in this video we are going to talk about folate deficiency. which is important topic to discuss. what causes folate deficiency, clinical symptoms of folate deficiency, pathophysiology of folate deficiency, use of folate, diagnosis of folate deficiency, treatment of folate deficiency.. this video is made for medical students and those trying for board exams such as USMLE, NEEt-PG, MCI.
Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/. With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep…. Disclaimer: I use affiliate links….. ►Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/… Check out my brand new “Electrolytes” course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. ► Right Now! You can get access to all my hand-written hematology video notes (the notes that I use on my videos) on Patreon…There is a direct link through which you can view, download, print and enjoy! Go to https://www.patreon.com/medicosis I have discussed Folate deficiency as well as Vitamin B12 deficiency before in separate videos.. This is a series on “anemia”, go to my playlist named: “hematology/oncology”.. RDW is elevated in both Vitamin B12 deficiency as well as in folate deficiency.. My FAVORITE BOOK to study Pathology and pathophysiology for step 1 USMLE is Goljan, you can check it out here: https://goo.gl/9ojg6M. My favorite book for internal medicine is Harrison’s, check it out here: http://amzn.to/2A7UEdj. My favorite book for surgery is this one, which contains notes and vignettes of Dr. Pestana, here: https://goo.gl/UdDGHq. My favorite book for Ob.GYN is Hacker and Moore: https://goo.gl/umFsjc. For a review book for USMLE step 1, check First Aid here: http://amzn.to/2zOU7w2. For a review book to study USMLE step 2CK, I recommend: http://amzn.to/2iI6zue. For a review book to study USMLE step 2CS, check http://amzn.to/2z24RtR. Check this pharmacology book, really easy to read, and inexpensive: Pharmacology made incredibly easy: https://goo.gl/or3DzB. If you would like a good pharmacology textbook, try Lippincott illustrated: https://goo.gl/PYEUP2. (Disclaimer: The medical information contained herein is intended for physician medical licensing exam review purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention.). Disclaimer: these links are affiliate links, so that I get paid a percentage of the sale, to support the channel, however, the customer is not affected as they pay the same price.. Get ready for your USMLE, NCLEX or COMLEX. Click the Subscribe button to get new videos every week.. To watch all my Hematology videos, check out this playlist: https://www.youtube.com/playlist?list=PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU. Like my page on Facebook:. https://www.facebook.com/medicosis/. Follow us on twitter: https://www.twitter.com/medicosis. Follow us on instagram here: https://www.instagram.com/medicosisperfectionalis/. -My website will launch next year, so stay tuned…. My dream is to do white board classroom teaching, audio podcast and live online webinars. But, I need your support to do this.. To help support me and keep my videos available on youtube, visit me on Patreon,https://www.patreon.com/medicosis. The funniest thing is that I have a playlist containing only mnemonics, yes, MEDICAL MNEMONICS, here: https://www.youtube.com/playlist?list=PLYcLrRDaR8_c4yXU3bwjIUNUk7C684ngd If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/. ► Visit my website: https://www.medicosisperfectionalis.com/ My Favorite Productivity App: https://airtable.com/invite/r/2zH40fus/
At 19 minute 40 seconds: Please note the CORRECTION.. Methylmalonate and homocysteine levels are elevated in cobalamin deficiency whereas in folate deficiency only homocysteine levels is elevated but methylmalonate is normal.. In this video I’m explaining one of the most important and high yiled concept that is to differentiate between folate and cobalamin deficiency. Both the deficiencies leads to megaloblastic anemia and macrocytic RBCs but the clinical sigens and laboratory test can differentiate both the deficiencies. While explaining that I have also briefly explained the causes for deficiency of folate and cobalamin like overcooking of greens, pernicious anemia, folate trap.. Link for my folate trap is video is as below.. https://www.youtube.com/watch?v=xG52KGiRPFM. Link for one of my video explaining the question on cobalamin and folate deficiency. https://www.youtube.com/watch?v=pMCSGSiULE8. Video link where I’m explaining a question on homocysteinemia. https://www.youtube.com/watch?v=5of5jeOCFJc. You Can Subscribe to my Channel for REGULAR UPDATES by clicking on SUBSCRIBE button above! You can follow me on my BLOG by clicking the link below. http://drmungli.blogspot.com/. You can follow my Facebook page Biochemistry Made Easy by Dr Prakash Mungli, MD by clicking the link below. Here I post USMLE step-1 style MCQs and you can participate in discussion.. https://www.facebook.com/drmungli
Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/. With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep…. Disclaimer: I use affiliate links….. ►Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/… Check out my brand new “Electrolytes” course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. ► Right Now! You can get access to all my hand-written hematology video notes (the notes that I use on my videos) on Patreon…There is a direct link through which you can view, download, print and enjoy! Go to https://www.patreon.com/medicosis If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/. ► Visit my website: https://www.medicosisperfectionalis.com/ My Favorite Productivity App: https://airtable.com/invite/r/2zH40fus/
Lesson on Folate Deficiency: In-Depth Overview of the Causes, Pathogenesis, Signs and Symptoms, Diagnosis and Treatment. Folate (or Vitamin B9) is an essential water soluble vitamin that is necessary for red blood cell development and maintenance, due to it being required in nucleic acid synthesis. There are several categories of causes of folate deficiency including reduced dietary intake, malabsorption, impaired metabolism, and increased utilization. In this lesson, we discuss in detail the many causes within each of these categories. We also discuss the classic signs and symptoms of folate deficiency, the characteristic findings on laboratory investigations, how to diagnose and what we do to treat folate deficiency. We also discuss why folate is important during pregnancy, specifically with regards to neural tube development.. I hope you find this lesson helpful. If you do, please consider liking, subscribing and clicking the notification bell to help support the channel.. Please help support this channel and future lessons by donating (and get some cool stuff) ➜ https://www.patreon.com/jjmedicine. *Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1. -- Try Audible and Get A Free Audiobook. https://www.amazon.com/dp/B00NB86OYE/?_encoding=UTF8&ref_=sv_adbl_subnav_ref1_1. For books and more information on these topics. https://www.amazon.com/shop/jjmedicine. Check out the best tool to help grow your YouTube channel (it’s helped me!). https://www.tubebuddy.com/jjmedicine. Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine. Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/. -- Check out some of my other lessons.. Medical Terminology The Basics Lesson 1: https://www.youtube.com/watch?v=04Wh2E9oNug. Fatty Acid Synthesis Pathway: https://www.youtube.com/watch?v=WuQS_LpNMzo. Wnt/B Catenin Signaling Pathway:. https://www.youtube.com/watch?v=NGVP4J9jpgs. Upper vs. Lower Motor Neuron Lesions: https://www.youtube.com/watch?v=itNd74V53ng. Lesson on the Purine Synthesis and Salvage Pathway: https://www.youtube.com/watch?v=e2KFVvI8Akk. Gastrulation | Formation of Germ Layers: https://www.youtube.com/watch?v=d6Kkn0SECJ4. Introductory lesson on Autophagy (Macroautophagy): https://www.youtube.com/watch?v=UmSVKzHc5yA. Infectious Disease Playlist. https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b. Dermatology Playlist. https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW. Pharmacology Playlist. https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR. Hematology Playlist. https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju. Rheumatology Playlist. https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle. Endocrinology Playlist. https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP. Nephrology Playlist. https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8. -- **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.. -- *Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*. I am always looking for ways to improve my lessons! Please don’t hesitate to leave me feedback and comments all of your feedback is greatly appreciated!:) And please don’t hesitate to send me any messages if you need any help I will try my best to be here to help you guys:). Thanks for watching! If you found this video helpful, please like and subscribe!. JJ
What is folate deficiency? Folate deficiency is a clinical condition that occurs because of low level of folate or folic acid in the body.. Find our complete video library only on Osmosis Prime: http://osms.it/more.. Hundreds of thousands of current & future clinicians learn by Osmosis. We have unparalleled tools and materials to prepare you to succeed in school, on board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more.. Subscribe to our Youtube channel at http://osms.it/subscribe.. Get early access to our upcoming video releases, practice questions, giveaways, and more when you follow us on social media: Facebook: http://osms.it/facebook. Twitter: http://osms.it/twitter. Instagram: http://osms.it/instagram. Our Vision: Everyone who cares for someone will learn by Osmosis.. Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: http://osms.it/mission. Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis’s properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
The symptoms of folate deficiency are often subtle. They include: fatigue; gray hair; mouth sores; tongue swelling; growth problems; The symptoms of anemia that occur due to. Keep in mind that adults need about 400 micrograms daily, and children need roughly 300 micrograms.
