaired, which becomes a significant contributor to aging.

“Exercise Is Medicine: How Physical Activity Boosts Health and Slows Aging” by Judy Foreman
from Exercise Is Medicine: How Physical Activity Boosts Health and Slows Aging
by Judy Foreman
Oxford University Press, Incorporated, 2020

In a variety of ways, telomerase helps prevent end joining fusions not only of telomeres with a double-stranded DNA break, but also of telomeres with other telomeres—all of which provides genomic stability (Chan et al., 2003).

“The Scientific Basis of Integrative Medicine, Second Edition” by Leonard A. Wisneski, Lucy Anderson
from The Scientific Basis of Integrative Medicine, Second Edition
by Leonard A. Wisneski, Lucy Anderson
CRC Press, 2009

Finally, some > DNA repair pathway must join the broken ends together, and the resulting molecule must provide some proliferative advantage to the cell.

“Encyclopedia of Cancer” by Manfred Schwab
from Encyclopedia of Cancer
by Manfred Schwab
Springer Berlin Heidelberg, 2011

However, our published and current work demonstrates that in the old, muscle stem cells remain numerous, avoid or repair DNA damage, and exhibit normal telomerase regulation (O’Connor et al. 2009).

“The Future of Aging: Pathways to Human Life Extension” by Gregory M. Fahy, Michael West, L. Steven Coles, Stephen B. Harris
from The Future of Aging: Pathways to Human Life Extension
by Gregory M. Fahy, Michael West, et. al.
Springer Netherlands, 2010

It is able to activate DNA repair and increase survival after UV [21].

“Principles and Practice of Photoprotection” by Steven Q. Wang, Henry W. Lim
from Principles and Practice of Photoprotection
by Steven Q. Wang, Henry W. Lim
Springer International Publishing, 2016

But actually what happens with aging is that NAD, which is the oxidizing side of that NAD/NADH couple, goes down, so we can actually become more reduced, and that’s what drives much of aging.

“The Transhumanism Handbook” by Newton Lee
from The Transhumanism Handbook
by Newton Lee
Springer International Publishing, 2019

Such dimers, unless repaired, may cause serious damage or death to cells because they cannot properly transcribe or replicate such DNA.

“Novel Food Processing Technologies” by Gustavo V. Barbosa-Canovas, Maria S. Tapia, M. Pilar Cano
from Novel Food Processing Technologies
by Gustavo V. Barbosa-Canovas, Maria S. Tapia, M. Pilar Cano
CRC Press, 2004

As the CHO genome resources mature, this may be the next step in the generation of cell lines with enhanced stability.

“Animal Cell Culture” by Mohamed Al-Rubeai
from Animal Cell Culture
by Mohamed Al-Rubeai
Springer International Publishing, 2014

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

[email protected]

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34 comments

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  • for what I understand nmn allow your body to create NAD+ (C21H27N7O14P2) that will repair your body. Why do you take nmn and not directly NAD+ C21H27N7O14P2?

  • Thank you for both this video and your first. What are your thoughts of utilizing a standardized dose of Berberine in place of Metformin? Different I know but perhaps with similar results?

  • Hello I take 1000 mg metformin daily and I feel fatigue and cant concentrate as I used to.Is there any way to counter these side effects?

  • Stem cell implantation

    https://www.facebook.com/cientificomarioncamacho/videos/1767590836590632?vh=e&d=n&sfns=mo

    Regenerative precesses for retina
    Optic nerves and other organs

    https://www.facebook.com/cientificomarioncamacho/videos/1762653680417681?vh=e&d=n&sfns=mo

    Karyna Camacho
    Bio medicine info

    https://www.facebook.com/kary.camacho.52831

  • Since NMN has to be converted in the body to NR (nicotinamide riboside) before it can pass through cellular walls, I just buy NR https://amzn.to/2W8XFV6. NR has been proven to raise NAD levels. NR is also much cheaper.

    Before NR was available, the price for NMN could barely be justified. Now that NR is available, the purchase of NMN can no longer be justified as the NIH published studies show NMN to be inferior.

    NMN gives you only fast energy. It’s like giving a red bull to a starving child.

    NR compels the body to naturally produce its own NAD and adds energy to the cells to make them work better so that you live longer, because your cells will act like a toddler’s cells.

    A couple years ago I encountered a study published in Science (one of the top scientific journals on the planet) showing that giving aged mice a supplement called nicotinamide riboside improved mitochondrial and stem cell function and extended their life span (Zhang et al. Science 352,1436 [2016]). This caught my attention, because there are very few molecules that have been shown to extend the life span of mice in carefully controlled studies, particularly when first administered later in life.

    I did a bit more research and found that NR (a.k.a. nicotinamide riboside) is a molecule that your body produces naturally (and gets to a lesser extent from diet) but levels decline substantially with age. It is a precursor for another molecule called NAD+, which is an ancient molecule that has been conserved throughout evolution and is essential for energy production and DNA repair in all cells (two processes that are thought by many to be at the root of aging). More research revealed that NR had been designated by the FDA as GRAS (generally regarded as safe), and a phase I clinical trial in humans had been completed, revealing no adverse effects.

  • western science needs to include eastern wisdom AHA amaerican heart association has recommended transcendental meditation (TM) to doctores AND NOT ANY OTHER TYPE OF MEDITATION maharishi ayurveda is a master degree program at miu.edu part of Premed and integrative medicine degree
    thats the solution TM is shown to reverse aging in some of the 400 per reviewed studies on TM published in 160 scientific journals TM and Maharishi ayur veda is ” total health care ” and most exellent prevention

  • I’ve been taking Metformin with my main meal, and at max, twice a day,. NR, with resveratrol, thiamine, ashwaganda,, for about 3 months, with only breakfast, and meal at about 5pm.
    The Metformin makes it very easy to get sore muscles with excercise,. When working out, you can feel the muscles really aching next day. I used magnesium bath to help with that. So I might just use 1 500mg Metformin with my main evening meal.
    Also, stomach is very squirmy and upset in mornings.
    I’ve lost a bit of weight, but not as much as I’d hoped.

  • Dr David Sinclair is going to change the world for good

    Certainly the molecules discover NMN-NAD that boost sirt 1 and for better endothelial function also will help these regenerative
    Processes.

    Regenerative treatments

    Páncreas regeneration

    https://www.facebook.com/cientificomarioncamacho/videos/2073447296004983?sfns=mo

    Neuronal refresh

    https://www.facebook.com/cientificomarioncamacho/videos/1902015503148164/

    Múltiple sclerosis

    https://www.facebook.com/cientificomarioncamacho/videos/1911795905503457/

    Macular degeneration

    https://www.facebook.com/cientificomarioncamacho/videos/1615588898457494?sfns=mo

    Retinitis pigmentosa

    https://www.facebook.com/896399837043074/posts/2755316424484730?sfns=mo

    https://www.facebook.com/cientificomarioncamacho/videos/1997767016906345/

    Retinitis pigmentosa

    https://www.facebook.com/cientificomarioncamacho/videos/329687151057184?

    https://www.facebook.com/kary.camacho.52831

    T cells vs cancer

    https://www.facebook.com/896399837043074/posts/2674198802596493/?d=n

    Stem cell implantation

    https://www.facebook.com/cientificomarioncamacho/videos/1767590836590632?vh=e&d=n&sfns=mo

    Regenerative processes for retina
    brain, and other organs

    https://www.facebook.com/cientificomarioncamacho/videos/1762653680417681?vh=e&d=n&sfns=mo

  • Apparently senolytics, specifically the combination of dasatinib and quercetin to remove senescent cells looks promising. Also apparently, anabolic steroids (and by extension probably other substances that bind to androgen receptors in the right areas as agonists) increase telomere length etc. Initially it was danazol in a study for that, then nandrolone being looked at for the same thing. But apparently as class most of them should do it.

  • THE LONGEST LIVING CHINESE MAN IN HISTORY LIVED SOMEWHERE OVER 250 YEARS? hE WAS A HERBILOGIST AND TOOK MANY GLOBAL TREATING HERBS TO EXTEND HIS LIFE SPAN…NOT JUST ONE OR TWO SO SEEMS A GLOBAL COLLECTION OF NURTRIENTS WILL BE FIRST WAYS WE EXTEND LIFE UNTIL WE GET DNA CHANGES AND ORAL TREATMENT THROUGH PILLS… sO MANY ITEMS ASSIST LONGER AND BETTER LIVING.

  • That’s why I take CLE Mineral Drops daily. I take 20 drops per day every morning. CLE Mineral Drops increases blood and oxygen flow.

  • Thanx Rhonda, for an excellent presentation! I’ve heard about this mainly from David Sinclair I am following closely, and I look forward to more input from you!

  • Cut out sugar and simple carbs and reduce complex carbs. Not quite paleo but close. Give yourself 10 quality years. Can’t do that, then just eat twice a day with a good fasting period between, but again no sugars. If you struggle with that then your eating to block your emotions.

  • As we age years of excessive sugar intake, toxins from processed foods, and sleep deprivation takes its toll on the average adult. Before the age of thirty the average adult is sedentary setting the stage for a steady decline in hormones. Waiting twenty more years for a treatment or stop eating at fast food places? It’s your choice

  • Thank you for your presentation. Please keep the updates coming. Regarding Statins, did you know that several studies have been done showing low dose, intermittent treatment (1 month in every 6-12 months) with a statin and a Sartan can rejuvenate the vascular system? Here is one abstract if you want to look further: https://www.liebertpub.com/doi/abs/10.1089/rej.2015.1722?src=recsys&journalCode=rej

  • What sort of person would watch this video and give it a thumbs down! I can imagine them thinking, well maybe not thinking, but say to them selves, err this is rubbish I’d rather die early or get Dementia. However on reflection, it maybe a good thing to remove them from the Gene pool.

  • IIRC Prof David Sinclair asserts he has evidence than Niacinamide will suppress Sirt1, while Niacin will not. ie it may have health benefits but not extend lifespan
    https://genetics.med.harvard.edu/sinclair/publications.php

  • Always trying to boost big Pharma. Reservatrol does the same thing with 0 side effects. https://www.intechopen.com/books/resveratrol-adding-life-to-years-not-adding-years-to-life/resveratrol-and-sirt1-activators-for-the-treatment-of-aging-and-age-related-diseases

  • That is great but I expected something concrete for us to do about it now or some supplement to take. Instead of the promise of some new medicine in the future

  • On top of advice of Dr. Sinclair (from this and many other videos) go vegan and watch the change it brings to your body and spirit! 7 years ago my blood work was all over the place, I was over 200lbs. and my health was deteriorating. My coworker suggested I should go on statins, but instead, after watching a few documentaries, (Food Matters, Forks over Knifes, Fat Sick and Nearly Dead etc.) I decided to change my diet. Now I’m vegan for 7 years, my blood work is in perfect normal range without any medications, and my weight is 170lbs, I’m getting better and better with my Bikram Yoga practice (5th year) my life totally changed for 10x better. When I’m in a food store I realize that 90% of what we got on shelves is poisonous junk and that what I actually need is only the produce section. Actually 6 visits to Amazon jungle assured me in it since I was only consuming plants, no bread, sugar, condiments, sodas etc… simply the food we are designed to eat and properly digest. I also try to not overeat and changed my relation with serving sizes… trying to do intermittent fasting… induce autophagy etc. I feel 10x better than 8 years ago before starting my vegan journey. I do not pollute my body, environment and I’m not causing harm to animals. Without all that junk food sensory pleasures/addiction I am actually more satisfied with my diet now since I’m fully aware that what I eat is conscious choice “for good only”, it is very tasty, and I’m silently observing that I’m starting (to my surprise) to be an example for others. Sorry for all of animal eaters who still consume dead corpses… Even pronouncing it feels gross but being a grave for other sentient beings which on top of it kills you and makes you sick… never ever again. It is the same story like with cigarettes 70 years ago… we just need to wake up and wait!

  • Degeneración Macular

    https://www.facebook.com/cientificomarioncamacho/videos/1615588898457494?vh=e&sfns=mo

    https://www.facebook.com/cientificomarioncamacho/videos/1754658037883912?vh=e&d=n&sfns=mo

    https://www.facebook.com/cientificomarioncamacho/videos/1831704950179220?vh=e&d=n&sfns=mo

    Retinitis pigmentosa
    Regenerative treatment

    https://www.facebook.com/cientificomarioncamacho/videos/1997767016906345?vh=e&d=n&sfns=mo

    https://www.facebook.com/cientificomarioncamacho/videos/2414046125497849?vh=e&d=n&sfns=mo

    Refresh neuronal
    Regenerative treatment

    https://www.facebook.com/cientificomarioncamacho/videos/1902015503148164?vh=e&d=n&sfns=mo

    https://www.facebook.com/cientificomarioncamacho/videos/1924172514265796?vh=e&d=n&sfns=mo

    https://www.facebook.com/cientificomarioncamacho/videos/1924156850934029?vh=e&d=n&sfns=mo

    Pancreas regeneration

    https://www.facebook.com/cientificomarioncamacho/videos/2073506792665700?vh=e&d=n&sfns=mo

    https://www.facebook.com/cientificomarioncamacho/videos/2132768123406233?vh=e&d=n&sfns=

  • All medicines have been poisons they either control a nerve impulse or an enzyme that’s terrible the end result is people need more medicines you AR taking people to even greater Health declines AMA medicine is a pile of waste

  • You can increase NAD and a standard processing supplement call cataplex B made in the 1940s all you need is 20 ml mg of niacin a day don’t take a hundred don’t take 60 take 20

  • Spirulina has been proven by Japanese scientist to reverse the aging of your circulatory system a teaspoon a day and water you can do this also with a hundred mg of grape seed extract and 300 mg of horse chestnut which I did in 2010 and got off all but one blood pressure medicine and then later on I got off all

  • How about the issue of Statins lowering CoQ10, do you supplement with CoQ10 to prevent this from happening, just like you supplement with B12 with the metformin?

  • Fun fact; big pharma kills more people than heart disease. Do yourself a favor and follow Dr. Darren Schmidt on his You Tube channel. Dr. Berg is a great one to follow, too.

  • Could you please advise what level of niacinamide you would recommend as I can only seem to find the comment that the maximum is 3g/day. I presume that the recommended dose would be less..so if you could advise how best to choose the optimum dosage, I would be grateful. Thanks

  • As a doc, I recommend all of you to avoid supplementation of NAD or etc…This guy is not sharing the real truth behind longevity and telomere lengthening, the secret behind antiaging is simply fasting!!

  • Mice. Always mice. When do Clinical Trials begin with actual human beings who are NOT mice. EDIT to add: Just noticed video is nearly TWO YEARS OLD by the time I saw it. So, everyone enjoying their NMN prescription? Thought not…

  • Remember that what works in mice does NOT always mean it will work in humans. In fact sometimes favorable results in mice can have a malicious affect in humans. Human trials overseen by uninvested sources that demonstrate it’s touted effects are what you should wait for before (confidently) taking this everyday.

  • I keep you, Dr Rhonda, will create a multi. One for deficient people. I know you say we require blood testing for correct dose. -and I know we trust you because you don’t push brands. In Australia at least we hear of unscrupulous brands so it’s hard to know which to trust. Thank you again.

  • He said there are two reliable sources of NMN, one company supplies the pure stuff to research laboratories, and the other makes available to consumers as a supplement. He didn’t mention the brand of the supplement or the name of the company that makes it.
    Remember, there is lots of fraud in the supplement industry. That’s why we need to find out where to get the good stuff.

  • I disagree. We can look at a person and estimate their age and in most cases be very close. This applies world wide across all cultures and continents. That has to point to a singular clock in all life forms. Figure the clock and you figure life times and change that you change age either way.

  • Oh come on, we just need one person to send bought NMN for testing and we would know that source is safe. If the molecule is NMN it can’t be anything else, the only concern is if this quantity has nothing else in it and it’s not too old and degraded.