Folate Deficiency Signs and symptoms – What exactly are indications of Folate Deficiency


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The symptoms of folate deficiency are often subtle. They include: fatigue; gray hair; mouth sores; tongue swelling; growth problems; The symptoms of anemia that occur due to. Keep in mind that adults need about 400 micrograms daily, and children need roughly 300 micrograms.

Here are nine common signs that you might be suffering from a folate deficiency: Poor immune function; frequently getting sick Chronic low energy (including chronic fatigue syndrome). The cells in your mouth and those of your skin turn over frequently, notes Armul, so it’s also common to see the first signs of folate deficiency with the following: Shallow sores in your mouth. There are some instances in which an individual’s body does not properly absorb the vitamin as it should, which can also lead to a nutritional deficiency. What are signs of deficiency? • Weakness • Depression • Mental confusion, feelings of being disoriented • Appetite changes • Dizziness and fatigue.

What are the symptoms of folic acid deficiency anemia? any kind of anemia can cause problems like:* fatigue* lack of energy* feeling short of breath* headaches* pale skin* racing heart* weight. Heavy bleeding can also lead to anemia. Foods rich in folic acid include citrus fruits, leafy green vegetables, and fortified cereals.

Some people have trouble absorbing folic acid from food. To check for folate deficiency anemia, your doctor will ask you about your symptoms. He might also order blood tests and a complete blood count (CBC) test to measure the number and appearance of. Common folic acid deficiency symptoms can include a loss of appetite, weakness and fatigue, irritability, and difficulty concentrating. There are a number of steps which people can take to reduce their risks of developing these folic acid deficiency symptoms.

Some of these symptoms can also happen in people who have a vitamin B12 deficiency but have not developed anaemia. Symptoms of folate deficiency. Additional symptoms in people with anaemia caused by a folate deficiency can include: symptoms related to anaemia. reduced sense of taste. Most folate-deficiency anemia is caused by a lack of folic acid in the diet.

Leafy vegetables, citrus fruits, beans, and whole grains are natural sources of folic acid. Folate-deficiency anemia in pregnancy may cause a neural tube defect.

List of related literature:

Folic acid deficiency anemia gradually produces many signs and symptoms characteristic of other megaloblastic anemias, including anorexia, fainting, progressive fatigue, forgetfulness, glossitis, headache, irritability, slight jaundice, nausea, pallor, palpitations, shortness of breath, and weakness.

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The symptoms are variable and may include tiredness and malaise (often in conjunction with anemia), diarrhea, steatorrhea, abdominal pain or bloating, weight loss, mouth ulcers, osteoporosis, and neurologic symptoms from pregnancy, the most common folate, presentation B6, or B12 is deficiency.

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In addition to anemia, other symptoms of folic acid deficiency include fatigue, pallor, headaches, palpitations, diarrhea, depression, and a swollen, red tongue.

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Folic acid deficiency may lead to megaloblastic anemia, diarrhea (macrocytic enterocytes), glossitis, neural tube defects in newborns (maternal folic acid deficiency in the first 2 weeks of pregnancy), and increased risk of colorectal cancer and cardiovascular disease.

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from Mayo Clinic Gastroenterology and Hepatology Board Review
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Oxford University Press, Incorporated, 2014

Consequences of inadequate intake are compounded when there is an increased folate requirement, such as during pregnancy, lactation, premature birth, and chronic hemolytic anemias, for example, sickle cell anemia and thalassemias (see Chapter 32).

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Decreased folic acid levels are seen in patients with folic acid deficiency anemia (megaloblastic anemia), hemolytic anemia, malnutrition, malabsorption syndrome, malignancy, liver disease, sprue, and celiac disease.

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Folate deficiency anemia causes fatigue, weakness, pallor, shortness of breath, palpitations, tachycardia upon exertion, glossitis, tiredness, lightheadedness, forgetfulness, difficulty in concentration, loss of appetite, weight loss, abdominal swelling, nausea, vomiting, diarrhea, headache, and agitation.

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Folate deficiency impairs cell division and protein biosynthesis; symptoms include megaloblastic anaemia, digestive system problems (heartburn, diarrhoea and constipation), suppression of the immune system, glossitis and problems with the nervous system (depression, fainting, fatigue, mental confusion).

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Folic acid deficiency leads to macrocytic anemia, hypersegmented neutrophils, and in pregnancy, fetal neural tube defects (spina bifida occulta, meningocele, meningomyelocele).

