Folate Deficiency Signs and symptoms – What exactly are indications of Folate Deficiency


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The symptoms of folate deficiency are often subtle. They include: fatigue; gray hair; mouth sores; tongue swelling; growth problems; The symptoms of anemia that occur due to. Keep in mind that adults need about 400 micrograms daily, and children need roughly 300 micrograms.

Here are nine common signs that you might be suffering from a folate deficiency: Poor immune function; frequently getting sick Chronic low energy (including chronic fatigue syndrome). The cells in your mouth and those of your skin turn over frequently, notes Armul, so it’s also common to see the first signs of folate deficiency with the following: Shallow sores in your mouth. There are some instances in which an individual’s body does not properly absorb the vitamin as it should, which can also lead to a nutritional deficiency. What are signs of deficiency? • Weakness • Depression • Mental confusion, feelings of being disoriented • Appetite changes • Dizziness and fatigue.

What are the symptoms of folic acid deficiency anemia? any kind of anemia can cause problems like:* fatigue* lack of energy* feeling short of breath* headaches* pale skin* racing heart* weight. Heavy bleeding can also lead to anemia. Foods rich in folic acid include citrus fruits, leafy green vegetables, and fortified cereals.

Some people have trouble absorbing folic acid from food. To check for folate deficiency anemia, your doctor will ask you about your symptoms. He might also order blood tests and a complete blood count (CBC) test to measure the number and appearance of. Common folic acid deficiency symptoms can include a loss of appetite, weakness and fatigue, irritability, and difficulty concentrating. There are a number of steps which people can take to reduce their risks of developing these folic acid deficiency symptoms.

Some of these symptoms can also happen in people who have a vitamin B12 deficiency but have not developed anaemia. Symptoms of folate deficiency. Additional symptoms in people with anaemia caused by a folate deficiency can include: symptoms related to anaemia. reduced sense of taste. Most folate-deficiency anemia is caused by a lack of folic acid in the diet.

Leafy vegetables, citrus fruits, beans, and whole grains are natural sources of folic acid. Folate-deficiency anemia in pregnancy may cause a neural tube defect.

List of related literature:

Folic acid deficiency anemia gradually produces many signs and symptoms characteristic of other megaloblastic anemias, including anorexia, fainting, progressive fatigue, forgetfulness, glossitis, headache, irritability, slight jaundice, nausea, pallor, palpitations, shortness of breath, and weakness.

“Illustrated Manual of Nursing Practice” by Lippincott Williams & Wilkins
from Illustrated Manual of Nursing Practice
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The symptoms are variable and may include tiredness and malaise (often in conjunction with anemia), diarrhea, steatorrhea, abdominal pain or bloating, weight loss, mouth ulcers, osteoporosis, and neurologic symptoms from pregnancy, the most common folate, presentation B6, or B12 is deficiency.

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In addition to anemia, other symptoms of folic acid deficiency include fatigue, pallor, headaches, palpitations, diarrhea, depression, and a swollen, red tongue.

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Folic acid deficiency may lead to megaloblastic anemia, diarrhea (macrocytic enterocytes), glossitis, neural tube defects in newborns (maternal folic acid deficiency in the first 2 weeks of pregnancy), and increased risk of colorectal cancer and cardiovascular disease.

“Mayo Clinic Gastroenterology and Hepatology Board Review” by Stephen Hauser, William Sanchez
from Mayo Clinic Gastroenterology and Hepatology Board Review
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Oxford University Press, Incorporated, 2014

Consequences of inadequate intake are compounded when there is an increased folate requirement, such as during pregnancy, lactation, premature birth, and chronic hemolytic anemias, for example, sickle cell anemia and thalassemias (see Chapter 32).

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Decreased folic acid levels are seen in patients with folic acid deficiency anemia (megaloblastic anemia), hemolytic anemia, malnutrition, malabsorption syndrome, malignancy, liver disease, sprue, and celiac disease.

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Folate deficiency anemia causes fatigue, weakness, pallor, shortness of breath, palpitations, tachycardia upon exertion, glossitis, tiredness, lightheadedness, forgetfulness, difficulty in concentration, loss of appetite, weight loss, abdominal swelling, nausea, vomiting, diarrhea, headache, and agitation.

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Folate deficiency impairs cell division and protein biosynthesis; symptoms include megaloblastic anaemia, digestive system problems (heartburn, diarrhoea and constipation), suppression of the immune system, glossitis and problems with the nervous system (depression, fainting, fatigue, mental confusion).

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Springer International Publishing, 2015

Folic acid deficiency leads to macrocytic anemia, hypersegmented neutrophils, and in pregnancy, fetal neural tube defects (spina bifida occulta, meningocele, meningomyelocele).

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Over 95% of macrocytic anaemias are secondary to acquired deficiencies of folate or vitamin B12, but many IEM of vitamin B12 and folate metabolism also present with macrocytic anaemia (with the notable exception of MTHFR deficiency) (7 Chapter 27) and one thiamine transporter deficiency (7 Chapter 28).

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from Inborn Metabolic Diseases: Diagnosis and Treatment
by Jean-Marie Saudubray, Matthias R. Baumgartner, John H. Walter
Springer Berlin Heidelberg, 2016

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

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  • I think the beauty of your video is you try to help us remember things, which unlike many professors I know who are just trying to show you how smart they are, listing out facts after facts in their lectures.

  • Hi! Can you help me with something? I have to little folate (5), my mcv is 95, b-evf 0.44 but my hemoglobin is 14. So this means i dont have anemia right? ��

  • Woow. Now everything that I had to learn by heart in medschool I can understand it now very clearly. Thank you so much Osmosis, you are helpful even in holidays ��

  • Thanks, but I have problem with stomach, I have bloated stomach, dry skin, dry scalp along with extensive dandruff and much more..which vitamin B could be. When up my diary consumption o feel better. But I am tired of diary, any suggestion?

  • Your videos are great…but as a high school student I don’t understand…any ways to improve it?I’d like to learn more stuff from you!

  • I love Osmosis videos in general but more often than not I feel they go into too much detail on specific and not useful information, as exemplified in this video, where all these enzymes, sub-products and precursors are explained without having any clear use in clinical practice and even in medical exams. I feel like there are many other points you guys could better cover instead of focusing on these minor details, like how to choose treatments, drug doses or important considerations.

  • Hi again! I was wondering how come this video and B12 are not part of the Biochemisty playlist? It took me a few mins to realize these B12 and Folate videos were made in 2017, not in 2020, like the playlist. I was waiting for Vitamin C, K, etc etc, I’m sure you have them around too.

  • A 12 years old girls was seen by her physician. Her chief complaints were shortness of breath, muscle weakness, abnormal paleness of the skin, glossitis (swollen tongue), loss of appetite/weight loss, diarrhea, nausea, fast heartbeat. The relevant lab results were as follows: Peripheral Blood Picture: MCV 110 fl (77 to 93 fl) MCH 34 pg (27 to 32 pg) MCHC 24 g/dl (20 to 25 g/dl) Hb low RBC count reduced DLC Marked neutropenia, hyper segmented neutrophils RBC shows Macrocytosis, anisocytosis, poikilocytosis, polychromasia. What is your diagnosis?

  • What about vitamin b deficiencies for people genetic issues, such as mthfr c677t? In my area the are either a lot of doctors that don’t know what vitamins I should take or what I have seen online is wrong. I know there are so many factors to consider, but what type of doctor can give me the correct information?

  • Sir my husband as vitamins B12 and D3 difficiency… I was carrying at 13 weeks came to know baby was with anencephaly… reason may be those deficiency or no… so that I can plan for other baby…. pls sir pls reply… ��

  • Awesome, but I have a question if b12 deficiency can I give folate as well with b12 or should I wait for folate lab value to confirm it’s deficiency?

  • hey, i’ve had this! it was a really terrible experience i was constantly exhausted and had terrible chest pain, it felt like i was constantly out of breath. i also got sores on my tongue that would last weeks. if you suspect you may have folate deficiency please don’t wait to see a doctor, it’ll save you a lot of pain!