4 Telltale Marks of High Inflammation to look at


Inflammatory Response, Animation

Video taken from the channel: Alila Medical Media


Concussion & POTS (Postural orthostatic tachycardia syndrome) | ACD Ep 80

Video taken from the channel: Complete Concussion Management


Osteoarthritis of the hip, Stephen Kantor, MD

Video taken from the channel: Dartmouth-Hitchcock


What Happens To Your Body When You Don’t Sleep?

Video taken from the channel: Dr. Tracey Marks


Addison’s vs Cushing’s | Endocrine System (Part 2)

Video taken from the channel: ICU Advantage


Signs Your Body Is Stressed Telltale Signs

Video taken from the channel: Dr. Tracey Marks


How inflammation in the body could be causing depression

Video taken from the channel: CBS This Morning

4 Telltale Marks of High Inflammation to Watch. by Molly Hurford. June 28, 2019. No Comments. Share it: Inflammation has become one of the fitness/wellness industry’s hot-button issues for 2019: You’ve likely seen it mentioned by a high-level athlete or influencer on their Instagram or spotted a blog post about it in recent months. It.

Persistent, low-level inflammation, such as inflammaging, will often spiral into diseases later on in a person’s life. Inflammaging chips away at the structural and functional integrity of cells and other molecular components that prolong youthfulness. 4 Telltale Signs That Inflammaging May Be Taking a Toll On Your Body. 4 Telltale Marks of High Inflammation to Watch Occasional, acute inflammation may be generally OK, but chronic inflammation isn’t.

4. 5 Foods to Avoid For a Better Night’s Sleep. All patients were tested for inflammation using the following markers: erythrocyte sedimentation rate (ESR), C-reactive protein, a-1 antitrypsin (A1AT), myeloperoxidase (MPO), and soluble tumor necrosis factor alpha-receptor type II (TNFR II). Bloating, gas, cramps, food sensitivities, and unexplained aches and pains can be disruptive to your daily life, and they’re also telltale gut inflammation symptoms to watch out. Inflammation can trigger episodes of abdominal pain, as the gut is sensitive to substances that provoke inflammation. Such episodes often include bouts of diarrhea and constipation, as well.

Additionally, it comes as no surprise that any level of gluten intolerance (a source of inflammation) can stimulate abdominal pain. 2. Typically, it’s pretty easy to tell if you’re experiencing acute inflammation. If you scrape your knee, your skin will turn red and hot. If you catch a cold, your runny nose and fever will tell the whole world that you’re inflamed.

So acute inflammation is a natural, healthy process that helps your body heal. pain. redness. swelling. loss of function. The specific symptoms you have depend on where in your body the inflammation is and what’s causing it.

Long-term inflammation. These include fever, rash, facial paralysis, and arthritis. Early Signs and Symptoms (3 to 30 Days After Tick Bite) “Classic” Erythema Migrans Rash Fever, chills, headache, fatigue, muscle and joint aches, and swollen lymph nodes may occur in the absence of rash. Signs The four cardinal signs of inflammation—redness (Latin rubor), heat (calor), swelling (tumor), and pain (dolor)—were described in the 1st century ad by the Roman medical writer Aulus Cornelius Celsus.

Redness is caused by the dilation of small blood vessels in the area of injury.

List of related literature:

Common symptoms include constitutional symptoms, weight loss, myalgias, arthralgias, and skin abnormalities such as necrotizing purpura or subcutaneous nodules, while peripheral nerve involvement including mononeuritis multiplex is also common and is seen in roughly 80% of cases [14].

“Absolute Rheumatology Review” by Petros Efthimiou
from Absolute Rheumatology Review
by Petros Efthimiou
Springer International Publishing, 2019

Last, the absence of inflammation on cytology does not necessarily rule out an inflammatory differential.3

“Cowell and Tyler's Diagnostic Cytology and Hematology of the Dog and Cat E-Book” by Amy C. Valenciano, Rick L. Cowell
from Cowell and Tyler’s Diagnostic Cytology and Hematology of the Dog and Cat E-Book
by Amy C. Valenciano, Rick L. Cowell
Elsevier Health Sciences, 2019

• Watch for signs and symptoms of embolization (such as petechiae, hematuria, pleuritic chest pain, left upper quadrant pain, and paresis), a common occurrence during the first 3 months of treatment.

“Springhouse Review for NCLEX-RN.” by Lippincott Williams & Wilkins
from Springhouse Review for NCLEX-RN.
by Lippincott Williams & Wilkins
Lippincott Williams & Wilkins, 2006

Acute episodes are characterized by local pain, heat, swelling and tenderness, sometimes accompanied by reddening of the overlying skin, and by systemic features of inflammation, such as fever and a raised C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).

“Textbook of Orthopaedics, Trauma and Rheumatology E-Book” by Raashid Luqmani, Benjamin Joseph, James Robb, Daniel Porter
from Textbook of Orthopaedics, Trauma and Rheumatology E-Book
by Raashid Luqmani, Benjamin Joseph, et. al.
Elsevier Health Sciences, 2012

Figure 4-5 shows a likely pattern of leukocyte changes through a typical inflammatory response, with a distinct onset of inflammation and then progressing uniformly to resolution.

“Small Animal Clinical Diagnosis by Laboratory Methods E-Book” by Michael D. Willard, Harold Tvedten
from Small Animal Clinical Diagnosis by Laboratory Methods E-Book
by Michael D. Willard, Harold Tvedten
Elsevier Health Sciences, 2011

CBC:WBC and erythrocyte sedimentation rate (ESR) increased during acute episodes b.

“Pass Cen!” by Robin Donohoe Dennison, Jill Suzette Johnson, Meg Blair
from Pass Cen!
by Robin Donohoe Dennison, Jill Suzette Johnson, Meg Blair
Elsevier Health Sciences Division, 2010

Repeated episodes of acute inflammation in the same tissue over time or low-grade, persistent immune reactions can also result in a chronic inflammatory response (Fig. 3.9).

“Pathology for the Physical Therapist Assistant E-Book” by Catherine C. Goodman, Kenda S. Fuller
from Pathology for the Physical Therapist Assistant E-Book
by Catherine C. Goodman, Kenda S. Fuller
Elsevier Health Sciences, 2016

In the evaluation of both acute and chronic GVHD, which usually includes a tissue biopsy, it is important to exclude other potential diagnoses such as infection, drug reaction, or second malignancies, which can mimic GVHD.

“Abeloff's Clinical Oncology E-Book” by Martin D. Abeloff, James O. Armitage, John E. Niederhuber, Michael B. Kastan, W. Gillies McKenna
from Abeloff’s Clinical Oncology E-Book
by Martin D. Abeloff, James O. Armitage, et. al.
Elsevier Health Sciences, 2008

These mediators, coupled with the neurogenically mediated vasodilatory erythematous ‘‘flare’’ surrounding the irritated site, produce erythema, edema, and activation of immune cells, including mast cells, that contribute to the clinical response of neurogenic inflammation.

“Handbook of Cosmetic Science and Technology” by Andre O. Barel, Howard I. Maibach
from Handbook of Cosmetic Science and Technology
by Andre O. Barel, Howard I. Maibach
CRC Press, 2001

Extraintestinal manifestations recorded in one series included peptic ulcer, arthritis, skin lesions (pyoderma gangrenosa or erythema nodosa), cholelithiasis, renal calculi, and eye lesions (uveitis).

“Principles and Practice of Surgery for the Colon, Rectum, and Anus” by Philip H. Gordon, Santhat Nivatvongs
from Principles and Practice of Surgery for the Colon, Rectum, and Anus
by Philip H. Gordon, Santhat Nivatvongs
CRC Press, 2007

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

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  • What about numbness even on the right side of the face to the skin of the head also on the right side. Also body hotness and palms.. people like.. do you have fever when i greet them and i can feel it for myself if i touch my body. Thank you Doc

  • Hey, psychiatrist in traaining here. The idea that certain types of depression are caused by inflammation is not new, it’s been around for 40 to 50 years. We haven’t really gotten to a point where we address depression by lowering information though. Once I finish my training specializing in psychiatry, I plan to focus almost entirely on lowering information to improve mental health.

  • There several foods to be avoided, tomatoes,eggplant,lemons,pasta,bagels,sugar, vegtable oil all inflame arthritus. Beware of pain tabs and anti inflammatory can cause more problems. and make you worse…PRP injections sounds promising that is the latest tech

  • Thank you for this video I’ve asked doctor’s & consolers what the effects would be on the human body after long turm stress chemicals = I’ve haven’t received any answers just confused looks that lead to both are frustration when I tried to exsplane ( my responce to the confused looks ) anyway this video dosent answer my question yet it dose help me not self dought = I litraly have every simptom mentioned plus some symptoms you mentioned in another video = all I knew was something is going on with my health that’s not being looked at & it’s been hard to make a list of symptoms THE GOOD NEWS IS your home work assinments have helped allot LOL & I’m a new subscriber so ya I noticed relief just trying to fugue these assignments out = enough relief that it lead me to doing the homework threw out the day every day this week because it’s like I’m stuck in a non stop trigger = 2 conslers in the last 3ish years didn’t understand what I mean by it’s like my fight & flight both got stuck on at the same time & i became disfuctional

    So yes thank you for your channel & thank the algorithm for recommending you LOL I lost my job of 8 year’s from this issue so I’m really grateful for the finatual stress relief of this new found solution plus it looks like I can become employable again = thank you very much

  • Wow. I am surprised that folks gave this video a few thumbs down. The information is life changing in a positive and informative way.

  • Excellent presentation ��������. Some of them were a surprise. I have Sarcoidosis, an autoimmune disease. So, I do my very best to do yoga 3x’,s a week, drink 3 cups of tea (one being green tea), take my meds as described & see a therapist. Since my world is different, I find myself really stressed out. I also do mindfulness, pray during my baths, but I am so tired all of the time. Any suggestions on how to not feel do stressed & reduce my cortisone levels? I absolutely love your videos. Thank you.
    Blessings ��

  • I have manic depression and I farm. It is very stressful. I thought it was the depression but now I know I have more to work on. Thanks Doc.

  • Hi doctor. My name is tsyyaba.Quite new information to know about greying of hair due ti stress. My question is, can we reverse this greying if ysir if the stress is controlled.

  • I never in a million years believed I would even be watching a video about stress and the causes. But unfortunately after watching this I’m beginning to see I’m extremely stressed and it’s never ending! I can’t see myself consulting a psychologist but I’m caught between knowing I’m stressed but not quite sure how to undo my stress levels in my head.

  • I graduate med school/get my MD in 2 weeks. I start my psychiatry residency this June. I am convinced a lot of mental health issues would be dramatically improved if people lowered their chronic low-grade inflammation, and plan on having be an important part of my treatment plans for patients.

  • Amen!!!!! Finally at least there’s someone who gets it. I am disabled and suffered greatly with inflammation and pain due to a failed surgery. I have only recently realize the correlation between the inflammation and my back pain but I live it every day. The mind and body are one and should be treated as such.

  • My high stress and sleep deprivation are what I suspect is a factor in my jaw clenching, body soreness, and the three colds I have had in the past month. Also, my periods get really intense and I have especially severe PMS and cramping. I love doing yoga to help with stress, which I have not done at all in the past month. It shows how important self-care really is, with proper sleep and exercise. I spend so much time taking care of others, that I do not leave enough time for my own wellness.

  • Good evening mam…..Saket from India…. I am suffering from anxiety suffered from Panic attack many times……I feel some time less control on body and feeling that not having control and mouth shapes is changing…..

  • When you say sleep deprivation kills you, what exactly do you mean? From health problems or it just kills you suddenly? This made my anxiety much worse. ��

  • I dont believe i have any other health problems that could be causing my anxiety becuase i used to play basketball and i was always active everyday until any of this started

  • Years ago my eye doctor said involuntary eye twitching was a sign of stress. Usually only one of my eyes will twitch but last week both eyes would alternate ����‍♀️

  • Cheers for this, I have been researching “blood tests osteoarthritis” for a while now, and I think this has helped. Have you heard people talk about Hanadelyn Banadison System (search on google )?

    It is a smashing one off guide for discovering how to get rid of arthritis minus the headache. Ive heard some pretty good things about it and my work buddy got amazing results with it.

  • Winner of a video, been searching for “inflammatory osteoarthritis” for a while now, and I think this has helped. You ever tried Hanadelyn Banadison System (Have a quick look on google cant remember the place now )?

    It is an awesome one off product for discovering how to get rid of arthritis minus the normal expense. Ive heard some incredible things about it and my friend got great success with it.

  • I had a panic attack at my new job 3 months ago, which I dont work there anymore, by the way, since I grew a phobia. After the panic attack, came a week of brain fog, anxiety, depression and disconnection from this world. Took a week to sort of get back to normal and then ringing in the ears started. I’ve had it ever since and it’s making my anxiety worse. My dr prescribed me to an antidepressant. What are your thoughts on this?

  • http://www.projectCBD.org/guidance/conditions

    Original Investigation
    August 29, 2018
    Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis
    A Randomized Clinical Trial
    Sagnik Bhattacharyya, MBBS, MD, PhD1; Robin Wilson, MBBS, MRCPsych1; Elizabeth Appiah-Kusi, MSc1; et al Aisling O’Neill, MSc1; Michael Brammer, PhD2; Jesus Perez, MBBS, MD, PhD3; Robin Murray, DSc, FRCPsych, FRS1; Paul Allen, PhD1,4; Matthijs G. Bossong, PhD1,5; Philip McGuire, MD, PhD, FRCPsych1
    Author Affiliations
    JAMA Psychiatry. Published online August 29, 2018. doi:10.1001/jamapsychiatry.2018.2309

    Results  Of the 16 participants in the CBD group, 6 (38%) were female, and the mean (SD) age was 22.43 (4.95) years; of 17 in the placebo group, 10 (59%) were female, and the mean (SD) age was 25.35 (5.24) years; and of 19 in the control group, 8 (42%) were female, and the mean (SD) age was 23.89 (4.14) years. Brain activation (indexed using the median sum of squares ratio of the blood oxygen level–dependent hemodynamic response effects model component to the residual sum of squares) was analyzed in 15 participants in the CBD group, 16 in the placebo group, and 19 in the control group.

    Participants receiving placebo had reduced activation relative to controls in the right caudate during encoding (placebo: median, −0.027; interquartile range [IQR], −0.041 to −0.016; control: median, 0.020; IQR, −0.022 to 0.056; P <.001) and in the parahippocampal gyrus and midbrain during recall (placebo: median, 0.002; IQR, −0.016 to 0.010; control: median, 0.035; IQR, 0.015 to 0.039; P <.001). Within these 3 regions, activation in the CBD group was greater than in the placebo group but lower than in the control group (parahippocampal gyrus/midbrain: CBD: median, −0.013; IQR, −0.027 to 0.002; placebo: median, −0.007; IQR, −0.019 to 0.008; control: median, 0.034; IQR, 0.005 to 0.059); the level of activation in the CBD group was thus intermediate to that in the other 2 groups. There were no significant group differences in task performance.
    Conclusions and Relevance  Cannabidiol may partially normalize alterations in parahippocampal, striatal, and midbrain function associated with the CHR state. As these regions are critical to the pathophysiology of psychosis, the influence of CBD at these sites could underlie its therapeutic effects on psychotic symptoms.

  • Telltale signs of stress: your bank account is too low, you are being black mailed, you are in the military, you are in prison, your in laws are coming to visit, you don’t remember if you took your medication and decided to take the pills and now you are not sure if you overdosed, you wake up in the middle of the night and notice you forgot to lock the drawer with the sharp knives and your partner is mad at you.

  • Thank you guys so much for watching! Please leave us a like if you enjoyed the video. We truly do appreciate it! Also we love hearing your comments so feel free to tell us what you think of the video. We hope that after this lesson, you will have a good understanding of the differences between Addison’s disease and Cushing’s syndrome. These are two disease processes from a dysfunction within the same endocrine system pathway, but they are quite different from one another based on the type of dysfunction that they represent.

    Don’t forget to check out these other great lessons that we have available!
    Hemodynamics: https://www.youtube.com/playlist?list=PL2oVjKTYocdMBZlcIcWlESbOFFaGugQS2
    Shock: https://www.youtube.com/playlist?list=PL2oVjKTYocdPP0K8Fi49GfUgprICS-xMf
    Blood Tubes Order of Draw: https://youtu.be/mAmwdDdbkUI
    Arterial Blood Gases: https://www.youtube.com/playlist?list=PL2oVjKTYocdMz1qF-3iS6iUZ-R_fKbeJw
    ECG/EKG Interpretation: https://www.youtube.com/playlist?list=PL2oVjKTYocdPMaNwn4xbg6xAIaAnyraMj
    Glasgow Coma Scale: https://youtu.be/zYwJVPIjW6I
    Heart Failure: https://www.youtube.com/playlist?list=PL2oVjKTYocdNdFoS31yGhylKwib9lRf73

    Don’t forget to check us out and give us a like on Facebook as well! https://www.facebook.com/ICUAdvantage

  • I don’t recall the last time I had a good night sleep.
    I have 3-4 hours sleep with wakes in between…
    Now I know the culprit of my weight gain

  • Anxiety disorder should have a separate name than the general feeling of anxiety since normies do not understand how serious it can get.

  • Typical M.D. perspectives: physiology lecture on areas like stool awareness, muscle contraction problems, hair problems, weight problems, sexual problems. The other dimension is there are psychological issues like money worries or interpersonal friction.

  • Could you do a video on the association of stress/anxiety with myoclonic and hypnic jerks? (Hypnic jerks while transitioning from wake to sleep) Thank you!

  • I get a really bad stress rash when I think I’m handling my stress but really not…I appreciate your videos…they really help me to acknowledge my feelings

  • WOW, the mind and the body of an individual belong together; nothing new to everybody I’d think. Or did doctors and most of the people really forget about this basic knowledge? I don’t get it… (Sarcasm)

  • This is an eye opener for me! I deal with each and everyone of these. I’m not of aware if I’m dealing with the weakened immune system.

    I was grinding me teeth the moment she mentioned it. I’m sleep deprived and wake up with a head ache every morning. I have very low sex drive which has been something that I didn’t understand why I had it.

    I’d like to fix these things but because of dealing with dysthymia, I don’t have motivation to do anything.

    I need serious help ����

  • Upright Health on YouTube has some good exercises. I’m trying homeopathy at this point in time. Anything to avoid surgery and to regrow my bone. Also saw product called AlgaeCal that looks promising. Fell 3x in 4 yrs, fell on ridge when I missed handle to pull self up, then plant wrapped around my leg landed on stomach, finally tripped in dark on city sidewalk. All serious injuries. It’s been painful nightmare.

  • My stress levels are out of control��! Primary care physician prescribed my anxiety hydroxyzine pamoate 50 mg BID PRN! Since 2003 I prescribed diazepam 10mg QID # 120! Prescribed the hydroxyzine Pamoate 50mg for allergies and sleep!

  • Excellent info…I never could have thought that inflammation arisen from dental issues could be the associated to/as the cause of depression.����

  • I just wanna say thank you for the extensive information you provide with your videos, and thank you for your videos in general. I couldn’t sleep and had symptoms of anxiety when I came across your videos whilst trying to distract myself. Although I’ve known I have anxiety for a while know, I wasn’t aware of how it can affect my body besides the usual stuff (heart racing, shortness of breath, lump in throat, etc). I immediately recognized most of the signs you listed as stuff I’ve been going through lately, and just the affirmation that they’re not something I’m going through because I’m crazy or anything helped calm me down. Thank you and keep up the good work, Dr. Marks!

  • Oh man have you ever hit the nail on the head this time. I am a 65 year old bipolar woman whose husband sleeps poorly. I am now his caregiver because of a terminal illness. At first I thought this would be a short term problem. Fortunately he has responded to treatment. However, in the last year I have gone from being in pretty good physical health to having high blood pressure, possible pre diabetes and I have to see a cardiologist. I thought it was only because I had gained weight due to taking so much more serequel. The sleep issue is huge. The biggest problem is how do I fix the sleep issue? Aging and looking after someone are hard partners.

  • We need to appreciate anxiety guys. They save our lives man. I work better with anxiety and do more. And feel safer like ever since I started taking meds and it took my racing thoughts and anxiety away I miss it and learned I need to push myself and learn to fight win and overcome it and most of all appreciate all the good that comes from it. Love y’all. And no one is dying.

  • G’day and greetings from Tasmania Australia a very articulate and informative talk. I am 63 yo and I have two total knees done and now I am possibly looking at a left hip replacement, I have suffered rheumatoid and osteoporosis arthritis for a very long time, currently I have taken my orthopaedic surgeon’s and had a cortisone injection in the hip to see if the pain could be coming from my back which I also have arthritis in. I learnt a lot from this and I thank the Doctor for putting this on the Webb thank you again. Kind regards John Kinnane

  • This is just another scam. Inflammation is caused by the medical establishment, fx dentistry, and pushes for the consumption of drugs. They’ve done this since the days of Aristotle. It’s part of the “shadow truth” that anyone in the medical field must oblige to. Our healthcare’s system is the cause. This is why we need medical revolution. Medicare For All and no “high blood pressure”-, or “inflammatory depression” medication

  • I’ve been diagnosed with major depression, GAD & adhd inattentive. I’m on meds for all. My heart rate has always been pretty high for as long as I can remember (sine I was like 15?) it was at the highest the last time I was at my psychiatrist, at 120BPM, it was finals week, but he wants to put me on a beta blocker, and I’m really not wanting to take another med. I explained to him it must be my stress. Wondering if you had any insights thank you so much. Xo.

  • Hello Dr. Tracey Marks, my question is, is stress an excuse for abusive behavior? When an abusive partner goes to therapy and reduces their stress, is it possible that they can discontinue their abusive behavior? Would mean a lot to me if you made a video about this, thank you!

  • Hello what are your thoughts on low fatigue? I work out and also work 8 hour days no matter what I’m doing i got exhausted and have to take a break? My stress level is on a medium level and i also deal with aniexty.

  • Why do I feel as if I’m hungry but I dont want to eat? Like I’m scared sometimes to eat because I gag. Also, when I eat I feel as if I’m not full. Is this part of stress maybe anxiety? I’ve been worrying about this for awhile now.

  • Which stage? Sleep deprivation if the person is healthy gives euphoria due to increased catecholamines release, chronic is another thing and it is not even the too much catecholamines release and build up but rather the byproducts not removed that act as toxins and/or nmda agonists, plus the no gh

    So if you sleep, with higher dopa or norepinephrine, still you gonna be OK, if not better etc etc

  • O.M.G. I thought I was a total mess because I have all those symptoms + depression but all that Time I was deeply stressed… thank you VERY much for this video!

  • When I had braces, I woke up with the plastic protection on the floor EVERY NIGHT, totally scratched from grinding my teeth too hard �� didn’t know it was that problematic

  • Great and helpful information, easy to share with friends and family who do not have an understanding of mental health, and ways of improving mental wellbeing.
    I am glad that you have dropped having background music in your more recent postings. As I found the music very distracting and Unhelpful.

  • https://www.ncbi.nlm.nih.gov/pubmed/28588483
    Front Pharmacol. 2017 May 23; 8:269. doi: 10.3389/fphar.2017.00269. eCollection 2017
    Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders.  Campos AC1, Fogaça MV1, Scarante FF1, Joca SRL2, Sales AJ2, Gomes FV3, Sonego AB1, Rodrigues NS1, Galve-Roperh I4,5, Guimarães FS1.

    Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric disorders, including anxiety, psychosis, and depression. The mechanisms responsible for these effects, however, are still poorly understood. Similar to clinical antidepressant or atypical antipsychotic drugs, recent findings clearly indicate that CBD, either acutely or repeatedly administered, induces plastic changes. For example, CBD attenuates the decrease in hippocampal neurogenesis and dendrite spines density induced by chronic stress and prevents microglia activation and the decrease in the number of parvalbumin-positive GABA neurons in a pharmacological model of schizophrenia.

    More recently, it was found that CBD modulates cell fate regulatory pathways such as autophagy and others critical pathways for neuronal survival in neurodegenerative experimental models, suggesting the potential benefit of CBD treatment for psychiatric/cognitive symptoms associated with neurodegeneration. These changes and their possible association with CBD beneficial effects in psychiatric disorders are reviewed here.


    Front Pharmacol. 2017 Feb 3; 8:20. doi: 10.3389/fphar.2017.00020. ECollection 2017            

    In Vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease.  Watt G1, Karl T2

    Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is affecting an increasing number of people. It is characterized by the accumulation of amyloid-β and tau hyperphosphorylation as well as neuroinflammation and oxidative stress. Current AD treatments do not stop or reverse the disease progression, highlighting the need for new, more effective therapeutics. Cannabidiol (CBD) is a non-psychoactive phytocannabinoid that has demonstrated neuroprotective, anti-inflammatory and antioxidant properties in vitro. Thus, it is investigated as a potential multifunctional treatment option for AD. Here, we summarize the current status quo of in vivo effects of CBD in established pharmacological and transgenic animal models for AD.

    The studies demonstrate the ability of CBD to reduce reactive gliosis and the neuroinflammatory response as well as to promote neurogenesis. Importantly, CBD also reverses and prevents the development of cognitive deficits in AD rodent models. Interestingly, combination therapies of CBD and Δ9-tetrahydrocannabinol (THC), the main active ingredient of cannabis sativa, show that CBD can antagonize the psychoactive effects associated with THC and possibly mediate greater therapeutic benefits than either phytocannabinoid alone. The studies provide “proof of principle” that CBD and possibly CBD-THC combinations are valid candidates for novel AD therapies. Further investigations should address the long-term potential of CBD and evaluate mechanisms involved in the therapeutic effects described.

  • When you say “shortened lifespand or sudden death”.. What exactly do you mean.. This made my anxiety 10 times worse. I don’t want to die..

  • i missed 3 days sleep and i got a racing heart beat i went to the doctor i did an ecg they said i was ok but on my ecg said abnormal

  • This was great, thanks, I been tryin to find out about “fight osteoarthritis naturally” for a while now, and I think this has helped. You ever tried Hanadelyn Banadison System (should be on google have a look )?

    It is a great exclusive product for discovering how to get rid of arthritis without the headache. Ive heard some extraordinary things about it and my work buddy got great results with it.

  • Weight gain is my nemesis when I am stressed or depressed. I fluxuate, but, hey, at 71 I am trying hard. Exercise and mindfulness are best and eating three small meals a day, six hours apart. Thank you!����‍♀️

  • i think i developed pots as a teenager but wasn’t diagnosed until 25 because my symptoms were so vague and ultimately i was able to live a normal life. people just called me lazy sometimes but i still played sports and did well in school. it wasn’t until college when i stopped being so active that my symptoms got worse enough to pursue a diagnosis

  • You lost me when you said Alopecia an autoimmune disease is not caused by stress. A vast majority of health issues are caused by stress. And I have lived it. An extended period of time with high stress affects your immune system and triggers disease.

  • Madam please tell how to reduce permanet delusion?and please make a series of vedio of permanet delusion thought and please make a vedio how to cure it permanently,that’s help more.thank you��

  • How would you differentiate clear cut between borderline and 2polar(meaning often interpersonal and work conflict is a trigger to both, which further destabilizes both the person and his/her cns, raging, kind off etc)? How a comorbid thing often manifests in this case please?

  • signs you have stress,…I break my teeth in my sleep, not just grind, like break. Im on my 2nd crown on one side and the other crown had to be metal not to be broken. I bite uncontrollably in my sleep and have bitten threw my lip and tongue. Im getting a mouth guard made after they fix this last crown. I had cushings disease and subsequent brain surgery and radiation surgery so issues are just part of my life now.

  • My grandfather died bone cancer. His wife (my grandma)had back surgery rheumatoid arthritis and her hands half paralyzed. My father refused back survery but had hip. My hip is scaring so bad and has slowly when young but now since started working as man I don’t think being young and considering it’s a signal for better posture or something body teaching.(always listen to the body and soul) I was young and didn’t know my fathers side background (divorce)and afraid now suffering the noise in hip is now worse and sounds so nasty and more space. But yea inside looks like a coconut ��
    When I was younger my leg pain was so bad I was basically hospitalized bedridden which came with fever and my eyes watering so bad but that was thought mixture growing pain but actually getting that now still while but when walking like my hip faster than my toes. But it’s every like back of heel sometimes it becomes so sensitive I can’t put no weight on it and I’m limping if I even can. Now a days I have to get a doctors note but it’s like a bear or lion when comes and sometimes the foot thing can stay away for years and sometimes closer. Then of course back I can’t sit anywhere or drive cause the pain or asking a gf to drive and my family is nascar fans. Yea my uncle had back surgery also and both him and father went college and does mostly desk work(main job at least)not sure what would of done but reason why talk abou cause ignored so long sees the list is def not just one thing but possibly genetic. I try to study my way out thinking maybe body interested in bones but def think should do a x ray and find out about hips now. Thank you for the lecture hoped helped someone maybe look earlier but I know not much able to be done and scary when young and time when finally independent as adult is so rushing and the world don’t wait.

  • This is a video that has lots of great information in it, but I found it hard to concentrate due to the music which was very distracting.

  • I have type two diabetes and I’m very over weight I’ve been on the keto diet for 4 months and I’ve lost 8 lbs I haven’t had a good night sleep referring to 6 hours or better in years despite how tired i am i end up falling a sleep at 2am and have to be up at 6am I’m 31 I’m still in college and work two part time jobs but i can’t seem to sleep do you have any suggestions???Thank you so much for your helpful videos����

  • Enjoy watching your videos because they’re informing the public of the causes and dangers us humans are susceptible to if we don’t take care of ourselves properly. Thank you so much!

  • Love the point on sleep for adhd… Melinton has only help my daughter develop better… Yes she adhd no other medication… And yes my whole life I slept well and I adhd. But struggling lately stress and think Strattera and 1.,25mg abilify is causing sleep issue…

  • The longest I’ve ever stayed up, was 6 days and twenty minutes, which left me with super human strength; there’s a little more 2 dis story. But how is that?

  • Dr. can you do a video on why anxiety symptoms change or shift? I had all but beaten my GAD and then my symptoms completely changed and I’m back to square one. I’m fighting my thoughts at every turn due to my health anxiety as well.

  • I need my hip replaced & I have not heard many talk about how bad the pain is & how it is not just in the hip it effects your knee down the shin muscle into your ankle your back, it keeps you awake and trying to get comfortable. Had my right hip down & my whole life changed for the better.” ✌️����

  • Fulvic Acid comes from the earth’s soil containing 70+ minerals and vitamins. It also contains electrolytes, prebiotics, enzymes, antioxidants, and amino acids. It is SO powerful. �� It has helped me tremendously with alkalizing my body, helping my hypothyroid, inflammation, weight loss, balancing my hormones, greater energy, and DETOXING on such a deep level.
    I can’t say enough good about the product! It also eliminates all of the toxicity/acidity and alkalizes in the body, rebuilding at a cellular level! I think it can be beneficial to every single person no matter the age. Feel free to look around on my website!

  • I usually get cold sore like probably once or twice a year but when I went though a lot of stress i now get them like 2 or once a month how do I fix this

  • What to do then? Especially after severe burnout. Should I stop for some time my work. In fact I had a very early retirement after a lot of hard work but continued at another level

  • Wow, so stress actually does turn your hair grey. I have chronic, long term stress due to various mental health diagnoses, and before I even had a diagnosis, at the age of 19, I noticed my first grey hair. After my cousin was murdered, my hair started greying faster, and since then, from 2004 I have been on a roller coaster of stressful life events as well as various mental health crises and diagnoses. Now my whole head is grey, and I consider myself far too young to have entirely grey hair. I have not even reached the age of fifty yet.

  • I suffer with a few Mental Disorders. Whilst in General Hosp they cut me off my sleepers. I suffer with Physchotic episodes, BPD, Terrible Suicidal Impulsions and PTSD.I was delirious in the General Hosp. Im on a sleeper which the General Hospital don’t recommend but don’t know the severity of my Mental condition. I am extremely sick mentally and without this Sleeper my life is in jeopardy as I suffer terrible with Chronic Sleep, hardly any. Would you recommend I stay on this sleeper as it is not harming me on a Physical level.

  • I have chronic diarrhea and vomit every morning. Been seeing a specialist but not getting answers. Could that be stress. I have alot going on right now with my family. Thank you.

  • Wow. I know I’m very stressed and I expected to have at least half of the symptoms, but I did not expect to have every single one! Why I’m shocked is beyond me, I was just diagnosed by a physiatrist, not even 3 months ago with panic disorder. Not only that, I’m about 95% sure I suffer from hypochondria. I constantly feel like I’m having some severe medical condition. Tonight I’m feeling stroke symptoms, hence why I’m watching Dr. Marks. The other night, I was positive I was having a brain aneurism. Living a life of constant fear, worry, stress and major physical symptoms is just hell. I truly feel like my severe anxiety (fear & worry) is just going to take me out one day. By heart attack, stroke or brain bleed. My local ER department know me by name now. Because I’m in the ER between 3 or 4 nights a week because of “symptoms”. And I know there’s people out there that know exactly what this is like, but escaping from this hell feels like the impossible. I have watched a million self help videos, the anxiety guy, meditation and relaxation videos, and I’m still living in this hell. And nobody in my life understands it, but I love the people on the Internet that get it.
    I’m a stay at home mom, that’s my only job and obligation in life. My husband works two jobs and is always gone. I feel like he should be more stressed than me because he has more responsibilities. Like 10 times the responsibilities I have. After all he does all the finances, plus watches over 50 sex offenders on his case load, plus all the children he sees in home as a quailed mental health professional. Yet I’m the one feeling like I’m dying every night of my life and can’t figure out why!?! I have two kids, 2 year old and a 4 year old. My 4 year old is developmentally delayed and can be quite taxing on the nerves at times, but nothing that I can blame this amount of stress on. Or anxiety or hypochondria. I tell my physiatrist how I feel, but I feel like he don’t believe me. Or he thinks I’m making it up. He put me on a whole slew of antidepressants, that have literally made everything 1000 times worse. I’m now 30lbs heavier, zero sex drive, plus can’t even have an orgasm the ONE TIME a month I do have sex. I feel worse about myself than ever, none of my clothes fit and honestly I prefer not to look in the mirror at all anymore. I have aged Drastically over the last few years and all I see when I do look in the mirror is dark circles under my eyes because I can’t sleep a wink hardly. And all of this just hit me at once. Like I was trucking through life fine as dandelion wine, then one day I woke up and had panic and anxiety. No traumatic event. No clue why I have all these fears and worries out of no where. Maybe just the stress of everyday life and managing my home and kids just caught up with me. After all I am a little bit of a neat freak or “perfectionist” as my husband calls it. But u can’t keep a perfect house and life with two toddlers, u just can’t. It took me a while to figure that out. I’ve had to learn how to let things go and prioritize task, and when ur pretty much OCD, it’s hard to let them things go.
    One more thing. So this one week about 6 months ago I convinced myself (all in one weeks time) I had ring worm, lock jaw, and tetanus from rusty earrings. I went to the ER 3 separate times over these illnesses. NOT ONE of them proven to be true. Well, at the end of that very long week my husband asked me for sex and I said “I can’t even believe u want to have sex after all considered this week! The ringworm, lock jaw and tetanus…” he literally Burst out laughing so hard and so did I because I realized at that point just how ridiculous that statement was. And how ridiculous it was to think I literally had all that non-sense. Sometimes it really is hilarious when I look back and think about all the “illnesses” but it’s never funny at the time u think u have them! But yeah, we look back and laugh A LOT at my made up disorders.

  • With the NHS in the state it’s in, the chances of being referred for total hip replacement are slim indeed. I am in a position now where the hip replacement I had nearly 10 years ago now is starting to wear out and my mobility is greatly reduced and I feel like my hip will give way every so often. My g.p. knows all this, but has yet to get me referred, despite my asking.

  • Dr. Tracey Having bipolar at age 60, the last five years I have felt more and more achy and my muscles feel like they are filled with concrete and are tight and painful to press on. I usually walk daily (unless I’m in one of my depressive phases). The exercise seems to have no effect on alleviating my soreness. I have seen several specialists who can’t find anything “wrong” with me. So is the discomfort all in my head?

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