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Over 95% of macrocytic anaemias are secondary to acquired deficiencies of folate or vitamin B12, but many IEM of vitamin B12 and folate metabolism also present with macrocytic anaemia (with the notable exception of MTHFR deficiency) (7 Chapter 27) and one thiamine transporter deficiency (7 Chapter 28).

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from Inborn Metabolic Diseases: Diagnosis and Treatment
by Jean-Marie Saudubray, Matthias R. Baumgartner, John H. Walter
Springer Berlin Heidelberg, 2016

Alexia Lewis RD

Registered Dietitian Nutritionist and Certified Heath Coach who believes life is better with science, humor, and beautiful, delicious, healthy food.

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  • I think the beauty of your video is you try to help us remember things, which unlike many professors I know who are just trying to show you how smart they are, listing out facts after facts in their lectures.

  • Hi! Can you help me with something? I have to little folate (5), my mcv is 95, b-evf 0.44 but my hemoglobin is 14. So this means i dont have anemia right? ��

  • Woow. Now everything that I had to learn by heart in medschool I can understand it now very clearly. Thank you so much Osmosis, you are helpful even in holidays ��

  • Thanks, but I have problem with stomach, I have bloated stomach, dry skin, dry scalp along with extensive dandruff and much more..which vitamin B could be. When up my diary consumption o feel better. But I am tired of diary, any suggestion?

  • Your videos are great…but as a high school student I don’t understand…any ways to improve it?I’d like to learn more stuff from you!

  • I love Osmosis videos in general but more often than not I feel they go into too much detail on specific and not useful information, as exemplified in this video, where all these enzymes, sub-products and precursors are explained without having any clear use in clinical practice and even in medical exams. I feel like there are many other points you guys could better cover instead of focusing on these minor details, like how to choose treatments, drug doses or important considerations.

  • Hi again! I was wondering how come this video and B12 are not part of the Biochemisty playlist? It took me a few mins to realize these B12 and Folate videos were made in 2017, not in 2020, like the playlist. I was waiting for Vitamin C, K, etc etc, I’m sure you have them around too.

  • A 12 years old girls was seen by her physician. Her chief complaints were shortness of breath, muscle weakness, abnormal paleness of the skin, glossitis (swollen tongue), loss of appetite/weight loss, diarrhea, nausea, fast heartbeat. The relevant lab results were as follows: Peripheral Blood Picture: MCV 110 fl (77 to 93 fl) MCH 34 pg (27 to 32 pg) MCHC 24 g/dl (20 to 25 g/dl) Hb low RBC count reduced DLC Marked neutropenia, hyper segmented neutrophils RBC shows Macrocytosis, anisocytosis, poikilocytosis, polychromasia. What is your diagnosis?

  • What about vitamin b deficiencies for people genetic issues, such as mthfr c677t? In my area the are either a lot of doctors that don’t know what vitamins I should take or what I have seen online is wrong. I know there are so many factors to consider, but what type of doctor can give me the correct information?

  • Sir my husband as vitamins B12 and D3 difficiency… I was carrying at 13 weeks came to know baby was with anencephaly… reason may be those deficiency or no… so that I can plan for other baby…. pls sir pls reply… ��

  • Awesome, but I have a question if b12 deficiency can I give folate as well with b12 or should I wait for folate lab value to confirm it’s deficiency?

  • hey, i’ve had this! it was a really terrible experience i was constantly exhausted and had terrible chest pain, it felt like i was constantly out of breath. i also got sores on my tongue that would last weeks. if you suspect you may have folate deficiency please don’t wait to see a doctor, it’ll save you a lot of pain!

  • I’m very impressed with your videos. Such a nice, clear explanation of a somewhat complex topic. Clarity, I find, is the most difficult thing to find in videos these days. Some people should absolutely not be making videos. But you sir are gold, very clear and precise. Thanks again, I’m not even a biology or medical student but I understand what you’re saying very clearly. ��

  • I think you missed a video in the playlist which should be before this one… i mean this video should be number 24 in the category Hematology/ Oncology and this one (Folate deficiency) should be number 25, am i right?

  • Thank you! What a great video ��
    1 question, increase homocysteine leads to thrombosis, and thrompocytopenia leads to bleeding, so what is the final result? ��

  • Thank you so much for discussing the storage statistics. Have been watching so many videos on this subject and all give only cursory, regurgitated information without any understanding of the actual processes.

  • Thank you for such a good explanation!
    But, a small doubt. Can jaundice be caused because of folate deficiency as there can be ineffective erythropoiesis and destruction of erythroid progenitors?