Here are nine common signs that you might be suffering from a folate deficiency: Poor immune function; frequently getting sick Chronic low energy (including chronic fatigue syndrome). The cells in your mouth and those of your skin turn over frequently, notes Armul, so it’s also common to see the first signs of folate deficiency with the following: Shallow sores in your mouth. There are some instances in which an individual’s body does not properly absorb the vitamin as it should, which can also lead to a nutritional deficiency. What are signs of deficiency? • Weakness • Depression • Mental confusion, feelings of being disoriented • Appetite changes • Dizziness and fatigue.
What are the symptoms of folic acid deficiency anemia? any kind of anemia can cause problems like:* fatigue* lack of energy* feeling short of breath* headaches* pale skin* racing heart* weight. Heavy bleeding can also lead to anemia. Foods rich in folic acid include citrus fruits, leafy green vegetables, and fortified cereals.
Some people have trouble absorbing folic acid from food. To check for folate deficiency anemia, your doctor will ask you about your symptoms. He might also order blood tests and a complete blood count (CBC) test to measure the number and appearance of. Common folic acid deficiency symptoms can include a loss of appetite, weakness and fatigue, irritability, and difficulty concentrating. There are a number of steps which people can take to reduce their risks of developing these folic acid deficiency symptoms.
Some of these symptoms can also happen in people who have a vitamin B12 deficiency but have not developed anaemia. Symptoms of folate deficiency. Additional symptoms in people with anaemia caused by a folate deficiency can include: symptoms related to anaemia. reduced sense of taste. Most folate-deficiency anemia is caused by a lack of folic acid in the diet.
Leafy vegetables, citrus fruits, beans, and whole grains are natural sources of folic acid. Folate-deficiency anemia in pregnancy may cause a neural tube defect.
List of related literature:
Folic acid deficiency anemia gradually produces many signs and symptoms characteristic of other megaloblastic anemias, including anorexia, fainting, progressive fatigue, forgetfulness, glossitis, headache, irritability, slight jaundice, nausea, pallor, palpitations, shortness of breath, and weakness.
The symptoms are variable and may include tiredness and malaise (often in conjunction with anemia), diarrhea, steatorrhea, abdominal pain or bloating, weight loss, mouth ulcers, osteoporosis, and neurologic symptoms from pregnancy, the most common folate, presentation B6, or B12 is deficiency.
In addition to anemia, other symptoms of folic acid deficiency include fatigue, pallor, headaches, palpitations, diarrhea, depression, and a swollen, red tongue.
Folic acid deficiency may lead to megaloblastic anemia, diarrhea (macrocytic enterocytes), glossitis, neural tube defects in newborns (maternal folic acid deficiency in the first 2 weeks of pregnancy), and increased risk of colorectal cancer and cardiovascular disease.
Consequences of inadequate intake are compounded when there is an increased folate requirement, such as during pregnancy, lactation, premature birth, and chronic hemolytic anemias, for example, sickle cell anemia and thalassemias (see Chapter 32).
Folate deficiency impairs cell division and protein biosynthesis; symptoms include megaloblastic anaemia, digestive system problems (heartburn, diarrhoea and constipation), suppression of the immune system, glossitis and problems with the nervous system (depression, fainting, fatigue, mental confusion).
Over 95% of macrocytic anaemias are secondary to acquired deficiencies of folate or vitamin B12, but many IEM of vitamin B12 and folate metabolism also present with macrocytic anaemia (with the notable exception of MTHFR deficiency) (7 Chapter 27) and one thiamine transporter deficiency (7 Chapter 28).
I think the beauty of your video is you try to help us remember things, which unlike many professors I know who are just trying to show you how smart they are, listing out facts after facts in their lectures.
Hi! Can you help me with something? I have to little folate (5), my mcv is 95, b-evf 0.44 but my hemoglobin is 14. So this means i dont have anemia right?
Woow. Now everything that I had to learn by heart in medschool I can understand it now very clearly. Thank you so much Osmosis, you are helpful even in holidays
Thanks, but I have problem with stomach, I have bloated stomach, dry skin, dry scalp along with extensive dandruff and much more..which vitamin B could be. When up my diary consumption o feel better. But I am tired of diary, any suggestion?
I love Osmosis videos in general but more often than not I feel they go into too much detail on specific and not useful information, as exemplified in this video, where all these enzymes, sub-products and precursors are explained without having any clear use in clinical practice and even in medical exams. I feel like there are many other points you guys could better cover instead of focusing on these minor details, like how to choose treatments, drug doses or important considerations.
Hi again! I was wondering how come this video and B12 are not part of the Biochemisty playlist? It took me a few mins to realize these B12 and Folate videos were made in 2017, not in 2020, like the playlist. I was waiting for Vitamin C, K, etc etc, I’m sure you have them around too.
A 12 years old girls was seen by her physician. Her chief complaints were shortness of breath, muscle weakness, abnormal paleness of the skin, glossitis (swollen tongue), loss of appetite/weight loss, diarrhea, nausea, fast heartbeat. The relevant lab results were as follows: Peripheral Blood Picture: MCV 110 fl (77 to 93 fl) MCH 34 pg (27 to 32 pg) MCHC 24 g/dl (20 to 25 g/dl) Hb low RBC count reduced DLC Marked neutropenia, hyper segmented neutrophils RBC shows Macrocytosis, anisocytosis, poikilocytosis, polychromasia. What is your diagnosis?
What about vitamin b deficiencies for people genetic issues, such as mthfr c677t? In my area the are either a lot of doctors that don’t know what vitamins I should take or what I have seen online is wrong. I know there are so many factors to consider, but what type of doctor can give me the correct information?
Sir my husband as vitamins B12 and D3 difficiency… I was carrying at 13 weeks came to know baby was with anencephaly… reason may be those deficiency or no… so that I can plan for other baby…. pls sir pls reply…
hey, i’ve had this! it was a really terrible experience i was constantly exhausted and had terrible chest pain, it felt like i was constantly out of breath. i also got sores on my tongue that would last weeks. if you suspect you may have folate deficiency please don’t wait to see a doctor, it’ll save you a lot of pain!
I’m very impressed with your videos. Such a nice, clear explanation of a somewhat complex topic. Clarity, I find, is the most difficult thing to find in videos these days. Some people should absolutely not be making videos. But you sir are gold, very clear and precise. Thanks again, I’m not even a biology or medical student but I understand what you’re saying very clearly.
I think you missed a video in the playlist which should be before this one… i mean this video https://www.youtube.com/watch?v=llVs-eMa_E should be number 24 in the category Hematology/ Oncology and this one (Folate deficiency) should be number 25, am i right?
Thank you! What a great video 1 question, increase homocysteine leads to thrombosis, and thrompocytopenia leads to bleeding, so what is the final result?
Thank you so much for discussing the storage statistics. Have been watching so many videos on this subject and all give only cursory, regurgitated information without any understanding of the actual processes.
Thank you for such a good explanation! But, a small doubt. Can jaundice be caused because of folate deficiency as there can be ineffective erythropoiesis and destruction of erythroid progenitors?
How does a folate deficiency and a mutation in the MTHFR Gene, C677T strand, impact a persons development? I.e. more high risk for stroke, seizures, seizure disorder? Thank you!
Hai… I really admire the way you make us understand with your beautiful explaination and the graphic illustrations that will stick in our mind… I am request for microbiology video… please… thank you in advance… love you…
You are great! I have an exam today in two hours, and had 5 lectures of anemia that I couldn’t understand because our doctor is so bad at teaching.. yesterday I only studied from your videos and I really feel confident to take the test. Thank you so so much
Love your videos. Very best one’s pit there. The pictures are at the right speed & clarity that a severe brain dead tired anemic like myself can get clarity from. Keep up the great work.
Thromboembolism,atherosclerosis, marfanoid sign, mental retardation,lence dislocation downward and medial,stroke and CAD,in Marfan syndrome lens dislocation superior and temporal
Methyl cobalamin active vitamin B12 directly transfers its methyl group to homocysteine in order to form methionine! While methyl tetrahydrofolate transfers its methyl group to the resulting cobalamin to replenish the methyl cobalamin again! So in case of folate deficiency, methyl cobalamin will not be readily available to provide methyl groups to homocysteine molecules resulting in elevated serum levels of homocysteine! While vitamin B12 deficiency results in SECONDARY FOLATE DEFICIENCY due to impaired conversion of methyl tetrahydrofolate to tetrahydrofolate ; the active form of folate!
Sir my b12 is 296 pg/ml and vit D is 32 Ng/ml, both are low again after 6 months, Last i was diagoned with the same deficiency, even more lower, it got increased to 496 6 months back, now again reduced so suffering from huge huge hairfall…plz recommend me supplements, as i cant take injection during this pandemic..
One of my family doctor recommend me to take 15 mg folic acid twice a day in place of injections….m confused…plz plz help Sir
Can you explain a case (mine) in which there’s decreased Hb (10.7) and Hct (35.3), MCV is normal (84.9), WBCs normal (5.82), Platelets high (354), Serum Folate 9.9 (normal), Vitamin B12 normal (613), Ferritin 7. Symptoms are very heavy/painful periods, fatigue, foggy brain, sleep disturbances, anxiety, headaches, muscle pain, numbness/tingling/burning sensation in extremities.
thanks for the clear video and info! I just got informed i’m folic deficient, been losing weight for months no idea why, I consume plenty fruit and veg, and am a 33yr old male so not pregnant lol. Also diagnosed with ADHD last year and I am wondering how long and how much of an impact this hidden deficiency has been having on me. Doctors prescribed me with folic acid tablets, but I am fairly sure they’re ignoring the fact that I tell them I eat plenty of B vit foods and even take a regular B vit complex too…
I don’t understand why/how goat milk can decrease the intake of folate? By the way, these videos are very helpful even though I am a DVM student not an MD student. Because of that, I would really like to be able to tell future client owners what goat milk can do…
18 years old student came to his physician with the following symptoms Abnormal paleness or lack of color of the skin, Yellowish skin, eyes, and mouth (jaundice), Dark-colored urine, Fever, Weakness, Dizziness, Confusion. His lab finding is as follows: Hb Decreased Reticulocytes Increased 5 to 20% MCV Normal MCHC Increased Bone marrow Erythroid hyperplasia Coombs test Direct is positive RDW Increased Serum bilirubin Raised RBC Morphology Normochromic and normocytic What is your diagnosis?
You said methionine is an essential amino acid. But it can be formed from homocysteine by methylation reaction. So then how can methionine be essential if it’s produced by the body?
Hi. Thanks a lot. It’s always a pleasure to watch your videos.
Concerning the neurological symptoms, in fact, they are present in both folate and vitamin B12 deficiency. In folate deficiency: we often have depression, dementia, and less commonly, peripheral neuropathy and subacute combined degeneration of the spinal cord. In Vit B12 deficiency: all of these neurological symptoms are possible.
Check out these articles: https://www.ncbi.nlm.nih.gov/pubmed/24365361 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/485067 https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1753-4887.1996.tb03851.x
I think the beauty of your video is you try to help us remember things, which unlike many professors I know who are just trying to show you how smart they are, listing out facts after facts in their lectures.
Hi! Can you help me with something? I have to little folate (5), my mcv is 95, b-evf 0.44 but my hemoglobin is 14. So this means i dont have anemia right?
Woow. Now everything that I had to learn by heart in medschool I can understand it now very clearly. Thank you so much Osmosis, you are helpful even in holidays
Thanks, but I have problem with stomach, I have bloated stomach, dry skin, dry scalp along with extensive dandruff and much more..which vitamin B could be. When up my diary consumption o feel better. But I am tired of diary, any suggestion?
Your videos are great…but as a high school student I don’t understand…any ways to improve it?I’d like to learn more stuff from you!
I love Osmosis videos in general but more often than not I feel they go into too much detail on specific and not useful information, as exemplified in this video, where all these enzymes, sub-products and precursors are explained without having any clear use in clinical practice and even in medical exams. I feel like there are many other points you guys could better cover instead of focusing on these minor details, like how to choose treatments, drug doses or important considerations.
Hi again! I was wondering how come this video and B12 are not part of the Biochemisty playlist? It took me a few mins to realize these B12 and Folate videos were made in 2017, not in 2020, like the playlist. I was waiting for Vitamin C, K, etc etc, I’m sure you have them around too.
A 12 years old girls was seen by her physician. Her chief complaints were shortness of breath, muscle weakness, abnormal paleness of the skin, glossitis (swollen tongue), loss of appetite/weight loss, diarrhea, nausea, fast heartbeat. The relevant lab results were as follows: Peripheral Blood Picture: MCV 110 fl (77 to 93 fl) MCH 34 pg (27 to 32 pg) MCHC 24 g/dl (20 to 25 g/dl) Hb low RBC count reduced DLC Marked neutropenia, hyper segmented neutrophils RBC shows Macrocytosis, anisocytosis, poikilocytosis, polychromasia. What is your diagnosis?
What about vitamin b deficiencies for people genetic issues, such as mthfr c677t? In my area the are either a lot of doctors that don’t know what vitamins I should take or what I have seen online is wrong. I know there are so many factors to consider, but what type of doctor can give me the correct information?
Sir my husband as vitamins B12 and D3 difficiency… I was carrying at 13 weeks came to know baby was with anencephaly… reason may be those deficiency or no… so that I can plan for other baby…. pls sir pls reply…
Awesome, but I have a question if b12 deficiency can I give folate as well with b12 or should I wait for folate lab value to confirm it’s deficiency?
hey, i’ve had this! it was a really terrible experience i was constantly exhausted and had terrible chest pain, it felt like i was constantly out of breath. i also got sores on my tongue that would last weeks. if you suspect you may have folate deficiency please don’t wait to see a doctor, it’ll save you a lot of pain!
I’m very impressed with your videos. Such a nice, clear explanation of a somewhat complex topic. Clarity, I find, is the most difficult thing to find in videos these days. Some people should absolutely not be making videos. But you sir are gold, very clear and precise. Thanks again, I’m not even a biology or medical student but I understand what you’re saying very clearly.
I think you missed a video in the playlist which should be before this one… i mean this video https://www.youtube.com/watch?v=llVs-eMa_E should be number 24 in the category Hematology/ Oncology and this one (Folate deficiency) should be number 25, am i right?
Thank you! What a great video
1 question, increase homocysteine leads to thrombosis, and thrompocytopenia leads to bleeding, so what is the final result?
Thank you so much for discussing the storage statistics. Have been watching so many videos on this subject and all give only cursory, regurgitated information without any understanding of the actual processes.
Thank you for such a good explanation!
But, a small doubt. Can jaundice be caused because of folate deficiency as there can be ineffective erythropoiesis and destruction of erythroid progenitors?
How does a folate deficiency and a mutation in the MTHFR Gene, C677T strand, impact a persons development? I.e. more high risk for stroke, seizures, seizure disorder? Thank you!
Hai… I really admire the way you make us understand with your beautiful explaination and the graphic illustrations that will stick in our mind… I am request for microbiology video… please… thank you in advance… love you…
You are great! I have an exam today in two hours, and had 5 lectures of anemia that I couldn’t understand because our doctor is so bad at teaching.. yesterday I only studied from your videos and I really feel confident to take the test. Thank you so so much
Love your videos. Very best one’s pit there. The pictures are at the right speed & clarity that a severe brain dead tired anemic like myself can get clarity from. Keep up the great work.
Thank you for the explanation
My hemoglobin is 153 ( High)
Mcv is 82.5 (low)
Iron serum is 25.8 (high) this is my functional medicine ranges but i am confused what type of anemia do i have? Is it pernicious?
Thromboembolism,atherosclerosis, marfanoid sign, mental retardation,lence dislocation downward and medial,stroke and CAD,in Marfan syndrome lens dislocation superior and temporal
Methyl cobalamin active vitamin B12 directly transfers its methyl group to homocysteine in order to form methionine! While methyl tetrahydrofolate transfers its methyl group to the resulting cobalamin to replenish the methyl cobalamin again! So in case of folate deficiency, methyl cobalamin will not be readily available to provide methyl groups to homocysteine molecules resulting in elevated serum levels of homocysteine! While vitamin B12 deficiency results in SECONDARY FOLATE DEFICIENCY due to impaired conversion of methyl tetrahydrofolate to tetrahydrofolate ; the active form of folate!
Sir my b12 is 296 pg/ml and vit D is 32 Ng/ml, both are low again after 6 months,
Last i was diagoned with the same deficiency, even more lower, it got increased to 496 6 months back, now again reduced so suffering from huge huge hairfall…plz recommend me supplements, as i cant take injection during this pandemic..
One of my family doctor recommend me to take 15 mg folic acid twice a day in place of injections….m confused…plz plz help Sir
Can you explain a case (mine) in which there’s decreased Hb (10.7) and Hct (35.3), MCV is normal (84.9), WBCs normal (5.82), Platelets high (354), Serum Folate 9.9 (normal), Vitamin B12 normal (613), Ferritin 7. Symptoms are very heavy/painful periods, fatigue, foggy brain, sleep disturbances, anxiety, headaches, muscle pain, numbness/tingling/burning sensation in extremities.
thanks for the clear video and info! I just got informed i’m folic deficient, been losing weight for months no idea why, I consume plenty fruit and veg, and am a 33yr old male so not pregnant lol. Also diagnosed with ADHD last year and I am wondering how long and how much of an impact this hidden deficiency has been having on me. Doctors prescribed me with folic acid tablets, but I am fairly sure they’re ignoring the fact that I tell them I eat plenty of B vit foods and even take a regular B vit complex too…
I don’t understand why/how goat milk can decrease the intake of folate? By the way, these videos are very helpful even though I am a DVM student not an MD student. Because of that, I would really like to be able to tell future client owners what goat milk can do…
18 years old student came to his physician with the following symptoms Abnormal paleness or lack of color of the skin, Yellowish skin, eyes, and mouth (jaundice), Dark-colored urine, Fever, Weakness, Dizziness, Confusion. His lab finding is as follows: Hb Decreased Reticulocytes Increased 5 to 20% MCV Normal MCHC Increased Bone marrow Erythroid hyperplasia Coombs test Direct is positive RDW Increased Serum bilirubin Raised RBC Morphology Normochromic and normocytic What is your diagnosis?
You said methionine is an essential amino acid. But it can be formed from homocysteine by methylation reaction. So then how can methionine be essential if it’s produced by the body?
One mistake-
Homocysteine is converted to methionine with the help of enzyme-methionine synthase. U have said Homocysteine synthase
Hi. Thanks a lot. It’s always a pleasure to watch your videos.
Concerning the neurological symptoms, in fact, they are present in both folate and vitamin B12 deficiency.
In folate deficiency: we often have depression, dementia, and less commonly, peripheral neuropathy and subacute combined degeneration of the spinal cord.
In Vit B12 deficiency: all of these neurological symptoms are possible.
Check out these articles:
https://www.ncbi.nlm.nih.gov/pubmed/24365361
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/485067
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1753-4887.1996.tb03851.x