  • How does a folate deficiency and a mutation in the MTHFR Gene, C677T strand, impact a persons development? I.e. more high risk for stroke, seizures, seizure disorder? Thank you!

  • Hai… I really admire the way you make us understand with your beautiful explaination and the graphic illustrations that will stick in our mind… I am request for microbiology video… please… thank you in advance… love you…

  • You are great! I have an exam today in two hours, and had 5 lectures of anemia that I couldn’t understand because our doctor is so bad at teaching.. yesterday I only studied from your videos and I really feel confident to take the test. Thank you so so much ����

  • Love your videos. Very best one’s pit there. The pictures are at the right speed & clarity that a severe brain dead tired anemic like myself can get clarity from. Keep up the great work.

  • Thank you for the explanation

    My hemoglobin is 153 ( High)

    Mcv is 82.5 (low)

    Iron serum is 25.8 (high) this is my functional medicine ranges but i am confused what type of anemia do i have? Is it pernicious?

  • Thromboembolism,atherosclerosis, marfanoid sign, mental retardation,lence dislocation downward and medial,stroke and CAD,in Marfan syndrome lens dislocation superior and temporal

  • Methyl cobalamin active vitamin B12 directly transfers its methyl group to homocysteine in order to form methionine! While methyl tetrahydrofolate transfers its methyl group to the resulting cobalamin to replenish the methyl cobalamin again! So in case of folate deficiency, methyl cobalamin will not be readily available to provide methyl groups to homocysteine molecules resulting in elevated serum levels of homocysteine! While vitamin B12 deficiency results in SECONDARY FOLATE DEFICIENCY due to impaired conversion of methyl tetrahydrofolate to tetrahydrofolate ; the active form of folate!

  • Sir my b12 is 296 pg/ml and vit D is 32 Ng/ml, both are low again after 6 months,
    Last i was diagoned with the same deficiency, even more lower, it got increased to 496 6 months back, now again reduced so suffering from huge huge hairfall…plz recommend me supplements, as i cant take injection during this pandemic..

    One of my family doctor recommend me to take 15 mg folic acid twice a day in place of injections….m confused…plz plz help Sir��

  • Can you explain a case (mine) in which there’s decreased Hb (10.7) and Hct (35.3), MCV is normal (84.9), WBCs normal (5.82), Platelets high (354), Serum Folate 9.9 (normal), Vitamin B12 normal (613), Ferritin 7. Symptoms are very heavy/painful periods, fatigue, foggy brain, sleep disturbances, anxiety, headaches, muscle pain, numbness/tingling/burning sensation in extremities.

  • thanks for the clear video and info! I just got informed i’m folic deficient, been losing weight for months no idea why, I consume plenty fruit and veg, and am a 33yr old male so not pregnant lol. Also diagnosed with ADHD last year and I am wondering how long and how much of an impact this hidden deficiency has been having on me. Doctors prescribed me with folic acid tablets, but I am fairly sure they’re ignoring the fact that I tell them I eat plenty of B vit foods and even take a regular B vit complex too…

  • I don’t understand why/how goat milk can decrease the intake of folate? By the way, these videos are very helpful even though I am a DVM student not an MD student. Because of that, I would really like to be able to tell future client owners what goat milk can do…

  • 18 years old student came to his physician with the following symptoms Abnormal paleness or lack of color of the skin, Yellowish skin, eyes, and mouth (jaundice), Dark-colored urine, Fever, Weakness, Dizziness, Confusion. His lab finding is as follows: Hb Decreased Reticulocytes Increased 5 to 20% MCV Normal MCHC Increased Bone marrow Erythroid hyperplasia Coombs test Direct is positive RDW Increased Serum bilirubin Raised RBC Morphology Normochromic and normocytic What is your diagnosis?

  • You said methionine is an essential amino acid. But it can be formed from homocysteine by methylation reaction. So then how can methionine be essential if it’s produced by the body?

  • One mistake-
    Homocysteine is converted to methionine with the help of enzyme-methionine synthase. U have said Homocysteine synthase

  • Hi. Thanks a lot. It’s always a pleasure to watch your videos.

    Concerning the neurological symptoms, in fact, they are present in both folate and vitamin B12 deficiency.
    In folate deficiency: we often have depression, dementia, and less commonly, peripheral neuropathy and subacute combined degeneration of the spinal cord.
    In Vit B12 deficiency: all of these neurological symptoms are possible.

    Check out these articles: